UY35763A - Compuestos de picolinamida macrocíclica con actividad fungicida. - Google Patents

Compuestos de picolinamida macrocíclica con actividad fungicida.

Info

Publication number
UY35763A
UY35763A UY0001035763A UY35763A UY35763A UY 35763 A UY35763 A UY 35763A UY 0001035763 A UY0001035763 A UY 0001035763A UY 35763 A UY35763 A UY 35763A UY 35763 A UY35763 A UY 35763A
Authority
UY
Uruguay
Prior art keywords
macrocyclic
fungicide activity
picolinamide compounds
picolinamide
compounds
Prior art date
Application number
UY0001035763A
Other languages
English (en)
Inventor
Boebel Timothy
Kevin G Meyer
James M Renga
Li Fangzheng
Yao Chenglin
Bravo-Altamirano Karla
Herrick Jessica
Wilmot Jeremy
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of UY35763A publication Critical patent/UY35763A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a las picolinamidas macrocíclicas de la fórmula I y a su uso como fungicidas.
UY0001035763A 2013-10-01 2014-10-01 Compuestos de picolinamida macrocíclica con actividad fungicida. UY35763A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361885417P 2013-10-01 2013-10-01
US201361885409P 2013-10-01 2013-10-01

Publications (1)

Publication Number Publication Date
UY35763A true UY35763A (es) 2015-04-30

Family

ID=52740742

Family Applications (2)

Application Number Title Priority Date Filing Date
UY0001035763A UY35763A (es) 2013-10-01 2014-10-01 Compuestos de picolinamida macrocíclica con actividad fungicida.
UY0001035764A UY35764A (es) 2013-10-01 2014-10-01 El uso de picolinamidas macrociclicas como fungicidas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
UY0001035764A UY35764A (es) 2013-10-01 2014-10-01 El uso de picolinamidas macrociclicas como fungicidas.

Country Status (6)

Country Link
US (3) US9629365B2 (es)
EP (2) EP3052489A4 (es)
CN (2) CN105705502A (es)
BR (2) BR112016006553A2 (es)
UY (2) UY35763A (es)
WO (2) WO2015050822A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3153020B1 (en) 2009-10-07 2018-11-28 Dow AgroSciences LLC Synergistic fungicidial mixtures for fungal control in cereals
ES2666144T3 (es) 2012-12-28 2018-05-03 Dow Agrosciences Llc Mezclas fungicidas sinérgicas para control fúngico en cereales
PL2938190T3 (pl) 2012-12-31 2018-05-30 Dow Agrosciences Llc Makrocykliczne pikolinamidy jako fungicydy
CN105705502A (zh) * 2013-10-01 2016-06-22 美国陶氏益农公司 具有杀真菌活性的大环吡啶酰胺化合物
US9549556B2 (en) 2013-12-26 2017-01-24 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
US9247741B2 (en) * 2013-12-26 2016-02-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
US20150322051A1 (en) 2014-05-06 2015-11-12 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
BR112017000104A2 (pt) 2014-07-08 2017-10-31 Dow Agrosciences Llc picolinamidas macrocíclicas como fungicidas
EP3166936A4 (en) 2014-07-08 2017-11-22 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
CA2972405A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Use of picolinamide compounds as fungicides
RU2703402C2 (ru) 2014-12-30 2019-10-16 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пиколинамиды с фунгицидной активностью
WO2016109305A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Use of picolinamides as fungicides
AU2015374458B2 (en) 2014-12-30 2018-02-15 Dow Agrosciences Llc Use of picolinamide compounds with fungicidal activity
RU2702697C2 (ru) 2014-12-30 2019-10-09 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Использование пиколинамидных соединений с фунгицидной активностью
CA2972091A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Fungicidal compositions comprising a derivative of uk-2a
US10334852B2 (en) 2016-08-30 2019-07-02 Dow Agrosciences Llc Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity
WO2018045003A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Picolinamide n-oxide compounds with fungicidal activity
WO2018044996A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Picolinamides as fungicides
US10231452B2 (en) 2016-08-30 2019-03-19 Dow Agrosciences Llc Thiopicolinamide compounds with fungicidal activity
BR102018000183B1 (pt) 2017-01-05 2023-04-25 Dow Agrosciences Llc Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta
TWI774761B (zh) 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於穀物中的真菌防治之協同性混合物
EP3618626A4 (en) 2017-05-02 2020-12-02 Dow Agrosciences LLC USE OF AN ACYCLIC PICOLINAMIDE COMPOUND AS A FUNGICIDE FOR FUNGAL GRASS INFESTATION
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
BR102019004480B1 (pt) 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
CA3115684A1 (en) 2018-10-15 2020-04-23 Dow Agrosciences Llc Methods for sythesis of oxypicolinamides

