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Vascular graft and blood supply method

Info

Publication number
WO1984002266A1
WO1984002266A1 PCT/US1983/001932 US8301932W WO1984002266A1 WO 1984002266 A1 WO1984002266 A1 WO 1984002266A1 US 8301932 W US8301932 W US 8301932W WO 1984002266 A1 WO1984002266 A1 WO 1984002266A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
blood
passage
means
graft
flow
Prior art date
Application number
PCT/US1983/001932
Other languages
French (fr)
Inventor
Zinon C Possis
Demetre M Nicoloff
Original Assignee
Possis Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/902Method of implanting
    • Y10S623/903Blood vessel

Abstract

A graft (36) is used to supply blood to one or more coronary artery branches (32, 33, 34, 35). The graft is also usable as a peripheral revascularization and inter position prosthesis to supply blood to desired blood vessels. The graft (36) has an elongated U-shaped tubular body (43) providing a continuous passage (40) for carrying blood from a high pressure blood supply (23) to a blood receiver (11). One or more openings in the body (43) allow blood to flow into the coronary artery branches (32, 33, 34, 35). The flow and pressure of the blood in the passage (40) is controlled by a restriction (44) providing a restricted passage (48) located remote from the inlet end (41) of the tubular body (43). In one embodiment, the restriction (244) is reinforced with a sleeve (245) to maintain a desired cross sectional area and length of the restricted passage (248). The pressure differential between the blood supply and blood receiver maintains continuous and adequate blood flow at a desired pressure in the continuous passage and provides a continual supply of blood for the coronary artery branches.

Description

VASCULAR GRAFT AND BLOOD SUPPLY METHOD FIELD OF INVENTION:

The invention relates to implants used in the body to replace natural blood vessels to supply arterial blood to organs and tissues throughout the body. More parti¬ cularly, the implants are vascular grafts used to supply blood to the tissue. BACKGROUND OF INVENTION:

Congenital defects, disease, or injury can render a person's blood vessels incapable of serving as an appro¬ priate conduit for blood. Autogenous blood vessels may be relocated from their original site in the person's body and grafted to a new site as a replacement for the diseased or traumatized native vessel. Synthetic or non- autogenous tissue origin vascular grafts may also be implanted in a person to replace diseased or traumatized native vasculature.

Infection, aneurysm, thrombosis, hyperplastic tissue response, stenosis at the anastomoses, are all problems which occur with any known vascular graft whether it be of autogenous or non-autogenous origin. Long term patency of vascular grafts is dependent upon many factors including the skill of the implanting surgeon, patient health status, quality of the vascular graft and other factors. The influence of any particular factor on successful long term function has not been quantified. However, it is commonly held that low velocity of blood flow and low flow rate are major factors which reduce patency. Conversely then, higher flow rate and higher velocity of flow are major factors which increase patency longevity.

The autogenous saphenous vein is used successfully

OMPI as a vascular conduit for coronary artery revasculari- zation. Although the search for a suitable prosthetic graft for aortocoronary bypass continues, nothing better than the autogenous saphenous vein is available. Sur- geons have been reluctant to use synthetic grafts in aortocoronary bypass because of few proved instances of long-term patency.

Although saphenous veins are used in aortocoronary bypass procedures, there are certain disadvantages: (1) unavailability, (2) small size, (3) non-uniform caliber, (4) varicosities, (5) large diameter, C6) sclerosis, (7) obstruction due to intimal hyper- plasia, (8) aneurysm formation, (9) considerable time required for harvesting, (10) leg discomfort and swell- ing, and (11) possible leg infection.

A significant number of patients requiring aorto¬ coronary bypass do not have suitable veins, or the veins have been used for previous aortocoronary bypass or for peripheral vascular bypass procedures. On occasion, the need for a graft may have been unforeseen prior to surgery, and the legs not prepared for harvesting of the vein. The cephalic vein from the arm has been used when the saphenous vein is not available. However, it is usually thin-walled and often of poor caliber. Fur- thermore, the cosmetic effect of harvesting the cephalic vein is unacceptable for some patients.

The internal mammary artery is widely accepted as suitable for myocardial revascularization, in that it has an excellent patency ratio, but is useful only for the left anterior descending and diagonal coronary arteries. Experience with free grafts of the internal mammary and radial arteries has been disappointing, since long-term patency has been poor.

The importance of the velocity of blood flow in autogenous vein grafts has been emphasized. There is evidence of an inverse relationship between the veloc¬ ity of blood flow in venous grafts and the amount of intimal proliferation observed. Autopsy studies indi- cate that occlusion of aortocoronary saphenous vein grafts more than one month after operation is most commonly caused by fibrous intimal proliferation. Although the cause of this lesion has not been defin- itely established, studies would suggest that it is probably related to a low velocity of flow through the graft. This suggests that every effort should be made to achieve a high velocity of flow in coronary artery bypass grafts. Synthetic vascular implants are disclosed by Liebig in U. S. Patents Nos. 3,096,560; 3,805,301 and 3,945,052. These grafts are elongated knit fabric tubes made of yarn, such as polyester fiber. Dardik in U. S. Patent No. 3,894,530 discloses the use of an umbilical cord for a vascular graft. Holman et al in U. S. Patent No. 4,240,794 disclose a method of preparing human and other animal umbilical cords for use as a vascular replacement. The fabric tubes and umbilical cords have been used to replace the saphenous vein implant. The ends of the tubes and cords are anastomosed to ends of arteries to by-pass diseased areas of the arteries. They replace the diseased portions of the arteries. SUMMARY OF INVENTION:

The goal of vascular reconstructive surgery is to effectively supply blood to organs and tissues whose blood vessels integrity are compromised by congenital defects or acquired disorders, such as arteriosclerosis, trauma, and other diseases. The invention is a graft and a method employing the graft for supplying blood to organs and tissues throughout the body.

According to the invention, there is provided a graft for supplying blood to one or more blood receivers, such as blood vessels. The graft includes an elongated means having a continuous passage for carrying blood from a supply of blood under pressure to one or more blood receivers. The elongated means has a body pro¬ viding a first passage for carrying of blood. The body has one or more openings and is connectable to at least one blood vessel for supplying blood to the opening to the blood vessel. The body has an inlet end means adapted to be connected to a supply of blood under pres¬ sure, whereby blood flows into the first passage and from the first passage into the blood vessel. The flow of blood and pressure of the blood in the first passage is controlled with a means having a restricted second passage connected to the distal portion of the body remote from the inlet end means. An outlet end means connects the means having the restricted second passage to blood receiving means. A pressure differential be¬ tween the blood supply means and the blood receiving means maintains continuous and adequate blood flow at a desired pressure and velocity through the first and second passages and provides a continual supply of blood for the blood vessels that are attached to the body.

