WO1992003475A1 - Enterovirus peptides - Google Patents
Enterovirus peptides Download PDFInfo
- Publication number
- WO1992003475A1 WO1992003475A1 PCT/SE1991/000542 SE9100542W WO9203475A1 WO 1992003475 A1 WO1992003475 A1 WO 1992003475A1 SE 9100542 W SE9100542 W SE 9100542W WO 9203475 A1 WO9203475 A1 WO 9203475A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thr
- val
- ala
- gly
- amino acid
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 66
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 44
- 241000709661 Enterovirus Species 0.000 title claims description 13
- 239000000427 antigen Substances 0.000 claims abstract description 51
- 102000036639 antigens Human genes 0.000 claims abstract description 51
- 108091007433 antigens Proteins 0.000 claims abstract description 51
- 241000709664 Picornaviridae Species 0.000 claims abstract description 40
- 241000710831 Flavivirus Species 0.000 claims abstract description 39
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims abstract description 32
- 201000010099 disease Diseases 0.000 claims abstract description 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 32
- 229960005486 vaccine Drugs 0.000 claims abstract description 15
- 208000015181 infectious disease Diseases 0.000 claims abstract description 13
- 238000003745 diagnosis Methods 0.000 claims description 27
- 210000002966 serum Anatomy 0.000 claims description 24
- 238000003018 immunoassay Methods 0.000 claims description 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 16
- 125000000539 amino acid group Chemical group 0.000 claims description 16
- 239000000126 substance Substances 0.000 claims description 16
- 230000001154 acute effect Effects 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 8
- 229920005989 resin Polymers 0.000 claims description 8
- 238000003556 assay Methods 0.000 claims description 7
- 230000000405 serological effect Effects 0.000 claims description 7
- 238000012360 testing method Methods 0.000 claims description 7
- 208000005155 Picornaviridae Infections Diseases 0.000 claims description 6
- 230000000890 antigenic effect Effects 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 241000991587 Enterovirus C Species 0.000 claims description 5
- 206010054261 Flavivirus infection Diseases 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 238000003127 radioimmunoassay Methods 0.000 claims description 4
- 241000709687 Coxsackievirus Species 0.000 claims description 3
- 241000725619 Dengue virus Species 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 238000003119 immunoblot Methods 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 2
- 241000710772 Yellow fever virus Species 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- -1 microplate Polymers 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
- 229940051021 yellow-fever virus Drugs 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- LQRJAEQXMSMEDP-XCHBZYMASA-N peptide a Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C/C=1C=CC=CC=1)C(N)=O)C(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C\C1=CC=CC=C1 LQRJAEQXMSMEDP-XCHBZYMASA-N 0.000 claims 1
- 102100029905 DNA polymerase epsilon subunit 3 Human genes 0.000 description 27
- 101710104359 F protein Proteins 0.000 description 27
- 150000001413 amino acids Chemical class 0.000 description 13
- 230000009257 reactivity Effects 0.000 description 9
- 101710197658 Capsid protein VP1 Proteins 0.000 description 8
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 8
- 241000700605 Viruses Species 0.000 description 8
- 101710132601 Capsid protein Proteins 0.000 description 7
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 description 7
- 101710108545 Viral protein 1 Proteins 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 5
- 208000006740 Aseptic Meningitis Diseases 0.000 description 4
- 206010027201 Meningitis aseptic Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000000295 complement effect Effects 0.000 description 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 3
