WO1992008130A1 - Systeme de calibrage insensible a la temperature - Google Patents
Systeme de calibrage insensible a la temperature Download PDFInfo
- Publication number
- WO1992008130A1 WO1992008130A1 PCT/US1991/007917 US9107917W WO9208130A1 WO 1992008130 A1 WO1992008130 A1 WO 1992008130A1 US 9107917 W US9107917 W US 9107917W WO 9208130 A1 WO9208130 A1 WO 9208130A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- calibration system
- phase
- calibration
- partial pressure
- amount
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0006—Calibrating gas analysers
Definitions
- the present invention is directed generally to a multi-phase control or calibration system and, more particularly, to such a system exhibiting relatively constant partial pressures with respect to certain diverse dissolved gaseous species of interest in one or more liquid phases over a range of ambient temperatures.
- the preferred fluid consists of a first non-aqueous liquid phase containing an amount of dissolved oxygen (0 2 ) in which the partial pressure of 0 2 is relatively temperature insensitive over an ambient temperature range of interest, a second, aqueous phase, immiscible with the first phase and containing an amount of dissolved carbon dioxide (C0 2 ) and one or more solute species that provide temperature stability with respect to the partial pressure of C0 2 over the ambient temperature range of interest.
- the liquid phases are in equilibrium with a vapor phase.
- perfluorocarbons are completely fluorinated organic compounds in which all the carbon-bound hydrogen atoms are replaced with fluorine atoms. These materials have an unique combination of properties.
- the compounds are extremely non-polar and have essentially no solvent action. They are so chemically inert and have such high thermal stability that they can be mixed with almost any material without fear of any adverse reactive effect either upon other mixture components or upon the material itself.
- the compounds also have a relatively high boiling points and low pour points giving them a relatively wide liquid range. Many of these perfluorocarbon materials also have a high, relatively stable, oxygen solubility.
- Aqueous perfluorocarbon multi ⁇ phase emulsions have been proposed for applications which involve the need to carry or sense oxygen in the presence of carbon dioxide and/or where pH needs to be controlled or sensed.
- One such emulsion system is illustrated and described in U.S. Patent 4 722 904 to Feil.
- Other such systems are disclosed in Turner (U.S. Patent 4 001 142), Cormier, et al. (U.S. Patent Nos. 4 299 728 and 4 369 127) and Sorenson, et al. (U.S. Patent Nos. 4 116 336 and 4 151 108).
- These fluids typically comprise an aqueous emulsion of the organic oxygen carrier. Certain of these emulsions may contain surfactant materials, pH buffers and preservative materials.
- the aqueous phase and the perfluorocarbon phase are chemically compatible but completely immiscible. While the perfluorocarbon phase reversibly carries the oxygen of interest, the aqueous phase reversibly carries other constituents of interest such as carbon dioxide and hydrogen ions.
- control system contains a known partial pressure of oxygen and a known partial pressure of carbon dioxide and be of a known pH. Accordingly, the control system must be supplied in gas-tight, sealed ampules, or the like containing known amounts of ' dissolved oxygen and carbon dioxide species so that equilibrium partial pressures remain constant.
- a known or control substance can later be used to check the relative accuracy of an instrument utilized to measure 0 2 and C0 2 concentration and the pH of such substances as blood.
- the temperature sensitivity of the partial pressures of dissolved gases of interest has been greatly reduced.
- the accuracy of calibration system established at a filling temperature of 20°C, for example, will not be sacrificed by later removal at, for example, 30°C.
- the oxygen carrying solution phase is a solution of oxygen in one or more perfluorocarbon materials.
- the preferred perfluorocarbon materials include FC-43, FC-75, FC-77, and others, manufactured by and available from the 3M Company of St. Paul, Minnesota.
- the aqueous solution phase contains a specific amount of C0 2 complexing agents such as ethylene diamine, HC0 3 " , Ca ++ and OH " or other compounds which buffer the partial pressure of carbon dioxide (C0 2 ) in the aqueous solution to changes in temperature.
- An amount of a compatible pH buffer can also be employed to stabilize the solution with respect to acidity.
- the multi-phase control/calibration system of the invention is prepared under tightly controlled conditions and transferred to containers designed to accommodate the desired amount.
- the filled containers are provided with a sealed storage atmosphere which maintains the desired conditions in equilibrium during the shelf life of the system.
- This atmosphere typically contains sufficient oxygen and carbon dioxide in a mixture with one or more other gases inert to the system to maintain the desired amount of 0 2 and C0 2 species in the liquid phases of the system.