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ506249A (en) * 1998-02-06 2003-04-29 Meiji Seika Kaisha Antifungal compounds and process for producing the same from UK-2
WO2000026191A1 (fr) 1998-11-04 2000-05-11 Meiji Seika Kaisha, Ltd. Derives de picolinamide et pesticides contenant ces derives comme ingredient actif
PL206415B1 (pl) 1999-07-20 2010-08-31 Dow Agrosciences Llc Heterocykliczny amid aromatyczny, kompozycja grzybobójcza heterocyklicznego amidu aromatycznego oraz sposób zwalczania lub zapobiegania zakażeniom grzybami
US20020177578A1 (en) 1999-07-20 2002-11-28 Ricks Michael J. Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
US6355660B1 (en) 1999-07-20 2002-03-12 Dow Agrosciences Llc Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
EP1516875A1 (en) 1999-07-20 2005-03-23 Dow AgroSciences LLC Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation
US20050239873A1 (en) * 1999-08-20 2005-10-27 Fred Hutchinson Cancer Research Center 2 Methoxy antimycin a derivatives and methods of use
CZ2002487A3 (cs) * 1999-08-20 2002-06-12 Dow Agrosciences Llc Fungicidní heterocyklické aromatické amidy, prostředky na jejich bázi, způsoby jejich pouľití a přípravy
EP1412351A4 (en) 2001-07-31 2005-04-06 Dow Agrosciences Llc REDUCTIVE CLEAVAGE OF THE EXOCYCLIC ESTERS OF UK 2A OR BZW. DERIVATIVES AND PRODUCTS MADE THEREFROM
WO2003031403A2 (en) * 2001-10-05 2003-04-17 Dow Agrosciences Llc Process to produce derivatives from uk-2a derivatives
AR037328A1 (es) * 2001-10-23 2004-11-03 Dow Agrosciences Llc Compuesto de [7-bencil-2,6-dioxo-1,5-dioxonan-3-il]-4-metoxipiridin-2-carboxamida, composicion que lo comprende y metodo que lo utiliza
EP1633191A1 (de) 2003-05-28 2006-03-15 Basf Aktiengesellschaft Fungizide mischungen zur bek mpfung von reispathogenen
DE10347090A1 (de) 2003-10-10 2005-05-04 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
EA201000429A1 (ru) 2007-09-26 2010-10-29 Басф Се Трехкомпонентные фунгицидные композиции, включающие боскалид и хлороталонил
ES2552820T3 (es) 2008-05-30 2015-12-02 Dow Agrosciences Llc Métodos para combatir patógenos fúngicos QoI-resistentes
EP3153020B1 (en) 2009-10-07 2018-11-28 Dow AgroSciences LLC Synergistic fungicidial mixtures for fungal control in cereals
WO2012070015A1 (en) 2010-11-24 2012-05-31 Stemergie Biotechnology Sa Inhibitors of the activity of complex iii of the mitochondrial electron transport chain and use thereof for treating diseases
EP2847187A4 (en) 2012-05-07 2015-10-28 Dow Agrosciences Llc MACROCYCLIC PICOLINAMIDE AS FUNGICIDES
RU2014149186A (ru) 2012-05-07 2016-06-27 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Макроциклические пиколинамиды в качестве фунгицидов
US8835462B2 (en) 2012-05-07 2014-09-16 Dow Agrosciences, Llc. Macrocyclic picolinamides as fungicides
PL2938190T3 (pl) 2012-12-31 2018-05-30 Dow Agrosciences Llc Makrocykliczne pikolinamidy jako fungicydy
CN105705502A (zh) * 2013-10-01 2016-06-22 美国陶氏益农公司 具有杀真菌活性的大环吡啶酰胺化合物
WO2016007525A1 (en) * 2014-07-08 2016-01-14 Dow Agrosciences Llc Macrocyclic picolinamides as a seed treatment

Also Published As

Publication number Publication date
US9265253B2 (en) 2016-02-23
US20150094341A1 (en) 2015-04-02
US20170183324A1 (en) 2017-06-29
CN105705502A (zh) 2016-06-22
UY35764A (es) 2015-04-30
US9629365B2 (en) 2017-04-25
BR112016006874A2 (pt) 2017-08-01
CN105745205A (zh) 2016-07-06
WO2015050822A1 (en) 2015-04-09
EP3052489A4 (en) 2017-05-17
BR112016006553A2 (pt) 2017-08-01
EP3052488A4 (en) 2017-05-24
US20150094281A1 (en) 2015-04-02
EP3052488A1 (en) 2016-08-10
WO2015050820A1 (en) 2015-04-09
EP3052489A1 (en) 2016-08-10

Similar Documents

Publication Publication Date Title
UY35763A (es) Compuestos de picolinamida macrocíclica con actividad fungicida.
CO2017006827A2 (es) Picolinamidas con actividad fungicida
CO2017006835A2 (es) Compuestos de picolinamida con actividad fungicida
CO2017006852A2 (es) Uso de compuestos de picolinamida con actividad fungicida
UY36481A (es) Compuestos de picolinamida con actividad fúngicida
UY35762A (es) Uso de picolinamidas macrocíclicas como fungicidas
ECSP14027269A (es) Picolinamidas macrocíclicas como fungicidas
UY36499A (es) Uso de picolinamidas como fungicidas
BR112017013062A2 (pt) compostos picolinamida macrocíclicos com atividade fungicida.
CR20160503A (es) Compuestos de [1,2,4] triazol e imidazol sustituidos, como fungicidas
BR112016025397A2 (pt) picolinamidas macrocíclicas como fungicidas
UY37386A (es) Compuestos de tiopicolinamida con actividad antifúngica
BR102017018526A8 (pt) compostos de tiopicolinamida com atividade fungicida
BR102017018482A8 (pt) compostos de tiopicolinamida com atividade fungicida

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20211215