WO1988000833A3 - Peptides antipyretiques et anti-inflammatoires - Google Patents

Peptides antipyretiques et anti-inflammatoires Download PDF

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Publication number
WO1988000833A3
WO1988000833A3 PCT/US1987/001994 US8701994W WO8800833A3 WO 1988000833 A3 WO1988000833 A3 WO 1988000833A3 US 8701994 W US8701994 W US 8701994W WO 8800833 A3 WO8800833 A3 WO 8800833A3
Authority
WO
WIPO (PCT)
Prior art keywords
tripeptide
antipyretic
protected
action
terminals
Prior art date
Application number
PCT/US1987/001994
Other languages
English (en)
Other versions
WO1988000833A2 (fr
Inventor
James M Lipton
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority to AT87905539T priority Critical patent/ATE75145T1/de
Priority to DE8787905539T priority patent/DE3778550D1/de
Publication of WO1988000833A2 publication Critical patent/WO1988000833A2/fr
Publication of WO1988000833A3 publication Critical patent/WO1988000833A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Tripeptide antipyrétique, présentant la séquence d'acides aminés lysine-proline-valine, et procédé d'utilisation du tripeptide pour réduire la fièvre et l'inflammation chez les mammifères. Le tripeptide peut être soit isolé à partir de sources naturelles, soit synthétisé chimiquement. Est également décrit un tripeptide ''protégé'' possédant une activité antipyrétique plus intense et une action de plus longue durée. Le tripeptide ''protégé'' contient un groupe acyle, tel qu'un groupe acétyle ou un groupe dibenzyloxycarbonyle, au niveau de ses terminaisons amino et est amidé ou estérifié au niveau de ses terminaisons carboxyle. Il est en outre possible d'améliorer l'activité antipyrétique et le sens d'action par l'administration combinée de sels de cuivre avec ledit tripeptide.
PCT/US1987/001994 1986-08-08 1987-08-07 Peptides antipyretiques et anti-inflammatoires WO1988000833A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT87905539T ATE75145T1 (de) 1986-08-08 1987-08-07 Fieber- und entzuendungshemmende peptide.
DE8787905539T DE3778550D1 (de) 1986-08-08 1987-08-07 Fieber- und entzuendungshemmende peptide.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89491086A 1986-08-08 1986-08-08
US894,910 1986-08-08
US7662587A 1987-07-23 1987-07-23
US076,625 1987-07-23

Publications (2)

Publication Number Publication Date
WO1988000833A2 WO1988000833A2 (fr) 1988-02-11
WO1988000833A3 true WO1988000833A3 (fr) 1988-05-19

Family

ID=26758298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/001994 WO1988000833A2 (fr) 1986-08-08 1987-08-07 Peptides antipyretiques et anti-inflammatoires

Country Status (6)

Country Link
EP (1) EP0317573B1 (fr)
JP (1) JPH02500361A (fr)
AU (1) AU604751B2 (fr)
CH (1) CH676425A5 (fr)
DE (1) DE3778550D1 (fr)
WO (1) WO1988000833A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2738746B1 (fr) * 1995-09-19 1997-11-14 Oreal Utilisation d'au moins un peptide dans une composition cosmetique ou pour la preparation d'un medicament
FR2784028B1 (fr) * 1998-10-01 2003-02-07 Oreal Utilisation d'un peptide prevenant les reactions d'intolerance de la peau, notamment dans des compositions cosmetiques
DE19900698C2 (de) * 1999-01-04 2001-04-26 Gabor Keresztury Ballonkatheter mit anpaßbarem Mittelteil
US7402559B2 (en) 1999-03-24 2008-07-22 Msh Pharma, Incorporated Composition and method of treatment for urogenital conditions
AU2001254625B2 (en) * 2000-05-02 2006-02-02 Action Pharma A/S Use of alpha-MSH and EPO for preventing or treating ischemic conditions
DE10106852A1 (de) 2001-02-14 2002-09-05 T Luger Entzündungshemmende Verbindungen
US6894028B2 (en) * 2001-04-06 2005-05-17 Zengen, Inc. Use of KPV tripeptide for dermatological disorders
US7683026B2 (en) 2003-01-24 2010-03-23 L'oreal Method for synthesizing KPV tripeptide diamide derivatives
FR2850383B1 (fr) * 2003-01-24 2005-04-15 Oreal Procede de synthese ameliore de derives diamides du tripeptide kpv
US20100204136A1 (en) * 2007-09-11 2010-08-12 Dorian Bevec Use of a peptide as a therapeutic agent
EP2187911A1 (fr) * 2007-09-11 2010-05-26 Mondobiotech Laboratories AG Utilisation du peptide yy, seul ou en combinaison avec un peptide de type glucagon, à usage médical
ES2514322T3 (es) 2011-04-07 2014-10-28 Fresenius Medical Care Deutschland Gmbh Péptidos para suprimir reacciones de inflamación en hemodiálisis
AU2012311440A1 (en) 2011-09-23 2014-03-06 Westfaelische Wilhelms-Universitaet Muenster Tripeptide KdDP for antiapoptotic treatment
KR20160058841A (ko) 2013-09-23 2016-05-25 독토르. 아우구스트 볼프 게엠베하 운트 코. 카게 아르쯔네이미텔 항염증성 트리펩티드

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. Rheumatol., volume 12, no. 5, October 1985, C.W. Denko et al.: "Effects of peptide hormones in urate crystal inflammation", pages 971-975 *
Peptides, volume 5, no. 4, 1984, Ankho International Inc., (US), D.B. Richards et al.: "Effect of x-MSH 11-13 (lysine-proline-valine) on fever in the rabbit", pages 815-817 *
The Journal of Immunology, volume 137, no. 7, 1 October 1986, American Association of Immunologists, (US), J.G. Cannon et al.: "x Melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1", pages 2232-2236 *

Also Published As

Publication number Publication date
EP0317573B1 (fr) 1992-04-22
EP0317573A1 (fr) 1989-05-31
AU604751B2 (en) 1991-01-03
DE3778550D1 (de) 1992-05-27
AU7851687A (en) 1988-02-24
WO1988000833A2 (fr) 1988-02-11
CH676425A5 (fr) 1991-01-31
JPH02500361A (ja) 1990-02-08

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