WO1986007059A3 - Composes d'oxodiazine - Google Patents

Composes d'oxodiazine

Info

Publication number
WO1986007059A3
WO1986007059A3 PCT/JP1986/000241 JP8600241W WO8607059A3 WO 1986007059 A3 WO1986007059 A3 WO 1986007059A3 JP 8600241 W JP8600241 W JP 8600241W WO 8607059 A3 WO8607059 A3 WO 8607059A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkoxy
alkyl
halogen
phenyl
agents
Prior art date
Application number
PCT/JP1986/000241
Other languages
English (en)
Other versions
WO1986007059A2 (fr
Inventor
Hideki Oa
Minoru Obata
Tsutomu Yamanaka
Hiroshi Mikashima
Original Assignee
Yoshitomi Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical filed Critical Yoshitomi Pharmaceutical
Priority to DE8686902913T priority Critical patent/DE3666434D1/de
Priority to AT86902913T priority patent/ATE47393T1/de
Priority to JP61502620A priority patent/JPS63500031A/ja
Publication of WO1986007059A2 publication Critical patent/WO1986007059A2/fr
Publication of WO1986007059A3 publication Critical patent/WO1986007059A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Composé d'oxodiazine de formule (I) ou son sel d'addition d'acide pharmaceutiquement acceptable, dans laquelle chacun de R1 et R2 est hydrogène, halogène, C1-4 alkyle, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkoxy, phényle C1-4 alkyle-oxy qui peut être éventuellement substitué par au moins un substituant sélectionné dans le groupe composé d'un halogène, C1-4 alkyle et C1-4 alkoxy sur le noyau de phényle, ou un phényle qui peut être substitué par au moins un substituant sélectionné dans le groupe composé d'un halogène, C1-4 alkyle et C1-4 alkoxy sur le noyau de phényle; X est -S-, -CH=N- ou bien -C(R3)=C(R4)-, ou chacun de R3 et R4 est hydrogène, halogène, C1-4 alkyle, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkoxy ou phényle -C1-4 alkyle-oxy qui peut être éventuellement substitué par au moins un substituant sélectionné dans le groupe composé d'un halogène, C1-4 alkyle et C1-4 alkoxy sur le noyau de phényle; et un de A et B est oxygène, soufre ou -NH- et l'autre est -C(R5) (R6)-, où chacun de R5 et R6 est hydrogène ou C1-4 alkyle. Ces composés sont utiles comme agents antithrombotiques, agents anti-angineux, agents améliorant la circulation coronarienne, agents améliorant la circulation cérébrale, agents améliorant la circulation périphérique, analgésiques et agents anti-inflammatoires.
PCT/JP1986/000241 1985-05-25 1986-05-12 Composes d'oxodiazine WO1986007059A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE8686902913T DE3666434D1 (de) 1985-05-25 1986-05-12 Oxodiazine compounds
AT86902913T ATE47393T1 (de) 1985-05-25 1986-05-12 Oxodiazinverbindungen.
JP61502620A JPS63500031A (ja) 1985-05-25 1986-05-12 オキソジアジン化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60/112715 1985-05-25
JP11271585 1985-05-25

Publications (2)

Publication Number Publication Date
WO1986007059A2 WO1986007059A2 (fr) 1986-12-04
WO1986007059A3 true WO1986007059A3 (fr) 1987-03-12

Family

ID=14593699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1986/000241 WO1986007059A2 (fr) 1985-05-25 1986-05-12 Composes d'oxodiazine

Country Status (4)

Country Link
US (1) US4713381A (fr)
EP (1) EP0226641B1 (fr)
DE (1) DE3666434D1 (fr)
WO (1) WO1986007059A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009469D0 (en) * 1990-04-27 1990-06-20 British Bio Technology Compounds
AU2004287847A1 (en) * 2003-10-28 2005-05-19 Sepracor Inc. Imidazo(1,2-a)pyridine anxiolytics
CN102596961B (zh) 2009-10-30 2015-12-02 詹森药业有限公司 咪唑并[1，2-b]哒嗪衍生物及其作为PDE10抑制剂的用途
AU2010331175B2 (en) * 2009-12-18 2014-08-28 Mitsubishi Tanabe Pharma Corporation Novel antiplatelet agent
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
CA2872216C (fr) 2012-06-26 2021-07-20 Janssen Pharmaceutica Nv Combinaisons comprenant des inhibiteurs de la pde 2 tels que des composes 1-aryl-4-methyl-[1,2,4]triazolo [4,3-a]-quinoxaline et des inhibiteurs de la pde 10 pour utilisation dans le traitement de troublesneurologiques ou metaboliques
WO2014009305A1 (fr) 2012-07-09 2014-01-16 Janssen Pharmaceutica Nv Inhibiteurs de l'enzyme phosphodiestérase 10

