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Application filed by Astrazeneca AbfiledCriticalAstrazeneca Ab
Priority to UY28515ApriorityCriticalpatent/UY28515A1/en
Publication of UY28515A1publicationCriticalpatent/UY28515A1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
La invención se refiere derivados de quinazolina de Fórmula I: en donde cada uno de R1, R2, W, X1, X2, Z, a y b son según se definen en la descripción; a procesos para su preparación; a composiciones farmacéuticas que los contienen y a su uso en la fabricación de un medicamento para producir unefecto antiproliferativo.Se espera que los derivados de quinazolina de Fórmula I sean útiles en el tratamiento de enfermedades tales como determinados cánceres mediados por las tirosina quinasas del receptor ervB, en particular la tirosina quinasa EGFR:The invention relates to quinazoline derivatives of Formula I: wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; to processes for its preparation; to pharmaceutical compositions containing them and to their use in the manufacture of a medicament for producing an antiproliferative effect. Quinazoline derivatives of Formula I are expected to be useful in the treatment of diseases such as certain cancers mediated by tyrosine kinases of the ervB receptor, in particular tyrosine kinase EGFR:
[(1H-INDOL-5-IL) -HETEROARILOXI] - (1-AZA-BICICLO [3.3.1] NONANS AS N-ACHR COLLINERIC LINKS FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS
DERIVATIVES OF N- (HETERO) ARIL-PIRROLIDINA DE PIRAZO-4-IL-PIRROLO [2,3-D] PIRIMIDINES AND PIRROL-3-IL-PIRROLO [2,3-D] PYRIMIDINES AS IHNIBITORS OF THE JANUS KINASE
COMPOUNDS DERIVED FROM ESPIRO-PIPERIDINE, VASOPRESIN V1A RECEPTOR MODULATORS; OBTAINING PROCESS; PHARMACEUTICAL COMPOSITION; AND USE IN THE TREATMENT OF DISEASES SUCH AS DISMENORREA, HYPERTENSION, ANXIETY AND DEPRESSIVE DISORDERS.