The graft is used to supply blood to one or more coronary artery branches in a primate heart. The heart has two atria for receiving blood from the vena cava and pulmonary veins and is connected to an aorta to carry blood under pressure from the heart. The graft comprises an elongated tubular means having a continuous longitudinal passage for carrying blood from the aorta to the atrium or a low pressure blood vessel. The tubular means has an inlet end anastomosed to the aorta so that blood under pressure flows from the aorta into the passage and is discharged through an outlet end into the atrium or other vessel of lower mean pressure than the aorta. The outlet end of the tubular means is anas¬ tomosed to the heart tissue around an opening in communi¬ cation with the atrium. The tubular means has one or more openings used to provide blood to one or more coro¬ nary arteries or branches. The coronary arteries are sutured to the tubular means whereby blood flows through the openings in the tubular means into the coronary artery branches. The flow rate, velocity of flow, and pressure of the blood in the passage is controlled by a restric¬ tion located remote from the inlet end of the tubular means. The area of restriction is a restricted second passage having a diameter that is less than one-half the diameter of the main or first passage of the tubular means. The restricted passage is also smaller than the passage in the outlet end of the tubular means. The tubular means is generally U-shaped and encircles the critical areas of the heart beginning at the aorta and ending at either the right or left atrium or pulmonary artery. The pressure differential between the aorta and

10 the atrium causes a continuous flow of blood in quanti¬ ties and at velocities that inhibit thrombosis, and provides a continuous supply of blood at a desired pres¬ sure to the arteries connected to the tubular means. In one embodiment of the invention, the tubular ■■-* means is an elongated synthetic tube, such as a poly- tetrafluoroethylene tube, a Dacron tube, or a tube of other synthetic bioco patible material. The tube is continuous and has a reduced diameter section proximal to the distal or outlet end thereof. The reduced diamete 0 section provides the restricted passage for controlling the blood flow and sustaining the pressure of the blood in the first passage of the tubular means. The restrict¬ ed passage also controls the flow and velocity of blood moving through the outlet end of the tubular means. 5 A second embodiment of the invention utilizes a human umbilical cord or other tissue tubes of any origin as the elongated means. The umbilical cord can be linear or shaped to encircle the critical areas of the heart. The outlet or distal end portion of the cord has a reduc¬ 0 ed diameter to provide a restricted passage for the flow of blood through the cord. Selected arteries are anas¬ tomosed to the body of the cord and are provided with openings whereby blood from the lumen of the cord can flow into the arteries. 5

In a third embodiment of the invention, the elon¬ gated tubular means comprises an autogenous saphenous vein having a large enough caliber to assure adequate blood flow. The vein encircles the heart from the

OMPI aorta and extends to the atrium. The distal or outlet end section of the vein accommodates an adjustable blood flow restrictor operable to reinforce the vein and reduce the cross sectional area of the vein passage to form a restricted passage. The restricted passage controls the flow of blood in the vein passage while maintaining a continuous flow of blood at a desired pressure. Selected portions of the vein are anastomosed to coronary arteries to provide continuous flow of blood to these arteries. According to a fourth embodiment of the invention, there is provided a graft for supplying blood to one or more blood receivers, such as blood vessels. The graft includes an elongated tubular means having a continuous passage for carrying blood from a supply of blood under pressure to one or more blood vessels and blood receiver means. The flow of blood, velocity of blood flow, and pressure of the blood in the continuous passage is con¬ trolled with reinforced means having a restricted pass¬ age connected to the distal portion of the elongated tubular means remote from the inlet end means. The reinforced means maintains the cross sectional and longitudinal dimensions of the restricted passage over an extended period of time. The reinforcing means has an annular reinforcing sleeve surrounding the body to maintain the shape and size of the restricted passage. Other means can be used to reinforce the tubular means to ensure the shape and size of the restricted passage. The reinforcing means can be an increased wall thickness of the tubular means surrounding the restricted passage, or thread or tape surrounding the tubular means. An outlet end means connects the reinforced means having the restricted passage to blood receiving means. The outlet end means has an outlet passage larger than the restricted passage so as to reduce the velocity and pres- sure of the blood flowing into the atrium or low pressure blood vessel. A pressure differential between the blood supply means and the blood receiving means maintains continuous and adequate blood flow at a desired pressure

OMPI through the passages and provides a continual supply of blood for the blood vessels that are attached to the elongated tubular means over a long period of time. The elongated tubular means can be.an autogenous blood vessel or a synthetic tube, such as a polytetra- fluoroethylene tube, a Dacron tube, or a tube of other bioco patible material. The tube is continuous and has a reduced cross sectional area or throat section proximal to the distal or outlet end thereof. An elongated annula sleeve of reinforcing material surrounds the throat sec¬ tion to maintain the cross sectional area of the restrict ed passage through the throat section. The reinforcing material can be a fiber plastic, fiber mesh, a carbon tubular member, or metal tubular member attached to the outside of the throat section. The fiber can comprise a plurality of substantially non-elastic interconnected strands or wire-like members of metal, plastic, or carbon The reinforcing material can be incorporated into the material of the throat section. The reinforcing material can be thread or tape wound around the throat section.

A sleeve of rigid material, such as molded plastic, metal or carbon can be located about the throat section. The wall thickness of the throat section can be enlarged to provide for reinforcement thereof. The reduced cross sectional area provides a restricted passage for control¬ ling the blood flow and sustaining the pressure of the blood in the first passage of the tubular means.

