WO1991012032A1 - Composition vitree bioactive destinee aux implants osseux, filaments formes a partir de celle-ci et methode - Google Patents
Composition vitree bioactive destinee aux implants osseux, filaments formes a partir de celle-ci et methode Download PDFInfo
- Publication number
- WO1991012032A1 WO1991012032A1 PCT/EP1991/000201 EP9100201W WO9112032A1 WO 1991012032 A1 WO1991012032 A1 WO 1991012032A1 EP 9100201 W EP9100201 W EP 9100201W WO 9112032 A1 WO9112032 A1 WO 9112032A1
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- WO
- WIPO (PCT)
- Prior art keywords
- filaments
- bone
- vitreous
- vitreous composition
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 64
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 46
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 8
- 239000007943 implant Substances 0.000 title claims description 15
- 238000000034 method Methods 0.000 title claims description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000004744 fabric Substances 0.000 claims abstract description 6
- 238000002513 implantation Methods 0.000 claims abstract description 6
- 229920000742 Cotton Polymers 0.000 claims abstract description 4
- 239000011247 coating layer Substances 0.000 claims abstract 2
- 230000007547 defect Effects 0.000 claims description 11
- 239000000470 constituent Substances 0.000 claims description 8
- 230000004927 fusion Effects 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- 239000000560 biocompatible material Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000003019 stabilising effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 22
- 239000000919 ceramic Substances 0.000 abstract description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000377 silicon dioxide Substances 0.000 abstract description 2
- 229910052593 corundum Inorganic materials 0.000 abstract 2
- 229910001845 yogo sapphire Inorganic materials 0.000 abstract 2
- 229910052681 coesite Inorganic materials 0.000 abstract 1
- 229910052906 cristobalite Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 229910052682 stishovite Inorganic materials 0.000 abstract 1
- 229910052905 tridymite Inorganic materials 0.000 abstract 1
- 239000011521 glass Substances 0.000 description 17
- 239000011159 matrix material Substances 0.000 description 16
- 239000000463 material Substances 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 238000007689 inspection Methods 0.000 description 6
- 230000002776 aggregation Effects 0.000 description 5
- 238000004220 aggregation Methods 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000001054 cortical effect Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 230000001788 irregular Effects 0.000 description 3
- 239000000395 magnesium oxide Substances 0.000 description 3
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000008512 biological response Effects 0.000 description 2
- 210000002449 bone cell Anatomy 0.000 description 2
- 230000010072 bone remodeling Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 210000000963 osteoblast Anatomy 0.000 description 2
- 210000005009 osteogenic cell Anatomy 0.000 description 2
- 230000002188 osteogenic effect Effects 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- UOTMYNBWXDUBNX-UHFFFAOYSA-N 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinolin-2-ium;chloride Chemical compound Cl.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 UOTMYNBWXDUBNX-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241001484259 Lacuna Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 238000004125 X-ray microanalysis Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000005313 bioactive glass Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- GFIKIVSYJDVOOZ-UHFFFAOYSA-L calcium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [Ca+2].[O-]P([O-])(F)=O GFIKIVSYJDVOOZ-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229920001577 copolymer Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 239000005337 ground glass Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052809 inorganic oxide Inorganic materials 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000036647 reaction Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Definitions
- the present invention relates to so-called bio- active vitreous compositions or glasses for bone implantation according to the preamble of Claim 1.
- these known glasses are also biodegradable by means of an inter- action mechanism which is explained below.
- a glass of the type in question When a glass of the type in question is put into contact with the interstitial liquids of a human or animal body, it creates a gel having an ionic composi ⁇ tion similar to that of the ossification front observed in the natural bone-remodelling process.
- the gel thus formed is recognized by the osteoblasts as a substrate for the deposition of an osteoid matrix.
- the inter ⁇ action between the collagen fibrils, the mucopoly- saccharides of the matrix and the gel is characterised by the precipitation of hydroxylapatite crystals which enable a stable bond to be formed between the glass and the newly-added bone matrix.
- the glass implant In many cases, it is desirable for the glass implant to degrade until it disappears completely as the bone gradually reforms and/or is remodelled to leave room for the latter.
- the particles Because of the non-uniform sizes of the particles, most of the smallest particles are reabsorbed completely during the bone reconstitution process, whilst the largest particles are not reabsorbed or degraded and cause undesirable vitreous inclusions in the reconstituted bone. constituting corresponding discontinuities.
