UY27522A1 - PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS - Google Patents

PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS

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Publication number
UY27522A1
UY27522A1 UY27522A UY27522A UY27522A1 UY 27522 A1 UY27522 A1 UY 27522A1 UY 27522 A UY27522 A UY 27522A UY 27522 A UY27522 A UY 27522A UY 27522 A1 UY27522 A1 UY 27522A1
Authority
UY
Uruguay
Prior art keywords
alkyl
optionally substituted
treatment
pde9 inhibitors
cardiovascular disorders
Prior art date
Application number
UY27522A
Other languages
Spanish (es)
Inventor
Anthony Wood
Michael Deninno
Bernadette Hughes
Mark KEMP
Michael Palmer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126395A external-priority patent/GB0126395D0/en
Priority claimed from GB0130695A external-priority patent/GB0130695D0/en
Priority claimed from GB0216761A external-priority patent/GB0216761D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of UY27522A1 publication Critical patent/UY27522A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Cardiology (AREA)
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Abstract

La invención se refiere a los inhibidores PDE9 para el tratamiento de trastornos cardiovasculares. Los inhibidores PDE9 preferidos son compuestos de la fórmula I en los que R1 es H o alquilo C1-6, en el que R1 está unido bien a N1 o N2, R2 es alquilo C1-6 opcionalmente sustituido con hidroxi o alcoxi; cicloalquilo C3-7 opcionalmente sustituido con alquilo, hidroxi, o alcoxi; un heterociclo saturado de 5-6 miembros opcionalmente sustituido con alquilo, hidroxi o alcoxi, het1 o Ar1, R3 es al quilo C1-6 opcionalmente sustituido con 1 o 2 grupos independientemente seleccionados entre: Ar2, cicloalquilo C3-7 opcionalmente sustiuido con alquilo C1-6; OAr2; SAr2; NHC(O) alquilo C1-6; het2; xanteno; naftaleno.The invention relates to PDE9 inhibitors for the treatment of cardiovascular disorders. Preferred PDE9 inhibitors are compounds of the formula I in which R1 is H or C1-6 alkyl, wherein R1 is bonded either to N1 or N2, R2 is C1-6 alkyl optionally substituted with hydroxy or alkoxy; C3-7 cycloalkyl optionally substituted with alkyl, hydroxy, or alkoxy; a saturated 5-6 membered heterocycle optionally substituted with alkyl, hydroxy or alkoxy, het1 or Ar1, R3 is C1-6 alkyl optionally substituted with 1 or 2 groups independently selected from: Ar2, C3-7 cycloalkyl optionally substituted with C1 alkyl -6; OAr2; SAr2; NHC (O) C1-6 alkyl; het2; xanthene; naphthalene

UY27522A 2001-11-02 2002-10-30 PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS UY27522A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0126395A GB0126395D0 (en) 2001-11-02 2001-11-02 Pyrazolo[4,3]pyrimidine derivatives and their use in treating disease
GB0130695A GB0130695D0 (en) 2001-12-21 2001-12-21 Pyrazola[4,3]pyrimidine
GB0216761A GB0216761D0 (en) 2002-07-18 2002-07-18 PDE9 Inhibitors for treating cardiovascular disorders

Publications (1)

Publication Number Publication Date
UY27522A1 true UY27522A1 (en) 2003-06-30

Family

ID=27256310

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27522A UY27522A1 (en) 2001-11-02 2002-10-30 PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS

Country Status (14)

Country Link
EP (1) EP1440073A1 (en)
JP (1) JP2005511575A (en)
AR (1) AR037329A1 (en)
BR (1) BR0214096A (en)
CA (1) CA2466824A1 (en)
DO (1) DOP2002000482A (en)
HN (1) HN2002000317A (en)
MX (1) MXPA04004171A (en)
PA (1) PA8557401A1 (en)
PE (1) PE20030702A1 (en)
SV (1) SV2004001373A (en)
TW (1) TW200300081A (en)
UY (1) UY27522A1 (en)
WO (1) WO2003037899A1 (en)

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