UY37627A - HPPD VARIATIONS AND METHODS OF USE - Google Patents
HPPD VARIATIONS AND METHODS OF USEInfo
- Publication number
- UY37627A UY37627A UY0001037627A UY37627A UY37627A UY 37627 A UY37627 A UY 37627A UY 0001037627 A UY0001037627 A UY 0001037627A UY 37627 A UY37627 A UY 37627A UY 37627 A UY37627 A UY 37627A
- Authority
- UY
- Uruguay
- Prior art keywords
- hppd
- inhibitors
- polypeptides
- variations
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Abstract
En la presente invención, se describen polipéptidos de HPPD y las plantas que los contienen que muestran una tolerancia plena contra uno o más herbicidas inhibidores de HPPD que pertenecen a varias clases químicas. Se diseñan un conjunto de polipéptidos de HPPD mutante que no tienen o solamente tienen una afinidad significativamente reducida a los herbicidas inhibidores de HPPD y, al mismo tiempo, la velocidad de disociación de los inhibidores de HPPD del polipéptido de HPPD mutante aumenta en tal medida que los inhibidores de HPPD se convierten en inhibidores completamente reversibles.In the present invention, HPPD polypeptides and plants containing them are described that show full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes. A set of mutant HPPD polypeptides are designed that do not have or only have a significantly reduced affinity to the HPPD inhibitor herbicides and, at the same time, the dissociation rate of the HPPD inhibitors of the mutant HPPD polypeptide increases to such an extent that HPPD inhibitors become completely reversible inhibitors.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762468035P | 2017-03-07 | 2017-03-07 | |
EP17160639 | 2017-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37627A true UY37627A (en) | 2018-09-28 |
Family
ID=58277227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037627A UY37627A (en) | 2017-03-07 | 2018-03-07 | HPPD VARIATIONS AND METHODS OF USE |
Country Status (2)
Country | Link |
---|---|
UY (1) | UY37627A (en) |
WO (1) | WO2018162329A1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6557142B2 (en) * | 2012-09-14 | 2019-08-07 | バイエル クロップサイエンス エルピーBayer Cropscience Lp | HPPD variants and methods of use |
WO2015078828A2 (en) * | 2013-11-28 | 2015-06-04 | Bayer Cropscience Ag | Use of 2-chloro-3-(methylsulfanyl)-n-(1-methyl-1h-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to hppd inhibitor herbicides |
MX360999B (en) * | 2014-03-11 | 2018-11-23 | Bayer Cropscience Ag | Hppd variants and methods of use. |
-
2018
- 2018-03-01 WO PCT/EP2018/055101 patent/WO2018162329A1/en active Application Filing
- 2018-03-07 UY UY0001037627A patent/UY37627A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2018162329A1 (en) | 2018-09-13 |
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