WO1988009188A1 - Apppareil d'injection - Google Patents

Apppareil d'injection Download PDF

Info

Publication number
WO1988009188A1
WO1988009188A1 PCT/SE1988/000257 SE8800257W WO8809188A1 WO 1988009188 A1 WO1988009188 A1 WO 1988009188A1 SE 8800257 W SE8800257 W SE 8800257W WO 8809188 A1 WO8809188 A1 WO 8809188A1
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
container
infusion
infusion liquid
liquid
Prior art date
Application number
PCT/SE1988/000257
Other languages
English (en)
Inventor
Tzafrir Ben Yehuda
Avi Zakai
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of WO1988009188A1 publication Critical patent/WO1988009188A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances

Definitions

  • the invention relates to an infusion apparatus for aut matically administrating a predetermined volume of a f infusion liquid followed by a second infusion liquid.
  • the object of the invention is to provide an infusion apparatus which is capable of automatically providing a desired transition from one source to the other.
  • the apparatus comprises a chamber having an inlet for said second infusion liquid, first means for providing fluid communication between said chamber and the interior of container for said first infusion liquid ⁇ a d second mea for providing fluid communicationbetween the interior o said container and an infusion outlet to a patient, whe by flow of air into the container from said chamber cau flow of said first infusion liquid out of the container through said infusion outlet.
  • said first means comprises a conduit having an inlet disposed at a predetermined height in s chamber, so as to lie above a volume in said chamber whi is slightly less than the volume of said first infusion l In said container, whereby an initial flow of said secon d infusion liquid into said chamber causes an initial flow of air from said chamber to flow through said conduit in said container thus causing outflow therefrom of said fi infusion liquid, and whereby a flow of said second infus liquid through said conduit into said container is cause when the level thereof in said chamber reaches said pre ⁇ determined height therein.
  • said chamber is configured to be relati ly narrow at the top to prevent an undesired supply of a instead of the second infusion liquid, when the chamber angularly displaced from the vertical.
  • said chamber is configured to define a support location for said container for said first infusion liquid.
  • the apparatus comprises a spike arranged for engag ment with the interior of said container for said first infusion liquid, said spike having one port communicatin with said second means and another port communicating wi said first means.
  • said conduit includes a one-directional- flow valve for permitting outflow therethrough from said chamber while preventing flow therethrough into said chamber.
  • said inlet of said conduit is disposed alongside the inlet of said chamber and thereabove to prevent inadvertent direct flow of said second infusion liquid to said conduit when the chamber is angularly displaced from the vertical.
  • Fig. 1 is a sectional illustration of an infusion apparatus designed and constructed in accordance with a preferred embodiment of the invention
  • Fig. 2 is a partially cut-away view of the apparatus of Fig. 1, taken in the direction of arrows II-II therein;
  • Fig. 3 is a sectional illustration of the apparatus of Fig. 1 during a first stage of infusion during which a first liquid is being supplied to a patient;
  • Fig. 4 is a partially cut-away view of the infusion apparatus during the first stage of infusion, taken in the direction of arrows IV-IV in Fig. 3;
  • Fig. 5 is a sectional illustration of the apparatus of Fig. 1 during a second stage of infusion during which a second liquid is being supplied to a patient;
  • Fig. 6 is a partially cut-away view of the infusion apparatus during the second stage of infusion, taken in the direction of arrows VI-VI in Fig. 5.
  • the infusio apparatus comprises a composite housing including a chamber 12 typically comprising a spike 14 for puncturing a container 22 for an infusion liquid 18.
  • the spike 14 is formed with a liquid entry port 16 for permitting flow of the infusion liquid 18, such as MACRODEX (Trademark of Pharmacia AB, Sweden) from the container 22 into the intermediate chamber 12 via a liquid conduit 20, typically at a rate of 20 to 30 cm 3 per minute.
  • MACRODEX Trademark of Pharmacia AB, Sweden
  • the chamber 12 is further formed with a liquid exit port shown generally at reference numeral 24.
