WO1992004024A3 - Toxic agent protective compounds, compositions and method - Google Patents

Toxic agent protective compounds, compositions and method Download PDF

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Publication number
WO1992004024A3
WO1992004024A3 PCT/GB1991/001462 GB9101462W WO9204024A3 WO 1992004024 A3 WO1992004024 A3 WO 1992004024A3 GB 9101462 W GB9101462 W GB 9101462W WO 9204024 A3 WO9204024 A3 WO 9204024A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
compositions
electrophiles
electrophilic
toxic agent
Prior art date
Application number
PCT/GB1991/001462
Other languages
French (fr)
Other versions
WO1992004024A2 (en
Inventor
David Glyndwr Upshall
Ian William Lawston
Original Assignee
Secr Defence Brit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Secr Defence Brit filed Critical Secr Defence Brit
Priority to AU85255/91A priority Critical patent/AU652183B2/en
Priority to GB9300657A priority patent/GB2262446B/en
Publication of WO1992004024A2 publication Critical patent/WO1992004024A2/en
Publication of WO1992004024A3 publication Critical patent/WO1992004024A3/en
Priority to KR1019930700616A priority patent/KR930701995A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel and known compounds are identified which possess protective properties against the toxic effects of electrophilic agents upon human and/or animal bodies, and the use of these compounds for the production of compositions for the protection of such bodies against those electrophiles is particularly provided. The compounds and compositions are effective against topically or systemically administered agents which are themselves electrophiles or which are metabolised to produce electrophilic products in the body. A particularly advantageous aspect of the present invention lies in the application of these compounds and compositions as protectants against inhaled electrophiles and their precursors. Some radioprotectant activity against intracellularly produced electrophiles will be provided due to the ability of the compounds to raise intracellular cysteine levels.
PCT/GB1991/001462 1990-08-31 1991-08-30 Toxic agent protective compounds, compositions and method WO1992004024A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU85255/91A AU652183B2 (en) 1990-08-31 1991-08-30 Toxic agent protective compounds, compositions and method
GB9300657A GB2262446B (en) 1990-08-31 1991-08-30 Toxic agent protective cysteine esters
KR1019930700616A KR930701995A (en) 1990-08-31 1993-02-27 Toxic agent protective compound, composition and manufacturing method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909018994A GB9018994D0 (en) 1990-08-31 1990-08-31 Toxic agent protective compounds
GB9018994.5 1990-08-31

Publications (2)

Publication Number Publication Date
WO1992004024A2 WO1992004024A2 (en) 1992-03-19
WO1992004024A3 true WO1992004024A3 (en) 1992-05-14

Family

ID=10681421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1991/001462 WO1992004024A2 (en) 1990-08-31 1991-08-30 Toxic agent protective compounds, compositions and method

Country Status (7)

Country Link
EP (1) EP0546063A1 (en)
JP (1) JPH06500113A (en)
KR (1) KR930701995A (en)
AU (1) AU652183B2 (en)
CA (1) CA2089158A1 (en)
GB (2) GB9018994D0 (en)
WO (1) WO1992004024A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711757D0 (en) * 1997-06-07 1997-08-06 Secr Defence Protective compositions
GB0520872D0 (en) * 2005-10-14 2005-11-23 Hofmann Thomas F Onion flavour compounds and use
US10881633B2 (en) 2015-01-13 2021-01-05 Case Western Reserve University Compositions and methods for stimulating ventilatory and/or respiratory drive
US10080732B2 (en) 2015-01-13 2018-09-25 Case Western Reserve University Compositions and methods for stimulating ventilatory and/or respiratory drive

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1114313A (en) * 1964-11-19 1968-05-22 Wyeth John & Brother Ltd Pharmaceutical compositions
JPS4538714B1 (en) * 1969-02-21 1970-12-07
JPS499598A (en) * 1972-05-24 1974-01-28
JPS5829303B2 (en) * 1972-08-21 1983-06-22 ウェルファイド株式会社 Cysteine availability
JPS49135942A (en) * 1973-05-14 1974-12-27
JPH0713011B2 (en) * 1985-09-13 1995-02-15 理研化学工業株式会社 Liver disease treatment agent
IL98310A (en) * 1990-06-08 1996-08-04 Astra Ab Pharmaceutical compositions comprising cystine derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Biochemical Pharmacology, vol. 27, no. 24, 1978, P. MOLDEUS: "Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse", pages 2859-2863, see entire document *
Chemical & Pharmaceutical Bulletin, vol. 20, no. 4, April 1972, S. AKABOSHI et al.: "Radiation protection by oral administration of L-cysteine ethyl ester hydrochloride in mice", pages 721-724, see entire document *
Chemical Abstracts, vol. 82, no. 23, 9 June 1975, (Columbus, Ohio, US), see page 652, abstract no. 156722r, & JP,A,74135942 (YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD) 27 December 1974, see the abstract *
Chemical Abstracts, vol. 82, no. 9, 3 March 1975, (Columbus, Ohio, US), see abstract no. 58109b, & JP,A,7495958 (YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD) 11 September 1974, see the abstract *
Folia Pharmacol. Japon, vol. 82, no. 1, K. GOTO et al: "Cysteine ethylester hydrochloride (Cystanin), pages 27-35, see the English abstract *

Also Published As

Publication number Publication date
GB2262446A (en) 1993-06-23
KR930701995A (en) 1993-09-08
GB9018994D0 (en) 1990-10-17
AU8525591A (en) 1992-03-30
CA2089158A1 (en) 1992-03-01
EP0546063A1 (en) 1993-06-16
WO1992004024A2 (en) 1992-03-19
GB2262446B (en) 1995-03-15
AU652183B2 (en) 1994-08-18
GB9300657D0 (en) 1993-04-14
JPH06500113A (en) 1994-01-06

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