- the random arrangement of the particles of different sizes encourages the bone fibres to grow in a similarly random arrangement when for the purposes of the mechanical strength of the bone, it is desirable for the fibres to be reconstituted in a regular arrangement.
- the use of a powder in a prosthetic implant is even dangerous since, on the one hand, the blood can form a kind of mixture with the powder which constitutes a barrier against the growth of bone and, on the other hand, the powder particles may be entrained in the bloodstream and form thromboses.
- the problem behind the present invention, in the first place, is that of providing a glass which can be used to produce bone implants without the a orementioned disadvantages.
- the invention also relates to filaments or fibres obtained by the drawing of said vitreous composition, to products obtained from said filaments, and to a method for the production of said filaments.
- Al 0 have the property of preventing a vitreous . composition from ceramising, by keeping it in an amorphous condition when it is drawn into a filament. The amorphous condition then persists during the life of the filament.
- K 0 in a bioactive vitreous composition is beneficial as regards bioactivity.
- K 0 also constitutes an advantageous substitute for Na 0 in implants destined to patients suffering, or liable to suffer from hypertension.
- vitreous composition including proportions of K C.0 and Al.0_i within the claimed ranges performs well under both aspects of fully preventing ceramising- of the drawn filaments and fully preserving their affinity to the bone tissues.
- FR-A-2 243 915 GB-A-2 080 281, DE-A-3 248 649 and EP-A-0 145 210 all disclose bioactive vitreous composi- tions containing K 0 in indeterminate percentages from zero (from 0.4% in ' FR-A-2 243 915) to 20%. Such documents do not teach the use of K 0 as an anti- ceramising agent.
- GB-A-2 080 281 and US-A 4 708 652 both disclose bioactive vitreous compositions containing indeterminate amounts from zero to _,- __ .— - Nb_0_. The percentage of A1_0_ is not specified.
- Al 0 ZrO and Nb_0_ are described in such ⁇ , __ 2 5 documents as reaction controllers in respect of bio- activity.
- Al 0 , ZrO and Nb 0 are known to be inhibitors in respect of bioactivity.
- the compositions disclosed by GB-A-2 080 281 and US-A-4 708 652, and containing Al 0 in indetermin ⁇ ate amounts, are mainly of the ceramic type. In other words, such documents do not teach the use of Al 0 as an anti-ceramising agent.
- filaments or fibres even with diameters of the order of 10-50 microns.
- products such as bundles of fibres, fabrics. particularly gauzes and nets, felts. and "cotton-wools" as well as particulate products made of shredded filaments and powders made by grinding of the filaments.
- a bundle of filaments or fibres of a vitreous composition as claimed can be used as an implant by being inserted in a bone defect with the filaments oriented in the direction in which it is envisaged that the bone fibres will grow. thus encouraging their regular development to the benefit of the mechanical strength of the reformed bone.
- the small diameters of the filaments or fibres ensure that they are completely degraded, that is, that they are completely replaced by. the bone tissue as it is gradually reformed and remodelled.
- the fabrics, particularly the nets and gauzes, as well as the felts and "cotton-wools" produced from the glass filaments of the invention behave in the same way as the ' bundles of ibres as regards degradation but enable the growth of bone in several preferred direc- tions to be planned.
- a net or a gauze can encourage the bone tissue to form a network similar to that of the original bone tissue.
- the filaments of the vitreous composition accord ⁇ ing to the invention can be broken into pieces or small cylinders whose lengths are of the same order of magnitude as their diameters.
- cylinders can be produced with diameters and lengths of the order of twenty microns.
- a particulate product thus obtained can be implanted as it is by the same technique as that by which the prior-art ground glasses were implanted but with the difference that the bone defect is filled with uniformly sized particles, ensuring the degradation of the implant and its complete replacement by bone tissue over a period of time.
- this application is justified only if there is no danger of the formation of clots with the blood and/or of the entrainment of the powder particles by the blood.
- a particulate material of the vitreous composition according to the invention is intended to be applied as an at least partial coating, for example, by the "plasma spray” technique, to a permanent prosthesis, for example of titanium, to improve its anchorage to the surrounding bone by virtue of the progressive, and .finally complete, replacement of the coating by bone tissue.
