WO1992003181A1 - Pompe centrifuge d'assistance de la fonction cardiaque - Google Patents

Pompe centrifuge d'assistance de la fonction cardiaque Download PDF

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Publication number
WO1992003181A1
WO1992003181A1 PCT/US1991/006049 US9106049W WO9203181A1 WO 1992003181 A1 WO1992003181 A1 WO 1992003181A1 US 9106049 W US9106049 W US 9106049W WO 9203181 A1 WO9203181 A1 WO 9203181A1
Authority
WO
WIPO (PCT)
Prior art keywords
impeller
chamber
pump
motor
blood
Prior art date
Application number
PCT/US1991/006049
Other languages
English (en)
Inventor
Louis Feldman
George P. Noon
Michael E. Debakey
Juan A. Fernandez
Original Assignee
Baylor College Of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Of Medicine filed Critical Baylor College Of Medicine
Publication of WO1992003181A1 publication Critical patent/WO1992003181A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/419—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being permanent magnetic, e.g. from a rotating magnetic coupling between driving and driven magnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/117—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body for assisting the heart, e.g. transcutaneous or external ventricular assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
    • A61M60/232—Centrifugal pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/35—Medical purposes thereof other than the enhancement of the cardiac output for specific surgeries, e.g. for Fontan procedure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
    • A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/804—Impellers
    • A61M60/806—Vanes or blades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/818—Bearings
    • A61M60/825—Contact bearings, e.g. ball-and-cup or pivot bearings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/827—Sealings between moving parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/871—Energy supply devices; Converters therefor
    • A61M60/876—Implantable batteries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/818—Bearings
    • A61M60/82—Magnetic bearings

