WO1991016010A1 - Composite living skin equivalents - Google Patents
Composite living skin equivalents Download PDFInfo
- Publication number
- WO1991016010A1 WO1991016010A1 PCT/AU1991/000160 AU9100160W WO9116010A1 WO 1991016010 A1 WO1991016010 A1 WO 1991016010A1 AU 9100160 W AU9100160 W AU 9100160W WO 9116010 A1 WO9116010 A1 WO 9116010A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- collagen
- skin
- skin equivalent
- layer
- porous
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
- A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
- C12N2503/06—Screening or testing on artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91908747A EP0526550B1 (en) | 1990-04-24 | 1991-04-24 | Composite living skin equivalents |
DK91908747T DK0526550T3 (en) | 1990-04-24 | 1991-04-24 | Composite equivalent to living skin |
US08/346,525 USRE35399E (en) | 1990-04-24 | 1991-04-24 | Composite living skin equivalents |
BR919106354A BR9106354A (en) | 1990-04-24 | 1991-04-24 | COMPOSITE LIVING SKIN EQUIVALENT, ITS PREPARATION PROCESS; TEST KIT, ITS PREPARATION PROCESS, AND TEST PROCESS FOR SUBSTANCE SKIN |
DE69128530T DE69128530T2 (en) | 1990-04-24 | 1991-04-24 | COMPOSED EQUIVALENT OF LIVING SKIN |
JP3508090A JPH0747043B2 (en) | 1990-04-24 | 1991-04-24 | Synthetic living skin equivalent |
RU92016420A RU2135191C1 (en) | 1990-04-24 | 1991-04-24 | Composition equivalent of living skin, method of its preparing, test-set |
CA002080693A CA2080693C (en) | 1990-04-24 | 1991-04-24 | Composite living skin equivalents |
HU9203338A HUT63319A (en) | 1990-04-24 | 1991-04-24 | Method for producing composition equivalent with living skin |
TW080108276A TW225986B (en) | 1990-04-24 | 1991-10-21 | |
NO92924034A NO924034L (en) | 1990-03-02 | 1992-10-19 | COMPOSITION MATERIAL EQUIVALENT FOR LIVE SKIN |
FI924773A FI924773A0 (en) | 1990-04-24 | 1992-10-21 | COMPOSITION SUBSTITUTION AV LEVANDE HUD |
GR980400647T GR3026463T3 (en) | 1990-04-24 | 1998-03-27 | Composite living skin equivalents |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ9819 | 1990-04-24 | ||
AUPJ981990 | 1990-04-24 | ||
AUPK4302 | 1991-01-22 | ||
AUPK430291 | 1991-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991016010A1 true WO1991016010A1 (en) | 1991-10-31 |
Family
ID=25643857
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1991/000160 WO1991016010A1 (en) | 1990-03-02 | 1991-04-24 | Composite living skin equivalents |
Country Status (15)
Country | Link |
---|---|
US (3) | US5282859A (en) |
EP (1) | EP0526550B1 (en) |
JP (1) | JPH0747043B2 (en) |
AT (1) | ATE161408T1 (en) |
BR (1) | BR9106354A (en) |
CA (1) | CA2080693C (en) |
DE (1) | DE69128530T2 (en) |
DK (1) | DK0526550T3 (en) |
ES (1) | ES2111566T3 (en) |
FI (1) | FI924773A0 (en) |
GR (1) | GR3026463T3 (en) |
HU (1) | HUT63319A (en) |
RU (1) | RU2135191C1 (en) |
TW (1) | TW225986B (en) |
WO (1) | WO1991016010A1 (en) |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995017526A1 (en) * | 1993-12-22 | 1995-06-29 | Prenosil, Jiri, E. | Process and device for producing a cellular structure on a semipermeable membrane |
WO1996033750A1 (en) * | 1995-04-27 | 1996-10-31 | Fidia Advanced Biopolymers S.R.L. | Artificial skin containing as support biocompatible materials based on hyaluronic acid derivatives |
US5610007A (en) * | 1993-01-21 | 1997-03-11 | Universite Laval | Chimeric sheets of epithelial cells |
WO1998013076A1 (en) * | 1996-09-24 | 1998-04-02 | Brigham And Women's Hospital | Cultured cell-seeded fibrous lattice for tissue replacement |
FR2757635A1 (en) * | 1996-12-24 | 1998-06-26 | Oreal | METHOD FOR EVALUATING DAMAGE INDUCED IN THE SKIN BY UV-A |
WO1998058255A1 (en) * | 1997-06-17 | 1998-12-23 | Universite Laval | Assessment of human skin damage following exposure to harmful agents |
