WO1983000621A1 - Suppository with incorporated buffer wick - Google Patents

Suppository with incorporated buffer wick Download PDF

Info

Publication number
WO1983000621A1
WO1983000621A1 PCT/EP1982/000177 EP8200177W WO8300621A1 WO 1983000621 A1 WO1983000621 A1 WO 1983000621A1 EP 8200177 W EP8200177 W EP 8200177W WO 8300621 A1 WO8300621 A1 WO 8300621A1
Authority
WO
WIPO (PCT)
Prior art keywords
suppository
tampon
tampon insert
suppositories
insert according
Prior art date
Application number
PCT/EP1982/000177
Other languages
German (de)
French (fr)
Inventor
Gulden Lomberg Chemische Fabrik Gesellschaft ... Byk
Ernst Keintzel
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of WO1983000621A1 publication Critical patent/WO1983000621A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks

Definitions

  • the invention relates to suppositories with tampon insert.
  • the plastic sleeve When in use, the plastic sleeve is removed from the blister pack and the suppository is pulled out of the plastic sleeve at the free ends of the sleeve after having expediently obtained access to the gauze sleeve ends stuffed into the sleeve end by means of a pointed object.
  • the object of the present invention was to provide suppositories with a tampon insert which are notable for their ease of manufacture and low packaging expenditure.
  • the two film parts 1 and 2 are welded together in area 3. Area 4 is excluded from the welding, so that the two film parts in area 4 form tabs which allow the welded films to be torn apart for the purpose of removing the suppository.
  • the rear ends 5 and 6 of the two film parts are bent apart at right angles around the edge 7 and together form a surface perpendicular to the welded area 3, which serves as the basis for applying the sealing film 8 for closing the for receiving the torpedo-shaped suppositories and the cavities 9, 10 provided from the suppositories projecting from the suppository.
  • incisions 11 are made between the receiving spaces 9, 10 parallel to their longitudinal axes, which allow simple removal of individually packaged suppositories from the film strip before use.
  • FIG. 2 shows the removal of an individual suppository 12 from a separate individual pack by pulling apart the tabs formed in region 4 by the non-welding of the foils.
  • Fig. 3 shows a removed suppository with tampon insert and on Eß ⁇ protruding gauze tube 13.
  • Fig. 4 shows a cross section through an inventive suppository with tampon insert.
  • the invention relates to the suppositories with tampon insert characterized in the claims.
  • the thermoformed double sheet is produced in a manner known per se.
  • the two film parts are welded, for example, by high-frequency welding or by heat welding of film laminated with a heat seal layer.
  • the liquid suppository mass is poured in the usual way by means of a metering pump into the thermoformed thermoformed double film. Connecting If the tampon insert is pressed into the still liquid suppository mass After the suppository mass has cooled, the protruding end of the tampon insert is stuffed into the cylindrical part of the receiving space.
  • the film strip is then closed, for example by sealing with aluminum tape or by direct welding.
  • the aluminum sealing tape or the sealing film can be printed for identification or coding.
  • the film strip is sawn or perforated between the receiving spaces for the suppositories, for example.
  • the invention makes it possible to manufacture suppositories with a tampon insert more simply and to provide them in a material-saving packaging which meets all hygiene and labeling requirements.
  • the suppositories with a tamper-evident insert reach the patient in the original sealed manner for the intended use.

Abstract

The torpedo-shaped suppository (12) with incorporated buffer wick (13) is packed between two bands presenting deep deformations (1, 2). The back ends (5, 6) of the two welded bands (1, 2) are folded back at right angles in the area (3) of the reception cavities (9, 10) of the suppositories, and the surface formed by the two folded edges receives a closure sheet (8).

