UY37170A - MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- UY37170A UY37170A UY0001037170A UY37170A UY37170A UY 37170 A UY37170 A UY 37170A UY 0001037170 A UY0001037170 A UY 0001037170A UY 37170 A UY37170 A UY 37170A UY 37170 A UY37170 A UY 37170A
- Authority
- UY
- Uruguay
- Prior art keywords
- antibodies
- pharmaceutical compositions
- compositions containing
- methods
- monoclonal antibodies
- Prior art date
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan anticuerpos monoclonales aislados que se fijan a IP-10 con alta afinidad, inhiben la fijación de IP-10 a su receptor, inhiben el flujo de calcio inducido por IP-10 e inhiben la migración celular inducida por IP-10. También se proporcionan moléculas de ácido nucleico que codifican a los anticuerpos de la invención, vectores, células huésped y métodos para expresar los anticuerpos de la invención. También se proporcionan inmunoconjugados, moléculas biespecíficas y composiciones farmacéuticas que los contienen. Se divulgan métodos para inhibir la actividad de IP-10 usando los anticuerpos de la invención, y métodos para tratar distintas enfermedades inflamatorias y autoinmunitarias.Isolated monoclonal antibodies are provided that bind IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit the flow of calcium induced by IP-10 and inhibit cell migration induced by IP-10. Nucleic acid molecules encoding the antibodies of the invention, vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions containing them are also provided. Methods for inhibiting the activity of IP-10 using the antibodies of the invention, and methods for treating various inflammatory and autoimmune diseases are disclosed.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662374622P | 2016-08-12 | 2016-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37170A true UY37170A (en) | 2017-09-29 |
Family
ID=60421906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037170A UY37170A (en) | 2016-08-12 | 2017-03-27 | MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR109237A1 (en) |
TW (1) | TW201805303A (en) |
UY (1) | UY37170A (en) |
-
2017
- 2017-03-07 TW TW106107456A patent/TW201805303A/en unknown
- 2017-03-27 UY UY0001037170A patent/UY37170A/en unknown
- 2017-03-27 AR ARP170100749A patent/AR109237A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
TW201805303A (en) | 2018-02-16 |
AR109237A1 (en) | 2018-11-14 |
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