WO1992004359A3 - Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof - Google Patents

Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof Download PDF

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Publication number
WO1992004359A3
WO1992004359A3 PCT/US1991/006458 US9106458W WO9204359A3 WO 1992004359 A3 WO1992004359 A3 WO 1992004359A3 US 9106458 W US9106458 W US 9106458W WO 9204359 A3 WO9204359 A3 WO 9204359A3
Authority
WO
WIPO (PCT)
Prior art keywords
monosaccharides
inflammatory activity
proliferation
compositions
inflammatory
Prior art date
Application number
PCT/US1991/006458
Other languages
French (fr)
Other versions
WO1992004359A2 (en
Inventor
Sundershan K Arora
Roy L Whistler
Albert V Thomas
Original Assignee
Greenwich Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greenwich Pharma filed Critical Greenwich Pharma
Priority to JP3515897A priority Critical patent/JPH06503813A/en
Publication of WO1992004359A2 publication Critical patent/WO1992004359A2/en
Publication of WO1992004359A3 publication Critical patent/WO1992004359A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Abstract

Derivatives of simple monosaccharides which exhibit anti-proliferative and/or anti-inflammatory activity and are useful for treating mammals having inflammatory disorders and/or autoimmune disorders. This invention also encompasses pharmaceutical compositions containing these compounds and methods of treating inflammatory and/or autoimmune disorders.
PCT/US1991/006458 1990-09-12 1991-09-12 Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof WO1992004359A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3515897A JPH06503813A (en) 1990-09-12 1991-09-12 Monosaccharides with antiproliferative and anti-inflammatory activity, compositions and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58154290A 1990-09-12 1990-09-12
US581,542 1990-09-12
US75781791A 1991-09-11 1991-09-11
US757,817 1991-09-11

Publications (2)

Publication Number Publication Date
WO1992004359A2 WO1992004359A2 (en) 1992-03-19
WO1992004359A3 true WO1992004359A3 (en) 1992-12-10

Family

ID=27078356

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/006458 WO1992004359A2 (en) 1990-09-12 1991-09-12 Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof

Country Status (7)

Country Link
EP (1) EP0548226A1 (en)
JP (1) JPH06503813A (en)
AU (1) AU8622991A (en)
CA (1) CA2091587A1 (en)
IE (1) IE913228A1 (en)
IL (1) IL99454A0 (en)
WO (1) WO1992004359A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360792A (en) * 1991-12-20 1994-11-01 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
FR2694753B1 (en) * 1992-07-09 1994-12-23 Picardie Jules Verne Universit Processes for the specific synthesis of new aminothioethers by substitution of hydroxylated sites on mono or polyhydroxylated molecules, products obtained by these processes and their applications.
US5432163A (en) * 1992-11-13 1995-07-11 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
AU7101994A (en) * 1993-06-11 1995-01-03 Boston Life Sciences, Inc. Immunomodulatory, anti-inflammatory, and anti-proliferative compounds: 5,6-dideoxy, 5-amino derivatives of idose and 6-deoxy, 6-amino derivatives of glucose
US20090048186A1 (en) * 2005-04-19 2009-02-19 Vishwajanani Jitendra Sattigeri Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents
US20080114031A1 (en) * 2006-03-29 2008-05-15 Sattigeri Viswajanani J Monosaccharide derivatives
US7790689B2 (en) 2006-05-30 2010-09-07 Ranbaxy Laboratories Limited Monosaccharide derivatives
US20080300196A1 (en) * 2006-10-03 2008-12-04 Ashwani Kumar Verma Monosaccharide derivatives

