UY26307A1 - EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF RHINOVIRUS PROTEASE INHIBITORS AND KEY INTERMEDIATES - Google Patents
EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF RHINOVIRUS PROTEASE INHIBITORS AND KEY INTERMEDIATESInfo
- Publication number
- UY26307A1 UY26307A1 UY26307A UY26307A UY26307A1 UY 26307 A1 UY26307 A1 UY 26307A1 UY 26307 A UY26307 A UY 26307A UY 26307 A UY26307 A UY 26307A UY 26307 A1 UY26307 A1 UY 26307A1
- Authority
- UY
- Uruguay
- Prior art keywords
- synthetic routes
- preparation
- key intermediates
- protease inhibitors
- efficient synthetic
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/2435—Loop-type reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2475—Membrane reactors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Las rutas sintéticas eficientes para la preparación del rinovirus de la fórmula I, así como también los intermedios claves útiles en esas rutas sintéticas. Los compuestos de la fórmula I, así como también las composiciones farmacéuticas que contienen esos compuestos, son adecuados para el tratamiento de pacientes o huéspedes infectados con uno o más picornavirus.Efficient synthetic routes for the preparation of the rhinovirus of formula I, as well as useful key intermediates in those synthetic routes. The compounds of formula I, as well as the pharmaceutical compositions containing those compounds, are suitable for the treatment of patients or hosts infected with one or more picornaviruses.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15035899P | 1999-08-24 | 1999-08-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY26307A1 true UY26307A1 (en) | 2001-04-30 |
Family
ID=22534156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY26307A UY26307A1 (en) | 1999-08-24 | 2000-08-23 | EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF RHINOVIRUS PROTEASE INHIBITORS AND KEY INTERMEDIATES |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1206450A1 (en) |
JP (1) | JP2003507453A (en) |
KR (1) | KR20020046283A (en) |
CN (1) | CN1168713C (en) |
AR (1) | AR025380A1 (en) |
AU (1) | AU770221B2 (en) |
BR (1) | BR0013306A (en) |
CA (1) | CA2376452A1 (en) |
CO (1) | CO5200782A1 (en) |
CZ (1) | CZ2002632A3 (en) |
HK (1) | HK1049336B (en) |
HU (1) | HUP0203365A3 (en) |
IL (1) | IL147674A0 (en) |
MX (1) | MXPA02001944A (en) |
PE (1) | PE20010517A1 (en) |
PL (1) | PL353997A1 (en) |
TW (1) | TWI245040B (en) |
UY (1) | UY26307A1 (en) |
WO (1) | WO2001014329A1 (en) |
ZA (1) | ZA200200504B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2205760T3 (en) | 1998-04-30 | 2004-05-01 | Agouron Pharmaceuticals, Inc. | ANTIPICORNAVIRAL COMPOUNDS, ITS PREPARATION AND ITS USE. |
BR0012970A (en) | 1999-08-04 | 2002-04-30 | Agouron Pharma | Antipicornaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
PE20020157A1 (en) | 1999-12-03 | 2002-02-22 | Agouron Pharma | PYRIDONE DERIVED COMPOUNDS AS PICORNAVIRAL 3C PROTEASE INHIBITORS, COMPOSITIONS, THEIR PHARMACEUTICAL USES AND MATERIALS FOR THEIR SYNTHESIS |
PE20011277A1 (en) | 2000-04-14 | 2002-01-07 | Agouron Pharma | ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES AND THE MATERIALS FOR THEIR SYNTHESIS |
JP2004503533A (en) | 2000-06-14 | 2004-02-05 | アグロン・ファーマシュウティカルズ・インコーポレーテッド | Anti-picornavirus compounds and compositions, their pharmaceutical use, and substances for their synthesis |
CN1309712C (en) * | 2004-04-02 | 2007-04-11 | 中国科学院上海有机化学研究所 | Precursor of key intermediate of AG 7088 class compound and its sythetic process |