Definitions

  • This invention relates to continuous delivery blood pumps.and more particularly a cardiac assist centrifugal blood pump that may be implanted in a body cavity or used extracorporeally.
  • Heart disease severe enough to require some means of cardiac support will affect tens of thousands of people a year.
  • the most effective treatment is cardiac transplantation, however, there is a large backlog of patients waiting for donor hearts because the number of potential recipients far outnumber donors. If the condition of these patients deteriorates before a donor heart becomes available, mechanical support systems must be used to keep the patients alive.
  • cardiac patients require a heart transplant.
  • cardiac patients who have some ventricular function but whose cardiac output is below that which will maintain sufficient blood circulation. These patients may function normally with a relatively small augmentation of their cardiac output. What is needed is a small, implantable, tether-free cardiac pumping device.
  • the present invention is a centrifugal pump that may be implanted in a cardiac patient's body to assist the heart in maintaining adequate blood circulation to sustain his life.
  • This invention has low power consumption and may be powered from portable batteries attached to the patient's body.
  • a patient not having sufficient cardiac circulation by his own heart, may function normally by means of the invention.
  • the pump system When pumping body fluids, especially blood, the pump system must be sterilizable to limit the risk of infection to the patient.
  • the materials used in the pump must not trigger the body's immunological defense system nor be adversely affected by corrosive elements normally found in the body. In dealing with blood, any device used must not destroy red blood cells (“hemolytic") or create blood clots
  • thrombogenetic In addition, small size, low power requirements and minimal heat generation are important features of any device that may be implanted in a cardiac patient's body and powered through the skin or by batteries. It is therefore an object of the present invention to provide a cardiac centrifugal pump including two separate chambers and an isolator, such as a wall, preventing liquids and gases from communicating between chambers.
  • One chamber houses part of a magnetic coupler and a pump impeller which propels the blood.
  • the second chamber contains a motor and the other part of the magnetic coupler.
  • Another object of the present invention is the use of a stabilizing pin to rotatably attach the impeller to the impeller chamber. Without this stabilizing pin the impeller would "float" in the blood in the chamber because there is no direct mechanical coupling between the impeller and the motor shaft. This floating action may make the impeller motion erratic and cause the spinning impeller to "lift” and hit the cover of the centrifugal pump housing with disastrous consequences. Thus, the stabilizing pin prevents irregular impeller motion within the impeller chamber. Irregular impeller motion within the impeller chamber may cause hemolysis.
  • Yet another object of the present invention is the use of a thin stainless steel sheet to stiffen the wall separating the impeller chamber from the motor chamber. The magnetic coupler requires close proximity for efficient operation, therefore, the distance between coupling magnets must be very short. Close spacing of the coupling magnets can only be reliably used when the rigidity and dimensional integrity of the isolator separating the two chambers is maintained.
  • Still another object of the present invention is the use of a face seal between the back of the impeller and the isolating wall face located in the impeller chamber.
  • Significant failures are caused in centrifugal pumps used in blood by clots forming in the impeller chamber.
  • the clot forms at the center of rotation where there is an area of low flow ("stasis").
  • the present invention uses a face seal to prevent blood from reaching the center of rotation of the stabilizing pin means.
  • the face seal consists of two parts, a stabilizing pin which has a flange and an ultra high molecular weight polyethylene disk or more preferably, a ceramic disk which rides on the raised rib, or more preferably an elastomer.
  • the disk may be press fitted into a cavity machined into the back of the impeller.
  • the integrity of this seal is maintained by the magnetic force keeping the two parts together, thus, making up for wear and improving the seal tolerances with use.
  • a second rib or elastomer may be placed between the first rib or elastomer and the shaft of the stabilizing pin.
  • Yet still another object of the present invention is the use of a nose cone on the front face of the impeller for gentler handling of blood as it flows onto the impeller blades. Blood is easily damaged and care in minimizing blood cell bruising will reduce hemolytic effects.
  • a further object of the present invention is the use of a motor with low temperature rise and materials of low friction coefficient so as to reduce the effects of heating. Blood exposed to temperatures of 45 degrees C will be hemolyzed. The present invention has not exceeded
  • Yet a further object of the present invention is implanting the pump in the abdominal cavity of the cardiac patient and using batteries to power the pump motor.
  • the batteries may be externally worn by the patient with electrical connections formed through the patient's skin.
  • the batteries may be internally mounted in the abdominal cavity and recharged by an inductive energy transfer means.
  • the patient's abdomen performs its intended function as a membrane seal without foreign objects protruding through it.
  • Still a further object of the present invention is to use the pump either internally or extracorporeally as a heart-lung machine during open heart surgery. Such uses are as a standby pump in cardiac catherization, retrieval of donor hearts from remote locations, and in cardiopulmonary bypass surgery in place of a roller pump.
  • the present invention is a cardiac assist centrifugal pump that may be implanted directly in a patient's body or used externally ("extracorporeally").
  • the present invention consists of a housing, a motor, an impeller, an inlet manifold including an inlet and an outlet.
  • the housing is divided into two chambers, one houses the motor and the other the impeller.
  • Magnetic coupler is used to transfer the rotational power of the motor to the impeller of the pump.
  • the impeller is rotatably attached to a wall of the impeller chamber, the wall located between the impeller and motor chambers, by a stabilizing pin. This stabilizing pin prevents irregular impeller motion which may cause hemolysis.
  • FIG. 1 is a side elevation view of a preferred embodiment of the present invention
  • FIG. 2 is a front elevation view of a preferred embodiment of the present invention