Description

Suppositorien mit Tamponeinlage Suppositories with tampon insert
Technisches GebietTechnical field
Die Erfindung bezieht sich auf Suppositorien mit Tamponeinlage.The invention relates to suppositories with tampon insert.
Stand der TechnikState of the art
Suppositorien mit Tamponeinlage kommen immer mehr in Gebrauch, weil sie erfahrungsgemäß gegenüber herkömmlichen Suppositorien ohne Tamponeinla-'' ge u.a. den Vorteil aufweisen, in geschmolzenem Zustand sich nicht vom- Analbereich weg in das Rektum zu bewegen. Weiterhin begünstigt die Tarn-, poneinlage eine örtlich gezielte Resorption der Wirkstoffe.Suppositories with pad insert come increasingly into use because they experience shows that compared to conventional suppositories without Tamponeinla- 'ge' have the advantage, not from- anal area to move in a molten state away into the rectum. Furthermore, the camouflage, pon insert favors a locally targeted absorption of the active ingredients.
Die Einarbeitung von Einlagen in Suppositorien bereitet technischeThe incorporation of deposits in suppositories prepares technical
Schwierigkeiten. Bisher sind nur zylindrische Suppositorien mit Tampon¬ einlagen im Handel. Ein handelsübliches Suppositorium mit Tamponeinla¬ ge wird so hergestellt, daß die Suppositorienmasse in eine zyl ndrische', einseitig spitz zulaufend verschlossene Kunststoffhülse gegossen wird. In die Suppositorienmasse wird dann als Tamponeinlage ein ungefähr bei halber Länge gefalteter Mullschlauch eingesteckt. Die beiden freien En¬ den des MullSchlauches werden oberhalb άer Suppositorienmasse in die Kunststoffhülse gestopft. Zum Schutz gegen Umwelteinflüsse wird das Sup¬ positorium samt Kunststoffhülse in eine Blisterpackung gepackt. Beim Ge- brauch wird die Kunststoffhülse aus der Blisterpackung entnommen und das Suppositorium an den freien Enden des ullschlauches aus der Kunststoff¬ hülse gezogen, nachdem man sich zweckmäßigerweise mittels einesspitzen Gegenstandes Zugriff zu den in das Hülsenende gestopften Mullschlauch¬ enden verschafft hat. Bei einem anderen, auf dem Markt befindlichen, in einer Kunststoffhülse steckenden zylindrischen Suppositorium wird die Blisterpackung und die Schwierigkeit beim Gebrauch wegen des Zugriffs zu den freien Mullschlauchenden dadurch vermieden, daß die aus der Suppositorienmasse herausragenden Enden des Mullschlauches außen um das offene Ende der Kunststoffhülse gewickelt werden und die-Kunststoffhül- se in dem umwickelten Teil von einem im Durchmesser weiteren Hülsenteil umgeben ist, der durch einen Schηappdeckel verschließbar gestaltet ist. Aus medizinisch-anatomischen Gründen. hat ein torpedoförmiges Supposi¬ torium Vorteil e beim Patienten. Es . ist daher wünschenswert, Supposito¬ rien mit Tamponeinlage nicht in Zylinderfoπn, sondern in Torpedoform zur Verfügung zu stell en. Dies ist nach der Methode der in Kunststoff - hülsen gegossenen Suppositorien nicht mögl ich, da das Suppositorium nicht ohne Zerstörung der Kunststoff hülse an . den freien Enden des Mull¬ schlauches herausgezogen werden kann. Aufgabe der vorliegenden Erfin¬ dung war es , Suppositorien mit Tamponeinlage zur Verfügung zu stel len, die sich durch einfache Herstell barkeit und geringen Verpackungsaufwand auszeichnen.Trouble. So far, only cylindrical suppositories with tampon inserts are on the market. A commercially available suppository with a tampon insert is produced in such a way that the suppository mass is poured into a cylindrical plastic sleeve which is tapered on one side. An approximately half-length folded gauze tube is then inserted into the suppository mass as a tampon insert. The two free ends of the gauze tube are stuffed into the plastic sleeve above the suppository mass. To