- a permanent prosthesis for example of titanium
- uniform and homogenous coatings are produced because of the uniform dimensions of the glass particles. This was impossible with known biocompatible glass powders, partly because of their non-uniform particle size but particularly because these known glasses became ceramic if they were applied by spraying at the high tem ⁇ peratures of the "plasma spray" process.
- Glass filaments or fibres, as well as fabrics produced from these fibres, are known from the document FR-A-2 548 658 and include calcium phosphate as the main constituent and not less than 80% by weight of Ca0+P 0_,
- •_. b possibly with the addition of an inorganic oxide selected from alumina, silica, sodium oxide, iron oxide, magnesium oxide, kaolin and mixtures thereof.
- these glass fibres are not biodegradable so that fabrics made of these fibres remain incorporated permanently in the reformed bone tissue.
- This composition is characterised essentially in that it has the following constituents in percentages by weight: Si0 50%; P 0 6%; CaO 16%; Na 0 20%; K 0 5%; MgO 1%; 2 2 5 2. ⁇ A1 2 0 3 2%.
- compositions are reduced to filaments by melting them in a crucible provided with a die at the bottom and drawing the molten composition through the die.
- the crucible is of substantially pure titanium.
- Composition I can be drawn into filaments very easily but within a fairly narrow temperature range of between about 900°C and 1050°C, in which the vitreous mass is very fluid. The only problem, therefore, is that the temperature of the fusion bath must be controlled very precisely.
- composition II the presence of B ._-0 widens the temperature range within which the composition can be drawn into filaments without becoming ceramic to between 800°C and 1050°C. Within this temperature range, however, the vitreous mass is yet more fluid than composition I so that the drawing rate must be controlled precisely. At least traces of calcium fluoride and/or calcium fluorophosphate may be added to the compositions in small proportions to catalyse certain biological proces ⁇ ses. Compositions including these fluorides are particularly suitable for making implants for dental surgery.
- Tests have been carried out in vivo on rats and rabbits, using compositions I and II both in fibre and powder form, according to an experimental protocol which provided for the insertion of the fibres and the powders in the marrow cavity of the tibia of each animal.
- optical micro ⁇ scopic examination of the specimens obtained revealed that they had cells with bas ⁇ philous cytoplasm which adhered to the surfaces of the fibres and the particles and were starting to produce a bony matrix. Inter alia, this confirmed an absence of rejection.
- both the fibres and the particulate material appeared to be completely surrounded by a bony matrix without the interposition of a connective membrane or capsule between the vitreous composition and the biological substrate. Moreover, some cells similar in appearance to primary bone cells appeared to be incorporated in the matrix near the vitreous composition. This confirmed the absence of a barrier which could arrest the growth of bone between the vitreous composition and the biological substrate.
- the cortical bone defect was complete ⁇ ly filled with newly-formed bone.
- the fibres of the vitreous composition incorporated in the bony matrix retained their individuality and appeared circular in histological sections taken in planes perpendicular to the major axes of the fibres and rectangular in histological sections taken in planes parallel to the major axes of the fibres.
- the particles of the vitreous composition formed aggregations with irregular profiles which, nevertheless, were incorporated in the bony matrix without the interposition of connective mem ⁇ branes.
- the vitreous material which had not come into contact with the osteogenic bone cells appeared to be surrounded by an inflammatory infiltrate constituted mainly by neutrophllous polymorphonucleates and giant multinucleate cells.
- the presence of the inflammatory infiltrate was evidence of a favourable intensification of the blood circulation.
- the experiments carried out appear to have demonstrated their osteoconductive properties, documented histo- logically by fact that the material was incorporated in the bony matrix without the interposition of connective tissue, provided that a sufficient number of cells differentiated towards osteogenic activity were present at the site of the implant.
- the fibres and particles of the vitreous composition inserted in the cortical bone defect both showed this property.
- the fibres when these were bathed in blood, they formed a three-dimensional network or "felt" which defined empty spaces between the fibres so that, as a whole, they offered an extensive surface for the attachment of osteogenic cells.
- the particles of the vitreous composition of the invention formed compact aggregations upon contact with the blood and only the outer surface was available for bonding.
- the chemical surface characteristics of the two forms of the composition that is, the fibres and the particles, are identical, their biological responses can vary according to their physical properties such as their shape and size.
- the fibres were more easily manipulated than the particles and were more evenly distribued in the bone defect.