US6051425A (en) * | 1994-09-19 | 2000-04-18 | Gunze Limited | Method for producing tissue formation and tissue culture kit |
FR2798735A1 (en) * | 1999-09-17 | 2001-03-23 | Serobiologiques Lab Sa | Evaluating aging of tissue, useful e.g. to screen for anti-aging agents, comprises model, especially dead skin, in which induced aging effects are determined by imaging |
FR2809313A1 (en) * | 2000-05-26 | 2001-11-30 | Coletica | Composite artificial skin having a porous collagenic layer coated with a collagenic film prepared by drying a collagen gel or by compression of a collagenic sponge |
WO2001092476A2 (en) * | 2000-05-31 | 2001-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | In vitro tissue test system |
WO2001091821A1 (en) * | 2000-05-26 | 2001-12-06 | Coletica | Collagen-based supports for tissue engineering and preparation of biomaterials |
WO2001092477A2 (en) * | 2000-05-31 | 2001-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Three-dimensional skin model |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
EP1273913A1 (en) * | 2001-07-02 | 2003-01-08 | Cognis France S.A. | Method for the determination of the interaction of keratinocytes and neurons |
US6541023B1 (en) | 2000-05-26 | 2003-04-01 | Coletica | Use of collagen of aquatic origin for the production of supports for tissue engineering, and supports and biomaterials obtained |
US6660280B1 (en) | 1999-05-19 | 2003-12-09 | Coletica | Collagen product containing collagen of marine origin with a low odor and preferably with improved mechanical properties, and its use in the form of cosmetic or pharmaceutical compositions or products |
US6790454B1 (en) * | 2000-05-26 | 2004-09-14 | Coletica | Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained |
US6974679B2 (en) | 2000-05-26 | 2005-12-13 | Coletica | Support with collagen base for tissue engineering and manufacture of biomaterials |
EP1754513A2 (en) | 2005-08-17 | 2007-02-21 | L'oreal | Use of 8-hexadecene-1,16-dicarboxylic acid as a care agent for promoting the horny layer cohesion |
EP1792980A1 (en) * | 2000-05-31 | 2007-06-06 | Arthro Kinetics AG | Collagen biomatrix and methods to poduce it |
DE10196234B4 (en) * | 2000-05-26 | 2008-04-30 | Engelhard Lyon S.A. | Composite collagen product, useful e.g. as artificial skin and for drug testing, comprises porous collagen layer and compacted collagen membrane |
US7741116B2 (en) | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
WO2012059703A1 (en) | 2010-11-05 | 2012-05-10 | Centre National De La Recherche Scientifique (Cnrs) | In vitro or ex vivo method for storing and/or keeping an epidermis alive |
US8227415B2 (en) | 2005-04-06 | 2012-07-24 | Fujifilm Manufacturing Europe B.V. | Non-porous film for culturing cells |
WO2012163974A1 (en) | 2011-05-30 | 2012-12-06 | L'oreal | Reconstructed scalp model and process for screening active molecules |
WO2013014435A1 (en) | 2011-07-27 | 2013-01-31 | University Of Durham | Micro organ comprising mesenchymal and epithelial cells |
EP2582791A2 (en) * | 2010-06-18 | 2013-04-24 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Hair follicle neogenesis |
US20130195958A1 (en) * | 2010-05-21 | 2013-08-01 | Rodrigo Focion Soto Pareja | Process for the production of patches or derssings of autologous skin through cultivation of autologous keratinocytes and fibroblasts with autologous serum for the generation of skin |
EP3031480A1 (en) | 2005-04-06 | 2016-06-15 | FUJIFILM Manufacturing Europe B.V. | A non-porous film for culturing cells |
WO2018020016A1 (en) | 2016-07-29 | 2018-02-01 | L'oreal | Skin equivalent with distinct juxtaposed dermal compartments |
WO2019063731A1 (en) | 2017-09-28 | 2019-04-04 | L'oreal | Molecular signatures of three sub-populations of dermal fibroblasts and dermal equivalent comprising one of these sub-populations |