protect against environmental influences, the suppository including the plastic sleeve is packed in a blister pack. When in use, the plastic sleeve is removed from the blister pack and the suppository is pulled out of the plastic sleeve at the free ends of the sleeve after having expediently obtained access to the gauze sleeve ends stuffed into the sleeve end by means of a pointed object. In the case of another cylindrical suppository, which is on the market and stuck in a plastic sleeve, the blister pack and the difficulty in use due to the access to the free ends of the gauze tube are avoided in that the ends of the gauze tube protruding from the suppository mass are wrapped around the open end of the plastic tube are and the plastic sleeve is surrounded in the wrapped part by a further diameter sleeve part, which is designed to be closable by a Schηappdeckel. For medical-anatomical reasons. has a torpedo-shaped suppository advantage in the patient. It. it is therefore desirable to provide suppositories with a tampon insert not in cylindrical form but in torpedo form. This is not possible according to the method of suppositories cast in plastic sleeves, since the suppository does not start without destroying the plastic sleeve. the free ends of the gauze tube can be pulled out. The object of the present invention was to provide suppositories with a tampon insert which are notable for their ease of manufacture and low packaging expenditure.
Darstel 1 ύng der" Erf ndungRepresentation 1 ύng of the " invention
Diese Aufgabe wird durch den in den Fig. 1 bis 4 erläuterten Gegenstand gelöst:This object is achieved by the subject explained in FIGS. 1 to 4:
Fig. 1 zeigt die als Gießform und Verpackung für die Suppositorien ge¬ eignete Tiefziehdoppelfol e als Folienstreifen. Die beiden Folienteile 1 und 2 sind im Bereich 3 miteinander verschweißt. Bereich 4 ist von der Verschweißung ausgenommen, so daß die beiden Folienteile im Bereich 4 Laschen bilden, die zum Zwecke der Entnahme des Suppositoriums ein Aus¬ einanderreißen der verschweißten Folien erlauben. Die rückwärtigen En¬ den 5 und 6 der beiden Folienteile sind rechtwinkling um die Kante 7 aus¬ einandergebogen und bilden zusammen eine zum verschweißten Bereich 3 senkrecht .stehende Fläche, die als Basis zum Aufbringen der Verschluß- folie 8 zum Verschließen der für die Aufnahme der torpedoförmigen Sup¬ positorien und der aus den Suppositorien herausragenden Mulleinlage vor¬ gesehenen Hohlräume 9 , 10 dient. Nach der Beschickung mit Supposito¬ rienmasse und Einbringen der Mullschlaucheinlage und Versiegeln mittels des Bandes 8 werden zwischen den Aufnahmeräumen 9, 10 parallel zu deren Längsachsen Einschnitte 11 angebracht, die ein einfaches Abtrennen von einzelnen verpackten Suppositorien vom Folienstreifen vor Gebrauch er¬ lauben.1 shows the deep-drawn double film suitable as a casting mold and packaging for the suppositories as a film strip. The two film parts 1 and 2 are welded together in area 3. Area 4 is excluded from the welding, so that the two film parts in area 4 form tabs which allow the welded films to be torn apart for the purpose of removing the suppository. The rear ends 5 and 6 of the two film parts are bent apart at right angles around the edge 7 and together form a surface perpendicular to the welded area 3, which serves as the basis for applying the sealing film 8 for closing the for receiving the torpedo-shaped suppositories and the cavities 9, 10 provided from the suppositories projecting from the suppository. After loading with suppository mass and introducing the gauze tube insert and sealing by means of the band 8, incisions 11 are made between the receiving spaces 9, 10 parallel to their longitudinal axes, which allow simple removal of individually packaged suppositories from the film strip before use.
