WO1988006899A3 - Neutralisation d'heparine - Google Patents

Neutralisation d'heparine Download PDF

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Publication number
WO1988006899A3
WO1988006899A3 PCT/US1988/000699 US8800699W WO8806899A3 WO 1988006899 A3 WO1988006899 A3 WO 1988006899A3 US 8800699 W US8800699 W US 8800699W WO 8806899 A3 WO8806899 A3 WO 8806899A3
Authority
WO
WIPO (PCT)
Prior art keywords
heparin
blood
heparinase
sulfatase
reductase
Prior art date
Application number
PCT/US1988/000699
Other languages
English (en)
Other versions
WO1988006899A2 (fr
Inventor
Robert A Heft
Ann Reese Comfort
Robert S Langer
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Priority to AT88903515T priority Critical patent/ATE81021T1/de
Priority to DE8888903515T priority patent/DE3875114T2/de
Publication of WO1988006899A2 publication Critical patent/WO1988006899A2/fr
Publication of WO1988006899A3 publication Critical patent/WO1988006899A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B01D69/1411—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes containing dispersed material in a continuous matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A61M1/3675—Deactivation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procédé d'élimination d'héparine de l'organisme ou de dérivés d'héparine de faible poids moléculaire dans lequel un filtre de sang contenant une enzyme immobilisé, se composant d'enzymes telles que l'héparinase, glucuronate-reductase, aldose-reductase, beta-glucuronidase, O-sulfatase, et N-sulfatase, ou d'autres composés de dégradation ou de neutralisation d'héparine, est conçu pour une utilisation au niveau de l'effluent d'un dispositif extracorporel. Le dispositif satisfait aux régles rigoureuses spécifiques à une utilisation clinique. La biocompatibilité du système dans son ensemble est la première condition. Deuxièmement, il doit être conçu pour éliminer les niveaux cliniques d'héparine à des débits variables allant jusqu'à 4 litres de sang/min pour un adulte et jusqu'à 50 ml de sang/min pour un enfant, avec des durées de perfusion variables allant de plusieurs heures jusqu'à entre deux et dix jours en cas de troubles respiratoires neo-natals. Des modes de réalisation spécifiques employant de l'héparinase liée par chlorure de trésyle ou par des techniques CNBr, à des dispositifs de fibre creuse de cellulose reconstituée ou du type utilisé pour la dialyse du foie, sont divulgués. Ces modes de réalisation incluent des dispositifs à étage unique ou multiple destinés à l'élimination d'héparine seule ou conjointement avec dialyse ou oxygénation. Des dispositifs analogues à feuilles de membranes multiples sont également divulgués.
PCT/US1988/000699 1987-03-10 1988-03-07 Neutralisation d'heparine WO1988006899A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT88903515T ATE81021T1 (de) 1987-03-10 1988-03-07 Neutralisierung von heparin.
DE8888903515T DE3875114T2 (de) 1987-03-10 1988-03-07 Neutralisierung von heparin.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2417587A 1987-03-10 1987-03-10
US024,175 1987-03-10

Publications (2)

Publication Number Publication Date
WO1988006899A2 WO1988006899A2 (fr) 1988-09-22
WO1988006899A3 true WO1988006899A3 (fr) 1988-12-01

Family

ID=21819246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/000699 WO1988006899A2 (fr) 1987-03-10 1988-03-07 Neutralisation d'heparine

Country Status (6)

Country Link
EP (1) EP0354916B1 (fr)
JP (1) JPH02503388A (fr)
AT (1) ATE81021T1 (fr)
CA (1) CA1315676C (fr)
DE (1) DE3875114T2 (fr)
WO (1) WO1988006899A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2001720C (fr) * 1988-10-31 2001-10-02 Randal A. Goffe Appareil a affinite de membrane et methodes de purification
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
US5262325A (en) * 1991-04-04 1993-11-16 Ibex Technologies, Inc. Method for the enzymatic neutralization of heparin
IT1304828B1 (it) * 1998-11-12 2001-04-05 Braun Carex Spa Filtro adsorbitore di eparina e/o endotossine nel plasma e/o nelsangue.
US9095818B2 (en) * 2009-06-15 2015-08-04 Biovec Transfusion, Llc Method of filtering platelets to remove antiplatelet and anticoagulant agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373023A (en) * 1980-10-14 1983-02-08 Massachusetts Institute Of Technology Process for neutralizing heparin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373023A (en) * 1980-10-14 1983-02-08 Massachusetts Institute Of Technology Process for neutralizing heparin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Polym. Mater. Sci. Eng., volume 51, 1984, H. Bernstein et al.:"Design of an immobilized enzyme reactor for removing heparin at the termination of extra corporeal therapy", pages 204-207 *

Also Published As

Publication number Publication date
CA1315676C (fr) 1993-04-06
ATE81021T1 (de) 1992-10-15
WO1988006899A2 (fr) 1988-09-22
EP0354916B1 (fr) 1992-09-30
DE3875114D1 (de) 1992-11-05
DE3875114T2 (de) 1993-03-04
JPH02503388A (ja) 1990-10-18
EP0354916A1 (fr) 1990-02-21

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