CA3174069A1 (en) | 2020-03-06 | 2021-09-10 | Pfizer Inc. | Methods of inhibiting sars-cov-2 replication and treating coronavirus disease 2019 |
CN115260074B (en) * | 2022-08-02 | 2024-06-21 | 爱斯特(成都)生物制药股份有限公司 | Preparation method of oral antiviral drug Paxlovid intermediate |
CN115322130B (en) * | 2022-08-02 | 2024-05-14 | 南京正济医药研究有限公司 | Preparation of (S) -2- (BOC-amino) -3- [ (S) -2-oxo-3-pyrrolidinyl ] propanoic acid methyl ester |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2254343A1 (en) * | 1996-05-14 | 1997-11-20 | Agouron Pharmaceuticals, Inc. | Inhibitors of picornavirus 3c proteases and methods for their use and preparation |
NZ501315A (en) * | 1997-03-28 | 2001-08-31 | Agouron Pharma | Carbonyl-ethyl-carboxamidyl-alkane and carbonyl-ethyl-thiocarboxamidyl-alkane derivatives useful as antipicornaviral agents |
US5962487A (en) * | 1997-12-16 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
ES2205760T3 (en) * | 1998-04-30 | 2004-05-01 | Agouron Pharmaceuticals, Inc. | ANTIPICORNAVIRAL COMPOUNDS, ITS PREPARATION AND ITS USE. |
-
2000
- 2000-08-22 PE PE2000000854A patent/PE20010517A1/en not_active Application Discontinuation
- 2000-08-23 CA CA002376452A patent/CA2376452A1/en not_active Abandoned
- 2000-08-23 IL IL14767400A patent/IL147674A0/en unknown
- 2000-08-23 UY UY26307A patent/UY26307A1/en not_active Application Discontinuation
- 2000-08-23 KR KR1020027002322A patent/KR20020046283A/en not_active Application Discontinuation
- 2000-08-23 JP JP2001518419A patent/JP2003507453A/en active Pending
- 2000-08-23 EP EP00955831A patent/EP1206450A1/en not_active Withdrawn
- 2000-08-23 AU AU67971/00A patent/AU770221B2/en not_active Ceased
- 2000-08-23 MX MXPA02001944A patent/MXPA02001944A/en active IP Right Grant
- 2000-08-23 BR BR0013306-0A patent/BR0013306A/en not_active IP Right Cessation
- 2000-08-23 CN CNB008118779A patent/CN1168713C/en not_active Expired - Fee Related
- 2000-08-23 HU HU0203365A patent/HUP0203365A3/en unknown
- 2000-08-23 WO PCT/US2000/023033 patent/WO2001014329A1/en not_active Application Discontinuation
- 2000-08-23 CZ CZ2002632A patent/CZ2002632A3/en unknown
- 2000-08-23 PL PL00353997A patent/PL353997A1/en not_active Application Discontinuation
- 2000-08-24 AR ARP000104401A patent/AR025380A1/en unknown
- 2000-08-24 CO CO00063457A patent/CO5200782A1/en not_active Application Discontinuation
- 2000-10-24 TW TW089117083A patent/TWI245040B/en active
-
2002
- 2002-01-21 ZA ZA200200504A patent/ZA200200504B/en unknown
-
2003
- 2003-02-27 HK HK03101461.5A patent/HK1049336B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CZ2002632A3 (en) | 2003-04-16 |
KR20020046283A (en) | 2002-06-20 |
ZA200200504B (en) | 2003-03-26 |
BR0013306A (en) | 2002-05-28 |
IL147674A0 (en) | 2002-08-14 |
MXPA02001944A (en) | 2002-10-31 |
EP1206450A1 (en) | 2002-05-22 |
HUP0203365A3 (en) | 2003-12-29 |
TWI245040B (en) | 2005-12-11 |
PL353997A1 (en) | 2003-12-15 |
CN1374947A (en) | 2002-10-16 |
PE20010517A1 (en) | 2001-05-16 |
CN1168713C (en) | 2004-09-29 |
AU770221B2 (en) | 2004-02-19 |
HUP0203365A2 (en) | 2003-02-28 |
WO2001014329A1 (en) | 2001-03-01 |
AR025380A1 (en) | 2002-11-20 |
JP2003507453A (en) | 2003-02-25 |
HK1049336A1 (en) | 2003-05-09 |
HK1049336B (en) | 2005-05-20 |
AU6797100A (en) | 2001-03-19 |
CA2376452A1 (en) | 2001-03-01 |
CO5200782A1 (en) | 2002-09-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20110721 |