WO1991016008A1 - Implantable semi-permeable exchange and diffusion chamber - Google Patents

Implantable semi-permeable exchange and diffusion chamber Download PDF

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Publication number
WO1991016008A1
WO1991016008A1 PCT/EP1991/000565 EP9100565W WO9116008A1 WO 1991016008 A1 WO1991016008 A1 WO 1991016008A1 EP 9100565 W EP9100565 W EP 9100565W WO 9116008 A1 WO9116008 A1 WO 9116008A1
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WO
WIPO (PCT)
Prior art keywords
implantable
exchange
diffusion chamber
cells
coated
Prior art date
Application number
PCT/EP1991/000565
Other languages
German (de)
French (fr)
Inventor
Jakob Bodziony
Original Assignee
Jakob Bodziony
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jakob Bodziony filed Critical Jakob Bodziony
Publication of WO1991016008A1 publication Critical patent/WO1991016008A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors

Definitions

  • Implantable semipermeable exchange and diffusion chamber Implantable semipermeable exchange and diffusion chamber.
  • the invention relates to an implantable exchange and diffusion chamber. It consists of a hollow fiber (or several hollow fibers) which is connected to the subcutaneous infusion port (or to the infusion ports) with a self-closing membrane by means of appropriate lines.
  • the hollow fiber can be coated with endo- or mesothelial cells, which are tolerated immunologically like own cells, which allows a multi-year implantation in the vascular system
  • the given implantable exchange and diffusion chamber should primarily be used as part of the extracorporeal or implantable bioartificial organs.
  • the specified system can also be used as an infusion cannula that has been implanted for several years, as a semipermeable chamber for the cells and tissues implanted in the vascular system and as a diffusion chamber for various exchange methods and medicaments.
  • the construction of the implantable semiperable exchange and diffusion chamber which on the one hand enables multi-year implantation in arteries and veins and rapid exchange of substances that are smaller than the permeability limit, and on the other hand flexible with different systems and bioartificial organs can be connected.
  • the object of the invention is industrially applicable through the manufacture of the implantable exchange and diffusion chambers with infusion ports described above.
  • the hollow fibers used as diffusion chambers can be coated with autogenous or tissue-typed and tissue-culture-produced allogeneic endo- and mesothelial cells at different time intervals before implantation in the vascular system and in this coated form e.g. be transported. Because the specified coated hollow fibers do not induce blood coagulation activation after implantation in the vascular system and have never been recognized as a foreign body either immunologically or biologically, they can be used flexibly for years, e.g.
  • a bioartificial organ used as an implantable infusion cannula, as a diffusion chamber for various exchange procedures, as a semi-permeable chamber for the cells and tissues implanted in the vascular system and as a diffusion chamber for various drugs.
  • Fig. 1 and 2 show the implantable exchange and diffusion chamber in an experimental (Fig. 1) and in a clinical (Fig. 2) situation.
  • the hollow fiber with the coating of cells that have a multi-year implantation enable in arteries and veins (A) is connected by Teflon lines (B) to the two subcutaneously implanted infusion ports (C).
  • the infusion ports allow direct access to the exchange and diffusion chamber and flexible connection with various systems and bioartificial organs.
  • Bodziony J . Hollow fiber with the coating of cells that allow multi-year implantation in arteries and veins.

Abstract

The implantable exchange and diffusion chamber is a further development of the subject of the prior patent application (Bodziony, P 39 41 873.1). The implantable exchange and diffusion chamber consists of one or more hollow fibres connected to the subcutaneous infusion port(s). The hollow fibre may be coated with endo or mesothetial cells which are immunologically tolerated like the body's own cells, permitting implantation into the vessel system for several years. The above implantable exchange and diffusion chamber is primarily for use as part of extra-corporal or implantable bio-artificial organs.

