WO1985000100A1 - Procede et appareil ameliores d'echantillonnage cytologique de l'endometre - Google Patents

Procede et appareil ameliores d'echantillonnage cytologique de l'endometre Download PDF

Info

Publication number
WO1985000100A1
WO1985000100A1 PCT/US1984/000846 US8400846W WO8500100A1 WO 1985000100 A1 WO1985000100 A1 WO 1985000100A1 US 8400846 W US8400846 W US 8400846W WO 8500100 A1 WO8500100 A1 WO 8500100A1
Authority
WO
WIPO (PCT)
Prior art keywords
tubular probe
probe
balloon
introducer tube
transparent membrane
Prior art date
Application number
PCT/US1984/000846
Other languages
English (en)
Inventor
Daniel D. Canale, Jr.
Original Assignee
Project U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Project U filed Critical Project U
Publication of WO1985000100A1 publication Critical patent/WO1985000100A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0291—Instruments for taking cell samples or for biopsy for uterus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/03—Automatic limiting or abutting means, e.g. for safety
    • A61B2090/033—Abutting means, stops, e.g. abutting on tissue or skin
    • A61B2090/036—Abutting means, stops, e.g. abutting on tissue or skin abutting on tissue or skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06—Measuring instruments not otherwise provided for
    • A61B2090/062—Measuring instruments not otherwise provided for penetration depth