A fifth embodiment of the invention utilizes a human umbilical cord or autogenous blood vessel as the elongated means for carrying blood to the blood receiving vessels. The outlet or distal end of the cord has a reduced size to provide a restricted passage for control¬ ling the flow, velocity and pressure of blood through the cord. The size of the restricted passage is maintained with an annular sleeve of reinforcing material mounted on the umbilical cord. The reinforcing material can be a fiber plastic, tape, a carbon tubular member, or metal tubular member surrounding a distal section of the umbilical cord. Selected arteries are anastomosed to the body of the cord and are provided with openings whereby blood from the lumen of the cord flows into the arteries. The invention includes a method of providing a con¬ tinuous supply of flowing blood at a desired pressure to one or more blood receiving vessels, such as coronary arteries of a primate. A graft having a blood flow res¬ tricting passage in the distal end section thereof is anastomosed to the aorta. The graft is placed adjacent the heart to locate portions thereof in proximity to selected coronary branch arteries. Selected portions of the graft are anastomosed to coronary arteries. The distal end of the graft is anastomosed to the atrium or low blood pressure section of the blood circulatory system. Blood under pressure continuously flows from the aorta into the graft, since there is a substantial blood pres¬ sure difference between the aorta and atrium. The res¬ tricted passage prevents the flow of blood from being excessive and maintains the blood pressure in the graft passage at substantially the same as the aorta blood pressure and controls the pressure and velocity of blood flowing from out of the graft to a low pressure vessel or atrium. The coronary arteries are perfused with sufficient quantities of blood. IN THE DRAWINGS:

Figure 1 is an anterior view of a human heart; Figure 2 is a schematic longitudinal sectional diagram of the heart of Figure 1; Figure 3 is an anterior view of a human heart having the graft of the invention;

Figure 4 is an enlarged partly sectioned plan view of the graft of Figure 3;

Figure 5 is an enlarged sectional view taken along the line 5-5 of Figure 4;

Figure 6 is an enlarged sectional view taken along the line 6-6 of Figure 4;

Figure 7 is an enlarged sectional view taken along

O PI the line 7-7 of Figure 4;

Figure 8 is an enlarged sectional view taken along the line 8-8 of Figure 4;

Figure 9 is an enlarged sectional view taken along the line 9-9 of Figure 3;

Figure 10 is an enlarged sectional view taken along the line 10-10 of Figure 3;

Figure 11 is an enlarged sectional view taken along the line 11-11 of Figure 3; Figure 12 is a plan view, partly sectioned, of a saphenous vein and distal and tubular blood flow restrictor anastomosed to the vein, usable as a graft of the invention;

Figure 13 is an enlarged sectional view taken along the line 13-13 of Figure 12;

Figure 14 is an enlarged sectional view taken along the line 14-14 of Figure 12;

Figure 15 is an enlarged sectional view taken along the line 15-15 of Figure 12; Figure 16 is an enlarged sectional view taken along the line 16-16 of Figure 12;

Figure 17 is an enlarged sectional view taken along the line 17-17 of Figure 12;

Figure 18 is a plan view, partly sectioned, of a graft and adjustable blood flow restrictor therefor;

Figure 19 is an enlarged sectional view taken along the line 19-19 of Figure 1;

Figure 20 is an enlarged sectional view taken along the line 20-20 of Figure 18; Figure 21 is an enlarged sectional view taken along the line 21-21 of Figure 18;

Figure 22 is an enlarged sectional view taken along the line 22-22 of Figure 18

Figure 23 is an anterior view of a human heart having a reinforced vascular graft of the invention;

Figure 24 is an enlarged partly sectioned plan view of the vascular graft of Figure 23;

Figure 25 is an enlarged sectional view taken along

OMPI the line 25-25 of Figure 24;

Figure 26 is an enlarged distal end view of the vascular graft of Figure 24;

Figure 27 is an enlarged sectional view taken along the line 27-27 of Figure 26;

Figure 28 is an enlarged sectional view taken along the line 28-28 of Figure 26;

Figure 29 is an enlarged sectional view taken along the line 29-29 of Figure 26; Figure 30 is an enlarged sectional view taken along the line 30-30 of Figure 26;

Figure 31 is an enlarged sectional view taken along the line 31-31 of Figure 26; and

Figure 32 is an enlarged sectional view taken along the line 32-32 of Figure 26.

DESCRIPTION OF PREFERRED EMBODIMENTS:

Referring to Figures 1, 2 and 3, there is shown an anterior view of a human heart indicated generally at

10. Heart 10 has a right atrium 11, right ventricle 12, left atrium 13, and left ventricle 14. Blood from the body flows through vena cava 16 into right atrium

11. The pressure of the blood in right atrium 11 is low as the blood flows into atrium 11. A heart valve 17 controls the flow of blood from atrium 11 into right ventricle 12. The blood is pumped from right ventricle 12 through valve 18 into pulmonary artery 19, which is connected to the lungs. The blood returns from the lungs via the pulmonary vein 20 to left atrium 13. The blood flows from left atrium 13 through heart valve 21 into a left ventricle 14 and is pumped from the left ventricle 14 through valve 22 into aorta 23. The pres¬ sure differential of the blood between aorta 23 and the atrium 11 is approximately 90 mm Hg. The muscle tissue of the heart is provided with a supply of blood from two coronary arteries 24 and 26. Left coronary artery - 24 extends from aorta 23 along the left side of the heart toward the apex 27. Coronary artery 24 has a number of branches 28, 29, 30 and 31, which supply blood to the muscle tissue. Left coronary artery 24 has a short common stem which bifurcates or trifurcates into branches 28-31. One branch 31, the anterior inter- ventricular branch, moves downward to the anterior interventricular groove and rounds the acute margin of the heart just to the right of apex 27 and ascends a short distance up the posterior interventricular groove Portions of the branch 31 anastomose with branches from the right coronary artery. These branches are very small in normal hearts. They may enlarge considerably in persons suffering from coronary arteriosclerosis in whom coronary arterial branches become obstructed or occluded. The right coronary artery 26 extends down the right side of the heart toward the apex or crux 27. Artery 26 has a number of branches 32, 33, 34 and 35, which feed blood to the heart tissue.

The right coronary artery 26 arises from the right anterior sinus of aorta 23 and runs along the right atrioventricular sulcus . It rounds the acute margin to reach the crux. It has a number of branches 32-35 to the anterior right ventricle wall. The right arterial branches of the right coronary artery 26 originate from the right coronary artery shortly after its take-off and ascends along the anteromedial wall of the right atrium. Variations of the branching pattern of the arteries 24 and 26 are common in the human heart. In about 67% of the cases, the right coronary artery 26 is dominant and supplies part of the left ventricle wall and ventricle septum. In 15% of the cases, the left coronary artery 19 is dominant and supplies all of the left ventricle and the ventricle septum, and part of the right ventricle wall, with blood. In about 18% of the cases, both coronary arteries 24 and 26 reach the crux 27. It is common for the first, second and third branches of the right coronary artery 26 to originate independently from the right sinus, rather than the parent artery. The graft of the invention can be used to provide an adequate supply of blood to these arteries.