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2370753A1 (en) * 1976-11-16 1978-06-09 Bruzzese Tiberio GLUCOFURANNOSE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
FR2457300A1 (en) * 1979-05-23 1980-12-19 Hisamitsu Pharmaceutical Co NOVEL ALKYL-CETOHEXOPYRANOSIDES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
US4735934A (en) * 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
EP0379397A2 (en) * 1989-01-09 1990-07-25 Greenwich Pharmaceuticals Incorporated Derivatives of alpha, D-glucofuranose and intermediates for preparing these derivatives
EP0404136A2 (en) * 1989-06-22 1990-12-27 Greenwich Pharmaceuticals Incorporated 3,5,6-Substituted derivatives of 1,2-0-isopropylidene-a,D-glucofuranose and intermediates for preparing these derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2370753A1 (en) * 1976-11-16 1978-06-09 Bruzzese Tiberio GLUCOFURANNOSE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
FR2457300A1 (en) * 1979-05-23 1980-12-19 Hisamitsu Pharmaceutical Co NOVEL ALKYL-CETOHEXOPYRANOSIDES DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
US4735934A (en) * 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
EP0379397A2 (en) * 1989-01-09 1990-07-25 Greenwich Pharmaceuticals Incorporated Derivatives of alpha, D-glucofuranose and intermediates for preparing these derivatives
EP0404136A2 (en) * 1989-06-22 1990-12-27 Greenwich Pharmaceuticals Incorporated 3,5,6-Substituted derivatives of 1,2-0-isopropylidene-a,D-glucofuranose and intermediates for preparing these derivatives

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 78, no. 25, 25 June 1973, (Columbus, Ohio, US), R. NEUMANN et al.: "Browning reactions of N-substituted 6-aminoaldoses. 1.", see page 453, abstract no. 160029e, & Z. CHEM. 1973, 13(2), 58-9, see abstract *
Chemical Abstracts, vol. 78, no. 25, 25 June 1973, (Columbus, Ohio, US), R. NEUMANN et al.: "Browning reactions of N-substituted 6-aminoaldoses. 1.", see page 453, abstract no. 160029e, & Z. CHEM. 1973, vol. 13, no. 2, pages 58-59, see abstract *
Chemical Abstracts, vol. 99, no. 3, 18 July 1983, (Columbus, Ohio, US), A. YAGI et al.: "Studies on the constituents of Zizyphi fructus. IV. Isolation of an antiallergic component, ethyl alpha-D-fructofuranoside from ethanol extract of Zizyphi fructus", see page 28, abstract no. 16149k, & YAKUGAKU ZASSHI 1981, 101(8), 700-7, see abstract *
Collection Czechoslov. Chem. Commun., vol. 34, 1969, J. JARY et al.: "Amino sugars. XX. Synthesis of 3-amino- and 6-amino-deoxyhexoses, of the gluco and allo configuration", pages 1452-1458, see page 1455, compound Va; page 1457, compound XVa *
J. Chem. Soc., Perkin I, 1981, R. CORTES-GARCIA et al.: "Acetalatin of sucrose by acetal exchange with concomitant fissin of the glycosidic bond. Some new acetals of D-glucose and methyl alpha-D fructofuranoside", pages 3176-3181, see page 3180, column 2, lines 24-32, compound 7 *
J. Med. Chem., vol. 25, 1982, American Chemical Society, Y. HARAGUCHI et al.: "A specific inhibitor of IgE-antibody formation: n-pentyl beta-D-fructopyranoside", pages 1495-1499, see page 1495, paragraph 1; page 1496, tables I,II, compounds 1,2,13 *
J. Med. Chem., vol. 32, 1989, American Chemical Society, A.B. REITZ et al.: "Carbohydrate biguanides as potential hypoglycemic agents", pages 2110-2116, see page 2113, column 2, lines 30-54 *

Also Published As

Publication number Publication date
CA2091587A1 (en) 1992-03-13
WO1992004359A2 (en) 1992-03-19
IL99454A0 (en) 1992-08-18
IE913228A1 (en) 1992-02-25
JPH06503813A (en) 1994-04-28
AU8622991A (en) 1992-03-30
EP0548226A1 (en) 1993-06-30

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