US10478526B2 (en) | 2013-05-03 | 2019-11-19 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Skin substitutes and methods for hair follicle neogenesis |
FR3111904A1 (en) | 2020-06-30 | 2021-12-31 | L'oreal | Bio-ink for bioprinting a model of invaginated dermal-epidermal junction |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976878A (en) * | 1987-04-28 | 1999-11-02 | The Regents Of The University Of California | Method and apparatus for preparing composite skin replacement |
HUT63319A (en) * | 1990-04-24 | 1993-08-30 | Mark Eisenberg | Method for producing composition equivalent with living skin |
US6399380B1 (en) * | 1991-02-28 | 2002-06-04 | Anti-Cancer, Inc. | Native-state histoculturing skin extracellular support |
US5888720A (en) * | 1992-10-27 | 1999-03-30 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs |
CA2119064A1 (en) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
US5489304A (en) * | 1994-04-19 | 1996-02-06 | Brigham & Women's Hospital | Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft |
DE4414755C2 (en) * | 1994-04-27 | 2000-11-16 | Lohmann Therapie Syst Lts | Collagen preparation for the controlled delivery of active ingredients, processes and use |
US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
US6080194A (en) * | 1995-02-10 | 2000-06-27 | The Hospital For Joint Disease Orthopaedic Institute | Multi-stage collagen-based template or implant for use in the repair of cartilage lesions |
US20040002772A1 (en) * | 1995-04-28 | 2004-01-01 | Organogenesis, Inc. | Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents |
US20020111695A1 (en) * | 1995-11-06 | 2002-08-15 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
AU7274696A (en) | 1995-11-06 | 1997-05-29 | Mount Sinai Hospital Corporation | Reconstituted mineralized cartilage tissue |
ES2117573B1 (en) * | 1996-07-19 | 1999-02-16 | Comunitario De Transfusion Del | DERMIC BASE ESPECIALLY DESIGNED FOR THE CULTIVATION OF KERATINOCITS. |
ES2132027B1 (en) * | 1997-07-04 | 2000-04-01 | Comunitario De Transfusion Del | DEVELOPMENT OF AN ARTIFICIAL SKIN THROUGH KERATINOCIT CULTIVATION ON A BASIS OF FIBRIN AND HUMAN FIBROBLASTES AND METHOD OF PREPARATION OF THIS SKIN FOR TRANSPLANTING. |
US7687057B2 (en) * | 1998-01-09 | 2010-03-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs, and uses related thereto |
WO1999046285A2 (en) | 1998-03-11 | 1999-09-16 | University Of Southern California | Method of promoting production of living tissue equivalents |
US6432710B1 (en) * | 1998-05-22 | 2002-08-13 | Isolagen Technologies, Inc. | Compositions for regenerating tissue that has deteriorated, and methods for using such compositions |
US6177514B1 (en) * | 1999-04-09 | 2001-01-23 | Sulzer Carbomedics Inc. | Blocked functional reagants for cross-linking biological tissues |
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Also Published As
Publication number | Publication date |
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CA2080693C (en) | 2001-11-27 |
FI924773A (en) | 1992-10-21 |
AU7756991A (en) | 1991-11-11 |
FI924773A0 (en) | 1992-10-21 |
EP0526550A4 (en) | 1993-06-30 |
ATE161408T1 (en) | 1998-01-15 |
ES2111566T3 (en) | 1998-03-16 |
DE69128530D1 (en) | 1998-02-05 |
TW225986B (en) | 1994-07-01 |
AU632693B2 (en) | 1993-01-07 |
BR9106354A (en) | 1993-04-27 |
HU9203338D0 (en) | 1993-01-28 |
US5282859A (en) | 1994-02-01 |
GR3026463T3 (en) | 1998-06-30 |
US6039760A (en) | 2000-03-21 |
CA2080693A1 (en) | 1991-10-25 |
DE69128530T2 (en) | 1998-08-20 |
USRE35399E (en) | 1996-12-10 |
HUT63319A (en) | 1993-08-30 |
EP0526550A1 (en) | 1993-02-10 |
RU2135191C1 (en) | 1999-08-27 |
JPH0747043B2 (en) | 1995-05-24 |
DK0526550T3 (en) | 1998-08-31 |
EP0526550B1 (en) | 1997-12-29 |
JPH05506169A (en) | 1993-09-16 |
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