WO1991018027A2 - Compounds - Google Patents
Compounds Download PDFInfo
- Publication number
- WO1991018027A2 WO1991018027A2 PCT/GB1991/000788 GB9100788W WO9118027A2 WO 1991018027 A2 WO1991018027 A2 WO 1991018027A2 GB 9100788 W GB9100788 W GB 9100788W WO 9118027 A2 WO9118027 A2 WO 9118027A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymer
- alkyl
- substitute sheet
- polymers
- nitrogen atom
- Prior art date
Links
- 0 CC(C)(CN)*(O)=O Chemical compound CC(C)(CN)*(O)=O 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
- C08F8/32—Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP91509109A JPH05506880A (en) | 1990-05-21 | 1991-05-20 | Compound |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9011332.5 | 1990-05-21 | ||
GB909011332A GB9011332D0 (en) | 1990-05-21 | 1990-05-21 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991018027A2 true WO1991018027A2 (en) | 1991-11-28 |
WO1991018027A3 WO1991018027A3 (en) | 1992-01-09 |
Family
ID=10676309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1991/000788 WO1991018027A2 (en) | 1990-05-21 | 1991-05-20 | Compounds |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0530242A1 (en) |
JP (1) | JPH05506880A (en) |
AU (1) | AU7867491A (en) |
GB (1) | GB9011332D0 (en) |
WO (1) | WO1991018027A2 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995034588A1 (en) * | 1994-06-10 | 1995-12-21 | Geltex Pharmaceuticals, Inc. | Cross-linked polymers for removing bile salts from a patient |
US5556619A (en) * | 1992-08-20 | 1996-09-17 | The Du Pont Merck Pharmaceutical Company | Crosslinked polymeric ammonium salts |
US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
US5665348A (en) * | 1992-01-14 | 1997-09-09 | Hisamitsu Pharmaceutical Co, Inc. | Cholesterol-lowering drug |
US5679717A (en) * | 1994-06-10 | 1997-10-21 | Geltex Pharmaceuticals, Inc. | Method for removing bile salts from a patient with alkylated amine polymers |
US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
FR2757866A1 (en) * | 1996-12-30 | 1998-07-03 | Catalyse | POLYMERS COMPRISING QUATERNARY AMMONIUMS GROUPS, THEIR USE FOR THE MANUFACTURE OF ANTIBACTERIAL PROPERTY MATERIAL AND METHODS FOR THEIR PREPARATION |
US5800809A (en) * | 1992-01-14 | 1998-09-01 | Hisamitsu Pharmaceutical Co, Inc | Non-crosslinked acrylic polymers and non-crosslinked anion exchange resins |
US5874522A (en) * | 1992-08-20 | 1999-02-23 | Dupont Pharmaceuticals Company | Crosslinked polymeric ammonium salts |
US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
US5925379A (en) * | 1997-03-27 | 1999-07-20 | Geltex Pharmaceuticals, Inc. | Interpenetrating polymer networks for sequestration of bile acids |
US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006052236A (en) * | 2002-07-30 | 2006-02-23 | Yukio Nagasaki | New compound having cholesterol-reducing activity |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2843573A (en) * | 1955-03-21 | 1958-07-15 | Rohm & Haas | New quaternary ammonium compounds in which the nitrogen atom carries an alkoxymethyl group |
US3787474A (en) * | 1969-09-12 | 1974-01-22 | Inveresk Res Int | Cross-linked polymers |
US4393145A (en) * | 1979-05-01 | 1983-07-12 | Etablissement Texcontor | Anionic ion exchange resins with cholesterol-decreasing properties |
FR2528435A1 (en) * | 1982-06-09 | 1983-12-16 | Inst Francais Du Petrole | Additive lowering middle distillate cloud pt. - is reaction prod. of polymerised unsaturated carboxylic acid or its ester with amine |
-
1990
- 1990-05-21 GB GB909011332A patent/GB9011332D0/en active Pending
-
1991
- 1991-05-20 JP JP91509109A patent/JPH05506880A/en active Pending
- 1991-05-20 AU AU78674/91A patent/AU7867491A/en not_active Abandoned
- 1991-05-20 WO PCT/GB1991/000788 patent/WO1991018027A2/en not_active Application Discontinuation
- 1991-05-20 EP EP91909433A patent/EP0530242A1/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2843573A (en) * | 1955-03-21 | 1958-07-15 | Rohm & Haas | New quaternary ammonium compounds in which the nitrogen atom carries an alkoxymethyl group |
US3787474A (en) * | 1969-09-12 | 1974-01-22 | Inveresk Res Int | Cross-linked polymers |
US4393145A (en) * | 1979-05-01 | 1983-07-12 | Etablissement Texcontor | Anionic ion exchange resins with cholesterol-decreasing properties |
