WO1987007836A3 - Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors - Google Patents

Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors Download PDF

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Publication number
WO1987007836A3
WO1987007836A3 PCT/FR1987/000230 FR8700230W WO8707836A3 WO 1987007836 A3 WO1987007836 A3 WO 1987007836A3 FR 8700230 W FR8700230 W FR 8700230W WO 8707836 A3 WO8707836 A3 WO 8707836A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
medicament
tumors
medicinal composition
viruses
Prior art date
Application number
PCT/FR1987/000230
Other languages
French (fr)
Other versions
WO1987007836A2 (en
Inventor
Jorge Vila
Nicole Thomasset
Alberto Epstein
Fabian Wild
Original Assignee
Jorge Vila
Nicole Thomasset
Alberto Epstein
Fabian Wild
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jorge Vila, Nicole Thomasset, Alberto Epstein, Fabian Wild, Inst Nat Sante Rech Med filed Critical Jorge Vila
Publication of WO1987007836A2 publication Critical patent/WO1987007836A2/en
Publication of WO1987007836A3 publication Critical patent/WO1987007836A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Said medicament is the L-glutamic acid gamma monohydroxamate (GAH). It inhibits totally viral multiplication (it is believed to belong to the category of inducers of the antiviral cellular state), and it shows a cytotoxic activity on different lines of human tumors (both solid tumors and lymphomas), the selectivity of action (cytolytic and irreversible on tumoral cells, and cytostatic reversible on normal cells) giving grounds to think that it uses a metabolic difference between tumoral cells and normal cells. The corresponding medicinal composition is in the form of a lyophilized powder, comprised of the active principle (GAH), to be dissolved extemporaneously in a physiological solution with a view to injection.
PCT/FR1987/000230 1986-06-19 1987-06-18 Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors WO1987007836A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR86/08872 1986-06-19
FR8608872A FR2600252A1 (en) 1986-06-19 1986-06-19 DRUG AND DRUG COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES DUE TO VIRUSES, AND FOR THE TREATMENT OF TUMORS

Publications (2)

Publication Number Publication Date
WO1987007836A2 WO1987007836A2 (en) 1987-12-30
WO1987007836A3 true WO1987007836A3 (en) 1988-08-11

Family

ID=9336486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1987/000230 WO1987007836A2 (en) 1986-06-19 1987-06-18 Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors

Country Status (3)

Country Link
EP (1) EP0253697A3 (en)
FR (1) FR2600252A1 (en)
WO (1) WO1987007836A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06504031A (en) * 1988-09-30 1994-05-12 オーストレイリアン・コマーシヤル・リサーチ・アンド・デイベロツプメント・リミテツド Amino acid transport proteins, amino acid analogs, assay devices, and their use in cancer treatment and diagnosis
HU221816B1 (en) 1991-10-11 2003-01-28 Bristol-Myers Squibb Pharma Company Cyclic carbonyls and pharmaceutical compositions
US5610294A (en) 1991-10-11 1997-03-11 The Du Pont Merck Pharmaceutical Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
USRE37781E1 (en) 1991-10-11 2002-07-02 Dupont Pharmaceuticals Company Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors
US6313110B1 (en) 1999-06-02 2001-11-06 Dupont Pharmaceuticals Company Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Colloques Internationaux C.N.R.S. no. 197, 1971, K. Yamada et al.: "Clinical and experimental studies on antileukemic action of l'Asparaginase", pages 311-322, see the abstract; tables X-XIV, in particular table XIV (Friend Leukamia) , pages 319,322 *
Pharmazie, vol. 31, no. 5, 1976, W.Werner et al.: Structur-Wirkungs-Beziehungen bei Mannichbasen mit und ohne Stickstofflost-gruppen und einigen Vergleichverbindungen als potentielle Immunsuppresiva", pages 282-287, see page 286, paragraph 2 *

Also Published As

Publication number Publication date
WO1987007836A2 (en) 1987-12-30
EP0253697A2 (en) 1988-01-20
FR2600252A1 (en) 1987-12-24
EP0253697A3 (en) 1988-12-28

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