WO1989008981A1 - Bain pour trayon - Google Patents

Bain pour trayon Download PDF

Info

Publication number
WO1989008981A1
WO1989008981A1 PCT/AU1989/000119 AU8900119W WO8908981A1 WO 1989008981 A1 WO1989008981 A1 WO 1989008981A1 AU 8900119 W AU8900119 W AU 8900119W WO 8908981 A1 WO8908981 A1 WO 8908981A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
teat
teat dip
fatty acid
bacteria
Prior art date
Application number
PCT/AU1989/000119
Other languages
English (en)
Inventor
Bruce Kefford
Original Assignee
Daratech Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daratech Pty Ltd filed Critical Daratech Pty Ltd
Publication of WO1989008981A1 publication Critical patent/WO1989008981A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/06—Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration

Definitions

  • This invention relates to animal health care products and in ⁇ particular to a teat dip for dairy cows.
  • mastitis The spread of bacterial infection from cow teats during the milking operation results in the spread of the infectious mammary disease known as mastitis.
  • the spread of this disease is usually reduced -by the use of known bacteriocides such as chlorine and iodine based compositions. These compositions are usually administered to the teat after removal of the milking cup by dipping or spraying the teat. It is believed these bacteriocides kill a substantial number of bacteria including mastitis pathogens, and thus reduce the spread of bacteria into the mammary gland where mastitis may become evident. There are usually insignificant residual effects of these bacteriocides between milkings. There are problems with the use of these agents including irritation to the teat and teat cracking. To alleviate these problems, emollient additives such as glycerine may be included in these compositions. However, even with the use of these emollients skin irritation can still occur.
  • this invention provides in one form a teat dip composition comprising an oil-in-water emulsion wherein the oil phase comprises an unsaturated fatty acid having a carbon chain length in the range C16 to C20.
  • the fatty acid has a chain length C18 and more preferably the fatty acid is linolenic acid.
  • the composition includes stabilising amounts of surfactants to enable a stable oil-in-water emulsion to be formed.
  • the surfactants include a non-ionic surfactant, in particular a polyethylene oxide derivative.
  • the surfactants are substantially non-ionic.
  • suitable surfactants are sorbitan onolaurate and ethoxylates thereof.
  • Surfactants are selected on the basis of their ability to form stable oil-in-water emulsions. Generally it is best if at least two surfactants are used, one with a HLB value less than 10 and one with a HLB value i .excess of 10. It is important that the surfactants when used in the teat dip composition do not result in unacceptable residues in milk.
  • the surfactants are used at art recognised levels and are typically of the order 1-20% by weight of oil phase. It is believed the surfactants also inhibit the adhesion of mastitis pathogens thereby improving the efficacy of the composition.
  • the pH of the composition is such that in use irritation to the teat is minimal and a pH in the range 6-8 is found to be particularly suitable.
  • the relative ratios of oil to water phases are not critical to the working of the composition although from a cost eff ctiveness viewpoint an oil-in-water ratio in the range of 1/5 to 1/25 is found to be useful in practice.
  • the composition could be packaged for sale at a higher oil-in-water ratio and diluted before use by the dairy farmer by the addition of water. Though this can cause some emulsion stability problems where water quality is poor.
  • deionised water is used in the compositions of the present invention. Though less preferred it is possible to sell the oil phase which is emulsified before use by the customer.
  • the fatty acids suitable for the compositions of the present invention can be selected from fatty acids derived from naturally occurring tri-glyceride oils such as vegetable oils, for example, linseed, perilla, soya and safflower. Synthetic unsaturated fatty acids may also be used. One particularly suitable active fatty acid is hydrolysed linseed oil. It will be appreciated that with both the synthetic and natural fatty acids, significant range of compositions of fatty acids can occur. Significant proportions of saturated fatty acid may be present. These are not unduly detrimental to the composition, other than diminishing the level of active unsaturated fatty acid in a given oil phase.
  • the unsaturated fatty acid may be selected, for example, from lauroleic, myristoleic, palmitoleic, oleic, ricinoleic, gadoleic, erueic.
  • the level of unsaturation is (-4H) or (-6H) such as in linoleic, linolenic, eleostearic, licanic and arachidic.
