WO1991002553A3 - Pastille dotee de stimulateurs de penetration pour la liberation transdermique de nitroglycerine - Google Patents

Pastille dotee de stimulateurs de penetration pour la liberation transdermique de nitroglycerine Download PDF

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Publication number
WO1991002553A3
WO1991002553A3 PCT/US1990/004456 US9004456W WO9102553A3 WO 1991002553 A3 WO1991002553 A3 WO 1991002553A3 US 9004456 W US9004456 W US 9004456W WO 9102553 A3 WO9102553 A3 WO 9102553A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitroglycerin
transdermal
penetration enhancers
patch
disclosed
Prior art date
Application number
PCT/US1990/004456
Other languages
English (en)
Other versions
WO1991002553A2 (fr
Inventor
Sharad K Govil
Edward M Rudnic
Dale G Sterner
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to KR1019920700359A priority Critical patent/KR950003696B1/ko
Publication of WO1991002553A2 publication Critical patent/WO1991002553A2/fr
Publication of WO1991002553A3 publication Critical patent/WO1991002553A3/fr
Priority to NO920605A priority patent/NO920605D0/no
Priority to FI920630A priority patent/FI920630A0/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Abstract

Une pastille pour la libération transdermique de nitroglycérine offrant des caractéristiques supérieures de pénétration de la nitroglycérine dans la peau comprend un stimulateur de pénétration au niveau percutané, ledit stimulateur pouvant être un seul ou plusieurs des éléments suivants comme du N-méthyle-2-pyrrolidone, de l'acide oléique, de l'alcool oléyle, de l'acide linoléique, du linoléate isopropyle, de l'azone et du butanediol. Est également présenté un modèle de pastille transdermique comprenant deux anneaux concentriques, dans lesquels les concentrations de nitroglycérine et de stimulateur de perméabilité varient.
PCT/US1990/004456 1989-08-17 1990-08-15 Pastille dotee de stimulateurs de penetration pour la liberation transdermique de nitroglycerine WO1991002553A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019920700359A KR950003696B1 (ko) 1989-08-17 1990-08-15 침투 증강제가 포함된 경피용 니트로글리세린 패취
NO920605A NO920605D0 (no) 1989-08-17 1992-02-14 Transdermalt nitroglyserinplaster med penetreringsforoekere
FI920630A FI920630A0 (fi) 1989-08-17 1992-02-14 Transdermalt nitroglycerinplaoster med penetration befraemjande medel.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39511989A 1989-08-17 1989-08-17
US395,119 1989-08-17

Publications (2)

Publication Number Publication Date
WO1991002553A2 WO1991002553A2 (fr) 1991-03-07
WO1991002553A3 true WO1991002553A3 (fr) 1991-04-04

Family

ID=23561776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/004456 WO1991002553A2 (fr) 1989-08-17 1990-08-15 Pastille dotee de stimulateurs de penetration pour la liberation transdermique de nitroglycerine

Country Status (11)

Country Link
EP (2) EP0486529A1 (fr)
AU (1) AU643230B2 (fr)
CA (1) CA2064845A1 (fr)
FI (1) FI920630A0 (fr)
HU (1) HUT59596A (fr)
IE (1) IE902970A1 (fr)
IL (1) IL95387A0 (fr)
NZ (1) NZ234919A (fr)
PT (1) PT95012A (fr)
WO (1) WO1991002553A2 (fr)
ZA (1) ZA906472B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653156B2 (en) * 1990-06-14 1994-09-22 Dermamed Transdermal administration to humans and animals
DE4210165A1 (de) * 1991-07-30 1993-02-04 Schering Ag Transdermale therapeutische systeme
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
US6635274B1 (en) * 2000-10-27 2003-10-21 Biochemics, Inc. Solution-based transdermal drug delivery system
JP5820206B2 (ja) 2011-09-13 2015-11-24 日東電工株式会社 経皮吸収促進用組成物および貼付製剤
JP5820207B2 (ja) * 2011-09-13 2015-11-24 日東電工株式会社 経皮吸収促進用組成物および貼付製剤
CA3209102A1 (fr) * 2020-12-23 2022-06-30 Christopher USREY Timbres transdermiques pour la reduction et/ou la recuperation de la gueule de bois, et/ou l'amelioration du sommeil

