WO1992004014A3 - Regulation de la proliferation de cellules neoplasiques par l'intermediaire d'un nouveau recepteur 5ht1a - Google Patents

Regulation de la proliferation de cellules neoplasiques par l'intermediaire d'un nouveau recepteur 5ht1a Download PDF

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Publication number
WO1992004014A3
WO1992004014A3 PCT/US1991/006175 US9106175W WO9204014A3 WO 1992004014 A3 WO1992004014 A3 WO 1992004014A3 US 9106175 W US9106175 W US 9106175W WO 9204014 A3 WO9204014 A3 WO 9204014A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
regulation
novel
neoplastic cell
5ht1a receptor
Prior art date
Application number
PCT/US1991/006175
Other languages
English (en)
Other versions
WO1992004014A2 (fr
Inventor
Thomas Martin Aune
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Publication of WO1992004014A2 publication Critical patent/WO1992004014A2/fr
Publication of WO1992004014A3 publication Critical patent/WO1992004014A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Procédé de régulation de la prolifération de cellules néoplasiques présentant un récepteur 5HT1a, consistant à introduire une quantité suffisante d'agonistes ou d'antagonistes pour accroître ou réduire la prolifération cellulaire. La prolifération cellulaire peut être régulée (1) par l'intermédiaire du récepteur 5HT et/ou (2) par l'intermédiaire de l'inhibition de la synthèse de la sérotonine.
PCT/US1991/006175 1990-09-04 1991-09-04 Regulation de la proliferation de cellules neoplasiques par l'intermediaire d'un nouveau recepteur 5ht1a WO1992004014A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57871090A 1990-09-04 1990-09-04
US578,710 1990-09-04

Publications (2)

Publication Number Publication Date
WO1992004014A2 WO1992004014A2 (fr) 1992-03-19
WO1992004014A3 true WO1992004014A3 (fr) 1992-05-14

Family

ID=24313971

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1991/006176 WO1992004015A2 (fr) 1990-09-04 1991-09-04 REGULATION DE LA PROLIFERATION DE LYMPHOCYTES T VIA UN NOUVEAU RECEPTEUR, LE 5HT1a
PCT/US1991/006175 WO1992004014A2 (fr) 1990-09-04 1991-09-04 Regulation de la proliferation de cellules neoplasiques par l'intermediaire d'un nouveau recepteur 5ht1a

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1991/006176 WO1992004015A2 (fr) 1990-09-04 1991-09-04 REGULATION DE LA PROLIFERATION DE LYMPHOCYTES T VIA UN NOUVEAU RECEPTEUR, LE 5HT1a

Country Status (5)

Country Link
EP (2) EP0547172A1 (fr)
JP (2) JPH06503816A (fr)
AU (2) AU8499891A (fr)
CA (2) CA2090688A1 (fr)
WO (2) WO1992004015A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409932A (en) * 1993-12-09 1995-04-25 Bayer Ag Piperazine-substituted pyrroloanthracenes
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
US5411960A (en) * 1993-12-09 1995-05-02 Bayer Aktiengesellschaft Substituted pyrroloanthracenes and -diones
WO1996001106A1 (fr) * 1994-07-06 1996-01-18 Bo Arne Hofmann Emploi d'agents pharmaceutiques pour attenuer ou traiter la dysfonction immunitaire liee a l'infection par le vih ou des virus associes
AU2880595A (en) * 1994-07-06 1996-01-25 Bo Arne Hofmann Use of pharmaceutical agents for restoring, alleviation, or treatment of immunodeficiency, including the alleviation or treatment of the immune dysfunction related to infection with human immunodeficiency viruses (hiv) or related viruses
EP0813878B1 (fr) * 1996-06-17 2002-02-06 Mitsubishi Chemical Corporation Agent pour accélérer la lacrimation contenant un ligand de la sérotonine, particuliérement un composé aminoalkoxybibenzyle
US6979447B2 (en) 2001-03-30 2005-12-27 Philadelphia Health And Education Corporation Immunomodulation and effect on cell processes relating to serotonin family receptors
CA2681267C (fr) 2007-04-13 2013-11-19 Southern Research Institute Agents anti-angiogeniques et procedes d'utilisation
CN113599370B (zh) * 2021-08-03 2023-12-08 复旦大学附属肿瘤医院 8-oh-dpat及其衍生物在制备抗肿瘤药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002527A1 (fr) * 1989-08-21 1991-03-07 Beth Israel Hospital Association Procede et composition de traitement d'hypersensibilite cutanee, oculaire et des muqueuses, d'etats inflammatoires et hyperproliferatifs en utilisant des preparations topiques d'antagonistes de serotonine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002527A1 (fr) * 1989-08-21 1991-03-07 Beth Israel Hospital Association Procede et composition de traitement d'hypersensibilite cutanee, oculaire et des muqueuses, d'etats inflammatoires et hyperproliferatifs en utilisant des preparations topiques d'antagonistes de serotonine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cancer Research, vol. 48, no. 15, 1 August 1988, (Philadelphia, US), T. MANDA et al.: "Important role of serotonin in the antitumor effects of recombinant human tumor necrosis factor-alpha in mice", pages 4250-4255, see the abstract *
European Journal of Pharmacology, vol. 170, no. 1/2, October 1989, (Amsterdam, NL), M.R. PRANZATELLI et al.: "Identification of 5-HT1A recognition sites in human ganglioneuroblastoma", pages 127-128, see the whole document *
Nature, vol. 335, 22 September 1988, (London, GB), A. FARGIN et al.: "The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor", pages 358-360, see page 359, right-hand column, lines 1-14; figure 4; table 1 (cited in the application) *
New England Journal of Medicine, vol. 277, no. 21, 1967, (Boston, US), K. ENGELMAN et al.: "Inhibition of serotonin synthesis by para-chlorophenylalanine in patients with the carcinoid syndrome", pages 1103-1108, see the abstract *
Proceedings of the National Academy of Sciences of USA, vol. 81, no. 6, March 1984, (Washington, DC, US), P. DANNIES et al.: "Spiperone: Evidence for uptake into secretory granules", pages 1867-1870, see the whole document *
The Merck Index, 11th edition (Eds. S. BUDAVARI et al.), 1989, Merck & Co., Rahway, NJ, US, see no 6097. Mianserin; no. 8707. Spiperone *

Also Published As

Publication number Publication date
CA2090688A1 (fr) 1992-03-05
WO1992004015A2 (fr) 1992-03-19
EP0555231A1 (fr) 1993-08-18
JPH06503816A (ja) 1994-04-28
EP0547172A1 (fr) 1993-06-23
WO1992004015A3 (fr) 1992-04-16
AU8848291A (en) 1992-03-30
CA2090689A1 (fr) 1992-03-05
AU8499891A (en) 1992-03-30
WO1992004014A2 (fr) 1992-03-19
JPH06500775A (ja) 1994-01-27

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