UY32226A - DERIVATIVES OF (DIHIDRO) NAFTIRIDINONE AS ANTAGONISTS OF THE H3 HISTAMINE RECEIVER - Google Patents

DERIVATIVES OF (DIHIDRO) NAFTIRIDINONE AS ANTAGONISTS OF THE H3 HISTAMINE RECEIVER

Info

Publication number
UY32226A
UY32226A UY0001032226A UY32226A UY32226A UY 32226 A UY32226 A UY 32226A UY 0001032226 A UY0001032226 A UY 0001032226A UY 32226 A UY32226 A UY 32226A UY 32226 A UY32226 A UY 32226A
Authority
UY
Uruguay
Prior art keywords
antagonists
naftiridinone
dihidro
derivatives
histamine
Prior art date
Application number
UY0001032226A
Other languages
Spanish (es)
Inventor
Davenport Adam James
Hallett Davis James
Townsend Robert James
Marlin Frederic
Original Assignee
Evotec Neurosciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Neurosciences Gmbh filed Critical Evotec Neurosciences Gmbh
Publication of UY32226A publication Critical patent/UY32226A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La invención se refiere a compuestos de la fórmula (I) en donde X1a, X2a, X1 a X5, n y R tienen el significado citado en la descripción y las reivindicaciones. Dichos compuestos son de utilidad como antagonistas del receptor de histamina H3. La invención también se refiere a composiciones farmacéuticas, la preparación de tales compuestos, así como la producción y el uso como medicamentos.The invention relates to compounds of the formula (I) wherein X1a, X2a, X1 to X5, n and R have the meaning cited in the description and claims. Such compounds are useful as histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds, as well as the production and use as medicaments.

UY0001032226A 2008-11-07 2009-11-06 DERIVATIVES OF (DIHIDRO) NAFTIRIDINONE AS ANTAGONISTS OF THE H3 HISTAMINE RECEIVER UY32226A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08168604 2008-11-07
US18669209P 2009-06-12 2009-06-12

Publications (1)

Publication Number Publication Date
UY32226A true UY32226A (en) 2010-05-31

Family

ID=40436423

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032226A UY32226A (en) 2008-11-07 2009-11-06 DERIVATIVES OF (DIHIDRO) NAFTIRIDINONE AS ANTAGONISTS OF THE H3 HISTAMINE RECEIVER

Country Status (4)

Country Link
AR (1) AR074299A1 (en)
TW (1) TW201030000A (en)
UY (1) UY32226A (en)
WO (1) WO2010052222A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8912176B2 (en) 2009-02-02 2014-12-16 Evotec Ag Azetidines as histamine H3 receptor antagonists
CN102532006A (en) * 2012-01-31 2012-07-04 江西华士药业有限公司 Preparation method of key intermediate 6-methylpyridine-3-formaldehyde of drug for treating rheumatic arthritis and rheumatoid arthritis
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
GB201416754D0 (en) 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
CN105061305A (en) * 2015-08-31 2015-11-18 河南师范大学 Method for synthesizing 3-methylpyridine-2-carboxylic acid methyl ester in one step
EP4105216A4 (en) * 2020-02-13 2024-02-28 Genfleet Therapeutics Shanghai Inc Dihydronaphthyridinone compound, and preparation method therefor and medical use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002254114A1 (en) * 2001-03-23 2002-10-08 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
EP1595881A1 (en) * 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands

Also Published As

Publication number Publication date
AR074299A1 (en) 2011-01-05
WO2010052222A1 (en) 2010-05-14
TW201030000A (en) 2010-08-16

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