FR2528435A1 (en) * | 1982-06-09 | 1983-12-16 | Inst Francais Du Petrole | Additive lowering middle distillate cloud pt. - is reaction prod. of polymerised unsaturated carboxylic acid or its ester with amine |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5800809A (en) * | 1992-01-14 | 1998-09-01 | Hisamitsu Pharmaceutical Co, Inc | Non-crosslinked acrylic polymers and non-crosslinked anion exchange resins |
US5665348A (en) * | 1992-01-14 | 1997-09-09 | Hisamitsu Pharmaceutical Co, Inc. | Cholesterol-lowering drug |
US5556619A (en) * | 1992-08-20 | 1996-09-17 | The Du Pont Merck Pharmaceutical Company | Crosslinked polymeric ammonium salts |
US5874522A (en) * | 1992-08-20 | 1999-02-23 | Dupont Pharmaceuticals Company | Crosslinked polymeric ammonium salts |
US5726284A (en) * | 1992-08-20 | 1998-03-10 | The Dupont Merck Pharmaceutical Company | Crosslinked polymric ammonium salts |
US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
US6060517A (en) * | 1993-06-02 | 2000-05-09 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5840766A (en) * | 1993-06-02 | 1998-11-24 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5919832A (en) * | 1994-06-10 | 1999-07-06 | Geltex Pharmaceuticals Inc. | Amine polymer sequestrant and method of cholesterol depletion |
US6066678A (en) * | 1994-06-10 | 2000-05-23 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
US7399821B2 (en) | 1994-06-10 | 2008-07-15 | Genzyme Corporation | Alkylated poly(allylamine) polymers and methods of use |
US7101960B2 (en) | 1994-06-10 | 2006-09-05 | Genzyme Corporation | Process for removing bile salts from a patient and alkylated compositions therefor |
US5693675A (en) * | 1994-06-10 | 1997-12-02 | Geltex Pharmaceuticals Inc. | Alkylated amine polymers |
US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
US5917007A (en) * | 1994-06-10 | 1999-06-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
WO1995034588A1 (en) * | 1994-06-10 | 1995-12-21 | Geltex Pharmaceuticals, Inc. | Cross-linked polymers for removing bile salts from a patient |
US6784254B2 (en) | 1994-06-10 | 2004-08-31 | Genzyme Corporation | Process for removing bile salts from a patient and alkylated compositions therefor |
US5679717A (en) * | 1994-06-10 | 1997-10-21 | Geltex Pharmaceuticals, Inc. | Method for removing bile salts from a patient with alkylated amine polymers |
US5969090A (en) * | 1994-06-10 | 1999-10-19 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
US5981693A (en) * | 1994-06-10 | 1999-11-09 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
AU694777B2 (en) * | 1994-06-10 | 1998-07-30 | Genzyme Corporation | Cross-linked polymers for removing bile salts from a patient |
US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
US6433026B2 (en) | 1994-06-10 | 2002-08-13 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
US6225355B1 (en) | 1994-06-10 | 2001-05-01 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and alkylated compositions therefor |
US6251967B1 (en) | 1996-12-30 | 2001-06-26 | Catalyse (Sarl) Limited Company | Antimicrobial polymers comprising quaternary ammonium groups, their use for making a material with antimicrobial properties and methods for preparing them |
US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
US6610283B1 (en) | 1996-12-30 | 2003-08-26 | Genzyme Corporation | Poly(diallylamine)-based bile acid sequestrants |
FR2757866A1 (en) * | 1996-12-30 | 1998-07-03 | Catalyse | POLYMERS COMPRISING QUATERNARY AMMONIUMS GROUPS, THEIR USE FOR THE MANUFACTURE OF ANTIBACTERIAL PROPERTY MATERIAL AND METHODS FOR THEIR PREPARATION |
US7125547B2 (en) | 1996-12-30 | 2006-10-24 | Genzyme Corporation | Poly(diallylamine)-based bile acid sequestrants |
WO1998029463A1 (en) * | 1996-12-30 | 1998-07-09 | Catalyse | Antimicrobial polymers comprising quaternary ammonium groups, their use for making a material with antimicrobial properties and methods for preparing them |
US5925379A (en) * | 1997-03-27 | 1999-07-20 | Geltex Pharmaceuticals, Inc. | Interpenetrating polymer networks for sequestration of bile acids |
US6423754B1 (en) | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
Also Published As
Publication number | Publication date |
---|---|
WO1991018027A3 (en) | 1992-01-09 |
JPH05506880A (en) | 1993-10-07 |
GB9011332D0 (en) | 1990-07-11 |
AU7867491A (en) | 1991-12-10 |
EP0530242A1 (en) | 1993-03-10 |
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