WO1990011758A3 - Use of a potassic agonist in the treatment of glaucoma - Google Patents

Use of a potassic agonist in the treatment of glaucoma Download PDF

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Publication number
WO1990011758A3
WO1990011758A3 PCT/FR1990/000223 FR9000223W WO9011758A3 WO 1990011758 A3 WO1990011758 A3 WO 1990011758A3 FR 9000223 W FR9000223 W FR 9000223W WO 9011758 A3 WO9011758 A3 WO 9011758A3
Authority
WO
WIPO (PCT)
Prior art keywords
potassic
agonist
glaucoma
treatment
chromene
Prior art date
Application number
PCT/FR1990/000223
Other languages
French (fr)
Other versions
WO1990011758A2 (en
Inventor
Patrick Gautier
Fur Gerard Le
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of WO1990011758A2 publication Critical patent/WO1990011758A2/en
Publication of WO1990011758A3 publication Critical patent/WO1990011758A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Use of a potassic agonist to reduce and/or control abnormally high intraocular pressure. Cyano-6 (dihydro-1,2 oxo-2 pyridyl-1)-4 dimethyl-2,2 chromene is especially favoured. Said potassic agonist can be used, according to the invention, in combination with an adrenergic beta-blocking agent and/or with an anti-inflammatory agent.
PCT/FR1990/000223 1989-03-30 1990-03-30 Use of a potassic agonist in the treatment of glaucoma WO1990011758A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8904180A FR2645021A1 (en) 1989-03-30 1989-03-30 USE OF A POTASSIC AGONIST IN THE TREATMENT OF GLAUCOMA
FR89/04180 1989-03-30

Publications (2)

Publication Number Publication Date
WO1990011758A2 WO1990011758A2 (en) 1990-10-18
WO1990011758A3 true WO1990011758A3 (en) 1990-11-29

Family

ID=9380209

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1990/000223 WO1990011758A2 (en) 1989-03-30 1990-03-30 Use of a potassic agonist in the treatment of glaucoma

Country Status (4)

Country Link
EP (1) EP0465583A1 (en)
JP (1) JPH04506208A (en)
FR (1) FR2645021A1 (en)
WO (1) WO1990011758A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9439862B2 (en) 2000-05-10 2016-09-13 Novartis Ag Phospholipid-based powders for drug delivery

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713498B2 (en) * 2001-05-30 2004-03-30 Alteon Incorporated Method for treating glaucoma VI

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2735046A1 (en) * 1976-08-04 1978-02-09 Abbott Lab USE OF BENZOPYRANS TO REDUCE INTRAOCULAR PRESSURE
DE2810801A1 (en) * 1977-03-14 1978-09-21 Abbott Lab ESTER OF 1,4-AETHANO-10-HYDROXY-5-OXO-5H- SQUARE CLAMP ON 1 SQUARE CLAMP CLOSE - BENZOPYRANO- SQUARE CLAMP ON 3.4-B SQUARE CLAMP CLOSE -PYRIDINE
BE868052A (en) * 1978-06-12 1978-10-02 Sisa Inc COMPOSITION AND METHOD FOR THE TREATMENT OF GLAUCOMA
US4348398A (en) * 1980-12-23 1982-09-07 Merck Sharp & Dohme (I.A.) Corp. Quinolinyl ethanolamines
DE3726261A1 (en) * 1986-12-23 1988-07-07 Merck Patent Gmbh CHROME DERIVATIVES
EP0296975A1 (en) * 1987-06-23 1988-12-28 MERCK PATENT GmbH 2,2-Dimethyl-3-chromanol derivatives, process of their preparation and pharmaceutical compositions containing them
EP0323745A2 (en) * 1988-01-06 1989-07-12 Beecham Group Plc Pharmaceutical preparations
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2735046A1 (en) * 1976-08-04 1978-02-09 Abbott Lab USE OF BENZOPYRANS TO REDUCE INTRAOCULAR PRESSURE
DE2810801A1 (en) * 1977-03-14 1978-09-21 Abbott Lab ESTER OF 1,4-AETHANO-10-HYDROXY-5-OXO-5H- SQUARE CLAMP ON 1 SQUARE CLAMP CLOSE - BENZOPYRANO- SQUARE CLAMP ON 3.4-B SQUARE CLAMP CLOSE -PYRIDINE
BE868052A (en) * 1978-06-12 1978-10-02 Sisa Inc COMPOSITION AND METHOD FOR THE TREATMENT OF GLAUCOMA
US4348398A (en) * 1980-12-23 1982-09-07 Merck Sharp & Dohme (I.A.) Corp. Quinolinyl ethanolamines
DE3726261A1 (en) * 1986-12-23 1988-07-07 Merck Patent Gmbh CHROME DERIVATIVES
EP0296975A1 (en) * 1987-06-23 1988-12-28 MERCK PATENT GmbH 2,2-Dimethyl-3-chromanol derivatives, process of their preparation and pharmaceutical compositions containing them
EP0323745A2 (en) * 1988-01-06 1989-07-12 Beecham Group Plc Pharmaceutical preparations
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Current Eye Research, Vol. 4, No. 4, 1985, IRL Press Limited, (Oxford, GB), J.L. RAE: "The Application of Patch Clamp Methods to Ocular Epithelia", pages 408-420 *
J. Med. Chem., Vol. 29, 1986, American Chemical Society, V.A. ASHWOOD et al.: "Synthesis and Antihypertensive Activity of 4-(Cyclic Amido)-2H-1-Benzopyrans", pages 2194-2201 *
Ophthalmology, Vol. 86, Janvier 1979, F.W. NEWELL et al.: "Nabilone: A Pressure-Reducing Synthetic Benzopyran in Open-Angle Glaucoma", pages 156-160 *
Ophthalmology, Vol. 88, No. 3, Mars 1981, American Academy of Ophthalmology, J.S. TIEDEMAN et al.: "Effect of Synthetic Cannabinoids on Elevated Intraocular Pressure", pages 270-277 *
Pharm. Therap., Vol. 43, No. 1, 1989, Maxwell Pergamon MacMillan Plc, (GB) M.F. SUGRUT: "The Pharmacology of Antiglaucoma Drugs", pages 91-138 *
Therapie, Vol. 44, No. 6, 1989, J.F. GIUDICELLI et al.: "Les Activateurs des Canaux Potassiques: de la Pharmacologie a la Therapeutique", pages 419-430 *
TIPS, Vol. 9, Janvier 1988, Elsevier Publications, (Cambridge, GB), N.S. COOK: "The Pharmacology of Potassium Channels and their Therapeutic Potential", pages 21-28 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9439862B2 (en) 2000-05-10 2016-09-13 Novartis Ag Phospholipid-based powders for drug delivery

Also Published As

Publication number Publication date
EP0465583A1 (en) 1992-01-15
WO1990011758A2 (en) 1990-10-18
FR2645021A1 (en) 1990-10-05
JPH04506208A (en) 1992-10-29

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