WO1992000759A3 - Complexes radiopharmaceutiques therapeutiques stabilises - Google Patents

Complexes radiopharmaceutiques therapeutiques stabilises Download PDF

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Publication number
WO1992000759A3
WO1992000759A3 PCT/US1991/004749 US9104749W WO9200759A3 WO 1992000759 A3 WO1992000759 A3 WO 1992000759A3 US 9104749 W US9104749 W US 9104749W WO 9200759 A3 WO9200759 A3 WO 9200759A3
Authority
WO
WIPO (PCT)
Prior art keywords
radionuclide
stable
therapeutic radiopharmaceutical
stabilized therapeutic
radiopharmaceutical complexes
Prior art date
Application number
PCT/US1991/004749
Other languages
English (en)
Other versions
WO1992000759A2 (fr
Inventor
Robert F Wolfangel
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Priority to EP91915301A priority Critical patent/EP0660722A1/fr
Priority to AU84242/91A priority patent/AU656915B2/en
Publication of WO1992000759A2 publication Critical patent/WO1992000759A2/fr
Publication of WO1992000759A3 publication Critical patent/WO1992000759A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procédé de préparation d'une composition radiopharmaceutique thérapeutique stable composée d'un radionuclide alpha ou bêta-radiateur et d'un ligand, en lyophilisant une solution dudit complexe. Le radionuclide a de préférence une demi-vie d'au moins douze heures. L'invention concerne également des compositions radiopharmaceutiques lyophilisées stables préparées selon ce procédé. Elle convient particulièrement à la préparation d'anticorps marqués par radionuclides sous une forme stable, qui requiert simplement une reconstitution au moment de l'usage.
PCT/US1991/004749 1990-07-09 1991-07-03 Complexes radiopharmaceutiques therapeutiques stabilises WO1992000759A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP91915301A EP0660722A1 (fr) 1990-07-09 1991-07-03 Complexes radiopharmaceutiques therapeutiques stabilises
AU84242/91A AU656915B2 (en) 1990-07-09 1991-07-03 Stabilized therapeutic radiopharmaceutical complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/549,981 US5219556A (en) 1990-07-09 1990-07-09 Stabilized therapeutic radiopharmaceutical complexes
US549,981 1990-07-09

Publications (2)

Publication Number Publication Date
WO1992000759A2 WO1992000759A2 (fr) 1992-01-23
WO1992000759A3 true WO1992000759A3 (fr) 1992-02-20

Family

ID=24195225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/004749 WO1992000759A2 (fr) 1990-07-09 1991-07-03 Complexes radiopharmaceutiques therapeutiques stabilises

Country Status (5)

Country Link
US (1) US5219556A (fr)
EP (1) EP0660722A1 (fr)
AU (1) AU656915B2 (fr)
CA (1) CA2087009A1 (fr)
WO (1) WO1992000759A2 (fr)

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MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
EP0600992B1 (fr) * 1991-08-29 2000-09-20 Mallinckrodt Medical, Inc. Utilisation de l'acide gentisique ou de l'alcool gentisyle pour stabiliser des peptides et proteines radiomarques
US20010055563A1 (en) 1999-09-09 2001-12-27 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
US6066309A (en) * 1996-02-02 2000-05-23 Rhomed Incorporated Post-labeling stabilization of radiolabeled proteins and peptides
JP2002514159A (ja) * 1996-06-24 2002-05-14 ザ・デュポン・マーク・ファーマシューティカル・カンパニー 新規放射性医薬組成物とマトリクスおよびそれらの使用
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
IL122094A (en) 1997-11-03 2003-07-06 Israel Atomic Energy Comm In situ-generated solid radiation source based on tungsten<188>/rhenium<188> and the use thereof
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
CA2371728C (fr) * 1999-06-11 2009-06-02 Neorx Corporation Complexe a forte dose de radionucleides destine a la suppression de la moelle osseuse
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE60041713D1 (de) 1999-11-30 2009-04-16 Scott Schenter Verfahren zur erzeugung von actinium-225 und töchtern
DE10016559A1 (de) * 2000-04-03 2001-10-18 Eucro Europe Contract Res Gmbh System für den Transport von Aktivstoffen in einem biologischen System
US20040254211A1 (en) * 2000-09-14 2004-12-16 Arison Byron H Alpha v integrin receptor antagonists
US20040082545A1 (en) * 2000-09-18 2004-04-29 Handreck Gregory Paul Diphosphonate solutions
EP1404376B1 (fr) * 2000-10-19 2009-10-14 Bracco Imaging SPA Formulations de produits radiopharmaceutiques
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) * 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) * 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
CA2526556C (fr) * 2003-07-24 2012-09-25 Bracco Imaging S.P.A. Compositions radiopharmaceutiques stables et methodes pour leur preparation
WO2006009894A1 (fr) * 2004-06-17 2006-01-26 Anazaohealth Corporation Agents radiopharmaceutiques stabilisés et lyophilisés pour détruire des tumeurs
US20070189965A1 (en) * 2004-06-17 2007-08-16 Kuperus John H Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
US7229603B2 (en) * 2004-06-17 2007-06-12 Anazaohealth Corporation Stablilized and lyophilized radiopharmaceutical agents
JP5264500B2 (ja) * 2005-12-22 2013-08-14 デューク ユニバーシティー 薬剤をα−粒子エミッターによって放射標識するための安定化組成物および方法
US20080206879A1 (en) * 2007-02-28 2008-08-28 The Lubrizol Corporation Analysis of Functional Fluids Using a Redox Indicator
CN113385118A (zh) * 2020-03-12 2021-09-14 益诺思生物技术海门有限公司 一种125i药物标记及纯化装置及其方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0081193A2 (fr) * 1981-12-03 1983-06-15 Nihon Medi-Physics Co., Ltd. Agent diagnostique radioactif stable et support non radioactif pour celui-ci
US4515766A (en) * 1980-06-23 1985-05-07 The Massachusetts General Hospital Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium
EP0164843A2 (fr) * 1984-06-04 1985-12-18 The Dow Chemical Company Complexes organiques d'acide aminophosphonique pour le traitement de tumeurs calcifiantes
EP0173424A1 (fr) * 1984-06-25 1986-03-05 University Of Utah Research Foundation Chélates de technétium radioactif marqués pour usage dans la détermination de la fonction rénale
EP0174853A2 (fr) * 1984-09-13 1986-03-19 Mallinckrodt, Inc. (a Delaware corporation) Fragments d'anticorps marqués
EP0196669A2 (fr) * 1985-04-03 1986-10-08 The Du Pont Merck Pharmaceutical Company Procédé de conjugaison de la métallothionéine avec des molécules biologiquement actives
EP0250966A1 (fr) * 1986-06-13 1988-01-07 University Of Cincinnati Procédé pour isoler et purifier des médicaments contenant du rhénium radioactif lié par coordination, leur usage et équipement