- 206010014909 Enterovirus infection Diseases 0.000 description 3
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 3
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 3
- 241001144416 Picornavirales Species 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241001466953 Echovirus Species 0.000 description 2
- 101710091045 Envelope protein Proteins 0.000 description 2
- 108700010908 HIV-1 proteins Proteins 0.000 description 2
- 241000709721 Hepatovirus A Species 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 208000000474 Poliomyelitis Diseases 0.000 description 2
- 101710188315 Protein X Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 102100021696 Syncytin-1 Human genes 0.000 description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 206010014599 encephalitis Diseases 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
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- 238000011835 investigation Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 108091032955 Bacterial small RNA Proteins 0.000 description 1
- 235000011297 Brassica napobrassica Nutrition 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 241000709677 Coxsackievirus B1 Species 0.000 description 1
- 241000256113 Culicidae Species 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 241000710829 Dengue virus group Species 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 206010057199 Flaviviral infections Diseases 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000009525 Myocarditis Diseases 0.000 description 1
- 206010061308 Neonatal infection Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000003152 Yellow Fever Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 108091036078 conserved sequence Proteins 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 238000012850 discrimination method Methods 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 208000012022 enterovirus infectious disease Diseases 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 108010023958 glycyl-threonyl-alanyl-methionyl-arginyl-isoleucyl-leucyl-glycyl-glycyl-valyl-isoleucine Proteins 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 238000002255 vaccination Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32311—Enterovirus
- C12N2770/32322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32711—Rhinovirus
- C12N2770/32722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Definitions
- antigenic parts thereof as used herein means antigenic parts in the essential amino acid sequence between R 1 and R 2 in the peptides according to the present invention.
- the invention can be considered to belong to a previously unknown class of sequences having a common structure and function.
- the peptides can be used for diagnosing diseases caused by both picornavirus and flavivirus, the peptides can, because of their common origin, structure and function, however with a certain, appropriate
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU84002/91A AU649473B2 (en) | 1990-08-16 | 1991-08-16 | Enterovirus peptides |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9002671A SE470074B (en) | 1990-08-16 | 1990-08-16 | Method for diagnosis of picorene and / or flavivirus infection, peptides, diagnostic antigens and vaccine composition with these peptides |
SE9002671-7 | 1990-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1992003475A1 true WO1992003475A1 (en) | 1992-03-05 |
Family
ID=20380170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1991/000542 WO1992003475A1 (en) | 1990-08-16 | 1991-08-16 | Enterovirus peptides |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0546031A1 (en) |
AU (1) | AU649473B2 (en) |
SE (1) | SE470074B (en) |
WO (1) | WO1992003475A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689879B2 (en) | 1998-12-31 | 2004-02-10 | Chiron Corporation | Modified HIV Env polypeptides |
US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
US7282364B2 (en) | 2001-08-31 | 2007-10-16 | Novartis Vaccines And Diagnostics, Inc. | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