JtJ E O PI Referring to Figures 4-8, there is shown a vascular graft of the invention indicated generally at 36. Graft 36 is an elongated member 37 having a generally U-shape and a continuous passage for carrying blood. Member 37 has a continuous cylindrical wall 38 having an inside surface 39 forming an elongated longitudinal passage 40. Tubular member 37 has a proximal aortic or inlet end 41 and a distal atrial or outlet end 42. A main generally U-shaped trunk 43 extends from inlet end 41 to a res- tricted or reduced diameter section 44. Restricted section 44 is connected to a distal end section 46. Preferably, restricted section 44 is about 2 to 5 cm from outlet end 42 when it is attached to the heart tissue. As shown in Figures 5-7, restricted section 44 has a cylindrical wall 47 integral with cylindrical wall 38 of the main trunk 43 and atrial end section 46. Wall 47 surrounds a throat passage 48 having a cross sectional area substantially smaller than the cross sectional area of passage 40. The cross sectional area of passage 40 is preferably more than four times larger than the cross sectional area of throat passage 48. Cylindrical wall 47 is joined to wall 38 with a converging conical wall portion 49 which directs the flow of blood into passage 48. The opposite ends of wall 47 are joined to a diverging conical wall portion 51 forming part of the atrial end section 46. Wall portion 51 surrounds an outlet passage 52 leading to the distal outlet end 42. The cross sectional area of outlet passage 52 is substan¬ tially the same as the cross sectional area of passage 40 of main trunk 43. The cross sectional area of outlet passage 52 can be larger than the cross sectional area of passage 40. Conical wall portions 49 and 51 each have a longitudinal length and an inside wall surface that has a gradual smooth taper to minimize turbulence in the blood flow. Preferably, cylindrical wall 47 surround¬ ing passage 48 has a longitudinal length that is shorter than the longitudinal length of the wall portions 49 and 51. Other length and size relationships can be used.

OMH The longer the length of restriction section 44, the greater the blood pressure drop for a given cross sec¬ tional area of passage 48. Passage 52 provides a chamber wherein the velocity of the blood flow and blood pressure are decreased before it flows into the atrium of the hear Distal end section 46 is of a size to permit easy attach¬ ment thereof to the heart tissue or blood receiving vesse

The entire member 37 is a tubular structure, prefer¬ ably made from a human umbilical cord. The umbilical cord can be pre-curved and tapered to form the desired restricted section 44 by processing. The tubular struc¬ ture can be made from other tissue, including but not limited to a bovine carotid artery, an ovine subcutaneous mandrel grown tubular member, a feline esophagus and feline intestines. Other tubular structures, such as a polytetrafluoroethylene tube or other synthetic tube, can be used for vascular graft 36.

Referring to Figure 3, vascular graft 36 is located adjacent the heart 10. Body 43 descends toward the mid- portion on the anterior surface of the heart and then encircles about to the posterior surface and ascends toward the right atrium. Restricted section 44 and atrial end section 46 are located adjacent atrium 11. As shown in Figure 9, proximal or aortal end 41 of tubu- lar member 37 is implanted into an aortic ostium 53 and anastomosed thereto with sutures 54. As shown in Figure

10, the outlet or atrial end 46 is implanted into an ostium 56 in heart 10 open to atrium 11 and anastomosed thereto with sutures 57. The blood continuously flows through passage 40 of tubular member 37, by reason of the blood pressure difference between aorta 23 and atrium

11. Restricted passage 48 prevents the flow of blood through passage 40 from being excessive. The distal end section 46 of tubular member 37 can be anastomosed to the left atrium 13, whereby the blood flows from aorta 23 through passage 40 and tubular member 37 and into left atrium 13.

The body 43 of graft 36 is located adjacent one or more of the coronary branches 28-31 and 32-35. The surgeon has the option to anastomose and, therefore, perfuse one or more of the coronary branches along the path of the graft 36. Referring to Figure 11, graft 36 is anastomosed to coronary branch 35 with sutures 58. The cylindrical wall 38 is provided with an opening 59 to allow blood to flow from passage 40 into the coronary artery passage 61. The restricted passage 48 adjacent the atrial end of the graft allows the coronary arteries to be perfused with sufficient quantities of blood at pressures within a few mm Hg of the aortic blood pressure. The flow of blood through restriction 48 is laminar and continues as a laminar flow through the passage 52 into atrium 11. There is a minimum of turbulence of the blood in graft 36. " The interior surface 39 of the tubular member 37 is smooth and continuous. It does not have any nitrics which can stagnate and coagulate the blood.

Ai adequate flow of blood through the graft passage Ϊ0 is insured by the diameter of the aortic anastomosis 53 of approximately 2500 ml per minute. Tests indicate thai using a 5 mm diameter tubular graft with a simulated aortic flow of approximately 6000 ml per minute and pressure of 100 mm Hg, approximately 500 ml per minute will flow through a 2 mm restriction into the right atrium. Since the cardiac output is limited only by the venous return, the left ventricle will have an additional load of about 8 per cent. Each coronary artery supplied with blood will require about 50 to 150 ml per minute of blood for adequate perfusion. Since the blood flow through an unrestricted 5 mm graft anastomosed to an aorta with blood flowing at 6000 ml per minute will pro¬ vide blood flow well in excess of 2000 ml per minute, an adequate blood supply is available for up to 10 coronary branches, each carrying 150 mm per minute. Calculations of blood flow through the throat passage 48 show a

Reynold's range of between 500 and 1000. The blood flow is laminar in passages 40 and 48.

In certain cases, a surgeon may choose to use the

OMH autogenous saphenous vein in lieu of synthetic graft 36 over the umbilical cord, as described herein. Re¬ ferring to Figures 12-17, there is shown a segment of an autogenous saphenous vein indicated generally at 70 comprising an elongated member 71. Member 71 has a continuous cylindrical wall 72 surrounding a passage or lumen 73 for accommodating flowing blood. The inlet or proximal end 74 of member 71 has an opening 75. The saphenous vein 70 follows a path about the heart to reach occluded arteries in the manner of graft 36, as shown in Figure 3. Lumen 73 has a generally uniform diameter from the inlet or aorta end 74 to the distal end 76.

A blood flow restrictor or tubular segment indicated generally at 77 is anastomosed to distal end 76 of vein 70. Blood flow restrictor 77 has an inlet end section 78 and an outlet end section 79 joined to an intermed¬ iate throat section 81. Section 78 has an inlet passage 82 longitudinally aligned with lumen 73. Inlet passage 82 communicates with a restricted passage 83 in throat section 81. Passage 83 opens to an outlet passage 84 in outlet end section 79. The cross sectional area of out¬ let passage 84 is substantially the same as the cross sectional area of the inlet passage 82. The size of restricted passage 83 canvary relative to the size of inlet passage 82. Preferably, the diameter of inlet passage 82 is more than twice the diameter of restricted passage 83. The cross sectional area of passage 82 is more than four times the cross sectional area of throat passage 83. Passage 83 allows blood to continuously flow through lumen 73 at a desired blood pressure in lumen 77 so that one or more coronary arteries can be perfused. The distal or atrial end section 79 has an open outlet 86 allowing blood to flow into the atrium of the heart when section 79 has been anastomosed to the atrium section of the heart.