- the presence of the siliceous residue in the bony matrix did not appear to interfere with the bone remodelling process so that, in the inspections made at 4 months, resorption lacunae were already observed in the region of the cortical defect which by that time was completely repaired.
- the osteoclasts appear to cause the resorption of the matrix but do not seem to attack the fibres of the particles incorporated therein so that, when the whole of the matrix which surrounds it has been reabsorbed, the vitreous composition is, in the lacunae, in contact with the vasal and cellular components.
- the histological appearance of the fibres at this stage showed fragmentation, suggesting that the process of dissolution of the vitreous composition was progressing and that the fragmen ⁇ ts were being absorbed by giant polynucleate cells.
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Materials Engineering (AREA)
- Ceramic Engineering (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019920701897A KR950008173B1 (ko) | 1990-02-08 | 1991-02-04 | 골 이식용 생물활성 유리질 조성물, 이것으로 제조된 필라멘트 및 그 방법 |
CA002075281A CA2075281A1 (fr) | 1990-02-08 | 1991-02-04 | Composition vitreuse bioactive pour implants osseux, filaments fabriques avec ladite composition et methode de fabrication |
BR919106030A BR9106030A (pt) | 1990-02-08 | 1991-02-04 | Composicao vitrea bioativa para implantes osseos |
NO92923075A NO923075L (no) | 1990-02-08 | 1992-08-05 | Bioaktiv glass-sammensetning for benimplantater, filamenter fremstilt derfra og fremgangsmaate for deres fremstilling |
FI923561A FI923561A (fi) | 1990-02-08 | 1992-08-07 | Bioktiv glaskomposition foer benimplantat, filament framstaellda daerav och framstaellningsfoerfarande. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT67096A IT1240938B (it) | 1990-02-08 | 1990-02-08 | Composizione vetrosa bioattiva per impianti ossei e prodotti ottenuti con tale composizione o che la comprendono |
IT67096A/90 | 1990-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991012032A1 true WO1991012032A1 (fr) | 1991-08-22 |
Family
ID=11299541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1991/000201 WO1991012032A1 (fr) | 1990-02-08 | 1991-02-04 | Composition vitree bioactive destinee aux implants osseux, filaments formes a partir de celle-ci et methode |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0514401A1 (fr) |
JP (1) | JPH05502603A (fr) |
KR (1) | KR950008173B1 (fr) |
AU (1) | AU639981B2 (fr) |
BR (1) | BR9106030A (fr) |
CA (1) | CA2075281A1 (fr) |
FI (1) | FI923561A (fr) |
HU (1) | HUT61899A (fr) |
IT (1) | IT1240938B (fr) |
WO (1) | WO1991012032A1 (fr) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2682968A1 (fr) * | 1991-10-28 | 1993-04-30 | Icmc | Procede de realisation d'un implant osseux, dispositif permettant de mettre en óoeuvre le procede et implant ainsi realise. |
WO1993017976A1 (fr) * | 1992-03-09 | 1993-09-16 | Turku Implant Team Oy | Verre bioactif utilise comme substitut osseux |
EP0730681A1 (fr) * | 1993-11-15 | 1996-09-11 | The Trustees Of The University Of Pennsylvania | Materiaux composites a base de fibres de verre et de ceramique a bioactivite osseuse |
US6054400A (en) * | 1995-01-13 | 2000-04-25 | Brink; Maria | Bioactive glasses and their use |
WO2000035509A1 (fr) * | 1998-12-11 | 2000-06-22 | Ylaenen Heimo | Produit bio-actif et utilisation |
US6121172A (en) * | 1993-11-15 | 2000-09-19 | The Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
EP1903012A1 (fr) * | 2006-09-20 | 2008-03-26 | Inion Oy | Compositions de verre bioactif |
EP2823829A1 (fr) | 2007-04-23 | 2015-01-14 | Baxter International Inc. | Compositions à base de fibrine contenant des composés de strontium pour stimuler l'ossification |
