WO1988007367A3 - Melatonin-derivatives for psychogenic stress and acute anxiety, and immuno-stimulant drugs - Google Patents

Melatonin-derivatives for psychogenic stress and acute anxiety, and immuno-stimulant drugs Download PDF

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Publication number
WO1988007367A3
WO1988007367A3 PCT/EP1988/000270 EP8800270W WO8807367A3 WO 1988007367 A3 WO1988007367 A3 WO 1988007367A3 EP 8800270 W EP8800270 W EP 8800270W WO 8807367 A3 WO8807367 A3 WO 8807367A3
Authority
WO
WIPO (PCT)
Prior art keywords
melatonin
immuno
derivatives
acute anxiety
psychogenic stress
Prior art date
Application number
PCT/EP1988/000270
Other languages
French (fr)
Other versions
WO1988007367A2 (en
Inventor
Walter Pierpaoli
Giorgio Maestroni
Original Assignee
Cell Eng Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878707792A external-priority patent/GB8707792D0/en
Priority claimed from GB878707793A external-priority patent/GB8707793D0/en
Application filed by Cell Eng Ag filed Critical Cell Eng Ag
Publication of WO1988007367A2 publication Critical patent/WO1988007367A2/en
Publication of WO1988007367A3 publication Critical patent/WO1988007367A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to the use of melatonin or related active chemical compounds for the production of pharmaceutical compositions for the treatment of psychogenic stress or acute anxiety as well as for the enhancement of immune resistance in a host against viral and parasitical infections.
PCT/EP1988/000270 1987-04-01 1988-04-01 Melatonin-derivatives for psychogenic stress and acute anxiety, and immuno-stimulant drugs WO1988007367A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB878707792A GB8707792D0 (en) 1987-04-01 1987-04-01 Compositions containing metatonin/homologues
GB8707793 1987-04-01
GB878707793A GB8707793D0 (en) 1987-04-01 1987-04-01 Compositions containing melatonin/homologues
GB8707792 1987-04-01

Publications (2)

Publication Number Publication Date
WO1988007367A2 WO1988007367A2 (en) 1988-10-06
WO1988007367A3 true WO1988007367A3 (en) 1989-01-26

Family

ID=26292085

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1988/000270 WO1988007367A2 (en) 1987-04-01 1988-04-01 Melatonin-derivatives for psychogenic stress and acute anxiety, and immuno-stimulant drugs

Country Status (3)

Country Link
EP (1) EP0311651A1 (en)
AU (1) AU1494788A (en)
WO (1) WO1988007367A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300630A3 (en) * 1987-07-03 1990-03-28 Schering Agrochemicals Limited Melatonin for regulating animal reproduction
US4945103A (en) * 1989-01-17 1990-07-31 Michael Cohen Method of treating pre-menstrual syndrome
GR900100024A (en) * 1989-01-17 1991-06-07 Amr Int Method of treating pre-menstual syndrome
EP0711553A1 (en) * 1994-08-09 1996-05-15 Mario Cagnoni Use of the Melatonin in the traetment of the articular symptoms of trheumatoid arthritis
US20040116520A1 (en) * 2001-01-24 2004-06-17 Amato Pharmaceutical Products, Ltd. Anti-stress agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J. Neutral Transm., suppl. 21, 1986, H.R. Lieberman: "Behavior, sleep and melatonin", pages 233-241 *
Medical Hypotheses, volume 7, no. 6, June 1981, J. Richardson et al.: "The mechanisms of stress and immunosuppression", pages 765-780 *
Peptides, volume 2, suppl. 1, 1981, ANKHO International Inc., (US), P.C. Datta: "Effects of melatonin on startle reflex in rat", pages 155-160 *
Pharmacology Biochemistry & Behavior, volume 15, 1981, ANKHO International Inc., (US), P. Golus et al.: "The effects of melatonin on open field behavior", pages 883-885 *
Pharmacology Biochemistry & Behavior, volume 24, no. 6, June 1986, ANKHO International Inc., (US), K. Neville et al.: "Anxiolytic-like action of melatonin on acquisition but not performance of DRL", pages 1497-1502 *

Also Published As

Publication number Publication date
EP0311651A1 (en) 1989-04-19
WO1988007367A2 (en) 1988-10-06
AU1494788A (en) 1988-11-02

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