In use, the surgeon harvests a section of the saphenous vein from the leg of the patient. A blood flow restrictor 77 having the desired size restricted passage

-^U £ 83 is secured with sutures 87 to distal end 76 of tubular member 71. The aortal end 74 is anastomosed to aorta 23. Tubular member 71 encircles the heart to locate atrium end 79 of restrictor 77 adjacent atrium 11. End 79 is anastomosed to the atrium section of the heart so that a continuous and adequate flow of blood is main¬ tained through tubular member 70 and restrictor 77. The blood is at a desired pressure so that one or more coron¬ ary arteries can be perfused. The surgeon can anastomose one or more coronary arteries along the path of tubular member 70 in a manner, as shown in Figure 11. This allows the continuous flow of blood under pressure from passage 73 into the lumen of the coronary arteries.

Referring to Figures 18-22, there is shown a tubular graft indicated generally at 90 usable to continuously supply blood to one or more coronary arteries of a human heart. Graft 90 has an elongated generally U-shaped member 91 having a continuous cylindrical wall 92. Wall 92 forms a generally uniform diameter passage 93. Member 91 has an aortic or proximal end 94 having an inlet open¬ ing 96 for receiving a continuous supply of blood from the aorta. The blood flows through passage 93 to a distal end 97 having an outlet opening 98. Distal end 97 is adapted to be anastomosed to the atrium section of the heart or a vein to receive blood therefrom.

As shown in Figures 18-22, an adjustable blood flow restrictor indicated generally at 99 is mounted on member 91 adjacent distal end 97 for restricting the flow of blood into distal end 97 while maintaining a continuous and adequate flow of blood at a desired pressure so that one or more coronary arteries can be perfused. Restrictor 99 also reinforces the tubular member forming the restricted passage. Blood flow restrictor 99 is a clamp unit having a first member 101 adjustably connected to a second member 102 with a pair of self-locking screws 103 and 104. Member 101 has an outwardly curved center section 101A located about an arcuate sector of member 91. Second member 102 has an oppositely outwardly curved center section 102A facing the curved center section 101A and engageable with an arcuate segment of member 91. Screws 103 and 104 are adjustable to move the first and second members 101 and 102 toward each other to adjust the size of the restricted passage 106, thereby adjust¬ ing the rate of flow of blood through passage 93 and adjusting the pressure of the blood in passage 93. A cylindrical mandrel having a desired cross sectional area is used to provide the restricted passage with a desired size or cross sectional area. The mandrel is inserted into the distal end section of member 91. Restrictor 99 is placed over the distal end section and clamped onto member 91. The curved center sections 101A and 102A move toward each other and force the wall of the member about the mandrel. This mandrel is then removed from the member 91. Restrictor 99 maintains the selected cross section of passage 106, as shown in Figure 22.

Referring to Figure 23, there is shown an anterior view of a human heart indicated generally at 210. Heart 210 has a right atrium 211, right ventricle 212, left atrium.213, and left ventricle 214. Blood from the body flows through vena cava 216 into right atrium 211. The pressure of the blood in right atrium 211 is low as the blood flows into atrium 211. A heart valve controls the flow of blood from atrium 211 into right ventricle 212. The blood is pumped from right ventricle 212 through a valve into pulmonary blood returns from the lungs via the pulmonary vein to left atrium 213. The blood flows from left atrium 213 through the heart valve into a left ventricle 214 and is pumped from the left ventricle 214 through the valve into aorta 223. The muscle tissue of the heart is provided with a supply of blood from two coronary arteries 224 and 226. Left coronary artery 224 extends from aorta 223 along the left side of the heart toward apex 227. Coronary artery 224 has a number of branches 228, 229, 230 and 231, which supply blood to the muscle tissue. Left coronary artery 224 has a short common stem which bifurcates or trifurcates into branches 228-

231. One branch 231, the anterior interventricular branch, moves downward to the anterior interventricular groove and rounds the acute margin of the heart.just to the right of apex 227 and ascends a short distance up the posterior interventricular groove. Portions of branch 231 anasto¬ mose with branches from the right coronary artery. These branches are very small in normal hearts. They may en¬ large considerably in persons suffering from coronary arteriosclerosis in whom coronary arterial branches be¬ come obstructed or occluded. The right coronary artery 226 extends down the right side of the heart toward apex or crux 227. Artery 226 has a number of branches

232, 233, 234 and 235, which feed blood to the heart tissue.

Referring to- Figures 24-28, there is shown a rein¬ forced vascular graft of the invention indicated generally at 236. Graft 236 is an elongated tubular member 237 having a generally U-shape and a continuous passage 240 for carrying blood. Member 237 has a continuous cylin¬ drical wall 238 having an inside surface 239 forming elongated longitudinal passage 240. Tubular member 237 has a proximal aortic or inlet end 241 and a distal atrial or outlet end 242. A main trunk 243 extends from inlet end 241 to a restricted or reduced section indicated generally by member 244. Restricted section 244 is connected to a distal end section 246. Preferably, restricted section 244 is about 2 to 5 cm from outlet end

242 when it is attached to the heart tissue. As shown in Figures 25-27, restricted section 244 has a cylindrical wall 247 integral with cylindrical wall 238 of main trunk

243 and atrial end section 246. Wall 247 surrounds a restricted passage 248 having a cross sectional area sub¬ stantially smaller than the cross sectional area of passage 240. The cross sectional area of passage 240 is preferably more than four times larger than the cross sectional area of restricted passage 248. Cylindrical wall 247 is joined to wall 238 with a converging conical

OMPI wall portion 249 which directs the flow of blood into passage 248. The opposite ends of wall 247 are joined to a diverging conical wall portion 251 forming, part of the atrial end section 246. Wall portion 251 surrounds an outlet passage 252 leading to the distal outlet end 242. The cross sectional area of outlet passage 252 is substantially the same as the cross sectional area of passage 240 of main trunk 243. Conical wall portions 249 and 251 each have a longitudinal length and an inside wall surface that has a gradual smooth taper to minimize turbu¬ lence in the blood flow. Preferably, cylindrical wall 247 surrounding passage 248 has a longitudinal length that is shorter than the longitudinal length of the wall portions 249 and 251. Other length and size relationships can be used. The longer the length of restricted section 244, the greater the blood pressure drop for a given cross sectional area of passage 248. Passage 252 provides a chamber wherein the velocity of the blood flow is de¬ creased before it flows into the atrium of the heart. Distal end section 246 is of a size to permit easy attachment thereof to the heart tissue or blood receiving vessel.

