WO1991009961A3 - Nouveaux produits - Google Patents

Nouveaux produits Download PDF

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Publication number
WO1991009961A3
WO1991009961A3 PCT/GB1990/001997 GB9001997W WO9109961A3 WO 1991009961 A3 WO1991009961 A3 WO 1991009961A3 GB 9001997 W GB9001997 W GB 9001997W WO 9109961 A3 WO9109961 A3 WO 9109961A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel products
paraherquamide
imi
oxides
preparing
Prior art date
Application number
PCT/GB1990/001997
Other languages
English (en)
Other versions
WO1991009961A2 (fr
Inventor
Rhona Mary Banks
Simon Edward Blanchflower
Christopher Reading
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898928844A external-priority patent/GB8928844D0/en
Priority claimed from GB909024716A external-priority patent/GB9024716D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of WO1991009961A2 publication Critical patent/WO1991009961A2/fr
Publication of WO1991009961A3 publication Critical patent/WO1991009961A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composés apparentés à la paraherquamide préparés par culture de Penicillium sp. IMI 332995. La présente invention décrit en outre une méthode synthétique de préparation des N-oxydes de dérivés de paraherquamide.
PCT/GB1990/001997 1989-12-21 1990-12-20 Nouveaux produits WO1991009961A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898928844A GB8928844D0 (en) 1989-12-21 1989-12-21 Novel compounds
GB8928844.3 1989-12-21
GB909024716A GB9024716D0 (en) 1990-11-14 1990-11-14 Novel products
GB9024716.4 1990-11-14

Publications (2)

Publication Number Publication Date
WO1991009961A2 WO1991009961A2 (fr) 1991-07-11
WO1991009961A3 true WO1991009961A3 (fr) 1991-10-31

Family

ID=26296401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/001997 WO1991009961A2 (fr) 1989-12-21 1990-12-20 Nouveaux produits

Country Status (6)

Country Link
EP (1) EP0506814A1 (fr)
JP (1) JPH05502163A (fr)
CA (1) CA2071982A1 (fr)
IE (1) IE904606A1 (fr)
PT (1) PT96298A (fr)
WO (1) WO1991009961A2 (fr)

Families Citing this family (43)

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JP3134936B2 (ja) * 1992-10-16 2001-02-13 沖電気工業株式会社 衝撃センサ
TW410227B (en) * 1993-06-16 2000-11-01 Upjohn Co 14-substituted marcfortines and derivatives useful as antiparasitic agents
TW334436B (en) * 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
ZA976761B (en) * 1996-09-09 1999-01-29 Upjohn Co 25 Methylene and 24,25-epoxy marcfortines and paraherquamides
AU4911097A (en) * 1996-11-15 1998-06-03 Pharmacia & Upjohn Company 1- and 2-substituted marcfortines and paraherquamides as antiparasitic agents
EP2364301B1 (fr) 2008-11-14 2015-09-02 Merial Limited Composés aryloazol-2-yl-cyanoéthylamino parasiticide énantiomériquement enrichis
WO2010059529A2 (fr) 2008-11-19 2010-05-27 Merial Limited Compositions comprenant un arylpyrazole et/ou une formamidine, procédés et utilisations de celles-ci
NZ593184A (en) 2008-12-04 2012-11-30 Merial Ltd Dimeric avermectin and milbemycin derivatives
US8846569B2 (en) 2009-12-04 2014-09-30 Merial Limited Pesticidal bis-organosulfur compounds
DK3078664T3 (da) 2009-12-17 2019-05-13 Merial Inc Antiparasitiske dihydroazol-sammensætninger
AU2010330844B2 (en) 2009-12-17 2014-11-27 Boehringer Ingelheim Animal Health USA Inc. Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
CA2818563C (fr) 2010-11-16 2019-11-12 Merial Limited Derives de monensine destines au traitement et a la prevention d'infections a protozoaires.
US20120329832A1 (en) 2011-06-27 2012-12-27 Jean Delaveau Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use
WO2013003505A1 (fr) 2011-06-27 2013-01-03 Merial Limited Composés et compositions d'amidopyridyléther et leur utilisation contre des parasites
PL2755473T3 (pl) 2011-09-12 2019-05-31 Merial Inc Kompozycje przeciwpasożytniczne zawierające izoksazolinową substancję czynną, sposoby i ich zastosowania
US20130079394A1 (en) 2011-09-23 2013-03-28 Cnrs (Centre National Recherche Scientifique) Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods
CN104023720B (zh) 2011-11-17 2016-10-26 梅里亚有限公司 包含芳基吡唑和取代咪唑的组合物，其方法和用途
MX358476B (es) 2011-12-02 2018-08-22 Merial Ltd Formulaciones de moxidectina inyectables de larga acción y formas de cristal de moxidectina novedosas.
AP2014007874A0 (en) 2012-02-06 2014-08-31 Merial Ltd Parasiticidal oral veterinary compositions comprising systemetically- acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
BR122015032742B1 (pt) 2012-04-20 2020-04-07 Merial Ltd composições parasiticídicas compreendendo derivados de benzimidazol, métodos e seus usos
NZ708350A (en) 2012-11-20 2016-08-26 Merial Inc Anthelmintic compounds and compositions and method of using thereof
EP3063144B1 (fr) 2013-11-01 2021-09-08 Boehringer Ingelheim Animal Health USA Inc. Composés d'isoxazoline antiparasitaires et pesticides
ES2765405T3 (es) 2014-04-17 2020-06-09 Boehringer Ingelheim Animal Health Usa Inc Utilización de compuestos de malononitrilo para proteger animales de parásitos
CN106536518B (zh) 2014-05-19 2020-05-12 勃林格殷格翰动物保健美国公司 驱蠕虫化合物
EP3517524B1 (fr) 2014-06-19 2021-05-26 Boehringer Ingelheim Animal Health USA Inc. Compositions parasiticides comprenant des dérivés d'indole, procédés et utilisations associés
NZ731446A (en) 2014-10-31 2018-09-28 Boehringer Ingelheim Animal Health Usa Inc Parasiticidal composition comprising fipronil
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
HUE055535T2 (hu) 2015-05-20 2021-12-28 Boehringer Ingelheim Animal Health Usa Inc Féreghajtó depszipeptid-vegyületek
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
WO2018039508A1 (fr) 2016-08-25 2018-03-01 Merial, Inc. Procédé de réduction d'effets indésirables dans des traitements antiparasitaires
JP2019535655A (ja) 2016-10-14 2019-12-12 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺虫性及び殺寄生虫性ビニルイソオキサゾリン化合物
WO2018093920A1 (fr) 2016-11-16 2018-05-24 Merial, Inc. Composés depsipeptidiques anthelminthiques
EP3668866B1 (fr) 2017-08-14 2023-01-18 Boehringer Ingelheim Animal Health USA Inc. Composés de pyrazole-isoxazoline à activité pesticide et parasiticide
WO2019157241A1 (fr) 2018-02-08 2019-08-15 Boehringer Ingelheim Animal Health USA Inc. Compositions parasiticides comprenant de l'éprinomectine et du praziquantel, procédés et utilisations associés
AU2019301510B2 (en) 2018-07-09 2024-06-13 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anthelminthic heterocyclic compounds
US11773066B2 (en) 2018-11-20 2023-10-03 Boehringer Ingelheim Animal Health USA Inc. Indazolylcyanoethylamino compound, compositions of same, method of making, and methods of using thereof
AR118215A1 (es) 2019-03-01 2021-09-22 Boehringer Ingelheim Animal Health Usa Inc Composiciones inyectables de clorsulón, sus métodos y usos
US11560388B2 (en) 2019-03-19 2023-01-24 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic aza-benzothiophene and aza-benzofuran compounds
WO2021242581A1 (fr) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Composés hétérocycliques anthelminthiques
CA3205997A1 (fr) 2020-12-21 2022-06-30 University Of Georgia Research Foundation Inc. Collier parasiticide comprenant des composes d'isoxazoline
WO2023156938A1 (fr) 2022-02-17 2023-08-24 Boehringer Ingelheim Vetmedica Gmbh Procédé et système pour fournir un dispositif d'expédition de produit fluide