- the preferred range of 0 2 (p0 2 ) partial pressure with respect to the system is from about 10 to about 200 mm Hg and the preferred range of partial pressure for C0 2 (pC0 2 ) is from about 5 to 100 mm Hg.
- the preferred temperature range of temperature relative partial pressure insensitivity is about 20°C to about 30°C. It is also contemplated that various phase components can be used, if desired, to expand the ambient temperature range of relative partial pressure insensitivity beyond the range of 20°C to 30°C, if desired.
- the range 20° to 30°C represents the normal range of temperatures for an indoor conditioned space.
- the solution of the calibration system of the invention consist of a single aqueous phase containing, in addition to a C0 2 binding component or components, one or more solutes which reversibly bind 0 2 , such as copper ions, hemoglobin, and transition metal macromolecular complexing agents.
- solutes such as copper ions, hemoglobin, and transition metal macromolecular complexing agents.
- Solutions formulated in accordance with the invention should exhibit stable overall solubilities of the gases of interest over a range of ambient temperatures between about 20°C and 30°C. This means that calibration/control systems in impermeable containers which are filled under strictly controlled conditions at one temperature may be removed from a storage atmosphere at a different temperature and used with complete confidence.
- control solutions including those in which oxygen is carried by a perfluorocarbon in one phase and carbon dioxide is carried in a second aqueous solution phase of controlled pH which are used to calibrate biological sensors utilized to detect dissolved oxygen, carbon dioxide and acidity. Because of the inherent properties of these systems, it has always been assumed that the temperature limitation with respect to exposure was one which had to be accommodated and could not be overcome.
- the solutions or liquid phases in accordance with the invention are prepared under controlled conditions. Known amounts of the dissolved gases 0 2 and C0 2 are present in the phases as prepared. However, it may be months or even years before the system is actually used so that long-term stability is required. To preserve the integrity of the system over the shelf life of the product, the calibration system is sealed in an impermeable fluid tight container together with an amount of storage atmosphere which contains sufficient p0 2 and pC0 2 to maintian the amount of dissolved species in the liquids over time.
- the container may be a glass ampule, or the like, but is preferably a polymeric envelope or laminated pouch which may consist of several layers of metallic foil and polymeric materials which make the pouch impervious to atmosphere exchange with the environment.
- the calibration system of the present invention maintains its known p0 2 , pC0 2 and pH for the relatively shorter time required to perform the control or calibration procedure, regardless of the ambient temperature at which the breach occurs as long as that temperature is in the range of relative stability for the system, e.g., 20°C-30°C.
- the calibration system of the present invention can also function well as a control system for analytical instruments of the class normally employing such controls as periodic checks. Controls generally require somewhat less precision than calibration systems.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Un système de commande et/ou calibrage multiphase consiste en une première phase liquide non aqueuse contenant une quantité d'oxygène dissous (O2) dans laquelle la pression partielle de O2 est rendue relativement insensible à la température sur une plage de températures ambiantes d'intérêt, une seconde solution aqueuse immiscible avec la première phase de solution et contenant une quantité de bioxyde de carbone dissous (CO2) et une ou plusieurs espèces en solution qui procurent une stabilité à la température par rapport à la pression partielle de CO2 sur la plage des températures ambiantes d'intérêt. Les phases liquides sont en équilibre avec une phase vapeur et le système peut être isolé hermétiquement avec une atmosphère de stockage.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60466690A | 1990-10-26 | 1990-10-26 | |
US604,666 | 1990-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992008130A1 true WO1992008130A1 (fr) | 1992-05-14 |
Family
ID=24420510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1991/007917 WO1992008130A1 (fr) | 1990-10-26 | 1991-10-25 | Systeme de calibrage insensible a la temperature |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU9022191A (fr) |