Vascular graft 236 is an elongated tube of synthetic material that is biologically inert and does not deter¬ iorate in the body over an extended period of time. Examples of suitable materials are Polytet^afluoroethy- lene and Dacron plastics. Other materials and combina¬ tions of materials can be used for vascular graft 236. The restricted section 244 is reinforced with a sleeve 245 to insure that the cross sectional area and length of passage 248 is maintained over a long period of time. The material of wall 247 does not expand in use when reinforced with sleeve 245 whereby the size and length of passage 248 is kept substantially constant during use of vascular graft 236. Sleeve 245 is a reinforcing structure for wall 247 to inhibit its dilation or expan¬ sion, contraction, and elongation so as to maintain desired dimensions of passage 248 over an extended period of time. This insures continuous and controlled flow of

OM blood through vascular gra t 236 an ma nta ns t e pres¬ sure of blood in passage 240 at a level to perfuse the coronary branches attached to trunk 38. Sleeve 245 can be a tubular fiber member of metal, plastic, or carbon fibers formed into a mesh surrounding restricted section 244. Tape and thread can be used to form sleeve 245. Sleeve 245 can be bonded or otherwise secured to the outer surface of restricted section 244. Reinforcing structure can be incorporated into the material of res- tricted section 244. The thickness of the wall of the restricted section can be increased to strengthen the restricted section. The sleeve can be a rigid plastic carbon or metal tubular member located about the res¬ tricted section. As shown in Figures 24, 26, 29 and 31, sleeve 245 surrounds wall 247 and conical wall portions 249 and 251 joined to wall 247. Sleeve 245 is continuous from conical wall portion 249 to conical wall portion 251 so as to reinforce both converging and diverging portions of the walls forming the restricted passage 248.

The entire vascular graft 236 can be a tubular struc¬ ture, made from a human umbilical cord. The umbilical cord is cured and tapered to form the desired restricted section 244. The restricted section is reinforced with mechanical reinforcing means as described herein. Other types of blood vessels and tissue tubes provided with a reinforced restricted section can be used as the graft.

Referring to Figure 23, vascular graft 236 is located adjacent heart 210. Body 243 descends toward the mid- portion on the anterior surface of the heart and then encircles about to the posterior surface and ascends toward the right atrium. Restricted section 244 and atrial end section 246 are located adjacent atrium 211. As shown in Figure 30, proximal or aortal end 241 of tubular member 237 is implanted into an aortic ostium

253 and anastomosed thereto with sutures 254. As shown in Figure 31, the outlet or atrial end 246 is attached to the heart 30 around ostium 256 open to atrium 211

OMPI and anastomosed thereto with sutures 257. The blood continuously flows through passage 240 of tubular member 237, since the blood pressure difference between aorta 223 and atrium 211 is about 90 mm Hg. Restricted passage 248 prevents the flow of blood through passage 240 from being excessive. Restricted section 244 reinforced with sleeve 245 maintains a controlled flow of blood through passage 248. The cross sectional area and length of passage 248 is retained during prolonged use by the reinforcing sleeve 245 in cooperation with wall 247. The distal end section 246 of tubular member 237 can be anas¬ tomosed to left atrium 213, whereby the blood flows from aorta 223 through passages 240, 248 and 252 and into left atrium 213. The body 243 of vascular graft 236 is located ad acent one or more of the coronary branches 228 to 231 and 232 to 235. The surgeon has the option to anastomose and, therefore, perfuse one or more of the coronary branches along the path of vascular graft 236. Referring to Figure 31, vascular graft 236 is anastomosed to coronary branch 235 with sutures 258. The cylindrical wall 238 is provided with an opening 259 to allow blood to flow from passage 240 into the coronary artery passage 261. The restricted passage 248 adjacent the atrial end of the vascular graft allows the coronary arteries to be perfused with sufficient quantities of blood at pressures within a few mm Hg of the aortic blood pressure. The flow of blood through restriction 248 is laminar and con¬ tinues as a laminar flow through the passage 252 into atrium 211. The outlet end passage 252 being larger than the restricted passage 248 reduces the pressure of the blood and velocity of the blood before it flows into atrium 211. There is a minimum of turbulence of the blood in graft 236. The interior surface 239 of the tubular member 237 is smooth and continuous. It does not have any nitrics which can stagnate and coagulate the blood.

The grafts of the invention can be used to carry blood in peripheral revascularization procedures of the lower extremities. For example, the graft would be inter¬ posed between the most distal arterial anastomosis and the popliteal vein or one of its major branches. The source of blood would be the femoral artery and the anastomosis would be made in the popliteal artery and/or its distal branches, the anterior tibia, posterior tibia, or peroneal arteries. The blood flow restricting passage or throat passage located between these arteries and the distal end of the graft controls the blood flow through the graft. The control of blood flow allows adequate perfusion of blood pressure to these arteries and at the same time insures continuous blood flow to maintain patency of the graft.

While there has been shown and described the prefer- red embodiments of the graft of the invention, and method of supplying a continuous blood flow to one or more arteries, it is understood that changes in the materials, size, length of the graft, and location of the graft may be made by those skilled in the art without departing from the invention. The invention is defined in the following claims .

