DOP2002000482A - PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS - Google Patents

PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS

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Publication number
DOP2002000482A
DOP2002000482A DO2002000482A DO2002000482A DOP2002000482A DO P2002000482 A DOP2002000482 A DO P2002000482A DO 2002000482 A DO2002000482 A DO 2002000482A DO 2002000482 A DO2002000482 A DO 2002000482A DO P2002000482 A DOP2002000482 A DO P2002000482A
Authority
DO
Dominican Republic
Prior art keywords
alkyl
optionally substituted
treatment
pde9 inhibitors
cardiovascular disorders
Prior art date
Application number
DO2002000482A
Other languages
Spanish (es)
Inventor
Mark Ian Kemp
Anthony Wood
Michael Paul Deninno
Bernadette Hughes
Michael John Palmer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126395A external-priority patent/GB0126395D0/en
Priority claimed from GB0130695A external-priority patent/GB0130695D0/en
Priority claimed from GB0216761A external-priority patent/GB0216761D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of DOP2002000482A publication Critical patent/DOP2002000482A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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Abstract

La invención se refiere a los inhibidores PDE9 para el tratamiento de trastornos cardiovasculares. Los inhibidores PDE9 preferidos son compuestos de la fórmula I en los que R1 es H o alquilo C1-6, en el que R1 está unido bien a N1 o N2; R2 es alquilo C16 opcionalmente sustituido con hidroxi o alcoxi; cicloalquilo C3-7, opcionalmente sustituido con alquilo, hidroxi, o alcoxi; un heterociclo saturado de 5-6 miembros opcionalmente sustituido con alquilo, ,hidroxi o alcoxi; het o Ar1 R3 es alquilo c-6 opcionalmente sustituido con 1 ó 2 grupos independientemente seleccionados entre: Ar2 cicloalquilo C3-7, opcionalmente sustituido con alquilo C,6 OAr2 SAr2 NHCO alquilo C,.6 het2 xanteno; y naft1eno.The invention relates to PDE9 inhibitors for the treatment of cardiovascular disorders. Preferred PDE9 inhibitors are compounds of the formula I in which R1 is H or C1-6 alkyl, wherein R1 is well linked to N1 or N2; R2 is C16 alkyl optionally substituted with hydroxy or alkoxy; C3-7 cycloalkyl, optionally substituted with alkyl, hydroxy, or alkoxy; a saturated 5-6 membered heterocycle optionally substituted with alkyl, hydroxy or alkoxy; het or Ar1 R3 is C-6 alkyl optionally substituted with 1 or 2 groups independently selected from: Ar2 C3-7 cycloalkyl, optionally substituted with C alkyl, 6 OAr2 SAr2 NHCO C alkyl, .6 het2 xanthene; and naphthine.

DO2002000482A 2001-11-02 2002-10-09 PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS DOP2002000482A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0126395A GB0126395D0 (en) 2001-11-02 2001-11-02 Pyrazolo[4,3]pyrimidine derivatives and their use in treating disease
GB0130695A GB0130695D0 (en) 2001-12-21 2001-12-21 Pyrazola[4,3]pyrimidine
GB0216761A GB0216761D0 (en) 2002-07-18 2002-07-18 PDE9 Inhibitors for treating cardiovascular disorders

Publications (1)

Publication Number Publication Date
DOP2002000482A true DOP2002000482A (en) 2003-05-31

Family

ID=27256310

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2002000482A DOP2002000482A (en) 2001-11-02 2002-10-09 PDE9 INHIBITORS FOR TREATMENT OF CARDIOVASCULAR DISORDERS

Country Status (14)

Country Link
EP (1) EP1440073A1 (en)
JP (1) JP2005511575A (en)
AR (1) AR037329A1 (en)
BR (1) BR0214096A (en)
CA (1) CA2466824A1 (en)
DO (1) DOP2002000482A (en)
HN (1) HN2002000317A (en)
MX (1) MXPA04004171A (en)
PA (1) PA8557401A1 (en)
PE (1) PE20030702A1 (en)
SV (1) SV2004001373A (en)
TW (1) TW200300081A (en)
UY (1) UY27522A1 (en)
WO (1) WO2003037899A1 (en)

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