UY37626A - HPPD VARIATIONS AND METHODS OF USE - Google Patents

HPPD VARIATIONS AND METHODS OF USE

Info

Publication number
UY37626A
UY37626A UY0001037626A UY37626A UY37626A UY 37626 A UY37626 A UY 37626A UY 0001037626 A UY0001037626 A UY 0001037626A UY 37626 A UY37626 A UY 37626A UY 37626 A UY37626 A UY 37626A
Authority
UY
Uruguay
Prior art keywords
hppd
inhibitors
polypeptides
variations
methods
Prior art date
Application number
UY0001037626A
Other languages
Spanish (es)
Inventor
Marc Linka Dr
Fabien Poree Dr
Bernd Laber Dr
Gudrun Lange Dr
Wayne Coco Dr
Michael Strerath Dr
Ernst Weber Dr
Nikolaus Pawlowski Dr
Sandra Geske
Balven-Ross Heike
Nina Wobst
Christina Thies
Manuel Dubald
Jan Tebbe Dr
Original Assignee
Bayer Cropscience Ag
Bayer Cropscience Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag, Bayer Cropscience Lp filed Critical Bayer Cropscience Ag
Publication of UY37626A publication Critical patent/UY37626A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)

Abstract

En la presente invención, se describen polipéptidos de HPPD y las plantas que los contienen que muestran una tolerancia plena contra uno o más herbicidas inhibidores de HPPD que pertenecen a varias clases químicas. Se diseñan un conjunto de polipéptidos de HPPD mutante que no tienen o solamente tienen una afinidad significativamente reducida a los herbicidas inhibidores de HPPD y, al mismo tiempo, la velocidad de disociación de los inhibidores de HPPD del polipéptido de HPPD mutante aumenta en tal medida que los inhibidores de HPPD se convierten en inhibidores completamente reversibles.In the present invention, HPPD polypeptides and plants containing them are described that show full tolerance against one or more HPPD inhibitor herbicides belonging to various chemical classes. A set of mutant HPPD polypeptides are designed that do not have or only have a significantly reduced affinity to the HPPD inhibitor herbicides and, at the same time, the dissociation rate of the HPPD inhibitors of the mutant HPPD polypeptide increases to such an extent that HPPD inhibitors become completely reversible inhibitors.

UY0001037626A 2017-03-07 2018-03-07 HPPD VARIATIONS AND METHODS OF USE UY37626A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762468040P 2017-03-07 2017-03-07
EP17160640 2017-03-13

Publications (1)

Publication Number Publication Date
UY37626A true UY37626A (en) 2018-09-28

Family

ID=58277228

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037626A UY37626A (en) 2017-03-07 2018-03-07 HPPD VARIATIONS AND METHODS OF USE

Country Status (2)

Country Link
UY (1) UY37626A (en)
WO (1) WO2018162330A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014356608B2 (en) * 2013-11-28 2018-09-06 Bayer Cropscience Aktiengesellschaft Use of 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to HPPD inhibitor herbicides
CN107075488A (en) * 2014-03-11 2017-08-18 拜耳作物科学股份公司 HPPD variants and application method

Also Published As

Publication number Publication date
WO2018162330A1 (en) 2018-09-13

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