WO1991001125A3 - Composes a activite de peroxydase du glutathione et leur utilisation - Google Patents

Composes a activite de peroxydase du glutathione et leur utilisation

Info

Publication number
WO1991001125A3
WO1991001125A3 PCT/US1990/003963 US9003963W WO9101125A3 WO 1991001125 A3 WO1991001125 A3 WO 1991001125A3 US 9003963 W US9003963 W US 9003963W WO 9101125 A3 WO9101125 A3 WO 9101125A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
glutathione peroxidase
peroxidase activity
present
cataracts
Prior art date
Application number
PCT/US1990/003963
Other languages
English (en)
Other versions
WO1991001125A2 (fr
Inventor
Abraham Spector
Stephen R Wilson
Paul A Zucker
Original Assignee
Univ Columbia
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Univ New York filed Critical Univ Columbia
Publication of WO1991001125A2 publication Critical patent/WO1991001125A2/fr
Publication of WO1991001125A3 publication Critical patent/WO1991001125A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention décrit des composés ayant une activité de peroxydase du glutathione et qui constituent donc des substitutions efficaces à la peroxydase du glutathione. Ces composés sont utiles comme médicaments pour la prévention des cataractes et comme antioxydants pour le H2O2 et d'autres peroxydes. La présente invention décrit en outre des méthodes et des préparations pharmaceutiques contenant ce composé.
PCT/US1990/003963 1989-07-19 1990-07-17 Composes a activite de peroxydase du glutathione et leur utilisation WO1991001125A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/383,189 US5128365A (en) 1989-07-19 1989-07-19 Compounds having glutathione peroxidase activity and use thereof
US383,189 1989-07-19

Publications (2)

Publication Number Publication Date
WO1991001125A2 WO1991001125A2 (fr) 1991-02-07
WO1991001125A3 true WO1991001125A3 (fr) 1991-03-21

Family

ID=23512091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/003963 WO1991001125A2 (fr) 1989-07-19 1990-07-17 Composes a activite de peroxydase du glutathione et leur utilisation

Country Status (3)

Country Link
US (2) US5128365A (fr)
AU (1) AU6061990A (fr)
WO (1) WO1991001125A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001853A (en) * 1996-01-26 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Hydroxylamine compositions for the prevention or retardation of cataracts
FR2757860B1 (fr) 1996-12-27 1999-04-23 Oxis International Sa Composes organoselenies cycliques, leur preparation et leurs utilisations, notamment therapeutiques
FR2757857B1 (fr) * 1996-12-27 1999-04-23 Oxis International Sa Diselenures et selenosulfures aromatiques, leur preparation et leurs utilisations, notamment therapeutiques
US6630442B1 (en) * 1997-01-10 2003-10-07 Theodore Hersh Reparatives for chemosurgery and laser (thermal) therapy
US6138683A (en) * 1997-09-19 2000-10-31 Thione International, Inc. Smokeless tobacco products containing antioxidants
US5922346A (en) * 1997-12-01 1999-07-13 Thione International, Inc. Antioxidant preparation
DE60211875T2 (de) * 2002-07-01 2006-10-26 Santhera Pharmaceuticals (Schweiz) Ag Screeningverfahren und Verbindungen zur Behandlung von Friedreich ataxia
US10572963B1 (en) 2017-07-14 2020-02-25 Synapse Technology Corporation Detection of items
JP6535710B2 (ja) * 2017-08-09 2019-06-26 有限会社オービット α−Ｃｒｙｓｔａｌｌｉｎの発現誘導剤、α−Ｃｒｙｓｔａｌｌｉｎの発現誘導剤を含む白内障予防・進行抑制剤、およびα−Ｃｒｙｓｔａｌｌｉｎの発現誘導剤の製造方法
US20210145762A1 (en) * 2019-11-15 2021-05-20 Redox Balance Llc Methods of treating oxidative stress to modulate redox balance, preventing oxidative stress induced cell damage and death

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730053A (en) * 1984-11-29 1988-03-08 A. Nattermann & Cie Gmbh S-[2-phenyl (alkyl) carbamoyl]-phenylselenylmercapto derivatives
US4910313A (en) * 1986-08-06 1990-03-20 Nattermann & Cie Gmbh Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and process for the treatment of certain diseases in humans

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0198277B1 (fr) * 1985-04-12 1989-05-03 A. Nattermann & Cie. GmbH Diséléno bisbenzamides d'amines primaires et secondaires, leurs procédés de préparation et compositions pharmaceutiques les contenant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4730053A (en) * 1984-11-29 1988-03-08 A. Nattermann & Cie Gmbh S-[2-phenyl (alkyl) carbamoyl]-phenylselenylmercapto derivatives
US4910313A (en) * 1986-08-06 1990-03-20 Nattermann & Cie Gmbh Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and process for the treatment of certain diseases in humans

Also Published As

Publication number Publication date
WO1991001125A2 (fr) 1991-02-07
US5128365A (en) 1992-07-07
AU6061990A (en) 1991-02-22
US5321138A (en) 1994-06-14

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