Definitions

  • the present invention relates to methods and apparatus for collecting and examining sample tissue from an endometrial cavity. More particularly, the invention relates to improved endometrial cytologic techniques which simplify accurate diagnosis of endometrial cancer. Discussion of the Prior Art
  • Reliable cytologic sampling of the endometrial ⁇ cavity is required in order to provide reliable diagnosis of endometrial cancer.
  • the sampling device must be sufficiently small to be inserted through the cervical opening, but must have a probe which includes a surface large enough to reliably contact and scrape cell samples from the wall of the endometrial cavity. This relatively large probe must not only be insertable into the cavity, but must also be withdrawn without destroying the sample and without causing pain to the patient.
  • the brush may then be rotated so as to contact the walls of the endometrial cavity and thereby collect cytologic samples.
  • the brush In order to withdraw the collected samples from the endometrial cavity, the brush is retracted into the sheath which is then removed from the vaginal canal. After such removal, the brush is once again projected from the sheath so that the collected samples may be smeared or otherwise transferred to a microscopic slide for examination.
  • OMPI OMPI
  • the technique as described above suffers from the disadvantage of requiring transfer of the collected sample to a microscopic slide. In the usual case, only a relatively small portion of the collected sample is actually transferred, thereby significantly reducing the reliability of the test for cancer cells.
  • the degree to which the bristles of the sampling device can be compressed or bent while withdrawn into the sheath without damage to the bristles severely limits the length or radial expanse of the bristles, thereby limiting the size of adequacy of the sample. This requires considerable manipulation of the probe when the brush has been projected out from the sheath in the endometrial cavity. This manipulation can cause considerable discomfort to the patient, thereby resulting in far less acceptance and willingness to submit to regular tests of this kind.
  • a further object of the present invention is to provide a method and apparatus for collecting and examining endometrial cytologic samples wherein a probe inserted into the endometrial cavity requires little or no manipulation to collect samples from the cavity wall.
  • a still further object of the present invention is to provide an endometrial cytologic sampling probe which easily enters the cervical opening and yet, is radially expandable to a greater distance than was heretofore possible with prior art probes.
  • a transparent terminal membrane is employed as a sampling device at the distal end of a probe.
  • the membrane is expandable when the probe is projected from its sheath so as to readily contact the endometrial walls without undue manipulation of the probe.
  • the membrane Upon contraction of the membrane and the removal of the probe, the membrane itself can be placed on a microscopic slide because of its transparency, thereby eliminating the unreliability involved in the step of transferring the collected samples from the probe to the slide.
  • the transparent membrane takes the form of a balloon-like member which, in its collapsed state, conforms to the tip and distal end section of the tubular probe.
  • One or more holes are defined in the distal end section of the probe so that air or other fluid under pressure can be introduced into the probe to selectively inflate the ' balloon-like member.
  • the balloon-like member When inflated, the balloon-like member need only contact the endometrial surface in order to gather cytologic samples on the exterior of the transparent membrane. Vigorous manipulation of the probe is thereby avoided as is the discomfort to the patient which results from such manipulation.
  • the essential feature is the transparent membrane, irrespective of how it is expanded once it is inserted into the endometrial cavity. Therefore, the invention encompasses within its scope any expandable configuration for a transparent membrane probe which permits the membrane to be selectively expanded and contracted so as to be temporarily stored in and projected radially outward from a sleeve or guide member.
  • Figure 1 is a view in plan of an endometrial cytologic sampling assembly constructed in accordance with the present invention, showing the assembly prior to deployment of its sampling membrane;
  • OMPI Figure 2 is a view similar to Figure 1 showing the assembly with the sampling membrane deployed;
  • Figure 3 is a view in plan of the core probe member of the assembly of Figures 1 and 2;
  • Figure 4 is a view in plan of the introducer sleeve member of the assembly in Figures 1 and 2;
  • Figure 5 is a view in plan of the body casing member of the assembly of Figures 1 and 2;
  • Figure 6 is a detailed illustration in partial section of the tip of the assembly of Figures 1 and 2, showing the tip prior to deployment in an endometrial cavity;
  • Figure 7 is a diagrammatic illustration in perspective showing the sampling membrane of the assembly of Figures 1 and 2 removed from the assembly and placed on a microscopic slide for examination.
  • a core probe member 10 is elongated and tubular and has a Luer female fitting 11 secured to its proximal end.
  • the distal end 13 of the core probe member 10 is closed and somewhat bulbous relative to the outer diameter of the core probe member throughout its length.
  • the core probe member 10 is 29.3 centimeters long, has an outer diameter of 0.02 inches and an inner diameter of 0.008 inches.
  • a plurality of inflation port openings 15 are' defined through the wall of the tubular portion of core probe member 10 at locations which are within approximately 1.8 centimeters of the distal end 13.
  • OMPI balloon sleeve member 17 is disposed in a tight fit concentric relation about the core probe member 10 with the forward-most end of the sleeve disposed approximately 1.8 centimeters from the distal end 13 of the core probe member.
  • the sleeve member 17 is approximately 0.250 inches in length and can be engaged about the core probe member by means of adhesive, a friction fit, or the like.
  • the core probe member 10 is disposed for longitudinal movement within an introducer sleeve 19 which takes the form of a tubular member which is shorter than the core probe member 10 by approximately 2.0 centimeters, not including the Luer fitting 11 as part of the core probe member length.
  • the introducer sleeve 19, in a typical embodiment, has an outer diameter of 0.063 inches and an inner diameter of 0.039 inches.
  • the inner diameter of the introducer sleeve is larger than the outer diameter of the balloon sleeve member 17 but is not larger than the diameter of the bulbous distal end 13 of core prove- member 10.
  • the bulbous end 13 of the core probe member serves as a stop for limiting retraction of the distal end of core probe member 10 into the introducer sleeve 19, as illustrated in Figure 6.
  • the proximal end of the core probe member extends approximately 1.8 centimeters out from the proximal end of the introducer sleeve 19.