  • FIG. 3 is a view taken along the line 3-3 of FIG. 1;
  • FIG. 4 is a view taken along the line 4-4 of FIG. 2;
  • FIG. 5 is an exploded sectional view of a preferred embodiment of an impeller and pin assembly of the present invention.
  • FIG. 6 is an assembled sectional view of the impeller and pin assembly of FIG. 5.
  • the reference 10 generally indicates a cardiac assist centrifugal pump of the present invention that may be implanted in a patient's body or mounted extracorporeally.
  • the cardiac assist pump 10 comprises a housing 12 having an inlet 14, an inlet manifold 16, an outlet 18, an impeller chamber cover 20 and a motor chamber cover 22.
  • the covers 20 and 22 may be secured to the housing 12 by screws 24.
  • the housing 12 of the cardiac assist pump 10 has two chambers, an impeller chamber 30 and a motor chamber 32.
  • the chambers 30 and 32 are isolated from each other and do not allow the transmission of either liquids or gases between chambers. Normally, body fluids such as blood flows through the impeller chamber 30 entering at the inlet 14 and exiting at the outlet 18.
  • the motor chamber 32 is a gas and liquid tight housing for an electric motor 34.
  • the electric motor 34 comprises a stator 36 and a rotor 38.
  • the rotor 38 has magnets 40 fixedly attached thereto.
  • An impeller 42, in the impeller chamber 30, has magnets 44 imbedded therein.
  • the impeller magnets 44 are in close proximity with the rotor magnets 40 for the purpose of efficiently coupling the rotational energy of the motor 34 to the impeller 42.
  • the rotational energy of the motor 34 is transmitted to the impeller 42 by a magnetic coupler comprised of closely coupled magnets 40 and 44.
  • the impeller chamber 30 and the motor chamber 32 may be totally isolated from each other.
  • Integral to housing 12 is a thin wall 46 which separates the chambers 30 and 32.
  • the impeller 42 is attached to the wall 46 by a stabilizing pin assembly 48.
  • the wall 46 may be made, for example, from polycarbonate plastic laminated with a thin stainless steel sheet 50.
  • the stainless steel sheet 50 may be used to reinforce the wall 46.
  • the stabilizing pin assembly 48 prevents irregular motion of the impeller 42. Any irregular motion of the impeller 42 may cause hemolysis. If the impeller 42 was not position stabilized with respect to the impeller chamber 30, then the impeller 42 could float in the blood and hit the cover 20 with disastrous consequences.
  • the present invention accomplishes a stable positional relationship between the impeller 42, the cover 20 and impeller chamber 30 by using of the stabilizing pin assembly 48.
  • the pin assembly 48 is attached to the wall 46 which isolates the impeller chamber 30 from the motor chamber
  • the pin assembly 48 includes a machined stainless steel shaft 52 having upper and lower threaded ends 57 and 55, respectively, a thin flange 53 machined between both threaded ends 55 and 57, a disk 54, and ball bearing bushings 56.
  • the disk 54 may be made of ultra high molecular weight polyethylene or, more preferably, ceramic.
  • the outside diameter of the flange 53 matches the outside diameter of the disk 54.
  • the inside diameter of the disk 54 matches the outside diameter of the shaft 52 and fits rotatably over it.
  • the ball bearing bushings 56 fit rotatably over the shaft 52 and are secured thereto by a locking nut 58 on the upper threaded end 57.
  • the stabilizing pin assembly may be press fitted into a precisely machined cavity 60 in the back of the impeller 42.
  • the lower threaded end 55 is fixedly attached to the wall 46 and steel sheet 50 by a locking nut 59.
  • the bottom face of the flange 53 forms a seal in cooperation with the wall 46 and steel sheet 50.
  • the impeller 42 may freely rotate about the axis of the stabilizing pin 48 without lifting or otherwise adversely moving in the impeller chamber 30.
  • Prior art centrifugal pumps have failed due to blood clot formation. Blood clots form at the center of impeller rotation where there is an area of low flow ("stasis").
  • the present invention includes a face seal 62 which prevents blood from reaching the stabilizing pin assembly 48, thus, eliminating an area of possible stasis.
  • the face seal 62 is comprised of a raised rib or elastomer 64 located on the outer circumference of the top face of the flange 53 and the bottom face of the disk 54.
  • the disk 54 rides on the raised rib or, more preferably, an elastomer 64 creating a rotating seal that is further aided by the attractive magnetic forces between magnets 40 and 44.
  • a second rib or, more preferably, a second elastomer 65 may be placed between the first rib or elastomer 64 and the shaft of the stabilizing pin.
  • the elastomer are biolor or silicons O-rings.
  • the attractive magnetic forces will maintain the integrity of the face seal 62 by compensating for any wear of the raised rib 64 and disk 54 faces.
  • the impeller 42 front comprises, as a preferred embodiment, six vanes 70 and a nose cone 72.
  • the nose cone 72 allows the blood to gently flow across the face of the impeller 42 while being accelerated by the vanes 70.
  • Materials used in the impeller assembly of the present invention may be, for example, ultra high molecular weight polyethylene or, more preferably, ceramic. This material is blood compatible and has excellent abrasion resistant qualities.
  • the motor 34 may be, for example, an Inland Motor, DC brushless model BM 1501. This motor is small, light weight, adequate power and long life.
  • the pancake type geometry allows compact packaging in the motor chamber 32.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention se rapporte à une pompe centrifuge d'assistance de la fonction cardiaque (10), qui est utilisée pour le pompage de sang humain et qui peut être implantée par voie chirurgicale dans le corps d'un patient ou utilisée à l'extérieur du corps. Cette pompe (10) se compose de deux chambres (30, 32) qui sont isolées l'une de l'autre et dont l'une contient un moteur électrique (34) et l'autre un rotor (42). Le rotor (42) est fixé rotatif au fond de la chambre (30) qui la contient au moyen d'une broche de stabilisation (48), utilisée pour éliminer tout flottement et tout autre mouvement du rotor (42) qui risqueraient d'endommager les cellules sanguines. Un joint à anneau glissant (62) sert à empêcher la stagnation du sang dans les zones de faible écoulement du rotor (62), stagnation qui pourrait causer la formation de caillots sanguins. Un raccord magnétique (40 et 44) sert à transférer la puissance de rotation du moteur au rotor (42) et à contribuer à maintenir l'intégrité de l'étanchéité d'anneau glissant (62) lors d'une exploitation prolongée et continue de la pompe (10).
PCT/US1991/006049 1990-08-24 1991-08-23 Pompe centrifuge d'assistance de la fonction cardiaque WO1992003181A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57342590A 1990-08-24 1990-08-24
US573,425 1990-08-24

