WO1987007836A3 - Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors - Google Patents
Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors Download PDFInfo
- Publication number
- WO1987007836A3 WO1987007836A3 PCT/FR1987/000230 FR8700230W WO8707836A3 WO 1987007836 A3 WO1987007836 A3 WO 1987007836A3 FR 8700230 W FR8700230 W FR 8700230W WO 8707836 A3 WO8707836 A3 WO 8707836A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- medicament
- tumors
- medicinal composition
- viruses
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Said medicament is the L-glutamic acid gamma monohydroxamate (GAH). It inhibits totally viral multiplication (it is believed to belong to the category of inducers of the antiviral cellular state), and it shows a cytotoxic activity on different lines of human tumors (both solid tumors and lymphomas), the selectivity of action (cytolytic and irreversible on tumoral cells, and cytostatic reversible on normal cells) giving grounds to think that it uses a metabolic difference between tumoral cells and normal cells. The corresponding medicinal composition is in the form of a lyophilized powder, comprised of the active principle (GAH), to be dissolved extemporaneously in a physiological solution with a view to injection.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8608872A FR2600252A1 (en) | 1986-06-19 | 1986-06-19 | DRUG AND DRUG COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES DUE TO VIRUSES, AND FOR THE TREATMENT OF TUMORS |
FR86/08872 | 1986-06-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1987007836A2 WO1987007836A2 (en) | 1987-12-30 |
WO1987007836A3 true WO1987007836A3 (en) | 1988-08-11 |
Family
ID=9336486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1987/000230 WO1987007836A2 (en) | 1986-06-19 | 1987-06-18 | Medicament and medicinal composition for the treatment of infectious diseases due to viruses, as well as for the treatment of tumors |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0253697A3 (en) |
FR (1) | FR2600252A1 (en) |
WO (1) | WO1987007836A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990003399A1 (en) * | 1988-09-30 | 1990-04-05 | Australian Commercial Research & Development Limited | Amino acid transport proteins, amino acid analogues, assay apparatus, uses thereof for treatment and diagnosis of cancer |
US5610294A (en) | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
USRE37781E1 (en) | 1991-10-11 | 2002-07-02 | Dupont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
JP3208140B2 (en) | 1991-10-11 | 2001-09-10 | デュポン・ファーマシュウティカルズ・カンパニー | Substituted cyclic carbonyls and their derivatives useful as retroviral protease inhibitors |
US6313110B1 (en) | 1999-06-02 | 2001-11-06 | Dupont Pharmaceuticals Company | Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor |
-
1986
- 1986-06-19 FR FR8608872A patent/FR2600252A1/en not_active Withdrawn
-
1987
- 1987-06-18 WO PCT/FR1987/000230 patent/WO1987007836A2/en unknown
- 1987-06-19 EP EP87401399A patent/EP0253697A3/en not_active Withdrawn
Non-Patent Citations (2)
Title |
---|
Colloques Internationaux C.N.R.S. no. 197, 1971, K. Yamada et al.: "Clinical and experimental studies on antileukemic action of l'Asparaginase", pages 311-322, see the abstract; tables X-XIV, in particular table XIV (Friend Leukamia) , pages 319,322 * |
Pharmazie, vol. 31, no. 5, 1976, W.Werner et al.: Structur-Wirkungs-Beziehungen bei Mannichbasen mit und ohne Stickstofflost-gruppen und einigen Vergleichverbindungen als potentielle Immunsuppresiva", pages 282-287, see page 286, paragraph 2 * |
Also Published As
Publication number | Publication date |
---|---|
WO1987007836A2 (en) | 1987-12-30 |
FR2600252A1 (en) | 1987-12-24 |
EP0253697A3 (en) | 1988-12-28 |
EP0253697A2 (en) | 1988-01-20 |
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