JPS57179118A - Antitumor agent - Google Patents
Antitumor agentInfo
- Publication number
- JPS57179118A JPS57179118A JP6359481A JP6359481A JPS57179118A JP S57179118 A JPS57179118 A JP S57179118A JP 6359481 A JP6359481 A JP 6359481A JP 6359481 A JP6359481 A JP 6359481A JP S57179118 A JPS57179118 A JP S57179118A
- Authority
- JP
- Japan
- Prior art keywords
- cysteine
- fluorouracil
- antitumor
- antitumor agent
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To prepare an antitumor agent having high safety, by combining 1-(2- tetrahydrofuryl)-5-fluorouracil with L-cysteine.
CONSTITUTION: The objective antitumor agent can be obtained by combining 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) with L-cysteine at a molar ratio of 1 to ≥0.3. The FT is a derivative of 5-fluorouracil (5-FU) having antitumor activity. The combined use of FT and L-cysteine remarkably raises the concentration of FT and 5-FU in the blood plasma and the liver, and improves the antitumor effect. Dose: preferably 15W500mg/kg/day for FT and ≥3mg/kg/day for L- cysteine. The agent is preferably administered in the form of an oral drug such as tablet, capsule, etc. for FT, and the above oral drug or an injection for L- cysteine.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6359481A JPS57179118A (en) | 1981-04-27 | 1981-04-27 | Antitumor agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6359481A JPS57179118A (en) | 1981-04-27 | 1981-04-27 | Antitumor agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57179118A true JPS57179118A (en) | 1982-11-04 |
JPS6348245B2 JPS6348245B2 (en) | 1988-09-28 |
Family
ID=13233743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6359481A Granted JPS57179118A (en) | 1981-04-27 | 1981-04-27 | Antitumor agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57179118A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041449A (en) * | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
-
1981
- 1981-04-27 JP JP6359481A patent/JPS57179118A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5041449A (en) * | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
Also Published As
Publication number | Publication date |
---|---|
JPS6348245B2 (en) | 1988-09-28 |
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