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US4062933A (en) * 1975-05-27 1977-12-13 Mallinckrodt, Inc. Colloidal compositions with protective agents suitable for radioactive labeling
USRE32417E (en) * 1979-10-29 1987-05-12 Summa Medical Corporation Radiolabeled antibody to anti-tumor associated antigen and process
US4341755A (en) * 1980-07-15 1982-07-27 Immuno Nuclear Corporation Parathyroid radioimmunoassay
US4485086A (en) * 1983-04-11 1984-11-27 Wong Dennis W Radiolabeled tumor imaging agent and method of preparation
US4636380A (en) * 1984-04-23 1987-01-13 Wong Dennis W Novel physiologic chemical method of labeling protein substances with the radionuclides of indium
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US5001072A (en) * 1984-05-23 1991-03-19 Icn Biomedicals Inc. Compositions and methods for multiple simultaneous immunoradiometric assay (IRMA) of analytes using radioisotope chelate labels
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
GB8510726D0 (en) * 1985-04-26 1985-06-26 Amersham Int Plc Stabilised radio-labelled compounds
US4778672A (en) * 1985-11-27 1988-10-18 University Of Cincinnati Method of isolating radioactive perrhenate or pertechnetate from an aqueous solution

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515766A (en) * 1980-06-23 1985-05-07 The Massachusetts General Hospital Labeled phosphonic acid compositions for investigations of in vivo deposits of calcium
EP0081193A2 (fr) * 1981-12-03 1983-06-15 Nihon Medi-Physics Co., Ltd. Agent diagnostique radioactif stable et support non radioactif pour celui-ci
EP0164843A2 (fr) * 1984-06-04 1985-12-18 The Dow Chemical Company Complexes organiques d'acide aminophosphonique pour le traitement de tumeurs calcifiantes
EP0173424A1 (fr) * 1984-06-25 1986-03-05 University Of Utah Research Foundation Chélates de technétium radioactif marqués pour usage dans la détermination de la fonction rénale
EP0174853A2 (fr) * 1984-09-13 1986-03-19 Mallinckrodt, Inc. (a Delaware corporation) Fragments d'anticorps marqués
EP0196669A2 (fr) * 1985-04-03 1986-10-08 The Du Pont Merck Pharmaceutical Company Procédé de conjugaison de la métallothionéine avec des molécules biologiquement actives
EP0250966A1 (fr) * 1986-06-13 1988-01-07 University Of Cincinnati Procédé pour isoler et purifier des médicaments contenant du rhénium radioactif lié par coordination, leur usage et équipement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. NUCL. MED., vol. 18, no. 5, 1977, (New York, US), B.W. WISTOW et al.: "An evaluation of 99mTc-labeled hepatobiliary agents", pages 455-461, see whole article (cited in the application) *

Also Published As

Publication number Publication date
AU8424291A (en) 1992-02-04
CA2087009A1 (fr) 1992-01-10
EP0660722A1 (fr) 1995-07-05
AU656915B2 (en) 1995-02-23
US5219556A (en) 1993-06-15
WO1992000759A2 (fr) 1992-01-23

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