Description

Beschreibung description
Titel:Title:
Implantable semipermeable Austausch- und Diffusionskammer.Implantable semipermeable exchange and diffusion chamber.
Gattung des Anmeldungsgegenstandes:Type of application:
Die Erfindung betrifft eine implantable Austausch- und Diffusionskammer. Sie besteht aus einer Hohlfaser (oder mehreren Hohlfasern) die mit dem subkutanen Infusionsport (oder mit den Infusionsports) mit selbstschließender Membrane durch entsprechende Leitungen verbunden ist. Die Hohlfaser kann mit Endo- oder Mesothelialzellen, die immunologisch wie eigene Zellen toleriert sind, beschichtet werden, was eine mehrjährige Implantation ins Gefäßsystem ermögliThe invention relates to an implantable exchange and diffusion chamber. It consists of a hollow fiber (or several hollow fibers) which is connected to the subcutaneous infusion port (or to the infusion ports) with a self-closing membrane by means of appropriate lines. The hollow fiber can be coated with endo- or mesothelial cells, which are tolerated immunologically like own cells, which allows a multi-year implantation in the vascular system
Angaben zur Gattung:Genre information:
Die vorgegebene implantable Austausch- und Diffusionskammer soll vor allem als ein Teil der extrakorporalen oder implantablen bioartifiziellen Organe benutzt werden. Das vorgegebene System kann auch als eine mehrjährig-implan- tierte Infusionskanüle, als eine semipermeable Kammer für die ins Gefäßsystem implantierte Zellen und Geweben und als eine Diffusionskammer für verschiede¬ ne Austauschverfahren und Arzneimittel benutzt werden.The given implantable exchange and diffusion chamber should primarily be used as part of the extracorporeal or implantable bioartificial organs. The specified system can also be used as an infusion cannula that has been implanted for several years, as a semipermeable chamber for the cells and tissues implanted in the vascular system and as a diffusion chamber for various exchange methods and medicaments.
•Stand der Technik: Das vorgegebene Austausch- und Diffusionssystem ist eine weitere Entwicklung der früheren Patentanmeldung (Bodziony, 1989). • State of the art: The specified exchange and diffusion system is a further development of the earlier patent application (Bodziony, 1989).
Kritik des Standes der Technik:Critique of the state of the art:
Die erstmal in früherer Anmeldung (Bodziony, 1989) beschriebene Hohlfaser mit der Beschichtung von Zellen, die eine mehrjährige Implantation in Arterien und Venen ermöglichen, war vor allem als die Hülle der in das Gefäßsystem implantablen Sensoren, Biosensoren und ionselektiven Elektroden vorgesehen. Für flexible Anwendungen als eine mehrjährig in das Gefäßsystem implantierte iffuεions- und A s _jschkammer waren noch einige Veibesserungen notwendig (siehe unten). Aufgabe:The hollow fiber first described in the earlier application (Bodziony, 1989) with the coating of cells that enable implantation in arteries and veins for several years was primarily intended as the sheath for the sensors, biosensors and ion-selective electrodes implantable in the vascular system. For flexible applications as an iffuεions- and A s _jschkammer implanted in the vascular system for several years, some improvements were still necessary (see below). Task:
Die Konstruktion der implantablen semiper eablen Austausch- und Diffusions¬ kammer, die einerseits die mehrjährige Implantation in Arterien und Venen und schnellen Austausch von Substanzen, die kleiner als die Permeabilitäts- grenze sind, ermöglicht, und andererseits flexibel mit verschiedenen Syste¬ men und bioartifiziellen Organen verbunden werden kann.The construction of the implantable semiperable exchange and diffusion chamber, which on the one hand enables multi-year implantation in arteries and veins and rapid exchange of substances that are smaller than the permeability limit, and on the other hand flexible with different systems and bioartificial organs can be connected.
Lösung:Solution:
Diese Aufgabe wird erfindungsmäßig dadurch gelöst, daß entsprechend der vor¬ herigen Patentanmeldung (Bodziony, 1989) angefertigtes Austauschteil mit einem oder zwei subkutan implantierbaren Infusionsports mit selbstchließender Membrane, wie auf dem Bild 1 und 2. gezeigt, durch' entsprechende Leitungen verbunden ist.This object is achieved according to the invention in that the replacement part made according to the previous patent application (Bodziony, 1989) is connected to one or two subcutaneously implantable infusion ports with a self-closing membrane, as shown in Figs. 1 and 2, by corresponding lines.
Erzielbare Vorteile:Achievable advantages:
Der Gegenstand der Erfindung ist gewerblich anwendbar durch die Herstellung der oben beschriebenen implantablen Austausch- und Diffusionskammern mit Infusionsports. Die als Diffusionskammern angewandte Hohlfasern können mit autogenen oder gewebetypisierten und gewebekulturproduzierten allogenen Endo- und Mesothelialzellen in verschiedenen Zeitabständen vor der Implantation in das Gefäßsystem beschichtet und in dieser beschichteten Form z.B. trans- portiert werden. Weil die vorgegebenen beschichteten Hohlfasern keine Aktivi- ruήg der Blutgerinnung nach der Implantation in das Gefäßsystem induzieren und auch nie imunologisch oder biologisch als Fremdkörper erkannt wurden, können sie flexibel jahrelang z.B. als ein Teil eines bioartifiziellen Organs als eine implantable In usionskanüle, als eine Diffusionskammer für verschie- dene Austauschverfahren, als eine semipermeable Kammer für die ins Gefäßsyste implantierte Zellen und Geweben und als eine Diffusionskammer für verschieden Arzneimittel benutzt werden.The object of the invention is industrially applicable through the manufacture of the implantable exchange and diffusion chambers with infusion ports described above. The hollow fibers used as diffusion chambers can be coated with autogenous or tissue-typed and tissue-culture-produced allogeneic endo- and mesothelial cells at different time intervals before implantation in the vascular system and in this coated form e.g. be transported. Because the specified coated hollow fibers do not induce blood coagulation activation after implantation in the vascular system and have never been recognized as a foreign body either immunologically or biologically, they can be used flexibly for years, e.g. used as part of a bioartificial organ as an implantable infusion cannula, as a diffusion chamber for various exchange procedures, as a semi-permeable chamber for the cells and tissues implanted in the vascular system and as a diffusion chamber for various drugs.
Beschreibung des Ausführungsbeispiels:Description of the embodiment:
Abb. 1 und 2 zeigen in einer experimentellen (Abb. 1) und in einer klinischen (Abb. 2) Situation die implantierbare Austausch- und Diffusionskammer. Die Hohlfaser mit der Beschichtung von Zellen, die eine mehrjährige Implantation in Arterien und Venen ermöglichen (A) ist durch Teflonleitungen (B) mit den zwei subkutan implantierten Infusionsports (C) verbunden. Die Infusionsports ermöglichen den direkten Zugang zur Austausch- und Diffusionskammer und flexible Verbindung mit verschiedenen Systemen und bioartifiziellen Organer.. Fig. 1 and 2 show the implantable exchange and diffusion chamber in an experimental (Fig. 1) and in a clinical (Fig. 2) situation. The hollow fiber with the coating of cells that have a multi-year implantation enable in arteries and veins (A) is connected by Teflon lines (B) to the two subcutaneously implanted infusion ports (C). The infusion ports allow direct access to the exchange and diffusion chamber and flexible connection with various systems and bioartificial organs.
Fundstellen:Locations:
1. Bodziony J.: Hohlfaser mit der Beschichtung von Zellen, die mehrjährige Implantation in Arterien und Venen ermöglichen. Deutsches Patentamt, 19S9, Patentanmeldung P 39 41 873.1. 1. Bodziony J .: Hollow fiber with the coating of cells that allow multi-year implantation in arteries and veins. German Patent Office, 19S9, patent application P 39 41 873.1.