Claims

1. A graft for supplying blood to coronary arteries of a primate heart having an atrium, pulmonary artery, and an aorta joined to the heart to receive blood there¬ from comprising: an elongated means having a continuous passage for carrying blood, said means having an inlet end attachable to the aorta whereby blood under pressure flows from the aorta into said passage, and an outlet end attachable to the heart to discharge blood into the atrium, said means being provided with one or more open¬ ings and being attachable to one or more arteries whereby blood flows from said passage through said openings into one or more of said arteries, and means for restrict¬ ing the flow of blood and sustaining the pressure of the blood in said passage located remote from the inlet and thereby maintaining a continuous flowing supply of blood to said arteries.
2. The graft of claim 1 wherein: said elongated means has a generally U-shaped tubular body.
3. The graft of claim 1 wherein: said elongated means and means for restricting the flow of blood com¬ prises a synthetic tube.
4. The graft of claim 1 wherein: said elongated means and means for restricting the flow of blood com¬ prises an umbilical cord.
5. The graft of claim 4 wherein: the umbilical cord has a distal end section, said distal end section having a throat passage smaller in size than the passage in the elongated means to sustain the pressure of the blood in the passage of the elongated means and restrict the amount of blood that flows through said passage in the elongated means.
6. The graft of claim 5- wherein: said throat passage is spaced upstream from the distal end of the umbilical cord. . e gra o c a m nc u ng: means o a e about a distal end section of the cord for reducing the cross sectional area of the passage of the cord to res¬ trict the amount of blood that flows through said passage of the cord.
8. The graft of claim 7 wherein: the means located about a distal end section of the cord comprises clamp means engageable with the cord.
9. The graft of claim 8 wherein: said clamp means includes means for adjusting the cross sectional area of the throat passage.
10. The graft of claim 1 wherein: said elongated means is a saphenous vein, and the means for restricting the flow of blood is attached to the outlet end of the saphenous vein.
11. The graft of claim 10 wherein: said means for restricting the flow of blood comprises tubular means having a throat passage with a cross sectional area smaller than the cross sectional area of the passage of the saphenous vein to restrict the flow of blood therein.
12. The graft of claim 11 wherein: the cross sec¬ tional area of the throat passage is less than one-half of the cross sectional area of the passage of the saphen¬ ous vein.
13. The graft of claim 1 wherein: said elongated means has a cylindrical wall having an inside cylindri¬ cal surface surrounding said passage, said wall being provided with said openings to feed blood to said arteries.
14. The graft of claim 13 wherein: said inside cylindrical surface has a generally uniform diameter.
15. The graft of claim 13 wherein: said means for restricting the flow of blood in said passage comprises a section of said cylindrical wall having an inside cross sectional area smaller than the cross sectional area of said passage thereby providing said passage with a throat. 16. The graft of claim 15 wherein: said cylindrical wall has an outlet end portion connected to said section, said portion having an outlet passage for carrying blood from the throat to the atrium.
17. The graft of claim 16 wherein: said outlet end portion has a length of less than 10 cm.
18. The graft of claim 16 wherein: said cylindrical wall has a generally U-shape.
19. The graft of claim 15 wherein: said passage has a diameter of about 5 mm and the throat has a diameter of about 2 mm.
20. The graft of claim 15 wherein: said throat has a cross sectional area that is less than one-half the cross sectional area of the passage.
21. The graft of claim 16 wherein: said outlet passage has a cross sectional area larger than the cross sectional area of the throat.
22. The graft of claim 1 including: means for re¬ inforcing the means for restricting the flow of blood to maintain the size and shape thereof.
23. The graft of claim 1 wherein: said means for reinforcing the means for restricting the flow of blood comprises an annular sleeve.
24. The graft of claim 23 wherein: the sleeve comprises fiber means providing a reinforcement.
25. The graft of claim 24 wherein: the fiber means comprise a plurality of substantially non-elastic strands.
26. The graft of claim 1 wherein: said means for restricting the flow of blood comprises tubular means having a restricted passage with a cross sectional area smaller than the cross sectional area of the continuous passage to restrict the flow of blood through the res¬ tricted passage, said means for reinforcing the means for restricting the flow of blood comprising a sleeve surrounding the tubular means forming the restricted passage. 27. The graft of claim 26 wherein: said elongated means and means for restricting the flow of blood com¬ prises a synthetic tube having a restricted section pro¬ viding a restricted passage, and said means for reinforc¬ ing the means for restricting the flow of blood comprises a sleeve located about and mounted on the restricted section.
28. The graft of claim 26 wherein: said elongated means, and means for restricting the flow of blood com¬ prises an umbilical cord having a restricted section providing a restricted passage, and said means for reinforcing the means for restricting the flow of blood comprises said sleeve located about and mounted on the restricted section.
29. The graft of claim 22 wherein: said means for restricting the flow of blood and sustaining the pressure of the blood in said passage comprises a tubular wall joined to a converging wall and a diverging wall, said means for reinforcing the means for restricting the flow of blood comprising a tubular sleeve surround¬ ing and mounted on the tubular wall, converging wall, and diverging wall.
30. The graft of claim 26 wherein: said elongated means comprises a synthetic tube having a restricted section providing a restricted passage, said restricted section having enlarged wall thickness to reinforce the restricted section.
31. A graft for supplying blood to one or more blood vessels comprising: an elongated means having an inlet end means adapted to be connected to means providing a supply of blood under pressure, a tubular body having a first passage adapted to be provided with one or more openings and connected to at least one blood vessel for supplying blood to said vessel, means having a res¬ tricted second passage connected to said body remote from said inlet end to control the flow of blood through the first passage and sustain the pressure of blood in the first passage, and an outlet end connected to the eans having a restricted second passage adapted to be connected to a receiver of blood having blood pressure lower than the pressure of the supply of blood.
32. The graft of claim 31 wherein: said body has a generally U-shape.
33. The graft of claim 31 wherein: said body means having a restricted second passage and an outlet end comprise a synthetic tube.
34. The graft of claim 31 wherein: said body means having a restricted second passage and an outlet, and said body including an umbilical cord.
35. The graft of claim 31 wherein: said body is a saphenous vein, and the means for controlling the flow of blood through the first passage is attached to the outlet end of the saphenous vein.
36. The graft of claim 35 wherein: said means for controlling the flow of blood comprises a body having said restricted second passage, and means connectable to the saphenous vein.
37. The graft of claim 31 wherein: said means having a restricted second passage is located adjacent said outlet end.
38. The graft of claim 37 wherein: said means having a restricted second passage is located within 10 cm of said outlet end.
39. The graft of claim 31 wherein: said means having a restricted second passage includes clamp means located about a distal section of said body for reducing the size of said distal section thereby providing said second passage.
40. The graft of claim 39 wherein: said clamp means includes means for adjusting the clamp means to vary the size of said distal section thereby adjusting the size of said second passage.
- TRlX£*
OMPI _ 41. The graft of claim 31 wherein: said second passage has a cross sectional area that is less than one-half the cross sectional area of the first passage.
42. The graft of claim 31 wherein: said outlet end has a third passage having a cross sectional area larger than the cross sectional area of said restricted second passage.
43. The graft of claim 31 including: reinforcing means cooperating with the means having a restricted second passage to maintain the sice and shape of said restricted second passage.
44. The graft of claim 43 wherein: the reinforcing means comprises a sleeve located about said means having a restricted second passage.
45. The graft of claim 43 wherein: the means having a restricted passage comprises a tubular wall joined to a converging wall and a diverging wall, said reinforc¬ ing means comprising a sleeve surrounding and mounted on the tubular wall, converging wall, and diverging wall.
46. The graft of claim 43 wherein: the means having a restricted passage comprises a synthetic tube, said reinforcing means including enlarged wall thickness of said tube to maintain the size and shape of said restricted passage.
47. A graft for supplying blood to one or more blood vessels comprising: an elongated means for carry¬ ing blood from a supply of blood under pressure to one or more blood vessels, said tubular means having body means providing a first passage for carrying blood, said body means being provided with one or more openings and connectable to at least one blood vessel for supplying blood through said one opening to said blood vessel, inlet end means adapted to be connected to the supply of blood under pressure whereby blood flows into said first passage and from said first passage into said blood vessel, means having a restricted second passage connected to said body means remote from said inlet and means to control the flow of blood through the first passage and sustaining the pressure of the blood in the first passage, and an outlet end means connected to the means having the restricted second passage adapted to be connected to means for receiving blood having blood pressure lower than the pressure of the supply of blood.
48. The graft of claim 47 wherein: said body means has a U-shape.
49. The graft of claim 47 wherein: said elongated means is a synthetic tube.
50. The graft of claim 47 wherein: said elongated means is an umbilical cord.
51. The graft of claim 47 wherein: said body means and inlet end means comprises a saphenous vein, and said means having a restricted second passage comprises a tubular member having said second passage, and means connectable to said saphenous vein.
52. The graft of claim 47 wherein: said means having a restricted second passage includes clamp means located about a distal section thereby adjusting the size of said second passage.
53. The graft of claim 52 wherein: said clamp means includes means for adjusting the clamp means to vary the size of said distal section thereby adjusting the size of said second passage.
54. The graft of claim 47 including: reinforcing means cooperating with the means having a restricted second passage to maintain the size and shape of said restricted second passage.
55. The graft of claim 54 wherein: the reinforcing means comprises a sleeve located about said means having a restricted second passage. 56. The graft of claim 54 wherein: the means having a restricted passage comprises a synthetic tube, said reinforcing means including enlarged wall thickness of said tube to maintain the size and shape of said restricted passage.
57. A method for providing a continuous supply of flowing blood to blood receiving vessels of a living body with an elongated graft having an inlet end, an outlet end, a continuous passage extended from the inlet end to the outlet end for accommodating a continu¬ ous flow of blood and blood flow restriction means in the distal portion thereof for sustaining the pressure of the blood in the continuous passage comprising: securing the inlet end of the graft to a supply of blood under pressure by operation of the heart in a manner to allow blood to flow in said continuous passage, secur¬ ing at least one portion of the graft between the inlet end and restriction means to a blood receiving vessel in a manner to allow blood to flow from said continuous passage into said blood receiving vessel, and securing the outlet end of the graft to blood accommodating means having blood pressure less than the blood pressure of the supply of blood whereby a continuous flow of blood flows through said passage from the inlet to the outlet end thereof, said blood flow restriction means being operable to maintain flowing blood at a pressure in said continuous passage sufficient to perfuse the blood receiving vessel.
58. The method of claim 57 wherein: the inlet end of the graft is anastomosed to the aorta whereby blood from the aorta flows through said passage in the graft.
59. The method of claim 58 wherein: the outlet end of the graft is anastomosed to the atrium section of the heart whereby blood flows from the passage into the atrium chamber of the heart. . e me o o c a m w re n a p of portions of the graft between the restriction means and inlet end are anastomosed to separate coronary arteries.
61. The method of claim 57 wherein: the outlet end of the graft is anastomosed to the atrium section of the heart whereby blood flows from the passage into the atrium chamber of the heart.
62. The method of claim 57 including: adjusting the rate of flow of blood through said continuous pass¬ age with the blood flow restriction means.
OMPI
PCT/US1983/001932 1982-12-13 1983-12-08 Vascular graft and blood supply method WO1984002266A1 (en)