  • the liquid exit port 24 includes a one-directional flow valve 26 to the upstream side of which is connected an exit conduit 28 and to the downstream side of which is connected an intermedia conduit 30.
  • a regulatable filtered air vent 32 for providing air to the liquid container 22. It will be appreciated that when a rigid container such as a bottle is being used, liquid flow therefrom only occurs when air is permitted to enter thereinto. Therefore, when the air vent 32 is close there is no liquid flow from container 22, and as the air vent 32 is progressively opened, the flow out of the con ⁇ tainer 22 increases accordingly.
  • the air vent 32 need not be opened or even pro ⁇ vided in order to initiate flow.
  • the chamber 12 is configured so as to define a container support location 34 which is adapted to support a containe 36, typically of size 20-50 cm 3 , of an infusion liquid 3 8, such as PROMIT (Trademark of Pharmacia AB, Sweden) to be administered before the liquid 18 to the patient.
  • the container 36 is punctured by a spike 40 mounted in a lower portion of support location 34, such that the spike commu ⁇ nicates with the interior of the container 36.
  • Formed within the second spike 40 are entry and exit po 42 and 44, respectively.
  • the entry port 42 communicates with the intermediate conduit 30 at a connection location 46 by means of a first conduit 48 formed internally of the spike 40 and is adapted to permit the entry of the liquid 18 into the container 36.
  • the exit port 44 communicates with a drip chamber 50 mo beneath the container support location 3 .
  • the conduit is thus adapted to permit the outflow of liquid from th container 36 into the drip chamber 50, from where the - liquid flows into a patient supply conduit 54.
  • the chamber 12 is configured to be relativel narrow at the top, so that a minimum of air remains in the chamber 12 when it is filled, thus preventing undes supply of air, instead of the second infusion liquid through exit port 24, when the chamber 12 is angularly displaced from the vertical.
  • the inlet 56 of the exit port is disposed alongside the bottom 58 of the infusion inle
  • the outlet 54 is clamped by apparatus not shown and a full container 36 of the fi infusion liquid 38 is mounted on the spike 40. There ⁇ after, a full container 22 of the second infusion liquid is mounted on the spike 14. When the outlet 54 is undam the liquid 18 begins to flow out of the container 22 and into the chamber 12.
  • the respective volumes of the chamber 12 and the containe '20 36 are such that the liquid 18 starts flowing into the container 36 when only a small residual volume of the liquid 38 remains in the container 36. This ensures a minimal mixing of the two infusion liquids 38 and 18, respectively, while preventing the supply of air by 25 infusion to the patient. By using this apparatus, it is ensured that the patient receives a minimum volume of the first liquid 38, typically at least 20 cm before it is mixed with the second liquid 18.
  • the infusion apparatus of the present invention is suitab 30 for use in techniques such as that described in the above referenced article by Safar et al.
  • the applicability of the apparatus of the present invention is not, however, limited to such techniques. It will be appreciated by persons skilled in the art that the present invention is not limited to that which has been particularly shown and described hereinabove. The scope of the present invention is, rather, limited solely by the claims which follow.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un appareil d'injection permettant d'administrer automatiquement un volume prédéterminé d'un premier liquide d'injection suivi d'un deuxième liquide d'injection comprend une chambre (12) possédant un orifice d'admission pour ledit deuxième liquide d'injection, des premiers moyens (30) pour établir une communication fluidique entre ladite chambre (12) et l'intérieur d'un récipient (36) destiné au premier liquide d'injection; et des seconds moyens (52) pour établir une communication fluidique entre l'intérieur dudit récipient (36) et un orifice de sortie d'injection (54) débouchant du côté du patient, l'écoulement d'air dans le récipient (36) depuis ladite chambre (12) provoquant l'écoulement du premier liquide d'injection hors du récipient (36) pour le faire passer par ledit orifice de sortie d'injection (54).
PCT/SE1988/000257 1987-05-21 1988-05-19 Apppareil d'injection WO1988009188A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL82619A IL82619A0 (en) 1987-05-21 1987-05-21 Infusion apparatus
IL82619 1987-05-21