CA (1) | CA2071540A1 (fr) |
WO (1) | WO1992008130A1 (fr) |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4126575A (en) * | 1977-11-22 | 1978-11-21 | Louderback Allan Lee | Blood control standard |
US4163734A (en) * | 1975-05-30 | 1979-08-07 | Radiometer A/S | Reference liquid for blood gas equipment |
US4279775A (en) * | 1979-12-31 | 1981-07-21 | Louderback Allan Lee | Blood gas control |
US4299728A (en) * | 1980-07-21 | 1981-11-10 | Instrumentation Laboratory Inc. | Blood gas control |
US4369127A (en) * | 1980-07-21 | 1983-01-18 | Instrumentation Laboratory Inc. | Blood gas control |
US4469792A (en) * | 1980-12-31 | 1984-09-04 | Allied Corporation | Blood gas calibration and control fluid utilizing stroma-free hemoglobin |
US4485174A (en) * | 1982-09-29 | 1984-11-27 | Instrumentation Laboratory Inc. | Hemoglobin-based blood gas control |
-
1991
- 1991-10-25 AU AU90221/91A patent/AU9022191A/en not_active Abandoned
- 1991-10-25 WO PCT/US1991/007917 patent/WO1992008130A1/fr active Application Filing
- 1991-10-26 CA CA 2071540 patent/CA2071540A1/fr not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4163734A (en) * | 1975-05-30 | 1979-08-07 | Radiometer A/S | Reference liquid for blood gas equipment |
US4126575A (en) * | 1977-11-22 | 1978-11-21 | Louderback Allan Lee | Blood control standard |
US4279775A (en) * | 1979-12-31 | 1981-07-21 | Louderback Allan Lee | Blood gas control |
US4299728A (en) * | 1980-07-21 | 1981-11-10 | Instrumentation Laboratory Inc. | Blood gas control |
US4369127A (en) * | 1980-07-21 | 1983-01-18 | Instrumentation Laboratory Inc. | Blood gas control |
US4469792A (en) * | 1980-12-31 | 1984-09-04 | Allied Corporation | Blood gas calibration and control fluid utilizing stroma-free hemoglobin |
US4485174A (en) * | 1982-09-29 | 1984-11-27 | Instrumentation Laboratory Inc. | Hemoglobin-based blood gas control |
Non-Patent Citations (1)
Title |
---|
M. WINDHOLZ et al., "The Merck Index", Tenth Edition, published by, MERCK & CO. INC. (NEW JERSEY), 1983, p. 549. * |
Also Published As
Publication number | Publication date |
---|---|
AU9022191A (en) | 1992-05-26 |
CA2071540A1 (fr) | 1992-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0705431B1 (fr) | Systeme de calibrage de fluide, stabilise en temperature | |
CA2143209C (fr) | Dispositif d'etalonnage, d'electrodes, par exemple | |
Emerson et al. | Accurate measurement of O2, N2, and Ar gases in water and the solubility of N2 | |
AU697326B2 (en) | Methods and apparatus for rapid equilibration of dissolved gas composition | |
US6196052B1 (en) | Piezoelectric gas sensing device for detection of a gas species a gaseous environment | |
AU2014242327A1 (en) | Humidity control system for wood products | |
US5231030A (en) | Temperature insensitive calibration system | |
WO1992008130A1 (fr) | Systeme de calibrage insensible a la temperature | |
Green | A redetermination of the solubility of oxygen in sea water and some thermodynamic implications of the solubility relations. | |
US4836673A (en) | Wavelength accuracy test solution and method | |
Erickson | The oxidation of water and inorganic nitrogen compounds by potassium ferrate (VI) | |
Maruyama et al. | The quantitative analysis of inhalational anaesthetics in forensic samples by gas chromatography/mass spectrometry/selected ion monitoring | |
GB2151784A (en) | Temperature indication | |
Schoene et al. | Determination of the solubility of vapours in polymers by automated headspace gas chromatography | |
AU710940B2 (en) | Methods and apparatus for rapid equilibration of dissolved gas composition | |
JPS61142443A (ja) | 亜硝酸イオンの検出方法および装置 | |
US4886965A (en) | Method for calibrating variable wavelength liquid chromatography detectors | |
Maharajh et al. | Thermodynamic solubility: properties of gas mixtures. Part 1.—Two component gas mixtures in water at 25° C | |
Piet et al. | METHOD 15" STATIC" HEAD-SPACE DETERMINATION OF VOLATILE ORGANIC HALOGEN COMPOUNDS IN WATER | |
Thompson et al. | Loss of carbon-14 and tritium from liquid scintillation counting vials | |
Dean | Physical aspects of Group V halide systems | |
Fries et al. | Direct radiometric measurement of vapor-liquid equilibria: Hydrogen sulfide-diethanolamine | |
Halling-Sørensen | Estimating parameters in ecotoxicology | |
Clark et al. | Mars aqueous chemistry experiment | |
Olson et al. | LOSS OF TRITIATED WATER DURING LIQUID SCINTILLATION COUNTING WITH SPECIAL REFERENCE TO POLYETHYLENE-FILM TUBES' |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 2071540 Country of ref document: CA |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU BR CA JP NO |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE |
|
122 | Ep: pct application non-entry in european phase |