  • a series of longitudinally-spaced markings 20 extend from the distal end of introducer sleeve 19 along a portion of the length of the introducer sleeve. Markings 20 are equally spaced and preferably take the form of colored bands which serve as a gauge for the insertion steps of the unit in the vaginal tract and endometrial cavity. In a typical embodiment, these markings 20 are 5 millimeters apart.
  • a body casing 21 includes an intermediate tubular portion 22, a tapered distal portion 23 and a radially enlarged proximal portion 24.
  • the tapered portion 23 of the body casing has a plurality of longitudinally spaced markings 25 appearing thereon, which markings are spaced by the same distance as the spacing between the series of markings 20 on the introducer sleeve 19.
  • the introducer sleeve is secured within the body casing by means of welding, or the like, to prevent against relative longitudinal motion between the body casing and introducer sleeve. When the introducer sleeve and body casing are thusly secured, the markings 20 and 25 provide an uninterrupted scale of equally spaced distance markers which permit the physician to monitor the insertion depth of the instrument.
  • the radially enlarged proximal end 24 of body casing 21 is large enough to receive the Luer fitting 11 therein.
  • the tapered distal end 23 of the body casings must be small enough at its outer diameter to permit it to be inserted into the vaginal canal of the patient.
  • Luer fitting 11 is adapted to be connected to a mating Luer lock fitting 27 disposed at the outlet end of a syringe 29.
  • the syringe has a selectively actuable plunger 30 which permits delivery of pressurized air through the fittings 27 and 11 into the core probe member 10. Initially, however, during insertion of the unit into a patient's endometrial cavity, the syringe is disconnected from the core probe member.
  • An inflatable balloon member 31 is secured about the distal end of core probe member 10 and extends to within the spacing between balloon sleeve member 17 and the exterior of the core probe member. The open end of the balloon member 31 is thus sealed between sleeve 17 and core probe member 10. When the balloon member 31 is uninflated, it conforms precisely to the contour of bulbous distal end 13 and the section of core probe 10 between sleeve 17 and distal end 13.
  • An important feature of the present invention is that the balloon member is made of a transparent membrane material which can be selectively and safely inflated by pressurized air delivered by syringe 29 to the interior of core probe member 10 and out through inflation ports 15.
  • balloon member 31 requires certain considerations in the construction of the unit, such as a smooth contour at the distal end 33 of introducer sleeve 19 where the bulbous tip 13 abuts in the retracted position of core probe member 10.
  • the balloon member 31 is made of a latex membrane. It must be readily inflatable to a radial expansion which permits the periphery of balloon member 31 to contact the walls of the endometrial cavity.
  • the instrument of the present invention is initially deployed in the retracted position of core member 10 as illustrated in Figure 6.
  • Syringe 29 is not yet connected to the Luer fitting 11 which extends outwardly from the widened proximal section 24 of body casing 21.
  • the physician places a speculum in the vaginal tract and visualizes the uterine cervical os.
  • the instrument is then grasped by body casing 21 and, taking advantage of the flexibility and suppleness of the introducer sleeve 19 and its interior core probe member 10, introduces the instrument through the vaginal tract and into the os.
  • the distal end of the instrument can be advanced within the endometrial cavity until resistance is felt, indicating that the probe has reached the endometrial vault.
  • the markings 20, 25 designate the distance from the cervical os to the vault of the endometrial cavity and serve as an additional guide for the physician in determing the proper length of probe insertion.
  • the physician withdraws the entire probe approximately 3.75 centimeters as measured by the markings 20, 25.
  • Core probe member 10 is then pushed longitudinally through the introducer sleeve from its proximal end at Luer fitting 11 until the Luer fitting contacts the proximal end of the introducer sleeve. This distance is approximately 1.8 centimeters and places the distal end 13 of the core probe member substantially centrally, in a longitudinal sense, within the endometrial cavity.
  • the syringe 29 may then be connected to the core probe member 10 by means of fittings 11 and 27 and a volume of air is injected into the core probe member 10.
  • the core probe member typically, 2 cubic centimeters of air would be so injected into the core probe member.
  • This injected air inflates balloon member 31 so that it expands into contact with the walls of the endometrial cavity.
  • the syringe may then rotate about its axis, causing the core probe member 10 and balloon member 31 to rotate.
  • the syringe plunger 10 may then be retracted to collapse balloon member 31.
  • the core probe member is retracted within the introducer sleeve 19 before the instrument is withdrawn from the patient so that the balloon member 31 is protected within the sleeves.
  • the core probe 10 is extended from the distal end of sleeve 19 so that the balloon-covered portion of the core probe is accessible.
  • the balloon is then cut from the core probe and placed on a microscope slide 35, as illustrated in Figure 8, to permit cytologic staining and examination of the gathered cytological samples by microscope 37.
  • a crucial feature of the present invention resides in the fact that the membrane-like balloon member 31 is transparent so that the cytological samples do not have to be transferred from the balloon member to the slide for examination; rather, the examination takes place with the gathered samples still on the balloon member.
  • the balloon member 31 is deflated before withdrawal of the probe so that discomfort is once again avoided. Since the unit is intended to be disposable after one use, cutting of the balloon member 31 after sampling may simply be with a knife or other suitable instrument, alternatively, a tool may be designed specifically for the purpose of removing the balloon from the core probe member.
  • OMPI OMPI
  • an inflatable balloon is only one mechanism whereby a transparent sample gathering member can be inserted into the endometrial cavity, expanded for the purpose of gathering cell samples, and collapsed to permit withdrawal of the instrument without discomfort.
  • Other techniques for inserting a transparent sample gathering member are intended to fall within the scope of the present invention.
  • an umbrella-like configuration may be employed wherein the transparent membrane takes the form of material interconnecting umbrella-like ribs which can be retracted into a sleeve such as the introducer sleeve 19 and automatically projects radially outward when extended longitudinally beyond the distal end of the sleeve.
  • the important feature is the use of a transparent sample-gathering element which can be placed directly on a microscope slide for examining the gathered sample so as to avoid transfer of the sample to the slide or other support mechanism.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endoscopes (AREA)

