HK1246716A1 - Novel fxr (nr1h4) binding and activity modulating azoles - Google Patents

Novel fxr (nr1h4) binding and activity modulating azoles

Info

Publication number
HK1246716A1
HK1246716A1 HK18106486.8A HK18106486A HK1246716A1 HK 1246716 A1 HK1246716 A1 HK 1246716A1 HK 18106486 A HK18106486 A HK 18106486A HK 1246716 A1 HK1246716 A1 HK 1246716A1
Authority
HK
Hong Kong
Prior art keywords
nr1h4
azoles
binding
activity modulating
novel fxr
Prior art date
Application number
HK18106486.8A
Other languages
Chinese (zh)
Inventor
Olaf Kinzel
Christoph Steeneck
Claus Kremoser
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11005722A external-priority patent/EP2545964A1/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1246716A1 publication Critical patent/HK1246716A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK18106486.8A 2011-07-13 2018-05-18 Novel fxr (nr1h4) binding and activity modulating azoles HK1246716A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161507153P 2011-07-13 2011-07-13
EP11005722A EP2545964A1 (en) 2011-07-13 2011-07-13 Novel FXR (NR1H4) binding and activity modulating compounds

Publications (1)

Publication Number Publication Date
HK1246716A1 true HK1246716A1 (en) 2018-09-14

Family

ID=62454900

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18104110.7A HK1244682A1 (en) 2011-07-13 2018-03-26 Novel fxr (nr1h4) binding and activity modulating compounds
HK18106486.8A HK1246716A1 (en) 2011-07-13 2018-05-18 Novel fxr (nr1h4) binding and activity modulating azoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18104110.7A HK1244682A1 (en) 2011-07-13 2018-03-26 Novel fxr (nr1h4) binding and activity modulating compounds

Country Status (4)

Country Link
JP (3) JP2018123152A (en)
HK (2) HK1244682A1 (en)
IL (3) IL253437A0 (en)
UY (1) UY39388A (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002532729A (en) * 1998-12-23 2002-10-02 グラクソ グループ リミテッド Assay for nuclear receptor ligands
BRPI0711875A2 (en) * 2006-05-24 2012-01-10 Lilly Co Eli compounds and methods for modulating fxr
EP1894924A1 (en) * 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Heterocyclic FXR binding compounds
EP2289883A1 (en) * 2009-08-19 2011-03-02 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
EP2545964A1 (en) * 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds

Also Published As

Publication number Publication date
JP2018123152A (en) 2018-08-09
HK1244682A1 (en) 2018-08-17
IL277570A (en) 2020-11-30
JP2021091727A (en) 2021-06-17
UY39388A (en) 2021-09-30
IL253437A0 (en) 2017-09-28
JP6878526B2 (en) 2021-05-26
JP2019214611A (en) 2019-12-19
IL265973B (en) 2020-10-29
IL265973A (en) 2019-06-30

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