UY25856A1 - 4 AND 5 ALKYNYLXOXYDOLS AND 4 AND 5 ALKYNYLXOXYDOLES WHICH ARE USEFUL AS ANTI-INFLAMMATORY AGENTS - Google Patents
4 AND 5 ALKYNYLXOXYDOLS AND 4 AND 5 ALKYNYLXOXYDOLES WHICH ARE USEFUL AS ANTI-INFLAMMATORY AGENTSInfo
- Publication number
- UY25856A1 UY25856A1 UY25856A UY25856A UY25856A1 UY 25856 A1 UY25856 A1 UY 25856A1 UY 25856 A UY25856 A UY 25856A UY 25856 A UY25856 A UY 25856A UY 25856 A1 UY25856 A1 UY 25856A1
- Authority
- UY
- Uruguay
- Prior art keywords
- conr6r7
- cor4
- coor4
- halogen
- useful
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los 4- y 5-alquiniloxindoles así como 4- y 5-alqueniloxindoles que tienen la fórmula I (como: rac-(Z)-1,3-dihidro-4-[3-hidroxi-3-(4-metoxifenil)-1-propinil]-3-[(3-metoxi-1H-pirrol-2-il)metilen]-2H-indol-2-ona (H)) y II (como por ejemplo: (Z)-1,3-dihidro-5-etinil-3-[(1H-pirrol-2-il)metilen]-2H-indol-2-ona (SSS)) en donde R1 es alquilo inferior que esta sustituido por arilo, ariloxi, heteroarilo, heteroarilo R2 es H, OR4, OCOR4, COR4, COOR4, CONR6R7, NR6R7, halogeno NO2, CN, SO2R4, etc; R3 se selecciona entre H, OR4, COR4, COOR4, CONR6R7, halogeno, CN, perfluororalquilo, etc; X es =n o CH; y el enlace en lines de puntos representado por Z es opcional; R11 es H, COR4, COOR4, CONR6R7, alquilo inferior, cicloalquilo, heterociclo, arilo, etc; R12 es H, OR4, OCOR4, COR4, COOR4, CONR6R7, NR6R7, halogeno, NO2, CN, SO2R4, etc. Una composición farmacéutica que comprende como ingrediente activo un compuesto de fórmula l o ll y un vehiculo o excipiente farmacéuticamente aceptable. Uso de dichos compuestos para la preparación de un medicamento que inhiben y modulan proteína quinasas, en particular proteína quinasas JNK y son útiles como agentes antiinflamatorios, en particular en el tratamiento de la artritis reumatoide.The 4- and 5-alkynyloxyindoles as well as 4- and 5-alkenyloxyindoles having the formula I (such as: rac- (Z) -1,3-dihydro-4- [3-hydroxy-3- (4-methoxyphenyl) - 1-propynyl] -3 - [(3-methoxy-1H-pyrrol-2-yl) methylene] -2H-indole-2-one (H)) and II (such as: (Z) -1,3- dihydro-5-ethynyl-3 - [(1H-pyrrol-2-yl) methylene] -2H-indole-2-one (SSS)) where R1 is lower alkyl which is substituted by aryl, aryloxy, heteroaryl, heteroaryl R2 it is H, OR4, OCOR4, COR4, COOR4, CONR6R7, NR6R7, halogen NO2, CN, SO2R4, etc; R3 is selected from H, OR4, COR4, COOR4, CONR6R7, halogen, CN, perfluororalkyl, etc; X is = n or CH; and the link in dotted lines represented by Z is optional; R11 is H, COR4, COOR4, CONR6R7, lower alkyl, cycloalkyl, heterocycle, aryl, etc; R12 is H, OR4, OCOR4, COR4, COOR4, CONR6R7, NR6R7, halogen, NO2, CN, SO2R4, etc. A pharmaceutical composition comprising as an active ingredient a compound of formula I or II and a pharmaceutically acceptable carrier or excipient. Use of said compounds for the preparation of a medicine that inhibit and modulate protein kinases, in particular JNK protein kinases and are useful as anti-inflammatory agents, in particular in the treatment of rheumatoid arthritis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11258998P | 1998-12-17 | 1998-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25856A1 true UY25856A1 (en) | 2001-07-31 |
Family
ID=27733543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25856A UY25856A1 (en) | 1998-12-17 | 1999-12-16 | 4 AND 5 ALKYNYLXOXYDOLS AND 4 AND 5 ALKYNYLXOXYDOLES WHICH ARE USEFUL AS ANTI-INFLAMMATORY AGENTS |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR035156A1 (en) |
| CO (1) | CO5261520A1 (en) |
| PE (1) | PE20001354A1 (en) |
| UY (1) | UY25856A1 (en) |
| ZA (1) | ZA200104281B (en) |
-
1999
- 1999-12-14 PE PE1999001247A patent/PE20001354A1/en not_active Application Discontinuation
- 1999-12-14 CO CO99078061A patent/CO5261520A1/en not_active Application Discontinuation
- 1999-12-15 AR ARP990106418 patent/AR035156A1/en unknown
- 1999-12-16 UY UY25856A patent/UY25856A1/en not_active Application Discontinuation
-
2001
- 2001-05-24 ZA ZA200104281A patent/ZA200104281B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO5261520A1 (en) | 2003-03-31 |
| AR035156A1 (en) | 2004-05-05 |
| PE20001354A1 (en) | 2000-11-29 |
| ZA200104281B (en) | 2002-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20091215 |