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129285A2 (fr) * 1983-06-21 1984-12-27 The Procter & Gamble Company Compositions pharmaceutiques topiques pénétrantes contenant de la N-(2-hydroxyéthyl)-pyrrolidone
EP0196769A2 (fr) * 1985-02-25 1986-10-08 Rutgers, The State University of New Jersey Unité de dosage pour l'absorption transdermique d'un produit pharmaceutique
EP0224981A2 (fr) * 1985-11-04 1987-06-10 Paco Research Corporation Système pour l'administration de nitroglycérine par voie transdermique
WO1987003490A2 (fr) * 1985-12-06 1987-06-18 Key Pharmaceuticals, Inc. Systeme d'administration transcutanee
EP0261249A1 (fr) * 1986-04-04 1988-03-30 Fanuc Ltd. Procede permettant de preparer des donnees de commande numerique d'une surface courbe composite
EP0290262A2 (fr) * 1987-05-08 1988-11-09 EASTMAN KODAK COMPANY (a New Jersey corporation) Thérapie de l'angine de poitrine par le nitrate
WO1988009676A1 (fr) * 1987-06-01 1988-12-15 Warner-Lambert Company Acides gras et leurs esters a petite chaine utilises a titre de renforcateurs de penetration dans des systemes aqueux
EP0341202A1 (fr) * 1988-04-22 1989-11-08 Ciba-Geigy Ag Systèmes monolithiques transdermaux

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
JPS63170316A (ja) * 1986-12-30 1988-07-14 Fujimoto Seiyaku Kk ニフエジピン経皮吸収外用製剤

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129285A2 (fr) * 1983-06-21 1984-12-27 The Procter & Gamble Company Compositions pharmaceutiques topiques pénétrantes contenant de la N-(2-hydroxyéthyl)-pyrrolidone
EP0196769A2 (fr) * 1985-02-25 1986-10-08 Rutgers, The State University of New Jersey Unité de dosage pour l'absorption transdermique d'un produit pharmaceutique
EP0224981A2 (fr) * 1985-11-04 1987-06-10 Paco Research Corporation Système pour l'administration de nitroglycérine par voie transdermique
WO1987003490A2 (fr) * 1985-12-06 1987-06-18 Key Pharmaceuticals, Inc. Systeme d'administration transcutanee
EP0261249A1 (fr) * 1986-04-04 1988-03-30 Fanuc Ltd. Procede permettant de preparer des donnees de commande numerique d'une surface courbe composite
EP0290262A2 (fr) * 1987-05-08 1988-11-09 EASTMAN KODAK COMPANY (a New Jersey corporation) Thérapie de l'angine de poitrine par le nitrate
WO1988009676A1 (fr) * 1987-06-01 1988-12-15 Warner-Lambert Company Acides gras et leurs esters a petite chaine utilises a titre de renforcateurs de penetration dans des systemes aqueux
EP0341202A1 (fr) * 1988-04-22 1989-11-08 Ciba-Geigy Ag Systèmes monolithiques transdermaux

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, volume 109, no. 26, 26 December 1988, (Columbus, Ohio, US), see page 395 *
STN File Server International (Karlsruhe), File CA & Chemical Abstracts, volume 107, no. 8, 24 August 1987, (Columbus, Ohio, US), A.F. Kydonieus: "Transdermal delivery from solid multilayered polymeric reservoir systems" *

Also Published As

Publication number Publication date
AU643230B2 (en) 1993-11-11
HUT59596A (en) 1992-06-29
ZA906472B (en) 1991-05-29
PT95012A (pt) 1991-05-22
NZ234919A (en) 1992-07-28
EP0417496A3 (en) 1991-07-03
AU6141090A (en) 1991-04-03
EP0486529A1 (fr) 1992-05-27
FI920630A0 (fi) 1992-02-14
CA2064845A1 (fr) 1991-02-18
IE902970A1 (en) 1991-02-27
IL95387A0 (en) 1991-06-30
HU9200459D0 (en) 1992-05-28
EP0417496A2 (fr) 1991-03-20
WO1991002553A2 (fr) 1991-03-07

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