Publications (1)

Publication Number Publication Date
WO1988009188A1 true WO1988009188A1 (fr) 1988-12-01

Family

ID=11057825

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1988/000257 WO1988009188A1 (fr) 1987-05-21 1988-05-19 Apppareil d'injection

Country Status (3)

Country Link
AU (1) AU1941188A (fr)
IL (1) IL82619A0 (fr)
WO (1) WO1988009188A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2871062A1 (fr) * 2004-06-02 2005-12-09 Aguettant Soc Par Actions Simp Poche de perfusion avec rincage integre
US9162038B2 (en) 2011-04-11 2015-10-20 The Spectranetics Corporation Needle and guidewire holder
US9283039B2 (en) 2006-04-04 2016-03-15 The Spectranetics Corporation Laser-assisted guidewire having a variable stiffness shaft
US9855100B2 (en) 2008-04-02 2018-01-02 The Spectranetics Corporation Liquid light-guide catheter with optically diverging tip
US10092357B2 (en) 2008-07-21 2018-10-09 The Spectranetics Corporation Tapered liquid light guide
CN108815633A (zh) * 2018-04-18 2018-11-16 周云香 一种医疗用半自动输液装置
US11083870B2 (en) 2011-04-11 2021-08-10 The Spectranetics Corporation Hypotube based support catheter

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993066A (en) * 1974-11-01 1976-11-23 Baxter Laboratories, Inc. Burette chamber for use with intravenous solution administration set
US4250879A (en) * 1979-02-28 1981-02-17 Abbott Laboratories Equipment sets and system for the sequential administration of medical liquids at dual flow rates employing a combined air barrier and liquid sequencing valve
US4333454A (en) * 1980-01-14 1982-06-08 Hargest Iii Thomas S Automatic tubular feeding apparatus and method
US4372306A (en) * 1979-02-28 1983-02-08 Abbott Laboratories Equipment sets having a combined air barrier and liquid sequencing device for the sequential administration of medical liquids at dual flow rates
US4573967A (en) * 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993066A (en) * 1974-11-01 1976-11-23 Baxter Laboratories, Inc. Burette chamber for use with intravenous solution administration set
US4250879A (en) * 1979-02-28 1981-02-17 Abbott Laboratories Equipment sets and system for the sequential administration of medical liquids at dual flow rates employing a combined air barrier and liquid sequencing valve
US4372306A (en) * 1979-02-28 1983-02-08 Abbott Laboratories Equipment sets having a combined air barrier and liquid sequencing device for the sequential administration of medical liquids at dual flow rates
US4333454A (en) * 1980-01-14 1982-06-08 Hargest Iii Thomas S Automatic tubular feeding apparatus and method
US4573967A (en) * 1983-12-06 1986-03-04 Eli Lilly And Company Vacuum vial infusion system

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006018555A1 (fr) * 2004-06-02 2006-02-23 Laboratoire Aguettant Poche de perfusion avec rincage integre
US7722594B1 (en) 2004-06-02 2010-05-25 Laboratoire Aguettant Infusion bag with integrated rinsing system
US7938816B2 (en) 2004-06-02 2011-05-10 Laboratoire Aguettant Infusion bag with integrated rinsing system
KR101190275B1 (ko) * 2004-06-02 2012-10-16 라보라토이레 아게트탕 일체식 세정 시스템을 구비한 수액 백
EP2210631A3 (fr) * 2004-06-02 2013-12-04 Laboratoire Aguettant Poche de perfusion avec rincage intégré
FR2871062A1 (fr) * 2004-06-02 2005-12-09 Aguettant Soc Par Actions Simp Poche de perfusion avec rincage integre
US11445892B2 (en) 2006-04-04 2022-09-20 The Spectranetics Corporation Laser-assisted guidewire having a variable stiffness shaft
US9283039B2 (en) 2006-04-04 2016-03-15 The Spectranetics Corporation Laser-assisted guidewire having a variable stiffness shaft
US10716625B2 (en) 2008-04-02 2020-07-21 The Spectranetics Corporation Liquid light-guide catheter with optically diverging tip
US9855100B2 (en) 2008-04-02 2018-01-02 The Spectranetics Corporation Liquid light-guide catheter with optically diverging tip
US10092357B2 (en) 2008-07-21 2018-10-09 The Spectranetics Corporation Tapered liquid light guide
US9668766B2 (en) 2011-04-11 2017-06-06 The Spectranetics Corporation Needle and guidewire holder
US10292727B2 (en) 2011-04-11 2019-05-21 The Spectranetics Corporation Needle and guidewire holder
US11083870B2 (en) 2011-04-11 2021-08-10 The Spectranetics Corporation Hypotube based support catheter
US9162038B2 (en) 2011-04-11 2015-10-20 The Spectranetics Corporation Needle and guidewire holder
CN108815633A (zh) * 2018-04-18 2018-11-16 周云香 一种医疗用半自动输液装置
CN108815633B (zh) * 2018-04-18 2021-02-19 孔德征 一种医疗用半自动输液装置

Also Published As

Publication number Publication date
AU1941188A (en) 1988-12-21
IL82619A0 (en) 1987-11-30

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