  • at least 20% by weight of the oil phase is unsaturated fatty acid and more preferably at least 30%.
  • compositions of the present invention are found to be effective in reducing the spread of mastitis within a herd of dairy cows and at the same time not increasing teat cracking. It is also noted that residues from the present compositions, in particular unsaturated fatty acids, which may ultimately be introduced into milk are believed to be non-harmful and indeed may be already present at low levels in milk. The present compositions also have a residual effect between milkings that is greater than the prior art compositions.
  • compositions such as glycerol. This may be present when hydrolysed vegetable oil is used.
  • the unsaturated fatty acid is effective in killing the Staphylococus aureus and Streptococci (gram positive bacteria) believed to contribute to mastitis disease control by post milking hygiene.
  • Other bacteria particularly gram negative bacteria are relatively unaffected.
  • some bacterial resistance remains from the unkilled bacteria.
  • harmless bacteria remain as a protective coating on the teats.
  • the compositions of the present invention provides some residual bacterial protection between milkings.
  • a teat dip composition was prepared by dissolving: . hydrolysed linseed oil fatty acid 5 . Tween 20 1
  • Span 60 is added to the hydrolysed linseed oil, heated and stirred until the Span 60 is dissolved, the Tween 20 is then added to this solution, after which this mixture is added to an equal volume of deionised water and agitated. An emulsion formed which was then diluted with more deionised water to lead to 93 parts of water in the overall composition. The resulting teat dip composition was stable over a period of several weeks with no evidence of the emulsion breaking. The composition was evaluated in vitro by appropriate cell counts of S-aureus bacteria. As controls water, chlorine and an iodine based commercial treatments were used. Generally the results showed the composition to be more effective in killing the bacteria than either of the commercial control materials.
  • Tween 20 is a polyethylene oxide sorbitan monolaurate, a non-ionic surfactant of HLB 16.7 manufactured by ICI Speciality Chemical Industries N.V. Approximately 20 ethylene oxide units are condensed onto the sorbitan.
  • Span 60 is sorbitan monostearate, a non-ionic surfactant of HLB .7 manufactured by ICI Speciality Chemical Industries N.V. Cone, (ug/ml) at which no growth was seen on agar plates
  • Streptococcus aqalactiae were much more sensitive to the active ingredient and Example 1 than the strains of Staphylococcus aureus.
  • a teat dip should prove effective in reducing the recoverable number of bacteria (mastitis pathogens) which have been experimentally applied to the teat.
  • a mastitis pathogen Staphylococcus aureus
  • Example 1 The composition of Example 1 was tested at the Gilbert Chandler Institute of Dairy Technology, Werribee, for its effect on cheese starter and yoghurt making bacteria. The effect of test compounds on these bacteria is measured in terms of the change in pH during the cheese yoghurt making. If the cheese containing a test compound, at a given concentration, has a pH at the end of the incubation > 0.2 units higher than the control batch then the test compound had a significant effect at that concentration. It was found with the composition of Example 1 that at concentrations ⁇ 1 ul/ml of milk there was no significant effect on cheese or yoghurt making. This concentration (1 ul composition of
  • Example 1/ml of milk represents a dilution of 1 :1000.
  • 20 ml of composition of Example 1 would be required to significantly affect cheese and yoghurt making.
  • Example 1 When the composition of Example 1 was tested on the two herds for its effect on teat skin, swabs were also taken of the teats that had been treated twice daily with either the composition of Example 1 , iodine (5000 ppm) or untreated for 8 weeks. At the end of the experiment swabs of all teats were taken 14 hours after treatment and serial dilutions of fluid from them were plated onto staphylococcal selective medium (sheep blood agar).
  • staphylococcal selective medium staphylococcal selective medium
  • Swabs from the composition of Example 1 treated teats when compared to iodine—treated teats have:
  • Swabs from the composition of Example 1 treated teats when compared with untreated teats have:
  • Example 1 The composition of Example 1 is more effective than iodine in holding staphylococcal numbers down between milkings.
  • Example 1 The composition of Example 1 promotes the survival of bacilli (and possibly other less pathogenic bacteria on teats which may lead to reduced reinfection of the teat through competition.