Claims

PatentansprücheClaims
Implantable Austausch- und Diffusionskammer, gekennzeichnet durch Hohlfaser (oder mehrere Hohlfasern) aus semipermeablem Material, die mit Endo- oder Mesothelialzellen beschichtet' werden kann, und die mit dem subkutanen Infu- sionsport (oder Infusionsports) mit selbstschließender Membrane durch ent¬ sprechende Leitungen verbunden ist. Implantable exchange and diffusion chamber, characterized by hollow fiber (or a plurality of hollow fibers) of semipermeable material that can 'be coated with endo- or mesothelial cells, and the sion sport with the subcutaneous Infu- (or infusion ports) associated with self-closing membrane by ent speaking lines is.
PCT/EP1991/000565 1990-04-14 1991-03-25 Implantable semi-permeable exchange and diffusion chamber WO1991016008A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4012079.1 1990-04-14
DE19904012079 DE4012079C2 (en) 1990-04-14 1990-04-14 Implantable exchange and diffusion chamber

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US07/772,349 Continuation-In-Part US5914095A (en) 1989-04-07 1991-10-07 Polychelants containg amide bonds

Publications (1)

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WO1991016008A1 true WO1991016008A1 (en) 1991-10-31

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AU (1) AU7572991A (en)
DE (1) DE4012079C2 (en)
WO (1) WO1991016008A1 (en)

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DE3422639A1 (en) * 1984-06-19 1985-12-19 Gebrüder Sulzer AG, Winterthur Glandula prosthesis
WO1988010103A1 (en) * 1987-06-18 1988-12-29 Gaskill Harold V Iii An intravascular artificial organ

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FR2270895A1 (en) * 1974-05-17 1975-12-12 Community Blood Council Greate
FR2337341A1 (en) * 1975-12-31 1977-07-29 Gambro Ag METHOD AND DEVICE FOR MEASURING THE CONCENTRATION OF COMPOUNDS WITH LOW MOLECULAR WEIGHT IN COMPLEX MEDIA, ESPECIALLY DURING MEDICAL TREATMENT
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WO1988010103A1 (en) * 1987-06-18 1988-12-29 Gaskill Harold V Iii An intravascular artificial organ

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AU7572991A (en) 1991-11-11
DE4012079A1 (en) 1991-10-24
DE4012079C2 (en) 1997-11-06

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