Abstract

On effectue un examen et un échantillonnage cytologiques de l'endomètre en insérant une membrane transparente dans la cavité de l'endomètre afin de recueillir l'échantillon cytologique, puis en plaçant la membrane transparente sur un porte-objet (35) afin de permettre la coloration et l'étude de l'échantillon sans avoir besoin de transférer l'échantillon du collecteur au porte-objet. La membrane transparente a de préférence la forme d'un organe similaire à un ballon (31) qui s'adapte à l'extrémité distale d'une sonde tubulaire (10) et qui peut être gonflée sélectivement après insertion grâce à l'application d'un fluide sous pression à l'extrémité proximale de la sonde (10). La sonde (10) peut sélectivement sortir d'un manchon d'introduction (19), et être rétractée dans celui-ci, le manchon étant utilisé pour guider l'unité à la profondeur voulue dans la cavité de l'endomètre. Une fois la sonde (10) correctement insérée, une seringue (29) peut être connectée à un montage approprié (11) afin de gonfler l'organe similaire à un ballon (31).
PCT/US1984/000846 1983-06-24 1984-05-30 Procede et appareil ameliores d'echantillonnage cytologique de l'endometre WO1985000100A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50766283A 1983-06-24 1983-06-24
US507,662 1983-06-24

Publications (1)

Publication Number Publication Date
WO1985000100A1 true WO1985000100A1 (fr) 1985-01-17

Family

ID=24019615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1984/000846 WO1985000100A1 (fr) 1983-06-24 1984-05-30 Procede et appareil ameliores d'echantillonnage cytologique de l'endometre

Country Status (3)

Country Link
EP (1) EP0151583A1 (fr)
AU (1) AU2968184A (fr)
WO (1) WO1985000100A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476775A (en) * 1990-05-29 1995-12-19 Chemgen Corporation Hemicellulase active at PH and temperature extremes
EP0746226A1 (fr) * 1993-12-30 1996-12-11 Boston Scientific Corporation Prelevement d'echantillon corporel
EP0918485A1 (fr) * 1996-01-11 1999-06-02 Symbiosis Corporation Instruments flexibles de microchirurgie comportant un fourreau qui possede des indicateurs de position visuels et tactiles
GB2341321A (en) * 1998-09-08 2000-03-15 James Philip Oliver Cell Collecting Device
WO2001037738A3 (fr) * 1999-11-29 2002-01-17 Ampersand Medical Corp Systeme d'analyse de cellules cervicales
US6475164B2 (en) 1999-11-29 2002-11-05 Ampersand Medical Corporation Physician's collector
US8992438B2 (en) 2004-07-07 2015-03-31 Colonix Limited Colorectal cell sampling device