Fig. 2 zeigt die Entnahme eines einzelnen Suppositoriums"12 aus einer abgetrennten Einzelpackung durch Auseinanderziehen der durch die Nicht- verschweißung der Folien im Bereich 4 gebildeten Laschen.FIG. 2 shows the removal of an individual suppository 12 from a separate individual pack by pulling apart the tabs formed in region 4 by the non-welding of the foils.
Fig. 3 zeigt ein entnommenes Suppositorium mit Tamponeinlage und am Eßά herausragendem Mullschlauch 13.Fig. 3 shows a removed suppository with tampon insert and on Eßά protruding gauze tube 13.
Fig. 4 zeigt einen Querschnitt durch ein erfindungsgemäßes Suppositorium mit Tamponeinlage.Fig. 4 shows a cross section through an inventive suppository with tampon insert.
Gegenstand der Erfindung sind die in den Ansprüchen gekennzeichneten Suppositorien mit Tamponeinlage. Die Herstellung der Tiefziehdoppelfolie erfolgt auf an sich bekannte Weise. Das Verschweißen der beiden Folien¬ teile geschieht beispielsweise durch Hochfrequenzschweißen oder durch Hitzeverschweißung von mit Heißsiegelschicht kaschierter Folie. Die flüssige Suppositorienmasse wird auf übliche Weise mittels einer Dosier- pumpe in die auf echtgestellte Tiefziehdoppelfolie gegossen. Anschließen Wird die Tamponeinlage in die noch flüssige Suppositorienmasse eingedrüc Nach dem Erkalten der Suppositorienmasse wird das überstehende Ende der Tamponeinlage in den zylindrischen Teil des Aufnahmeraumes gestopft. An¬ schließend wird der Folienstreifen verschlossen, beispielsweise durch Versiegelung mit Aluband oder durch Direktverschweißung. Das Aluminium¬ verschließband oder die Verschlußfolie können zur Kennzeichnung oder Codierung bedruckt sein. Um ein leichtes Abtrennen einzelner verpackter Suppositorien vom Folienstreifen zu ermöglichen, wird der Fol enstreifen zwischen den Aufnahmeräumen für die Suppositorien beispielsweise einge¬ sägt oder perforiert.The invention relates to the suppositories with tampon insert characterized in the claims. The thermoformed double sheet is produced in a manner known per se. The two film parts are welded, for example, by high-frequency welding or by heat welding of film laminated with a heat seal layer. The liquid suppository mass is poured in the usual way by means of a metering pump into the thermoformed thermoformed double film. Connecting If the tampon insert is pressed into the still liquid suppository mass After the suppository mass has cooled, the protruding end of the tampon insert is stuffed into the cylindrical part of the receiving space. The film strip is then closed, for example by sealing with aluminum tape or by direct welding. The aluminum sealing tape or the sealing film can be printed for identification or coding. In order to make it easy to separate individual packaged suppositories from the film strip, the film strip is sawn or perforated between the receiving spaces for the suppositories, for example.
Durch die Erfindung ist es möglich-, Suppositorien mit Tamponeinlage ein- facher herzustellen und in einer materialsparenden Verpackung bereit¬ zustellen, die allen Anforderungen bezüglich Hygiene und Kennzeichnung gerecht wird. In dieser Verpackung erreichen die Suppositorien mit Tam¬ poneinlage den Patienten originalverschlossen zum bestimmungsgemäßen Ge¬ brauch.The invention makes it possible to manufacture suppositories with a tampon insert more simply and to provide them in a material-saving packaging which meets all hygiene and labeling requirements. In this packaging, the suppositories with a tamper-evident insert reach the patient in the original sealed manner for the intended use.
-£JRE- - £ JRE-

