UY24652A1 - PROCEDURE FOR THE PREPARATION OF NEW COMPOUNDS - Google Patents

PROCEDURE FOR THE PREPARATION OF NEW COMPOUNDS

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Publication number
UY24652A1
UY24652A1 UY24652A UY24652A UY24652A1 UY 24652 A1 UY24652 A1 UY 24652A1 UY 24652 A UY24652 A UY 24652A UY 24652 A UY24652 A UY 24652A UY 24652 A1 UY24652 A1 UY 24652A1
Authority
UY
Uruguay
Prior art keywords
paroxetine hydrochloride
preparation
procedure
new compounds
solvate
Prior art date
Application number
UY24652A
Other languages
Spanish (es)
Inventor
Victor Witold Jacewicz
Neal Ward
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from LU88711A external-priority patent/LU88711A1/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of UY24652A1 publication Critical patent/UY24652A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento para la preparación del anhidro de clorhidrato de paroxetina esencialmente exento de propan-2-ol, que comprende la cristalización del clorhidrato de paroxetina, ya sea: a- en un solvente orgánico o en una mezcla de solventes orgánicos que forman un solvato con el clorhidrato de paroxetina y que no pueden ser eliminados por técnicas, de secado convencionales; ya sea b- en un solvente orgánico o en una mezcla de solventes orgánicos que forman un solvato con el clorhidrato de paroxetina, pero que pueden ser eliminadosp or un secado convencional en un horno al vacío; en consecuencia en el caso a- el desplazamiento de o de los solventes solvateados utilizando un agente de desplazamiento y, en el caso b- la eliminación del solvente. Los compuestos preparados son útiles en tratamientos médicos, particularmente como antidepresivo.Process for the preparation of anhydrous paroxetine hydrochloride essentially free of propan-2-ol, which comprises the crystallization of paroxetine hydrochloride, either: a- in an organic solvent or in a mixture of organic solvents that form a solvate with the Paroxetine hydrochloride and that cannot be removed by conventional drying techniques; either b- in an organic solvent or in a mixture of organic solvents that form a solvate with paroxetine hydrochloride, but that can be removed by conventional drying in a vacuum oven; consequently in case a- the displacement of the solvated solvents using a displacement agent and, in case b- the removal of the solvent. The compounds prepared are useful in medical treatments, particularly as an antidepressant.

UY24652A 1996-02-05 1997-07-30 PROCEDURE FOR THE PREPARATION OF NEW COMPOUNDS UY24652A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU88711A LU88711A1 (en) 1995-02-06 1996-02-05 New compounds
UY24621A UY24621A1 (en) 1996-02-05 1997-07-15 NEW COMPOUNDS

Publications (1)

Publication Number Publication Date
UY24652A1 true UY24652A1 (en) 1998-01-23

Family

ID=38812479

Family Applications (2)

Application Number Title Priority Date Filing Date
UY24621A UY24621A1 (en) 1996-02-05 1997-07-15 NEW COMPOUNDS
UY24652A UY24652A1 (en) 1996-02-05 1997-07-30 PROCEDURE FOR THE PREPARATION OF NEW COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY24621A UY24621A1 (en) 1996-02-05 1997-07-15 NEW COMPOUNDS

Country Status (1)

Country Link
UY (2) UY24621A1 (en)

Also Published As

Publication number Publication date
UY24621A1 (en) 2001-08-27

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20160823