Abstract

La composition pour bain pour trayon décrite est destinée à être utilisée dans le traitement de la mastite chez les vaches laitières. Sous sa forme prête pour l'application, cette composition se présente comme une émulsion d'huile dans l'eau. La phase d'huile contient un acide gras non saturé, constitué par exemple par un acide gras d'huile de lin, dont la longueur de la chaîne de carbones est comprise entre 16 et 20.
PCT/AU1989/000119 1988-03-21 1989-03-21 Bain pour trayon WO1989008981A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI7342 1988-03-21
AUPI734288 1988-03-21

Publications (1)

Publication Number Publication Date
WO1989008981A1 true WO1989008981A1 (fr) 1989-10-05

Family

ID=3772936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1989/000119 WO1989008981A1 (fr) 1988-03-21 1989-03-21 Bain pour trayon

Country Status (3)

Country Link
EP (1) EP0406275A4 (fr)
NZ (1) NZ228431A (fr)
WO (1) WO1989008981A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2899061A1 (fr) * 2006-03-31 2007-10-05 Cid Lines Nv Composition d'hygiene et/ou comestique et/ou desinfectante contenant au moins un agent anti-parasitaire repulsif et/ou insectifuge.
CN111991385A (zh) * 2020-08-17 2020-11-27 暨南大学 棕榈油酸在抑制水产病原菌中的应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9913859B1 (en) 2013-03-15 2018-03-13 Webco Chemical Corporation Dairy animal teat disinfectant

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949071A (en) * 1972-09-18 1976-04-06 Ferraton Aktieselskab Method and composition for treating burns and scalds
AU3896778A (en) * 1977-08-18 1980-02-21 Brown And Jerome Setliff Robert Styptic composition
AU1758983A (en) * 1982-08-09 1984-02-16 Regents Of The University Of California, The Fatty acid formulation to protect gastric mucosa and liver against ethanol
AU1994783A (en) * 1982-10-07 1984-04-12 Novartis Ag Non-steroidal, anti-inflammatory oil in water emulsion.
WO1984002271A1 (fr) * 1982-12-09 1984-06-21 Hafsten Raymond J Jr Emulsions d'acide gras pretes a l'absorption
AU1493283A (en) * 1982-05-25 1984-11-29 Edward Sturdy Wilson Iodophor compositions for sterilisation
AU6269686A (en) * 1985-09-16 1987-03-19 American Cyanamid Company Emulsion compositions for the parenteral and/or oral administration of sparingly water soluble ionizable hydrophobic drugs
AU7180487A (en) * 1986-04-21 1987-10-22 Jon Joseph Kabara Antimicrobial compositions and methods
AU7180387A (en) * 1986-04-21 1987-10-22 Jon Joseph Kabara Topical antimicrobial pharmaceutical compositions and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769420A (en) * 1970-12-30 1973-10-30 Schuyler Dev Corp Mastitis treatment
IL52045A (en) * 1976-08-25 1979-12-30 Mundipharma Ag Sprayable germicidal foam compositions
JPS56140911A (en) * 1980-04-07 1981-11-04 Nisshin Oil Mills Ltd:The Miticide
US4668419A (en) * 1984-12-17 1987-05-26 Moseman Roger E Liquid foot treatment composition

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949071A (en) * 1972-09-18 1976-04-06 Ferraton Aktieselskab Method and composition for treating burns and scalds
AU3896778A (en) * 1977-08-18 1980-02-21 Brown And Jerome Setliff Robert Styptic composition
AU1493283A (en) * 1982-05-25 1984-11-29 Edward Sturdy Wilson Iodophor compositions for sterilisation
AU1758983A (en) * 1982-08-09 1984-02-16 Regents Of The University Of California, The Fatty acid formulation to protect gastric mucosa and liver against ethanol
AU1994783A (en) * 1982-10-07 1984-04-12 Novartis Ag Non-steroidal, anti-inflammatory oil in water emulsion.
WO1984002271A1 (fr) * 1982-12-09 1984-06-21 Hafsten Raymond J Jr Emulsions d'acide gras pretes a l'absorption
AU6269686A (en) * 1985-09-16 1987-03-19 American Cyanamid Company Emulsion compositions for the parenteral and/or oral administration of sparingly water soluble ionizable hydrophobic drugs
AU7180487A (en) * 1986-04-21 1987-10-22 Jon Joseph Kabara Antimicrobial compositions and methods
AU7180387A (en) * 1986-04-21 1987-10-22 Jon Joseph Kabara Topical antimicrobial pharmaceutical compositions and methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cosmetic and Drug Preservation 1984 JOHN J KABARA 'Medium-Chain Fatty Acids and Esters as Antimicrobial Agents, see pages 275-304, especially pages 279-283. *
See also references of EP0406275A4 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2899061A1 (fr) * 2006-03-31 2007-10-05 Cid Lines Nv Composition d'hygiene et/ou comestique et/ou desinfectante contenant au moins un agent anti-parasitaire repulsif et/ou insectifuge.
EP1842425A1 (fr) 2006-03-31 2007-10-10 Cid Lines N.V. Composition d'hygiène et/ou cosmétique et/ou désinfectante contentant au moins un agent anti-parasitaire répulsif et/ou insectifuge
CN111991385A (zh) * 2020-08-17 2020-11-27 暨南大学 棕榈油酸在抑制水产病原菌中的应用

Also Published As

Publication number Publication date
EP0406275A1 (fr) 1991-01-09
NZ228431A (en) 1991-08-27
EP0406275A4 (en) 1992-05-06

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