AR025380A1 - THE EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF INHIBITORS OF THE PROTEASA DEL RINOVIRUS. - Google Patents

THE EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF INHIBITORS OF THE PROTEASA DEL RINOVIRUS.

Info

Publication number
AR025380A1
AR025380A1 ARP000104401A ARP000104401A AR025380A1 AR 025380 A1 AR025380 A1 AR 025380A1 AR P000104401 A ARP000104401 A AR P000104401A AR P000104401 A ARP000104401 A AR P000104401A AR 025380 A1 AR025380 A1 AR 025380A1
Authority
AR
Argentina
Prior art keywords
synthetic routes
preparation
inhibitors
rinovirus
proteasa
Prior art date
Application number
ARP000104401A
Other languages
Spanish (es)
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of AR025380A1 publication Critical patent/AR025380A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2415—Tubular reactors
    • B01J19/2435—Loop-type reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/24—Stationary reactors without moving elements inside
    • B01J19/2475—Membrane reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
    • B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
    • B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00159—Controlling the temperature controlling multiple zones along the direction of flow, e.g. pre-heating and after-cooling

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Las rutas sintéticas eficientes para la preparacion de inhibidores de la proteasa del rinovirus de la formula 1, así como también los intermedios clavesutiles en esas rutas sintéticas. Los compuestos de la formula 1, así como también lascomposicione s farmacéuticas que contienen esos compuestos, son adecuadospara el tratamiento de pacientes o huéspedes infectados con uno o más picornavirus. Los sustituyentes Z, Z1, R1 a R6 están definidos en la memoria descriptiva.The efficient synthetic routes for the preparation of rhinovirus protease inhibitors of formula 1, as well as the keyutile intermediates in those synthetic routes. The compounds of the formula 1, as well as the pharmaceutical compositions containing those compounds, are suitable for the treatment of patients or hosts infected with one or more picornaviruses. The substituents Z, Z1, R1 to R6 are defined in the specification.

ARP000104401A 1999-08-24 2000-08-24 THE EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF INHIBITORS OF THE PROTEASA DEL RINOVIRUS. AR025380A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15035899P 1999-08-24 1999-08-24

Publications (1)

Publication Number Publication Date
AR025380A1 true AR025380A1 (en) 2002-11-20

Family

ID=22534156

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000104401A AR025380A1 (en) 1999-08-24 2000-08-24 THE EFFICIENT SYNTHETIC ROUTES FOR THE PREPARATION OF INHIBITORS OF THE PROTEASA DEL RINOVIRUS.

Country Status (20)

Country Link
EP (1) EP1206450A1 (en)
JP (1) JP2003507453A (en)
KR (1) KR20020046283A (en)
CN (1) CN1168713C (en)
AR (1) AR025380A1 (en)
AU (1) AU770221B2 (en)
BR (1) BR0013306A (en)
CA (1) CA2376452A1 (en)
CO (1) CO5200782A1 (en)
CZ (1) CZ2002632A3 (en)
HK (1) HK1049336B (en)
HU (1) HUP0203365A3 (en)
IL (1) IL147674A0 (en)
MX (1) MXPA02001944A (en)
PE (1) PE20010517A1 (en)
PL (1) PL353997A1 (en)
TW (1) TWI245040B (en)
UY (1) UY26307A1 (en)
WO (1) WO2001014329A1 (en)
ZA (1) ZA200200504B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69928140D1 (en) 1998-04-30 2005-12-08 Agouron Pharma Antipicornaviral compounds, their preparation and use
WO2001010894A2 (en) 1999-08-04 2001-02-15 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
PE20020157A1 (en) 1999-12-03 2002-02-22 Agouron Pharma PYRIDONE DERIVED COMPOUNDS AS PICORNAVIRAL 3C PROTEASE INHIBITORS, COMPOSITIONS, THEIR PHARMACEUTICAL USES AND MATERIALS FOR THEIR SYNTHESIS
PA8515201A1 (en) 2000-04-14 2002-10-24 Agouron Pharma ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS; YOUR PHARMACEUTICAL USES AND MATERIALS FOR SYNTHESIS
NZ523134A (en) 2000-06-14 2004-08-27 Agouron Pharma Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
CN1309712C (en) * 2004-04-02 2007-04-11 中国科学院上海有机化学研究所 Precursor of key intermediate of AG 7088 class compound and its sythetic process
JP2021138694A (en) 2020-03-06 2021-09-16 ファイザー・インク Methods of Inhibiting SARS-CoV-2 Replication and Treating Coronavirus Disease 2019
CN115322130B (en) * 2022-08-02 2024-05-14 南京正济医药研究有限公司 Preparation of (S) -2- (BOC-amino) -3- [ (S) -2-oxo-3-pyrrolidinyl ] propanoic acid methyl ester

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2242225T3 (en) * 1996-05-14 2005-11-01 Agouron Pharmaceuticals, Inc. 3C ANTIPICORNAVIRAL PROTEASE INHIBITORS AND CORRESPONDING USE AND PREPARATION PROCEDURES.
DE69817798T2 (en) * 1997-03-28 2004-08-05 Agouron Pharmaceuticals, Inc., La Jolla COMPOUNDS AGAINST PICORNA VIRUSES, COMPOSITIONS THAT CONTAIN THESE COMPOUNDS AND METHODS FOR THEIR USE
US5962487A (en) * 1997-12-16 1999-10-05 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and methods for their use and preparation
DE69928140D1 (en) * 1998-04-30 2005-12-08 Agouron Pharma Antipicornaviral compounds, their preparation and use

Also Published As

Publication number Publication date
UY26307A1 (en) 2001-04-30
WO2001014329A1 (en) 2001-03-01
KR20020046283A (en) 2002-06-20
ZA200200504B (en) 2003-03-26
CN1168713C (en) 2004-09-29
MXPA02001944A (en) 2002-10-31
CO5200782A1 (en) 2002-09-27
AU770221B2 (en) 2004-02-19
EP1206450A1 (en) 2002-05-22
AU6797100A (en) 2001-03-19
CN1374947A (en) 2002-10-16
PL353997A1 (en) 2003-12-15
TWI245040B (en) 2005-12-11
HUP0203365A2 (en) 2003-02-28
IL147674A0 (en) 2002-08-14
HK1049336B (en) 2005-05-20
JP2003507453A (en) 2003-02-25
CZ2002632A3 (en) 2003-04-16
CA2376452A1 (en) 2001-03-01
HUP0203365A3 (en) 2003-12-29
BR0013306A (en) 2002-05-28
HK1049336A1 (en) 2003-05-09
PE20010517A1 (en) 2001-05-16

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