UY37907A - 3-PHENYLQUINAZOLIN-4 (3H) -UNES REPLACED AND ITS USES - Google Patents
3-PHENYLQUINAZOLIN-4 (3H) -UNES REPLACED AND ITS USESInfo
- Publication number
- UY37907A UY37907A UY0001037907A UY37907A UY37907A UY 37907 A UY37907 A UY 37907A UY 0001037907 A UY0001037907 A UY 0001037907A UY 37907 A UY37907 A UY 37907A UY 37907 A UY37907 A UY 37907A
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- preparation
- phenylquinazolin
- unes
- replaced
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- WAIHFZPSLVDBRV-UHFFFAOYSA-N 3-phenylquinazolin-4-one Chemical class C1=NC2=CC=CC=C2C(=O)N1C1=CC=CC=C1 WAIHFZPSLVDBRV-UHFFFAOYSA-N 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003176 fibrotic effect Effects 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención abarca compuestos de 3-fenilquinazolin-4(3H)-ona sustituidos de la fórmula general (I) como se describe y se define en el presente, procedimientos para la preparación de dichos compuestos, compuestos intermedios útiles para la preparación de dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la elaboración de composiciones farmacéuticas para el tratamiento o la profilaxis de enfermedades, en especial para el tratamiento y/o la profilaxis de diversas enfermedades inflamatorias y fibróticas del tracto respiratorio y de los pulmones, así como del cáncer de pulmón, como único agente o en combinación con otros ingredientes activos.The present invention encompasses substituted 3-phenylquinazolin-4 (3H) -one compounds of the general formula (I) as described and defined herein, processes for the preparation of said compounds, intermediate compounds useful for the preparation of said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for the preparation of pharmaceutical compositions for the treatment or prophylaxis of diseases, especially for the treatment and / or prophylaxis of various inflammatory and fibrotic diseases of the respiratory tract and of the lungs, as well as lung cancer, as the sole agent or in combination with other active ingredients.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17193995 | 2017-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37907A true UY37907A (en) | 2019-04-30 |
Family
ID=59997232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037907A UY37907A (en) | 2017-09-29 | 2018-09-27 | 3-PHENYLQUINAZOLIN-4 (3H) -UNES REPLACED AND ITS USES |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR112840A1 (en) |
TW (1) | TW201922724A (en) |
UY (1) | UY37907A (en) |
WO (1) | WO2019063704A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021167883A1 (en) * | 2020-02-21 | 2021-08-26 | The Children's Medical Center Corporation | Method for treating asthma or allergic disease |
CN112370529B (en) * | 2020-11-30 | 2022-11-11 | 中国药科大学 | Compound preparation for treating pulmonary hypertension and preparation method thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
IL145357A0 (en) | 1999-03-17 | 2002-06-30 | Astrazeneca Ab | Amide derivatives |
GB0124627D0 (en) | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
US20040132732A1 (en) | 2002-10-21 | 2004-07-08 | Wei Han | Quinazolinones and derivatives thereof as factor Xa inhibitors |
CN101001845A (en) * | 2004-06-15 | 2007-07-18 | 阿斯利康(瑞典)有限公司 | Substituted quinazolones as anti-cancer agents. |
JP5419706B2 (en) | 2006-12-20 | 2014-02-19 | タケダ カリフォルニア インコーポレイテッド | Glucokinase activator |
US8791162B2 (en) | 2011-02-14 | 2014-07-29 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
SG11201507615SA (en) | 2013-03-20 | 2015-10-29 | Bayer Pharma AG | 3-acetylamino-1-(phenyl-heteroaryl-aminocarbonyl or phenyl-heteroaryl-carbonylamino)benzene derivatives for the treatment of hyperproliferative disorders |
JP6492012B2 (en) * | 2013-12-06 | 2019-03-27 | カルナバイオサイエンス株式会社 | Novel quinazoline derivatives |
-
2018
- 2018-09-27 WO PCT/EP2018/076287 patent/WO2019063704A1/en active Application Filing
- 2018-09-27 TW TW107134050A patent/TW201922724A/en unknown
- 2018-09-27 AR ARP180102771A patent/AR112840A1/en unknown
- 2018-09-27 UY UY0001037907A patent/UY37907A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW201922724A (en) | 2019-06-16 |
WO2019063704A1 (en) | 2019-04-04 |
AR112840A1 (en) | 2019-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20231114 |