WO1990015145A3 - Poliovirus chimaeras - Google Patents

Poliovirus chimaeras Download PDF

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Publication number
WO1990015145A3
WO1990015145A3 PCT/GB1990/000841 GB9000841W WO9015145A3 WO 1990015145 A3 WO1990015145 A3 WO 1990015145A3 GB 9000841 W GB9000841 W GB 9000841W WO 9015145 A3 WO9015145 A3 WO 9015145A3
Authority
WO
WIPO (PCT)
Prior art keywords
poliovirus
dra
sal
vector
sites
Prior art date
Application number
PCT/GB1990/000841
Other languages
French (fr)
Other versions
WO1990015145A2 (en
Inventor
Jeffrey William Almond
David John Evans
Karen Lesley Burke
Original Assignee
Medical Res Council
Univ Reading
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898912495A external-priority patent/GB8912495D0/en
Priority claimed from GB909009644A external-priority patent/GB9009644D0/en
Priority to CA002033190A priority Critical patent/CA2033190C/en
Application filed by Medical Res Council, Univ Reading filed Critical Medical Res Council
Publication of WO1990015145A2 publication Critical patent/WO1990015145A2/en
Publication of WO1990015145A3 publication Critical patent/WO1990015145A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32611—Poliovirus
    • C12N2770/32622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A cassette vector suitable for use in constructing poliovirus chimaeras, which vector comprises, under the control of a promoter, a full length infectious cDNA of an attenuated strain of type 1 poliovirus having Sal 1 and Dra 1 sites flanking atigenic site 1 of the poliovirus (I), where the numbers represent the numbers of amino acids of the VP1 capsid protein and X represents intervening nucleotides of DNA, present in sufficient numbers to allow the vector to be digested with both Sal 1 and Dra 1, the said Sal 1 and Dra 1 sites being the only Sal 1 and Dra 1 sites in the vector.
PCT/GB1990/000841 1989-05-25 1990-05-31 Poliovirus chimaeras WO1990015145A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002033190A CA2033190C (en) 1989-05-25 1990-05-25 N-phenylalkyl substituted alpha-amino carboxamide derivatives and process for their preparation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8912495.2 1989-05-31
GB898912495A GB8912495D0 (en) 1989-05-31 1989-05-31 Poliovirus chimaeras
GB9009644.7 1990-04-30
GB909009644A GB9009644D0 (en) 1990-04-30 1990-04-30 Poliovirus chimaeras

Publications (2)

Publication Number Publication Date
WO1990015145A2 WO1990015145A2 (en) 1990-12-13
WO1990015145A3 true WO1990015145A3 (en) 1991-01-24

Family

ID=26295424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1990/000841 WO1990015145A2 (en) 1989-05-25 1990-05-31 Poliovirus chimaeras

Country Status (3)

Country Link
EP (1) EP0478588A1 (en)
CA (1) CA2055613A1 (en)
WO (1) WO1990015145A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125896D0 (en) * 1991-12-05 1992-02-05 Almond Jeffrey W Bicistronic viruses
MX9206981A (en) * 1991-12-06 1994-08-31 Whitehead Biomedical Inst RECOMBINANT VACCINES AND METHOD FOR PRODUCING THEM.
US5965124A (en) * 1991-12-06 1999-10-12 Whitehead Institute For Biomedical Research Replication-competent recombinant viral vaccines and method of producing same
EP0698100A1 (en) * 1993-05-13 1996-02-28 Connaught Laboratories Limited Hybrid picornaviruses expressing chlamydial epitopes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217325A (en) * 1988-04-08 1989-10-25 British Bio Technology Synthetic gene encoding tumour necrosis factor alpha
EP0302801B1 (en) * 1987-08-07 1995-10-18 Institut Pasteur Vaccines of which the characteristic epitope is incorporated in a picorna virus protein, particularly in that of the polio virus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302801B1 (en) * 1987-08-07 1995-10-18 Institut Pasteur Vaccines of which the characteristic epitope is incorporated in a picorna virus protein, particularly in that of the polio virus
GB2217325A (en) * 1988-04-08 1989-10-25 British Bio Technology Synthetic gene encoding tumour necrosis factor alpha

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
EMBO Journal, Volume 7, No. 9, 1988, IRL Press Limited, (Oxford, GB), A. MARTIN et al.: "Engineering a Poliovirus Type 2 Antigenic Site on a Type 1 Capsid Results in a Chimaeric Virus which is Neurovirulent for Mice", pages 2839-2847 see the whole article (cited in the application) *
J. Gen Virol., Volume 70, 1989, SGM, (GB), K.L. BURKE et al.: "A Cassette Vector for the Construction of Antigen Chimaeras of Poliovirus", pages 2475-2479 see the whole article *
Joint ESACT/IABS Meeting on the use of Heteroploid and other Cell Substrates for the Production of Biologicals, Heidelberg, F.R. Germany, 1981, Develop. Biol. Standard, S. Karger, (Basel, CH), H. KOPECKA et al.: "Restriction Map of Poliovirus Type 1 cDNA", pages 301-309 see firgures *
Nature, Volume 339, No. 6223, 1 June 1989, (London, GB), D.J. EVANS et al.: "An Engineered Poliovirus Chimaera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies", pages 385-388 see the whole article *
Proc. Natl. Acad. Sci. USA, Volume 85, January 1988, R.J. KUHN et al.: "Construction of a "Mutagenesis Cartridge" for Poliovirus Genome-Linked Viral Protein: Isolation and Characterization of Viable and Nonviable Mutants", pages 519-523 see the whole article (cited in the application) *
Proc. Natl. Acad. Sci. USA, Volume 85, May 1988, M.G. MURRAY et al.: "Poliovirus Type 1/Type 3 Antigenic Hybrid Virus Contructed in Vitro Elicits Type 1 and Type 3 Neutralizing Antibodies in in Rabbits and Monkeys", pages 3203-3207 see the whole article (cited in the application) *

Also Published As

Publication number Publication date
EP0478588A1 (en) 1992-04-08
CA2055613A1 (en) 1990-12-01
WO1990015145A2 (en) 1990-12-13

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