UY35697A - FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS - Google Patents

FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS

Info

Publication number
UY35697A
UY35697A UY35697A UY35697A UY35697A UY 35697 A UY35697 A UY 35697A UY 35697 A UY35697 A UY 35697A UY 35697 A UY35697 A UY 35697A UY 35697 A UY35697 A UY 35697A
Authority
UY
Uruguay
Prior art keywords
cd32b
specific
cd79b
monovalent
diabodies
Prior art date
Application number
UY35697A
Other languages
Spanish (es)
Inventor
Bonvini Ezio
Shah Kalpana
Leslie S Johnson
Huang Ling
Moore Paul
Chen Wei
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of UY35697A publication Critical patent/UY35697A/en

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención está dirigida a diacuerpos monovalentes bi-específicos que compren den un dominio Fc de inmunoglobulina (?diacuerpos de Fc monovalentes b i-específicos?) y están compuestos de tres cadenas de polipéptido y que poseen por lo menos un sitio de unión específico para un epítopo de CD32B y un sitio de unión específico para un epítopo de CD7 9b (es decir , un ?diacuerpo de Fc monovalente bi-específico CD32B x CD79b?). Los diacuerpos de Fc monovalentes bi-específicos de la presente invención son capaces de la unión simultánea a CD32B y CD79b. La invención está dirigida a dichas composiciones, a composiciones farmacéuticas que contienen dichos diacuerpos de Fc monovalentes bi-específicos y a métodos para su uso en el tratamiento de enfermedades o condiciones inflamatorias, y en particular, lupus eritematoso sistémico (SLE) y enfermedad de injerto contra huésped.The present invention is directed to bi-specific monovalent diabodies that purchase an immunoglobulin Fc domain (? Bi-specific monovalent Fc diabodies?) And are composed of three polypeptide chains and possess at least one specific binding site for a CD32B epitope and a specific binding site for a CD7 9b epitope (ie, a? monovalent bi-specific CD32B x CD79b? diabody). The bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to CD32B and CD79b. The invention is directed to said compositions, to pharmaceutical compositions containing said bi-specific monovalent Fc diabodies and to methods for use in the treatment of inflammatory diseases or conditions, and in particular, systemic lupus erythematosus (SLE) and graft disease against Guest.

UY35697A 2013-08-09 2014-08-06 FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS UY35697A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201313618642A 2013-08-09 2013-08-09
US201361866416P 2013-08-15 2013-08-15
US201361869519P 2013-08-23 2013-08-23
US201361907525P 2013-11-22 2013-11-22

Publications (1)

Publication Number Publication Date
UY35697A true UY35697A (en) 2015-02-27

Family

ID=52705343

Family Applications (1)

Application Number Title Priority Date Filing Date
UY35697A UY35697A (en) 2013-08-09 2014-08-06 FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS

Country Status (1)

Country Link
UY (1) UY35697A (en)

Similar Documents

Publication Publication Date Title
DOP2016000044A (en) BIO-SPECIFIC MONOVALENT FC DIACUES THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF THE SAME
CL2018000422A1 (en) Bispecific monovalent diabodies that are capable of binding to b7-h3 and cd3, and uses thereof
ECSP16096342A (en) COVALENTLY LINKED DIACBODIES HAVING IMMUNOREACTIVITY WITH PD-1 AND LAG-3, AND METHODS OF USE OF THE SAME
NI201700018A (en) ANTI-LAG3 ANTIBODIES AND ANTIGEN BINDING FRAGMENTS
CO2017012553A2 (en) Lag-3 binding molecules
CO2018009995A2 (en) Binding proteins and methods of use thereof
GT201700131A (en) COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING BMP6
DOP2017000083A (en) MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN CD19 AND CD3, AND USES OF THE SAME
PE20160193A1 (en) BISPECIFIC MONOVALENT DIACBODIES THAT CAN BE BOUND TO GPA33 AND CD3, AND USES
EA201691974A1 (en) ANTIBODIES AGAINST OX40 AND METHODS OF THEIR APPLICATION
CL2019001043A1 (en) Anti-il-33 antibodies and uses thereof.
GT201700188A (en) ANTIBODIES AGAINST TAU AND ITS USES
UY37030A (en) ANTIBODIES DIRECTED TO CD32B AND METHODS OF USE OF THE SAME
CL2020002539A1 (en) Multispecific anti-hla-g antibodies and their use
MX2024005841A (en) Methods for the use of cd32b x cd79b-binding molecules in the treatment of inflammatory diseases and disorders.
AR101671A1 (en) ANTIBODIES ANTI PROTEIN SIMILAR TO ANGIOPOYETINA-4 (ANGPTL4) AND METHODS OF USE
CL2017000212A1 (en) Angiopoietin 4-like anti-protein antibodies and methods of use
UY35697A (en) FC BI-SPECIFIC MONOVALENT SPECIFICS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF MY SMOS
AR097260A1 (en) FC BI-SPECIFIC MONOVALENT DIACUMS THAT ARE ABLE TO JOIN CD32B AND CD79B AND USES OF THE SAME
AR105714A1 (en) MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN B7-H3 AND CD3, AND USES OF THE SAME
AR097404A1 (en) MONOVALENT BIESPECFIC DIACUMS THAT ARE ABLE TO JOIN GPA33 AND CD3, AND USES OF THE SAME
ECSP17016757A (en) ANTI-LAG3 ANTIBODIES AND ANTIGEN BINDING FRAGMENTS
TH1601000655A (en) Bi-specific monovalent Fc diabody that binds CD32B and CD79b and its uses