UY37170A - MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
UY37170A
UY37170A UY0001037170A UY37170A UY37170A UY 37170 A UY37170 A UY 37170A UY 0001037170 A UY0001037170 A UY 0001037170A UY 37170 A UY37170 A UY 37170A UY 37170 A UY37170 A UY 37170A
Authority
UY
Uruguay
Prior art keywords
antibodies
pharmaceutical compositions
compositions containing
methods
monoclonal antibodies
Prior art date
Application number
UY0001037170A
Other languages
Spanish (es)
Inventor
Mohan Srinivasan
Shrikant Deshpande
Qihong Zhao
Huadong Sun
Ginger RAKESTRAW
Richard Y Huang
Cristian Rodriguez
John P Throup
Rose A Dibella
Guodong Chen
Steven Sheriff
Original Assignee
Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware filed Critical Bristol-Myers Squibb Company Una Corporación Del Estado De Delaware
Publication of UY37170A publication Critical patent/UY37170A/en

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporcionan anticuerpos monoclonales aislados que se fijan a IP-10 con alta afinidad, inhiben la fijación de IP-10 a su receptor, inhiben el flujo de calcio inducido por IP-10 e inhiben la migración celular inducida por IP-10. También se proporcionan moléculas de ácido nucleico que codifican a los anticuerpos de la invención, vectores, células huésped y métodos para expresar los anticuerpos de la invención. También se proporcionan inmunoconjugados, moléculas biespecíficas y composiciones farmacéuticas que los contienen. Se divulgan métodos para inhibir la actividad de IP-10 usando los anticuerpos de la invención, y métodos para tratar distintas enfermedades inflamatorias y autoinmunitarias.Isolated monoclonal antibodies are provided that bind IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit the flow of calcium induced by IP-10 and inhibit cell migration induced by IP-10. Nucleic acid molecules encoding the antibodies of the invention, vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions containing them are also provided. Methods for inhibiting the activity of IP-10 using the antibodies of the invention, and methods for treating various inflammatory and autoimmune diseases are disclosed.

UY0001037170A 2016-08-12 2017-03-27 MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM UY37170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662374622P 2016-08-12 2016-08-12

Publications (1)

Publication Number Publication Date
UY37170A true UY37170A (en) 2017-09-29

Family

ID=60421906

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037170A UY37170A (en) 2016-08-12 2017-03-27 MONOCLONAL ANTIBODIES AGAINST IP-10 AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (3)

Country Link
AR (1) AR109237A1 (en)
TW (1) TW201805303A (en)
UY (1) UY37170A (en)

Also Published As

Publication number Publication date
TW201805303A (en) 2018-02-16
AR109237A1 (en) 2018-11-14

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