UY29592A1 - AMINOPIRIMIDINS AS KINASE MODULATORS - Google Patents
AMINOPIRIMIDINS AS KINASE MODULATORSInfo
- Publication number
- UY29592A1 UY29592A1 UY29592A UY29592A UY29592A1 UY 29592 A1 UY29592 A1 UY 29592A1 UY 29592 A UY29592 A UY 29592A UY 29592 A UY29592 A UY 29592A UY 29592 A1 UY29592 A1 UY 29592A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- trkb
- kit
- flt3
- aminopirimidins
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos aminopirimidínicos de Fórmula I: donde R3, B,Z,Q,p y R1 son lo definido en la presente, al uso de tales compuestos como moduladores de proteína tirosina quinasas, en particular inhibidores de FLT3 y/o c-Kit y/oTrKB, al uso de tales compuestos para reducir o inhibir la actividad de quinasa de FLT3 y/o c-Kit y/o TrKB en una célula o un sujeto, y al uso de tales compuestos para prevenir o tratar en un sujeto un trastorno proliferativo celular y/o trastornos relacionados con FLT3 y/o c-Kit y/o TrKB. La presente invención además se refiere a composiciones farmacéuticas que comprenden los compuestos de la presente invención y a métodos para tratar afecciones tales como cánceres y otros trastornos proliferativos celulares.The invention relates to aminopyrimidine compounds of Formula I: wherein R3, B, Z, Q, and R1 are defined herein, to the use of such compounds as protein tyrosine kinase modulators, in particular FLT3 and / or c inhibitors. -Kit and / or TrKB, to the use of such compounds to reduce or inhibit the kinase activity of FLT3 and / or c-Kit and / or TrKB in a cell or a subject, and to the use of such compounds to prevent or treat in a subject a cell proliferative disorder and / or disorders related to FLT3 and / or c-Kit and / or TrKB. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68971705P | 2005-06-10 | 2005-06-10 | |
| US65108405P | 2005-12-16 | 2005-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY29592A1 true UY29592A1 (en) | 2006-10-02 |
Family
ID=38813184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY29592A UY29592A1 (en) | 2005-06-10 | 2006-06-08 | AMINOPIRIMIDINS AS KINASE MODULATORS |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY29592A1 (en) |
-
2006
- 2006-06-08 UY UY29592A patent/UY29592A1/en unknown
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