Publications (1)

Publication Number Publication Date
WO1992003181A1 true WO1992003181A1 (fr) 1992-03-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/006049 WO1992003181A1 (fr) 1990-08-24 1991-08-23 Pompe centrifuge d'assistance de la fonction cardiaque

Country Status (2)

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AU (1) AU8515791A (fr)
WO (1) WO1992003181A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004834A1 (fr) 1996-07-29 1998-02-05 Kyocera Corporation (Also Trading As Kyocera Kabushiki Kaisha) Pompe centrifuge pour le pompage du sang et d'autres liquides sensibles au cisaillement
EP0699447B1 (fr) * 1994-08-31 2001-11-14 Jostra AG Pompe à sang centrifuge
US8118724B2 (en) 2003-09-18 2012-02-21 Thoratec Corporation Rotary blood pump
WO2012034569A3 (fr) * 2010-09-18 2012-10-26 Juriqa Holding Aps Pompe à sang centrifuge portative
US9512852B2 (en) 2006-03-31 2016-12-06 Thoratec Corporation Rotary blood pump
CN107080870A (zh) * 2016-02-16 2017-08-22 上海微创医疗器械（集团）有限公司 血泵及心室辅助循环装置
CN107080871A (zh) * 2016-02-16 2017-08-22 上海微创医疗器械（集团）有限公司 导管鞘和心室辅助循环装置
CN107412892A (zh) * 2016-02-16 2017-12-01 上海微创医疗器械（集团）有限公司 导管鞘和心室辅助循环装置
WO2019173596A1 (fr) * 2018-03-09 2019-09-12 Boston Scientific Scimed, Inc. Coupleur magnétique pour scellement de rotor hémostatique
US10722631B2 (en) 2018-02-01 2020-07-28 Shifamed Holdings, Llc Intravascular blood pumps and methods of use and manufacture
US11185677B2 (en) 2017-06-07 2021-11-30 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en) 2017-11-13 2022-11-29 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US12102815B2 (en) 2019-09-25 2024-10-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible pump housings
US12121713B2 (en) 2020-09-25 2024-10-22 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3411450A (en) * 1967-03-07 1968-11-19 Little Giant Corp Pump
US3932068A (en) * 1966-10-04 1976-01-13 March Manufacturing Company Magnetically-coupled pump
US4226574A (en) * 1977-05-06 1980-10-07 Villette Guy J Magnetically driven pump

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932068A (en) * 1966-10-04 1976-01-13 March Manufacturing Company Magnetically-coupled pump
US3411450A (en) * 1967-03-07 1968-11-19 Little Giant Corp Pump
US4226574A (en) * 1977-05-06 1980-10-07 Villette Guy J Magnetically driven pump

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0699447B1 (fr) * 1994-08-31 2001-11-14 Jostra AG Pompe à sang centrifuge
US6155969A (en) * 1996-07-29 2000-12-05 Kyocera Corporation Centrifugal pump for pumping blood and other shear-sensitive liquids
WO1998004834A1 (fr) 1996-07-29 1998-02-05 Kyocera Corporation (Also Trading As Kyocera Kabushiki Kaisha) Pompe centrifuge pour le pompage du sang et d'autres liquides sensibles au cisaillement
US8118724B2 (en) 2003-09-18 2012-02-21 Thoratec Corporation Rotary blood pump
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