US9421302B2 (en) | 2006-05-26 | 2016-08-23 | Baxter International Inc. | Injectable fibrin composition for bone augmentation |
WO2019108558A1 (fr) * | 2017-11-28 | 2019-06-06 | Corning Incorporated | Verre bioactif à viscosité de liquidus élevée |
US10751367B2 (en) | 2016-05-27 | 2020-08-25 | Corning Incorporated | Bioactive glass microspheres |
WO2020236501A1 (fr) * | 2019-05-22 | 2020-11-26 | Corning Incorporated | Compositions de verre bioactives |
US10857259B2 (en) | 2017-11-28 | 2020-12-08 | Corning Incorporated | Chemically strengthened bioactive glass-ceramics |
US11198638B2 (en) | 2017-11-28 | 2021-12-14 | Corning Incorporated | Bioactive borate glass and methods thereof |
US11274059B2 (en) | 2017-11-28 | 2022-03-15 | Corning Incorporated | Bioactive glass compositions and dentin hypersensitivity remediation |
US11814649B2 (en) | 2016-05-27 | 2023-11-14 | Corning Incorporated | Lithium disilicate glass-ceramic compositions and methods thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI117963B (fi) | 2001-04-26 | 2007-05-15 | Eija Marjut Pirhonen | Luuta korvaavat materiaalit |
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FR2243915A1 (fr) * | 1973-09-17 | 1975-04-11 | Leitz Ernst Gmbh | |
GB2080281A (en) * | 1980-06-11 | 1982-02-03 | Nippon Kogaku Kk | Biologically active glass |
DE3248649A1 (de) * | 1982-01-07 | 1983-07-14 | Nippon Kogaku K.K., Tokyo | Zahnimplantat und verfahren zu seiner herstellung |
EP0154513A2 (fr) * | 1984-03-01 | 1985-09-11 | Pfizer Hospital Products Group, Inc. | Compositions de verre pour liaison à des alliages |
US4708652A (en) * | 1984-03-06 | 1987-11-24 | Nippon Kogaku K. K. | Apatite composite ceramics |
DE3806215A1 (de) * | 1987-02-28 | 1988-09-08 | Hoya Corp | Anorganisches biomaterial und verfahren zu dessen herstellung |
DE3939831A1 (de) * | 1988-12-01 | 1990-06-07 | Nippon Electric Glass Co | Biokompatible glaskeramik |
-
1990
- 1990-02-08 IT IT67096A patent/IT1240938B/it active IP Right Grant
-
1991
- 1991-02-04 BR BR919106030A patent/BR9106030A/pt not_active Application Discontinuation
- 1991-02-04 JP JP3503103A patent/JPH05502603A/ja active Pending
- 1991-02-04 EP EP91902954A patent/EP0514401A1/fr not_active Withdrawn
- 1991-02-04 KR KR1019920701897A patent/KR950008173B1/ko active IP Right Grant
- 1991-02-04 AU AU71491/91A patent/AU639981B2/en not_active Ceased
- 1991-02-04 HU HU9202578A patent/HUT61899A/hu unknown
- 1991-02-04 WO PCT/EP1991/000201 patent/WO1991012032A1/fr not_active Application Discontinuation
- 1991-02-04 CA CA002075281A patent/CA2075281A1/fr not_active Abandoned
-
1992
- 1992-08-07 FI FI923561A patent/FI923561A/fi not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2243915A1 (fr) * | 1973-09-17 | 1975-04-11 | Leitz Ernst Gmbh | |
GB2080281A (en) * | 1980-06-11 | 1982-02-03 | Nippon Kogaku Kk | Biologically active glass |
DE3248649A1 (de) * | 1982-01-07 | 1983-07-14 | Nippon Kogaku K.K., Tokyo | Zahnimplantat und verfahren zu seiner herstellung |
EP0154513A2 (fr) * | 1984-03-01 | 1985-09-11 | Pfizer Hospital Products Group, Inc. | Compositions de verre pour liaison à des alliages |
US4708652A (en) * | 1984-03-06 | 1987-11-24 | Nippon Kogaku K. K. | Apatite composite ceramics |
DE3806215A1 (de) * | 1987-02-28 | 1988-09-08 | Hoya Corp | Anorganisches biomaterial und verfahren zu dessen herstellung |
DE3939831A1 (de) * | 1988-12-01 | 1990-06-07 | Nippon Electric Glass Co | Biokompatible glaskeramik |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2682968A1 (fr) * | 1991-10-28 | 1993-04-30 | Icmc | Procede de realisation d'un implant osseux, dispositif permettant de mettre en óoeuvre le procede et implant ainsi realise. |