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2701559A (en) * 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US2955592A (en) * 1955-12-29 1960-10-11 Kenneth S Maclean Diagnostic instrument
US3074396A (en) * 1959-04-16 1963-01-22 Kenneth S Maclean Diagnostic instrument
US3480017A (en) * 1966-04-27 1969-11-25 Wallace B Shute Cervical dilator
US3664328A (en) * 1971-04-28 1972-05-23 Henry Dinwoodey Moyle Jr Cancer test specimen gathering device
US3774606A (en) * 1972-03-07 1973-11-27 Bard Inc C R Adjustable needle hub
US3841304A (en) * 1972-10-16 1974-10-15 A Jones Inflatable leakage inhibitor
US3900033A (en) * 1973-03-07 1975-08-19 Ortho Pharma Corp Dilator for cervical canal
US3961620A (en) * 1971-03-12 1976-06-08 Research Industries Corporation Cervical sampling apparatus
US3978863A (en) * 1974-06-06 1976-09-07 Bruce E. Fettel Expanding tip embolectomy catheter with indicator balloon
GB1547328A (en) * 1978-01-19 1979-06-13 Celestin L R Apparatus for insertion into a body cavity
US4217045A (en) * 1978-12-29 1980-08-12 Ziskind Stanley H Capsule for photographic use in a walled organ of the living body
US4224929A (en) * 1977-11-08 1980-09-30 Olympus Optical Co., Ltd. Endoscope with expansible cuff member and operation section
US4227537A (en) * 1978-03-08 1980-10-14 Tucson Medical Instruments, Inc. Endometrial brush with slidable protective sleeve
US4248234A (en) * 1979-03-08 1981-02-03 Critikon, Inc. Catheter with variable flexural modulus and method of using same
US4261339A (en) * 1978-03-06 1981-04-14 Datascope Corp. Balloon catheter with rotatable support
US4299226A (en) * 1979-08-08 1981-11-10 Banka Vidya S Coronary dilation method
US4396022A (en) * 1980-07-22 1983-08-02 Marx Alvin J Endometrial tissue sampling apparatus

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2701559A (en) * 1951-08-02 1955-02-08 William A Cooper Apparatus for exfoliating and collecting diagnostic material from inner walls of hollow viscera
US2955592A (en) * 1955-12-29 1960-10-11 Kenneth S Maclean Diagnostic instrument
US3074396A (en) * 1959-04-16 1963-01-22 Kenneth S Maclean Diagnostic instrument
US3480017A (en) * 1966-04-27 1969-11-25 Wallace B Shute Cervical dilator
US3961620A (en) * 1971-03-12 1976-06-08 Research Industries Corporation Cervical sampling apparatus
US3664328A (en) * 1971-04-28 1972-05-23 Henry Dinwoodey Moyle Jr Cancer test specimen gathering device
US3774606A (en) * 1972-03-07 1973-11-27 Bard Inc C R Adjustable needle hub
US3841304A (en) * 1972-10-16 1974-10-15 A Jones Inflatable leakage inhibitor
US3900033A (en) * 1973-03-07 1975-08-19 Ortho Pharma Corp Dilator for cervical canal
US3978863A (en) * 1974-06-06 1976-09-07 Bruce E. Fettel Expanding tip embolectomy catheter with indicator balloon
US4224929A (en) * 1977-11-08 1980-09-30 Olympus Optical Co., Ltd. Endoscope with expansible cuff member and operation section
GB1547328A (en) * 1978-01-19 1979-06-13 Celestin L R Apparatus for insertion into a body cavity
US4261339A (en) * 1978-03-06 1981-04-14 Datascope Corp. Balloon catheter with rotatable support
US4261339B1 (fr) * 1978-03-06 1990-09-25 Datascope Corp
US4227537A (en) * 1978-03-08 1980-10-14 Tucson Medical Instruments, Inc. Endometrial brush with slidable protective sleeve
US4217045A (en) * 1978-12-29 1980-08-12 Ziskind Stanley H Capsule for photographic use in a walled organ of the living body
US4248234A (en) * 1979-03-08 1981-02-03 Critikon, Inc. Catheter with variable flexural modulus and method of using same
US4299226A (en) * 1979-08-08 1981-11-10 Banka Vidya S Coronary dilation method
US4396022A (en) * 1980-07-22 1983-08-02 Marx Alvin J Endometrial tissue sampling apparatus