WO2014140166A2 (en) * | 2013-03-15 | 2014-09-18 | Glaxosmithkline Biologicals S.A. | Vaccine |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0106837A2 (en) * | 1982-10-05 | 1984-04-25 | IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte | Use of peptides |
WO1986006414A1 (en) * | 1985-04-29 | 1986-11-06 | Genetic Systems Corporation | Synthetic antigens for the detection of aids-related disease |
WO1988003032A1 (en) * | 1986-10-27 | 1988-05-05 | Fournier Maurielle J | Diagnosis of and vaccine for japanese encephalitis virus and related viruses |
EP0284791A1 (en) * | 1987-03-20 | 1988-10-05 | IMMUNO Aktiengesellschaft | DNA and RNA molecules of the western-subtype TBE virus, polypeptides coded by these molecules and their use |
US4810492A (en) * | 1986-06-05 | 1989-03-07 | The Research Foundation For Microbial Diseases Of Osaka University | Flavivirus antigen |
GB2209764A (en) * | 1987-09-16 | 1989-05-24 | Nippon Zeon Co | Recombinant vaccinia virus |
EP0358485A2 (en) * | 1988-09-08 | 1990-03-14 | The Wellcome Foundation Limited | Human rhinovirus peptides |
-
1990
- 1990-08-16 SE SE9002671A patent/SE470074B/en not_active IP Right Cessation
-
1991
- 1991-08-16 AU AU84002/91A patent/AU649473B2/en not_active Ceased
- 1991-08-16 EP EP91915656A patent/EP0546031A1/en not_active Withdrawn
- 1991-08-16 WO PCT/SE1991/000542 patent/WO1992003475A1/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0106837A2 (en) * | 1982-10-05 | 1984-04-25 | IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte | Use of peptides |
WO1986006414A1 (en) * | 1985-04-29 | 1986-11-06 | Genetic Systems Corporation | Synthetic antigens for the detection of aids-related disease |
US4810492A (en) * | 1986-06-05 | 1989-03-07 | The Research Foundation For Microbial Diseases Of Osaka University | Flavivirus antigen |
WO1988003032A1 (en) * | 1986-10-27 | 1988-05-05 | Fournier Maurielle J | Diagnosis of and vaccine for japanese encephalitis virus and related viruses |
EP0284791A1 (en) * | 1987-03-20 | 1988-10-05 | IMMUNO Aktiengesellschaft | DNA and RNA molecules of the western-subtype TBE virus, polypeptides coded by these molecules and their use |
GB2209764A (en) * | 1987-09-16 | 1989-05-24 | Nippon Zeon Co | Recombinant vaccinia virus |
EP0358485A2 (en) * | 1988-09-08 | 1990-03-14 | The Wellcome Foundation Limited | Human rhinovirus peptides |
Non-Patent Citations (21)
Title |
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Advances in veterinary science and comparative medicine, Vol. 33, 1989 J M HOGLE et al.: "Poliovirus: Three-dimensional Structure of a Viral Antigen", see page 65 - page 91, see in particular pages 72-73 and 80-81. * |
Aids, Vol. 3, No. 12, 1989 R B FERNS et al.: "Epitope location of 13 anti-gag HIV-1 monoclonal antibodies using oligopeptides and their cross reactivity with HIV-2", see page 829 - page 834, see table 3. * |
Am.J.Trop.Med.Hyg., Vol. 40, No. 6, 1989 B L INNIS et al.: "Identification of continuous epitopes of the envelope glycoprotein of dengue type 2 virus", see page 676 - page 687, see fig 1, hexapeptides 310-330 and Table 2, domain 17. * |
Arch Virol, Vol. 105, 1989 J.G. AASKOV et al.: "Serologically defined linear epitopes in the envelope protein of dengue 2", see page 209 - page 221; figure 1. * |
CHEMICAL ABSTRACTS, Volume 113, No. 19, 5 November 1990, (Columbus, Ohio, US), HINKULA J et al.: "Epitope mapping of the HIV-1 gag region with monoclonal antibodies", see page 519, Abstract 169943x, & Mol.Immunol. 1990, 27(5), 395-403. * |
Dialog Information Services, File 155, Medline 66-91, Dialog Accession No. 06304270, HALL RA et al.: "An enzyme immunoassay to detect Australian flaviviruses and indentify the encephalitic subgroup using monoclonal antibodies", Immunol Cell Biol Feb 1987, 65 (Pt 1) p 103-10. * |
Dialog Information Services, File 155, Medline 66-91, Dialog Accession No. 06323973, SRIVASTAVA AK et al.: "Antigenicity of Japanese encephalitis virus envelope glycoproteinV3 (E) and its cyanogen bromide cleaved fragments examined by monoclonal antibodies and western blotting", Arch Virol 1987, 96 (1-2) p * |
