WO1991018027A3 - Compounds - Google Patents

Compounds Download PDF

Info

Publication number
WO1991018027A3
WO1991018027A3 PCT/GB1991/000788 GB9100788W WO9118027A3 WO 1991018027 A3 WO1991018027 A3 WO 1991018027A3 GB 9100788 W GB9100788 W GB 9100788W WO 9118027 A3 WO9118027 A3 WO 9118027A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
therapy
lowering agents
cholesterol lowering
polymethacrylate polymers
Prior art date
Application number
PCT/GB1991/000788
Other languages
French (fr)
Other versions
WO1991018027A2 (en
Inventor
Gregory Martin Benson
Deirdre Mary Bernadette Hickey
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Priority to JP91509109A priority Critical patent/JPH05506880A/en
Publication of WO1991018027A2 publication Critical patent/WO1991018027A2/en
Publication of WO1991018027A3 publication Critical patent/WO1991018027A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Polymethacrylate polymers and their use in therapy as cholesterol lowering agents.
PCT/GB1991/000788 1990-05-21 1991-05-20 Compounds WO1991018027A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP91509109A JPH05506880A (en) 1990-05-21 1991-05-20 Compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909011332A GB9011332D0 (en) 1990-05-21 1990-05-21 Compounds
GB9011332.5 1990-05-21

Publications (2)

Publication Number Publication Date
WO1991018027A2 WO1991018027A2 (en) 1991-11-28
WO1991018027A3 true WO1991018027A3 (en) 1992-01-09

Family

ID=10676309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1991/000788 WO1991018027A2 (en) 1990-05-21 1991-05-20 Compounds

Country Status (5)

Country Link
EP (1) EP0530242A1 (en)
JP (1) JPH05506880A (en)
AU (1) AU7867491A (en)
GB (1) GB9011332D0 (en)
WO (1) WO1991018027A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE183924T1 (en) * 1992-01-14 1999-09-15 Hisamitsu Pharmaceutical Co CHOLESTEROL LEVEL LOWERING AGENT
US5800809A (en) * 1992-01-14 1998-09-01 Hisamitsu Pharmaceutical Co, Inc Non-crosslinked acrylic polymers and non-crosslinked anion exchange resins
US5556619A (en) * 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
MX9602812A (en) * 1994-01-18 1997-06-28 Du Pont Crosslinked polymeric ammonium salts.
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
FR2757866B1 (en) * 1996-12-30 2004-12-17 Catalyse POLYMERS COMPRISING QUATERNARY AMMONIUM GROUPS, THEIR USE FOR THE MANUFACTURE OF AN ANTIBACTERIAL PROPERTY MATERIAL AND THEIR PREPARATION METHODS
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
JP2006052236A (en) * 2002-07-30 2006-02-23 Yukio Nagasaki New compound having cholesterol-reducing activity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2843573A (en) * 1955-03-21 1958-07-15 Rohm & Haas New quaternary ammonium compounds in which the nitrogen atom carries an alkoxymethyl group
US3787474A (en) * 1969-09-12 1974-01-22 Inveresk Res Int Cross-linked polymers
US4393145A (en) * 1979-05-01 1983-07-12 Etablissement Texcontor Anionic ion exchange resins with cholesterol-decreasing properties
FR2528435A1 (en) * 1982-06-09 1983-12-16 Inst Francais Du Petrole Additive lowering middle distillate cloud pt. - is reaction prod. of polymerised unsaturated carboxylic acid or its ester with amine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2843573A (en) * 1955-03-21 1958-07-15 Rohm & Haas New quaternary ammonium compounds in which the nitrogen atom carries an alkoxymethyl group
US3787474A (en) * 1969-09-12 1974-01-22 Inveresk Res Int Cross-linked polymers
US4393145A (en) * 1979-05-01 1983-07-12 Etablissement Texcontor Anionic ion exchange resins with cholesterol-decreasing properties
FR2528435A1 (en) * 1982-06-09 1983-12-16 Inst Francais Du Petrole Additive lowering middle distillate cloud pt. - is reaction prod. of polymerised unsaturated carboxylic acid or its ester with amine

Also Published As

Publication number Publication date
WO1991018027A2 (en) 1991-11-28
JPH05506880A (en) 1993-10-07
GB9011332D0 (en) 1990-07-11
AU7867491A (en) 1991-12-10
EP0530242A1 (en) 1993-03-10

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