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0301742A2 (fr) * 1987-07-28 1989-02-01 Merck & Co. Inc. Paraherquamide et dihydroparaherquamide comme agents antiparasitaires
EP0322937A2 (fr) * 1987-11-27 1989-07-05 Merck & Co. Inc. Dérivés de la paraherquamide isolés à partir d'un bouillon de fermentation et actifs comme agents antiparasitaires
US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
EP0354615A1 (fr) * 1988-08-12 1990-02-14 Merck & Co. Inc. Dérivés synthétiques de paraherquamide
US4923867A (en) * 1988-08-24 1990-05-08 Merck & Co., Inc. Synthetic marcfortine derivatives useful as antiparasitic agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0301742A2 (fr) * 1987-07-28 1989-02-01 Merck & Co. Inc. Paraherquamide et dihydroparaherquamide comme agents antiparasitaires
EP0322937A2 (fr) * 1987-11-27 1989-07-05 Merck & Co. Inc. Dérivés de la paraherquamide isolés à partir d'un bouillon de fermentation et actifs comme agents antiparasitaires
EP0354615A1 (fr) * 1988-08-12 1990-02-14 Merck & Co. Inc. Dérivés synthétiques de paraherquamide
US4866060A (en) * 1988-08-19 1989-09-12 Merck & Co., Inc. Use of the natural product marcfortines as antiparasitic agents
US4923867A (en) * 1988-08-24 1990-05-08 Merck & Co., Inc. Synthetic marcfortine derivatives useful as antiparasitic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J. Am. Chem. Soc., vol. 110, No. 17, August 1988, R.M. Williams et al: "Facial selectivity of the intramolecular SN2' cyclization: Stereocontrolled total synthesis of brevianamide B", pages 5927-5929, see compound 6 *
J. Am. Chem. Soc., vol. 111, April 1989, R.M. Williams et al: "Remarkable, enantiodivergent biogenesis of brevianamide A and B", pages 3064-3065, see compound 7 *

Also Published As

Publication number Publication date
PT96298A (pt) 1991-09-30
JPH05502163A (ja) 1993-04-22
CA2071982A1 (fr) 1991-06-22
IE904606A1 (en) 1991-07-03
EP0506814A1 (fr) 1992-10-07
WO1991009961A2 (fr) 1991-07-11

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