Priority Applications (2)

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US06448955 US4546499A (en) 1982-12-13 1982-12-13 Method of supplying blood to blood receiving vessels
US06489798 US4562597A (en) 1982-12-13 1983-04-29 Method of supplying blood to blood receiving vessels

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB8418112A GB2141939B (en) 1982-12-13 1983-12-08 Vascular graft and blood supply method
DE19833390385 DE3390385C2 (en) 1982-12-13 1983-12-08 vascular implants
RU2023438C1 RU2023438C1 (en) 1982-12-13 1984-08-10 Blood vessel prosthesis
DK385384A DK385384D0 (en) 1982-12-13 1984-08-10 heart Implant
FI843186A FI82371C (en) 1982-12-13 1984-08-13 Foer tillfoersel of the transplant of blood.

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BE (1) BE900533A (en)
CA (1) CA1238153A (en)
DE (2) DE3390385C2 (en)
DK (1) DK385384D0 (en)
EP (1) EP0128215B1 (en)
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Also Published As

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DE3390385C2 (en) 1994-07-07 grant
EP0128215B1 (en) 1990-04-11 grant
GB8418112D0 (en) 1984-08-22 grant
GB2169208B (en) 1987-05-20 grant
EP0128215A4 (en) 1986-07-17 application
EP0128215A1 (en) 1984-12-19 application
ES284576U (en) 1986-03-01 application
CA1238153A (en) 1988-06-21 grant
BE900533A (en) 1985-01-02 grant
DE3390385T (en) 1985-02-21 application
GB2141939B (en) 1987-05-20 grant
ES284576Y (en) 1986-12-01 grant
DK385384A (en) 1984-08-28 application
FI82371B (en) 1990-11-30 application
US4546499A (en) 1985-10-15 grant
FI843186D0 (en) grant
GB2141939A (en) 1985-01-09 application
US4562597A (en) 1986-01-07 grant
RU2023438C1 (en) 1994-11-30 grant
US4601718A (en) 1986-07-22 grant
FI843186A (en) 1984-08-13 application
FI82371C (en) 1991-03-11 grant
GB8602617D0 (en) 1986-03-12 grant
JPH0447576B2 (en) 1992-08-04 grant
BE900533A1 (en) grant
GB2169208A (en) 1986-07-09 application
JPS60500244A (en) 1985-02-28 application
FI843186A0 (en) 1984-08-13 application
CA1238153A1 (en) grant
DK385384D0 (en) 1984-08-10 grant

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