Claims

P a t e n t a n s p r ü c h e Patent claims
1. Suppositorium mit Tamponeinlage, dadurch gekennzeichnet, daß das Suppositorium torpedoförmig ist.1. suppository with tampon insert, characterized in that the suppository is torpedo-shaped.
2. Suppositorium mit Tamponeinlage nach Anspruch 1, dadurch gekennzeich¬ net, daß die Tamponeinlage aus dem hinteren Ende des Suppositoriums herausragt.2. suppository with tampon insert according to claim 1, characterized gekennzeich¬ net that the tampon insert protrudes from the rear end of the suppository.
3. Suppositorium mit Tamponeinlage nach einem der Ansprüche 1 oder 2, dadurch gekennzeichnet, daß die Tamponeinlage ein Schlauch aus Mull- gewebe ist.3. suppository with tampon insert according to one of claims 1 or 2, characterized in that the tampon insert is a tube made of gauze fabric.
4. Suppositorium mit Tamponeinlage nach einem der Ansprüche 1 bis 3, da- durch gekennzeichnet, daß das Suppositorium in einer Doppeltiefzieh- folie, bestehend aus zwei im Bereich (3). um den Aufnahmeraum (9, 10) für das Suppositorium verschweißten Folienteilen (1, 2) besteht, de¬ ren rückwärtige Enden (5, 6) rechtwinkling auseinandergebogen die Ba¬ sis zum Aufbringen einer Verschlußfolie \8) darstellen.4. suppository with tampon insert according to one of claims 1 to 3, characterized in that the suppository in a double thermoformed film, consisting of two in the area (3). around the receiving space (9, 10) for the suppository sealed film parts (1, 2), their rear ends (5, 6) bent at right angles to each other represent the basis for applying a sealing film \ 8).
5. Suppositorium mit Tamponeinlage nach Anspruch 4, dadurch gekennzeich- net3 daß der Aufnahmeraum (9, 10) im vorderen Teil (9) torpedoförmig und im hinteren Teil (10) zylindrisch ist.5. suppository with pad insert according to claim 4, characterized gekennzeich- net 3 that the receiving space (9, 10) in the front part (9) torpedo-shaped, and in the rear part (10) is cylindrical.
6. Suppositorium mit Tamponeinlage nach einem der Ansprüche4 oder 5, da¬ durch gekennzeichnet, daß die vorderen Enden (4) der Folienteile (1, 2) laschenartig auseinanderziehbar sind.6. suppository with tampon insert according to one of claims 4 or 5, da¬ characterized in that the front ends (4) of the film parts (1, 2) can be pulled apart like a tab.
7. Suppositorium mit Tamponeinlage nach einem der Ansprüche 4 bis 6, da- durch gekennzeichnet, daß zwischen den Aufnahmeräumen (9, 10) die Auf¬ trennung in einzeln verpackte Suppositorien erleichternde Einschnitte (11) angebracht sind. 7. suppository with tampon insert according to one of claims 4 to 6, characterized in that between the receiving spaces (9, 10) the Auf¬ separation into individually packed suppositories facilitating incisions (11) are made.
PCT/EP1982/000177 1981-08-26 1982-08-23 Suppository with incorporated buffer wick WO1983000621A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEG8124881.4U810826 1981-08-26
DE8124881 1981-08-26

Publications (1)

Publication Number Publication Date
WO1983000621A1 true WO1983000621A1 (en) 1983-03-03

Family

ID=6730651

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1982/000177 WO1983000621A1 (en) 1981-08-26 1982-08-23 Suppository with incorporated buffer wick

Country Status (3)

Country Link
EP (1) EP0099361A1 (en)
IT (2) IT8222721V0 (en)
WO (1) WO1983000621A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3636174A1 (en) * 1986-10-24 1988-04-28 Cito Pac Verpackungs Gmbh Suppository filling station

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1139013A (en) * 1955-12-22 1957-06-24 Equipment for manufacturing by casting any object having a master torque greater than the inlet or outlet, in particular so-called torpedo-shaped suppositories
FR1231098A (en) * 1959-04-01 1960-09-26 Improvements to plastic packaging
FR1485597A (en) * 1966-03-29 1967-06-23 Suppository perfected
FR1510884A (en) * 1965-10-22 1968-01-26 Sterwin Ag Suppository packaging and manufacturing process

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1139013A (en) * 1955-12-22 1957-06-24 Equipment for manufacturing by casting any object having a master torque greater than the inlet or outlet, in particular so-called torpedo-shaped suppositories
FR1231098A (en) * 1959-04-01 1960-09-26 Improvements to plastic packaging
FR1510884A (en) * 1965-10-22 1968-01-26 Sterwin Ag Suppository packaging and manufacturing process
FR1485597A (en) * 1966-03-29 1967-06-23 Suppository perfected

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Page 1, column 2, lines 36-42; page 2, column 1, lines 1-17 and lines 24-27 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3636174A1 (en) * 1986-10-24 1988-04-28 Cito Pac Verpackungs Gmbh Suppository filling station

Also Published As

Publication number Publication date
IT8222721V0 (en) 1982-08-25
IT8222960A0 (en) 1982-08-25
EP0099361A1 (en) 1984-02-01
IT1152082B (en) 1986-12-24

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