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476775A (en) * 1990-05-29 1995-12-19 Chemgen Corporation Hemicellulase active at PH and temperature extremes
EP0746226A1 (fr) * 1993-12-30 1996-12-11 Boston Scientific Corporation Prelevement d'echantillon corporel
EP0746226A4 (fr) * 1993-12-30 1998-05-13 Boston Scient Corp Prelevement d'echantillon corporel
EP0918485A1 (fr) * 1996-01-11 1999-06-02 Symbiosis Corporation Instruments flexibles de microchirurgie comportant un fourreau qui possede des indicateurs de position visuels et tactiles
EP0918485A4 (fr) * 1996-01-11 2000-10-04 Symbiosis Corp Instruments flexibles de microchirurgie comportant un fourreau qui possede des indicateurs de position visuels et tactiles
GB2341321A (en) * 1998-09-08 2000-03-15 James Philip Oliver Cell Collecting Device
WO2001037738A3 (fr) * 1999-11-29 2002-01-17 Ampersand Medical Corp Systeme d'analyse de cellules cervicales
US6475164B2 (en) 1999-11-29 2002-11-05 Ampersand Medical Corporation Physician's collector
US8992438B2 (en) 2004-07-07 2015-03-31 Colonix Limited Colorectal cell sampling device

Also Published As

Publication number Publication date
EP0151583A1 (fr) 1985-08-21
AU2968184A (en) 1985-01-25

Similar Documents

Publication Publication Date Title
US4340066A (en) Medical device for collecting a body sample
US4227537A (en) Endometrial brush with slidable protective sleeve
EP3079598B1 (fr) Dispositif de collecte un échantillon biologique
US4957486A (en) Rectal-stomal insert apparatus and method
US3766907A (en) Method of preparing endometrial samples
US3777743A (en) Endometrial sampler
JP6535790B2 (ja) 子宮内膜サンプリング装置
US7108661B2 (en) Method and collection device for Barrett's esophagus cells
US20100145224A1 (en) Canal dilation device
JPS6125377B2 (fr)
US10098617B2 (en) Medical apparatus for sampling cervical tissue
US7207951B1 (en) Apparatus for obtaining biological samples
KR19990022305A (ko) 신체 관강의 결함을 측정하는 장치
CN110537937B (zh) 一种妇科检查取样装置
WO1985000100A1 (fr) Procede et appareil ameliores d'echantillonnage cytologique de l'endometre
US5865765A (en) Dilator/sampler for sampling materials and fluid from a body cavity
US6402700B1 (en) Pap smear apparatus and method
IL267194B2 (en) Biopsy brush device, kit and method
WO1987002877A1 (fr) Dispositif de prelevement de tissus ou de glaire
CN210871737U (zh) 子宫腔采样器
CN102791184B (zh) 包括监测用中空部分的用于子宫颈检查的导管及含该导管的检测器
CN108852459B (zh) 一种可塑形多功能颅脑造通器
JP2003535622A (ja) バレット食道細胞学デバイス
CN112969417A (zh) 活检器械、成套部件和方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU JP

Designated state(s): AU JP

AL Designated countries for regional patents

Designated state(s): AT BE CH DE FR GB LU NL SE

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB LU NL SE