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085227A1 (fr) * 1981-11-12 1983-08-10 Imperial Chemical Industries Plc Dérivés de thiadiazine ainsi que compositions pharmaceutiques les contenant
EP0120589A1 (fr) * 1983-02-25 1984-10-03 Fujisawa Pharmaceutical Co., Ltd. Composés imidazo-hétérocycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0180158A1 (fr) * 1984-10-29 1986-05-07 Yoshitomi Pharmaceutical Industries, Ltd. Composé thiadiazinique, procédé pour sa préparation et compositions pharmaceutiques le contenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0085227A1 (fr) * 1981-11-12 1983-08-10 Imperial Chemical Industries Plc Dérivés de thiadiazine ainsi que compositions pharmaceutiques les contenant
EP0120589A1 (fr) * 1983-02-25 1984-10-03 Fujisawa Pharmaceutical Co., Ltd. Composés imidazo-hétérocycliques, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0180158A1 (fr) * 1984-10-29 1986-05-07 Yoshitomi Pharmaceutical Industries, Ltd. Composé thiadiazinique, procédé pour sa préparation et compositions pharmaceutiques le contenant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No relevant documents have been disclosed. *

Also Published As

Publication number Publication date
US4713381A (en) 1987-12-15
WO1986007059A2 (fr) 1986-12-04
DE3666434D1 (de) 1989-11-23
EP0226641A1 (fr) 1987-07-01
EP0226641B1 (fr) 1989-10-18

Similar Documents

Publication Publication Date Title
ATE150462T1 (de) Pyrazolopyridinverbindungen und verfahren zu ihrer herstellung
AU565898B2 (en) 1,8-naphthyridine derivatives
IL109918A0 (en) Pyridazines and pharmaceutical compositions containing them
AU1433588A (en) 1-phenyl-3-naphthalenyloxypropanamines
AU589427B2 (en) Pyridonecarboxylic acid derivatives and process for their preparation
AU591640B2 (en) Quinolonecarboxylic acid derivatives
TW232013B (fr)
AU552908B2 (en) 4 n-phenyl benzyl-aminomethyl-imidazole
EP0671390A3 (fr) Agents antithrombotiques
AU577772B2 (en) Di-acyloxy naphthalenes & di-hydroxy intermediates as anti-psoriatic agents
WO1986007059A3 (fr) Composes d'oxodiazine
AU4290989A (en) Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
EP0288969A3 (en) Antiulcer composition
AU580277B2 (en) Naphthalene anti-psoriatic agents
CA2118425A1 (fr) Derive du benzothiazolesulfamide, son mode de preparation et son utilisation
WO1994003425A3 (fr) Derives de carbostyrile pour le traitement de l'arythmie cardiaque
ES8505993A1 (es) Un metodo para preparar un derivado de 3-indolcarboxamida
IE812033L (en) Quinolones
IE820868L (en) Imidazole derivatives
ES8800255A1 (es) Procedimiento para preparar n6 -benzopirano- y benzotiopirano-adenosinas.
EP0201349A3 (fr) Dérivés de tétrazole
EP0123146A3 (en) Compounds with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom
FI883507A (fi) Naftotiazepinderivat och deras framstaellning.
EP0230474A4 (fr) Derives de bis-dioxopiperazine et compositions de medicaments les contenant.
EP0323604A3 (fr) Agent modifiant l'extensibilité veineuse et supprimant l'hypertrophie cardiaque renfermant un composé de la dihydropyridine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE FR GB IT NL SE

WWE Wipo information: entry into national phase

Ref document number: 1986902913

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE FR GB IT NL SE

WWP Wipo information: published in national office

Ref document number: 1986902913

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1986902913

Country of ref document: EP