UY29587A1 - AMINOQUINOLINE AND AMINOQUINAZOLINE QUINASA MODULATORS - Google Patents
AMINOQUINOLINE AND AMINOQUINAZOLINE QUINASA MODULATORSInfo
- Publication number
- UY29587A1 UY29587A1 UY29587A UY29587A UY29587A1 UY 29587 A1 UY29587 A1 UY 29587A1 UY 29587 A UY29587 A UY 29587A UY 29587 A UY29587 A UY 29587A UY 29587 A1 UY29587 A1 UY 29587A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- aminoquinoline
- aminoquinazoline
- trkb
- flt3
- Prior art date
Links
- 150000005010 aminoquinolines Chemical class 0.000 title abstract 2
- CZAAKPFIWJXPQT-UHFFFAOYSA-N quinazolin-2-amine Chemical compound C1=CC=CC2=NC(N)=NC=C21 CZAAKPFIWJXPQT-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 3
- 101150056950 Ntrk2 gene Proteins 0.000 abstract 3
- 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 abstract 3
- 230000002062 proliferating effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 229940076155 protein modulator Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención está dirigida a compuestos aminoquinolina y aminoquinazolina de Fórmula I: en la cual R1, R2, R3, B, Z, Q, p, q y X son tal como se han definido aquí, el uso de dichos compuestos como moduladores de la proteína tirosinquinasa, particularmente inhibidores de FLT3 y/o TrKB, al uso de dichos compuestos para reducir e inhibir la actividad de quinasa de FLT3 y/o TrKB en una célula o un sujeto, y al uso de dichos compuestos para prevenir o tratar en un sujeto, un desorden y/o desórdenes proliferativos de células relacionados con FLT3 y/o TrKB. La presente invención está además dirigida a composiciones farmacéuticas que comprenden los compuestos de la presente invención y a los métodos para tratar los trastornos tales como cánceres y otros desórdenes proliferativos de células.The invention is directed to aminoquinoline and aminoquinazoline compounds of Formula I: in which R1, R2, R3, B, Z, Q, p, q and X are as defined herein, the use of said compounds as protein modulators tyrosine kinase, particularly inhibitors of FLT3 and / or TrKB, to the use of said compounds to reduce and inhibit the kinase activity of FLT3 and / or TrKB in a cell or a subject, and to the use of said compounds to prevent or treat in a subject , a disorder and / or proliferative disorders of cells related to FLT3 and / or TrKB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating disorders such as cancers and other proliferative cell disorders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UY29587A UY29587A1 (en) | 2006-06-08 | 2006-06-08 | AMINOQUINOLINE AND AMINOQUINAZOLINE QUINASA MODULATORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UY29587A UY29587A1 (en) | 2006-06-08 | 2006-06-08 | AMINOQUINOLINE AND AMINOQUINAZOLINE QUINASA MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY29587A1 true UY29587A1 (en) | 2006-10-02 |
Family
ID=38813183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY29587A UY29587A1 (en) | 2006-06-08 | 2006-06-08 | AMINOQUINOLINE AND AMINOQUINAZOLINE QUINASA MODULATORS |
Country Status (1)
| Country | Link |
|---|---|
| UY (1) | UY29587A1 (en) |
-
2006
- 2006-06-08 UY UY29587A patent/UY29587A1/en unknown
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