UY39388A - NEW COMPOUNDS THAT JOIN THE NR 1 H4 RECEIVER (FXR) AND ACT AS ANTAGONISTS TO FXR4 - Google Patents

NEW COMPOUNDS THAT JOIN THE NR 1 H4 RECEIVER (FXR) AND ACT AS ANTAGONISTS TO FXR4

Info

Publication number
UY39388A
UY39388A UY0001039388A UY39388A UY39388A UY 39388 A UY39388 A UY 39388A UY 0001039388 A UY0001039388 A UY 0001039388A UY 39388 A UY39388 A UY 39388A UY 39388 A UY39388 A UY 39388A
Authority
UY
Uruguay
Prior art keywords
fxr4
fxr
antagonists
act
new compounds
Prior art date
Application number
UY0001039388A
Other languages
Spanish (es)
Inventor
Claus Kremoser
Olaf Kinzel Dr
Christoph Steeneck
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11005722A external-priority patent/EP2545964A1/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of UY39388A publication Critical patent/UY39388A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención se refiere a nuevos compuestos que se unen al receptor NR1H (FXR) y actúan como antagonistas de FXR4 ; teniendo el compuesto la fórmula (ver representación gráfica de la fórmula)The present invention relates to new compounds that bind to the NR1H receptor (FXR) and act as antagonists of FXR4; the compound having the formula (see graphic representation of the formula)

UY0001039388A 2011-07-13 2021-08-18 NEW COMPOUNDS THAT JOIN THE NR 1 H4 RECEIVER (FXR) AND ACT AS ANTAGONISTS TO FXR4 UY39388A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161507153P 2011-07-13 2011-07-13
EP11005722A EP2545964A1 (en) 2011-07-13 2011-07-13 Novel FXR (NR1H4) binding and activity modulating compounds

Publications (1)

Publication Number Publication Date
UY39388A true UY39388A (en) 2021-09-30

Family

ID=62454900

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001039388A UY39388A (en) 2011-07-13 2021-08-18 NEW COMPOUNDS THAT JOIN THE NR 1 H4 RECEIVER (FXR) AND ACT AS ANTAGONISTS TO FXR4

Country Status (4)

Country Link
JP (3) JP2018123152A (en)
HK (2) HK1244682A1 (en)
IL (3) IL253437A0 (en)
UY (1) UY39388A (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639078B1 (en) * 1998-12-23 2003-10-28 Smithkline Beecham Corporation Assays for ligands for nuclear receptors
CA2651373A1 (en) * 2006-05-24 2007-12-06 Eli Lilly And Company Compounds and methods for modulating fxr
EP1894924A1 (en) * 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Heterocyclic FXR binding compounds
EP2289883A1 (en) * 2009-08-19 2011-03-02 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
EP2545964A1 (en) * 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds

Also Published As

Publication number Publication date
JP2018123152A (en) 2018-08-09
JP2021091727A (en) 2021-06-17
JP6878526B2 (en) 2021-05-26
IL265973B (en) 2020-10-29
HK1246716A1 (en) 2018-09-14
HK1244682A1 (en) 2018-08-17
IL265973A (en) 2019-06-30
IL277570A (en) 2020-11-30
IL253437A0 (en) 2017-09-28
JP2019214611A (en) 2019-12-19

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