UY25185A1 - PROCEDURE FOR PREPARING SUBSTITUTED TETRAHYDRONAPHTHALENES AND RELATED COMPOUNDS - Google Patents

PROCEDURE FOR PREPARING SUBSTITUTED TETRAHYDRONAPHTHALENES AND RELATED COMPOUNDS

Info

Publication number
UY25185A1
UY25185A1 UY25185A UY25185A UY25185A1 UY 25185 A1 UY25185 A1 UY 25185A1 UY 25185 A UY25185 A UY 25185A UY 25185 A UY25185 A UY 25185A UY 25185 A1 UY25185 A1 UY 25185A1
Authority
UY
Uruguay
Prior art keywords
carbon atoms
cycloalkyl
compounds
saturated
substituted
Prior art date
Application number
UY25185A
Other languages
Spanish (es)
Inventor
Brandes Dr
Logers Dr
Stoltefub Dr
Dr Schmidt
Bremm Dr
Schmitdt Dr
Antons Dr
Holger Paulsen Dr
Dr Muller
Paul Naab Dr
Dr Scmeck
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of UY25185A1 publication Critical patent/UY25185A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/48—Halogenated derivatives
    • C07C35/52—Alcohols with a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/192—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PREPARAN TETRAHIDRONAFTALENOS Y COMPUESTOS ANALOGOS REDUCIENDO O CONDENSANDO LOS CORRESPONDIENTES SUBTITUYENTES FUNCIONALES ANALOGOS POR METODOS HABITUALES Y TRANSFORMANDO LOS GRUPOS FUNCIONALES DE ESTE TIPO Y MODO EN LOS GRUPOS DESEADOS.LOS COMPUESTOS CONFORME A LA INVENCION SON ADECUADOS COMO PRINCIPIOS ACTIVOS EN MEDICAMENTOS,EN ESPECIAL EN MEDICAMENTOS PARA EL TRATAMIENTO DE ARTERIOSCLEROSIS ASI COMO DE DISLIPIDEMIAS. Esta invención se refiere a compuestos de fórmula (I) en la que a es cicloaquilo de 3 a 8 átomos de Carbono o representa arilo de 6 a10 átomos de carbono, o heterocilco de 5a 7 eslabones saturado o no; E es cicloalquilo de de 3 a8 átomos de C o alquilo de cadena lineal o ramificado de 8 átomos de C que dado el caso, está sustituído por cicloalquilo; R1 y R2 forman conjuntamente una cadena de alquileno lineal o ramificada de hasta 7 átomos de C que debe estar sustituída con un grupo carbonilo, etc. Ejemplo: (compuesto de partida) 8-Hidroxi-7-(metoxicarbonil)-3,3-dimetil-1-oxo-1,2,3,4-tetrahidro-6-naftilacetato de metiloTETRAHYDRONAPHTHALENES AND ANALOG COMPOUNDS ARE PREPARED BY REDUCING OR CONDENSING THE CORRESPONDING ANALOGUE FUNCTIONAL SUBTITUENTS BY COMMON METHODS AND TRANSFORMING THE FUNCTIONAL GROUPS OF THIS TYPE AND MODE INTO THE SPECIAL ASSETS CONFORMED TO THE MAIN ADDITIONAL COMPOUNDS. FOR THE TREATMENT OF ARTERIOSCLEROSIS AS WELL AS DYSLIPIDEMIAS. This invention relates to compounds of formula (I) in which a is cycloalkyl of 3 to 8 carbon atoms or represents aryl of 6 to 10 carbon atoms, or saturated or not saturated 5 to 7 membered heterocyl; E is cycloalkyl of 3 to 8 carbon atoms or straight chain or branched alkyl of 8 carbon atoms which, if appropriate, is substituted by cycloalkyl; R1 and R2 together form a straight or branched alkylene chain of up to 7 C atoms which must be substituted with a carbonyl group, etc. Example: (starting compound) 8-Hydroxy-7- (methoxycarbonyl) -3,3-dimethyl-1-oxo-1,2,3,4-tetrahydro-6-naphthylacetate

UY25185A 1997-09-18 1998-09-18 PROCEDURE FOR PREPARING SUBSTITUTED TETRAHYDRONAPHTHALENES AND RELATED COMPOUNDS UY25185A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19741050 1997-09-18
DE19832159A DE19832159A1 (en) 1997-09-18 1998-07-17 New tetrahydronaphthalene derivatives

Publications (1)

Publication Number Publication Date
UY25185A1 true UY25185A1 (en) 1999-03-15

Family

ID=7842736

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25185A UY25185A1 (en) 1997-09-18 1998-09-18 PROCEDURE FOR PREPARING SUBSTITUTED TETRAHYDRONAPHTHALENES AND RELATED COMPOUNDS

Country Status (9)

Country Link
AR (1) AR015453A1 (en)
DE (2) DE19832159A1 (en)
GT (1) GT199800147A (en)
PA (1) PA8459801A1 (en)
PE (1) PE119599A1 (en)
SV (1) SV1998000115A (en)
TN (1) TNSN98174A1 (en)
UY (1) UY25185A1 (en)
ZA (1) ZA988492B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1404302B1 (en) 2001-06-22 2010-11-03 Pfizer Products Inc. Pharmaceutical compositions comprising adsorbates of amorphous drug
EP1404300B1 (en) 2001-06-22 2009-09-30 Pfizer Products Inc. Pharmaceutical compositions of dispersions of drugs and neutral polymers
CL2004001884A1 (en) 2003-08-04 2005-06-03 Pfizer Prod Inc DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS.
US8617604B2 (en) 2005-02-03 2013-12-31 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Also Published As

Publication number Publication date
DE59812757D1 (en) 2005-06-02
PA8459801A1 (en) 2000-05-24
AR015453A1 (en) 2001-05-02
TNSN98174A1 (en) 2005-03-15
SV1998000115A (en) 1999-05-25
ZA988492B (en) 1999-03-31
GT199800147A (en) 2000-03-11
DE19832159A1 (en) 1999-03-25
PE119599A1 (en) 1999-12-30

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