UY29991A1 - SALTS, PROMARMS AND FORMULATIONS OF 1- (5- (4-AMINO-7-ISOPROPIL-7H-PIRROLO (2,3-D) PIRIMIDIN-5-CARBON) -2-METOXI-PHENIL) -3- (2,4 -DICLORO-PHENIL) -UREA - Google Patents

SALTS, PROMARMS AND FORMULATIONS OF 1- (5- (4-AMINO-7-ISOPROPIL-7H-PIRROLO (2,3-D) PIRIMIDIN-5-CARBON) -2-METOXI-PHENIL) -3- (2,4 -DICLORO-PHENIL) -UREA

Info

Publication number
UY29991A1
UY29991A1 UY29991A UY29991A UY29991A1 UY 29991 A1 UY29991 A1 UY 29991A1 UY 29991 A UY29991 A UY 29991A UY 29991 A UY29991 A UY 29991A UY 29991 A1 UY29991 A1 UY 29991A1
Authority
UY
Uruguay
Prior art keywords
phenil
promarms
isopropil
pirimidin
metoxi
Prior art date
Application number
UY29991A
Other languages
Spanish (es)
Inventor
Franzanne Vreeland
Ravi Mysore Shanker
Douglas Alan Lorenz
Susan Deborah Lagreca
Feng Gluo
Tracy Lee Boyden
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY29991A1 publication Critical patent/UY29991A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a compuestos de la fórmula o una sal farmacéuticamente aceptable, profármaco o hidratos de los mismos. La invención también se refiere a composiciones farmacéuticas que contienen los compuestos de fórmula 1 y a métodos para tratar trastornos hiperproliferativos en un mamífero por medio de la ad ministración de los compuestos de fórmula 1.The invention relates to compounds of the formula or a pharmaceutically acceptable salt, prodrug or hydrates thereof. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods for treating hyperproliferative disorders in a mammal by means of the administration of the compounds of formula 1.

UY29991A 2005-12-09 2006-12-06 SALTS, PROMARMS AND FORMULATIONS OF 1- (5- (4-AMINO-7-ISOPROPIL-7H-PIRROLO (2,3-D) PIRIMIDIN-5-CARBON) -2-METOXI-PHENIL) -3- (2,4 -DICLORO-PHENIL) -UREA UY29991A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74907005P 2005-12-09 2005-12-09

Publications (1)

Publication Number Publication Date
UY29991A1 true UY29991A1 (en) 2007-07-31

Family

ID=38123252

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29991A UY29991A1 (en) 2005-12-09 2006-12-06 SALTS, PROMARMS AND FORMULATIONS OF 1- (5- (4-AMINO-7-ISOPROPIL-7H-PIRROLO (2,3-D) PIRIMIDIN-5-CARBON) -2-METOXI-PHENIL) -3- (2,4 -DICLORO-PHENIL) -UREA

Country Status (8)

Country Link
AR (1) AR058293A1 (en)
DO (1) DOP2006000271A (en)
GT (1) GT200600496A (en)
NL (1) NL2000337A1 (en)
PE (1) PE20071037A1 (en)
TW (1) TW200733965A (en)
UY (1) UY29991A1 (en)
WO (1) WO2007066189A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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RU2010119924A (en) * 2007-10-19 2011-11-27 Эбботт Гмбх Унд Ко.Кг (De) A PRODUCT OF A SOLID DISPERSION CONTAINING A N-Aryl Urea Compound
AU2008313622A1 (en) * 2007-10-19 2009-04-23 Abbott Gmbh & Co. Kg Solid dispersion product of N-aryl urea-based drugs
WO2010045542A2 (en) * 2008-10-16 2010-04-22 The Regents Of The University Of California Fused ring heteroaryl kinase inhibitors
US8580803B2 (en) 2009-12-30 2013-11-12 Arqule, Inc. Substituted pyrrolo-aminopyrimidine compounds
CA2802541A1 (en) * 2010-06-23 2011-12-29 Metabolex, Inc. Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
JP6342805B2 (en) 2011-09-02 2018-06-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Substituted pyrazolo [3,4-D] pyrimidine and uses thereof
US20140004192A1 (en) * 2012-04-13 2014-01-02 Ziopharm Oncology, Inc. Pharmaceutical formulations of indibulin and uses thereof
CN107383009B (en) 2012-06-13 2020-06-09 因塞特控股公司 Substituted tricyclic compounds as FGFR inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
CA2886240A1 (en) 2012-09-26 2014-04-03 The Regents Of The University Of California Modulation of ire1
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
SG11201508328PA (en) 2013-04-19 2015-11-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CN107438607B (en) 2015-02-20 2021-02-05 因赛特公司 Bicyclic heterocycles as FGFR inhibitors
MA41551A (en) 2015-02-20 2017-12-26 Incyte Corp BICYCLIC HETEROCYCLES USED AS FGFR4 INHIBITORS
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
CN107722012B (en) * 2016-08-11 2020-05-29 斯福瑞（南通）制药有限公司 Process for preparing 4-chloro-7H-pyrrolo [2,3-d ] pyrimidines
AR111960A1 (en) 2017-05-26 2019-09-04 Incyte Corp CRYSTALLINE FORMS OF A FGFR INHIBITOR AND PROCESSES FOR ITS PREPARATION
CA3099116A1 (en) 2018-05-04 2019-11-07 Incyte Corporation Salts of an fgfr inhibitor
AU2019262195B2 (en) 2018-05-04 2024-09-12 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2022552324A (en) 2019-10-14 2022-12-15 インサイト・コーポレイション Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3163875A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (en) 2019-12-04 2022-09-29 인사이트 코포레이션 Derivatives of FGFR inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US12065494B2 (en) 2021-04-12 2024-08-20 Incyte Corporation Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
JP2024522189A (en) 2021-06-09 2024-06-11 インサイト・コーポレイション Tricyclic Heterocycles as FGFR Inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0901786T3 (en) * 1997-08-11 2007-10-08 Pfizer Prod Inc Solid pharmaceutical dispersions with increased bioavailability
UA80171C2 (en) * 2002-12-19 2007-08-27 Pfizer Prod Inc Pyrrolopyrimidine derivatives

Also Published As

Publication number Publication date
WO2007066189A2 (en) 2007-06-14
TW200733965A (en) 2007-09-16
NL2000337A1 (en) 2007-06-12
WO2007066189A3 (en) 2008-08-14
PE20071037A1 (en) 2007-11-19
AR058293A1 (en) 2008-01-30
GT200600496A (en) 2007-07-17
DOP2006000271A (en) 2007-08-15

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Effective date: 20161213