PE119599A1 - SUBSTITUTED TETRAHIDRONAFTALENOS AND ANALOG COMPOUNDS - Google Patents

SUBSTITUTED TETRAHIDRONAFTALENOS AND ANALOG COMPOUNDS

Info

Publication number
PE119599A1
PE119599A1 PE1998000892A PE00089298A PE119599A1 PE 119599 A1 PE119599 A1 PE 119599A1 PE 1998000892 A PE1998000892 A PE 1998000892A PE 00089298 A PE00089298 A PE 00089298A PE 119599 A1 PE119599 A1 PE 119599A1
Authority
PE
Peru
Prior art keywords
substituted
alkyl
alkylene
cycloalkyl
halogen
Prior art date
Application number
PE1998000892A
Other languages
Spanish (es)
Inventor
Arndt Brandes
Michael Logers
Hilmar Bischoff
Delf Schmidt
Paul Naab
Holger Paulsen
Jurgen Stoltefub
Stefan Antons
Stephan Nicholas Muller
Gunter Schmidt
Carsten Schmeck
Klaus-Dieter Bremm
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE119599A1 publication Critical patent/PE119599A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/48—Halogenated derivatives
    • C07C35/52—Alcohols with a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/192—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES CICLOALQUILO C3-C8, ARILO, HETEROCICLO DE 5-7 MIEMBROS OPCIONALMENTE BENZOCONDENSADO OPCIONALMENTE SUSTITUIDOS CON CIANO, HALO, -NR3R4, ENTRE OTROS; R3 Y R4 SON H, FENILO, ALQUILO C1-C6; D ES -L-R5, -C(R6)(R7)(R8), R9-T-V-X-; R5, R6 Y R9 SON CICLOALQUILO C3-C7, ARILO, HETEROCICLO DE 5-7 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON HALOGENO, TRIFLUOROMETILO, OR10, SR11, SO2R12, -NR13R14, ENTRE OTROS; R10, R11 Y R12 SON ARILO DISUSTITUIDO; R13 Y R14 SON R2 Y R3; O R5 Y R6 JUNTOS SON COMPUESTOS DE FORMULA a, b; R7 ES H, HALOGENO, METILO; R8 ES H, HALOGENO, AZIDO, TRIFLUOROMETILO, ENTRE OTROS; O R7 Y R8 FORMAN =O, NR17; R17 ES H, ALQUILO, ALCOXI O ACILO; L ES ALQUILENO O ALQUENILENO; T Y/O X SON ALQUILENO, ENLACE; V ES O, S, NR18; R18 ES H, ALQUILO; E ES CICLOALQUILO C3-C8, ALQUILO; R1 Y R2 FORMAN JUNTOS UN ALQUILENO SUSTITUIDO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA TRATAR HIPERLIPOPROTEINEMIAS, ARTERIOSCLEROSIS, EN PARTICULAR DISLIPIDEMIASIT REFERS TO A COMPOUND OF FORMULA I, WHERE IS CYCLOALKYL C3-C8, ARYL, HETERO-CYCLE OF 5-7 MEMBERS OPTIONALLY BENZOCONENSED, SUBSTITUTED WITH CIANO, HALO, -NR3R4, AMONG OTHERS; R3 and R4 ARE H, PHENYL, C1-C6 ALKYL; D ES -L-R5, -C (R6) (R7) (R8), R9-T-V-X-; R5, R6 AND R9 ARE CYCLOALKYL C3-C7, ARYL, HETERO-CYCLE OF 5-7 MEMBERS OPTIONALLY SUBSTITUTED WITH HALOGEN, TRIFLUOROMETILE, OR10, SR11, SO2R12, -NR13R14, AMONG OTHERS; R10, R11 AND R12 ARE DISSTITUTED ARIL; R13 AND R14 ARE R2 AND R3; OR R5 AND R6 TOGETHER ARE COMPOSED OF FORMULA a, b; R7 IS H, HALOGEN, METHYL; R8 IS H, HALOGEN, AZIDO, TRIFLUOROMETILO, AMONG OTHERS; O R7 AND R8 FORMAN = O, NR17; R17 IS H, ALKYL, ALCOXY OR ACIL; L IS ALKYLENE OR ALKYLENE; T AND / OR X ARE ALKYLENE, LINK; V ES O, S, NR18; R18 IS H, ALKYL; E IS CYCLOALKYL C3-C8, ALKYL; R1 AND R2 TOGETHER TOGETHER A SUBSTITUTED ALKYLENE. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I MAY BE USEFUL FOR TREATING HYPERLIPOPROTEINEMIAS, ARTERIOSCLEROSIS, IN PARTICULAR DYSLIPIDEMIAS

PE1998000892A 1997-09-18 1998-09-17 SUBSTITUTED TETRAHIDRONAFTALENOS AND ANALOG COMPOUNDS PE119599A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19741050 1997-09-18
DE19832159A DE19832159A1 (en) 1997-09-18 1998-07-17 New tetrahydronaphthalene derivatives

Publications (1)

Publication Number Publication Date
PE119599A1 true PE119599A1 (en) 1999-12-30

Family

ID=7842736

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000892A PE119599A1 (en) 1997-09-18 1998-09-17 SUBSTITUTED TETRAHIDRONAFTALENOS AND ANALOG COMPOUNDS

Country Status (9)

Country Link
AR (1) AR015453A1 (en)
DE (2) DE19832159A1 (en)
GT (1) GT199800147A (en)
PA (1) PA8459801A1 (en)
PE (1) PE119599A1 (en)
SV (1) SV1998000115A (en)
TN (1) TNSN98174A1 (en)
UY (1) UY25185A1 (en)
ZA (1) ZA988492B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03010165A (en) 2001-06-22 2004-03-10 Pfizer Prod Inc Pharmaceutical compositions of adsorbates of amorphous drug.
JP2004534812A (en) 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク Pharmaceutical composition of dispersion of drug and neutral polymer
CL2004001884A1 (en) 2003-08-04 2005-06-03 Pfizer Prod Inc DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS.
EP1844078B1 (en) 2005-02-03 2016-09-28 Bend Research, Inc Pharmaceutical compositions with enhanced performance
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Also Published As

Publication number Publication date
SV1998000115A (en) 1999-05-25
DE59812757D1 (en) 2005-06-02
PA8459801A1 (en) 2000-05-24
GT199800147A (en) 2000-03-11
ZA988492B (en) 1999-03-31
AR015453A1 (en) 2001-05-02
UY25185A1 (en) 1999-03-15
TNSN98174A1 (en) 2005-03-15
DE19832159A1 (en) 1999-03-25

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Legal Events

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