Dialog Information Services, File 155, Medline 66-91, Dialog Accession No. 07059248, KURANE I et al.: "Dengue virus-specific human T cell clones. Serotype crossreactive proliferation, interferon gamma production, and cytotoxic activity", J Exp Med Sep 1 1989, 170 (3) p 763-75. * |
Dialog Information Services, File 155, Medline 83-91, Dialog Accession No. 04796728, HEINZ FX et al.: "Monoclonal antibodies to the structural glycoprotein of tick-borne encephalitis virus", Infect Immun Sep 1982, 37 (3) p 869-74. * |
Immunology, Vol. 67, 1989 T. MATHIESEN et al.: "Mapping of IGG subclass and T-cell epitopes on HIV proteins by synthetic peptides", see page 453 - page 459, see page 455, peptides 29 and 30. * |
Infection and Immunity, Vol. 37, No. 3, 1982 FRANZ X. HEINZ et al.: "Monoclonal Antibodies to the Structural Glycoprotein of Tick-Borne Encephalitis Virus", see page 869 - page 874. * |
Journal of Acquired Immune Deficiency Syndromes, Vol. 4, 1989, B. WAHREN, et al.: "HIV-1 peptides induce a proliferative response in lymphocytes from infected persons", see page 448 - page 456, see page 449, peptide 30, table 2, peptides 235-237. * |
Journal of Virology, Vol. 63, No. 2, 1989 C W MANDL et al.: "Antigenic structure of the flavivirus envelope protein E at the molecular level, using tick-borne encephalitis virus as a model", see fig 1 and tables 2 and 3, fragment IRF1. * |
Journal of Virology, Vol. 63, No. 8, August 1989 M NIEDRIG et al.: "Epitope Mapping of Monoclonal Antibodies against Human Immunodeficiency Virus Type 1 Structural Proteins by Using Peptides", see page 3525 - page 3528, see table 1. * |
Journal of Virology, Vol. 64, No. 2, 1990 M ROIVAINEN et al.: "Improved distribution of Antigenic Site Specificity of Poliovirus-Neutralizing Antibodies Induced by a Protease-Cleaved Immunogen in Mice", see page 559 - page 562. * |
Journal of Virology, Vol. 64, No. 5, May 1990, C E FRICKS et al.: "Cell-Induced Conformational Change in Poliovirus:Externalization of the Amino Terminus of VPI Is Responsible for Liposome Binding", see page 1934 - page 1945, see page 1944, last paragraph. * |
Nature, Vol. 317, September 1985 M G ROSSMANN et al.: "Structure of a human common cold virus and functional relationship to other picornaviruses", see page 145 - page 153; figure 4. * |
Proc. Natl. Acad. Sci., Vol. 82, February 1985, M. CHOW et al.: "Synthetic peptides from four seprate regions of the poliovirus type 1 capsid protein VP1 induce neutralizing antibodies", see page 910 - page 914. * |
Virology, Vol. 174, 1990 A G PLETNEV et al.: "Nucleotide Sequence of the Genome and Complete Amino Acid Sequence of the Polyprotein of Tick-Borne Encephalitis Virus", see page 250 - page 263; figure 4. * |
Virology, Vol. 177, 1990 J T ROEHRIG et al.: "Antibodies to Dengue 2 Virus E-Glycoprotein Synthetic Peptides Identify Antigenic Conformation", see page 668 - page 675, see peptide 07 in tables 1 and 3. * |
Virology, Vol. 180, 1991 M ROIVAINEN et al.: "Antigenic Regions of Poliovirus Type 3/Sabin Capsid Proteins Recognized by Human Sera in the Peptide Scanning Technique", see page 99 - page 107, see in particular page 100 (peptides 13 and 14). * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689879B2 (en) | 1998-12-31 | 2004-02-10 | Chiron Corporation | Modified HIV Env polypeptides |
US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
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WO2014140166A3 (en) * | 2013-03-15 | 2014-11-20 | Glaxosmithkline Biologicals S.A. | Vaccine |
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Also Published As
Publication number | Publication date |
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SE9002671D0 (en) | 1990-08-16 |
AU8400291A (en) | 1992-03-17 |
SE470074B (en) | 1993-11-01 |
AU649473B2 (en) | 1994-05-26 |
SE9002671L (en) | 1992-02-17 |
EP0546031A1 (en) | 1993-06-16 |
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