WO1993017976A1 (fr) * | 1992-03-09 | 1993-09-16 | Turku Implant Team Oy | Verre bioactif utilise comme substitut osseux |
US6121172A (en) * | 1993-11-15 | 2000-09-19 | The Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
EP0730681A1 (fr) * | 1993-11-15 | 1996-09-11 | The Trustees Of The University Of Pennsylvania | Materiaux composites a base de fibres de verre et de ceramique a bioactivite osseuse |
EP0730681A4 (fr) * | 1993-11-15 | 1998-07-15 | Univ Pennsylvania | Materiaux composites a base de fibres de verre et de ceramique a bioactivite osseuse |
EP0871504A2 (fr) * | 1993-11-15 | 1998-10-21 | The Trustees Of The University Of Pennsylvania | Materiaux composites comprenant des fibres bioactives de verre et de ceramique utilisees pour constituer des implants osseux |
EP0871504A4 (fr) * | 1993-11-15 | 2000-08-16 | Univ Pennsylvania | Materiaux composites comprenant des fibres bioactives de verre et de ceramique utilisees pour constituer des implants osseux |
US6054400A (en) * | 1995-01-13 | 2000-04-25 | Brink; Maria | Bioactive glasses and their use |
WO2000035509A1 (fr) * | 1998-12-11 | 2000-06-22 | Ylaenen Heimo | Produit bio-actif et utilisation |
US6517857B2 (en) | 1998-12-11 | 2003-02-11 | Ylaenen Heimo | Bioactive product and its use |
AU761459B2 (en) * | 1998-12-11 | 2003-06-05 | Vivoxid Oy | A novel bioactive product and its use |
US9724449B2 (en) | 2006-05-26 | 2017-08-08 | Baxter International Inc. | Injectable fibrin composition for bone augmentation |
US9421302B2 (en) | 2006-05-26 | 2016-08-23 | Baxter International Inc. | Injectable fibrin composition for bone augmentation |
US8093166B2 (en) | 2006-09-20 | 2012-01-10 | Inion Oy | Bioactive glass compositions |
EP1903012A1 (fr) * | 2006-09-20 | 2008-03-26 | Inion Oy | Compositions de verre bioactif |
EP2823829A1 (fr) | 2007-04-23 | 2015-01-14 | Baxter International Inc. | Compositions à base de fibrine contenant des composés de strontium pour stimuler l'ossification |
US10751367B2 (en) | 2016-05-27 | 2020-08-25 | Corning Incorporated | Bioactive glass microspheres |
US11814649B2 (en) | 2016-05-27 | 2023-11-14 | Corning Incorporated | Lithium disilicate glass-ceramic compositions and methods thereof |
WO2019108558A1 (fr) * | 2017-11-28 | 2019-06-06 | Corning Incorporated | Verre bioactif à viscosité de liquidus élevée |
CN111433165A (zh) * | 2017-11-28 | 2020-07-17 | 康宁股份有限公司 | 高液相线粘度生物活性玻璃 |
US10857259B2 (en) | 2017-11-28 | 2020-12-08 | Corning Incorporated | Chemically strengthened bioactive glass-ceramics |
US11198638B2 (en) | 2017-11-28 | 2021-12-14 | Corning Incorporated | Bioactive borate glass and methods thereof |
US11274059B2 (en) | 2017-11-28 | 2022-03-15 | Corning Incorporated | Bioactive glass compositions and dentin hypersensitivity remediation |
US11384009B2 (en) | 2017-11-28 | 2022-07-12 | Corning Incorporated | High liquidus viscosity bioactive glass |
US11446410B2 (en) | 2017-11-28 | 2022-09-20 | Corning Incorporated | Chemically strengthened bioactive glass-ceramics |
WO2020236501A1 (fr) * | 2019-05-22 | 2020-11-26 | Corning Incorporated | Compositions de verre bioactives |
Also Published As
Publication number | Publication date |
---|---|
IT1240938B (it) | 1993-12-27 |
CA2075281A1 (fr) | 1991-08-09 |
KR950008173B1 (ko) | 1995-07-26 |
IT9067096A0 (it) | 1990-02-08 |
BR9106030A (pt) | 1993-03-02 |
AU7149191A (en) | 1991-09-03 |
JPH05502603A (ja) | 1993-05-13 |
AU639981B2 (en) | 1993-08-12 |
HUT61899A (en) | 1993-03-29 |
FI923561A0 (fi) | 1992-08-07 |
IT9067096A1 (it) | 1991-08-08 |
EP0514401A1 (fr) | 1992-11-25 |
FI923561A (fi) | 1992-08-07 |
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