UY24036A1 - Mejoras en (o relativas a) agentes anti- protozoarios - Google Patents

Mejoras en (o relativas a) agentes anti- protozoarios

Info

Publication number
UY24036A1
UY24036A1 UY24036A UY24036A UY24036A1 UY 24036 A1 UY24036 A1 UY 24036A1 UY 24036 A UY24036 A UY 24036A UY 24036 A UY24036 A UY 24036A UY 24036 A1 UY24036 A1 UY 24036A1
Authority
UY
Uruguay
Prior art keywords
protozoal agents
antiprotozoal
combination
combinations
activity
Prior art date
Application number
UY24036A
Other languages
English (en)
Inventor
Victoria Susan Latter
William Henry George Richards
Alan Thomas Hudson
Anthony Winchester Randall
Original Assignee
The Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Ltd filed Critical The Wellcome Foundation Ltd
Publication of UY24036A1 publication Critical patent/UY24036A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Laminated Bodies (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento para peparar una formulación terapéutica que comprende una combinación de 2-(4-(4`-clorofenil ) ciclohexil )-3-hidroxi-1,4-naftoquinona y un 4-piridinol o un éster alcanoico del mismo donde la proporción en peso de la naftoquinona al 4-piridinol o éster alcanoico del mismo es una proporción potenciadora dentro de la gama de 1:500 a 1:1, cuyo procedimiento comprende llevar dicha combinación a asociación con un vehículo farmacéutico aceptable para la misma. La conbinación de naftoquinona del invento con piridinol, como agente terapéutico, por ejemplo para usar en el tratamiento o profiláxis de una enfermedad causada por protozoarios. Estas enfermedades incluyen la coccidiosis e infecciones en el caso de malaria. Los piridinoles preferidos incluyen aquellos de la formula II en la cual cada R3 es igual o diferentes y es un grupo alquilo con uno a cuatro átomos de C y cada X es igual o diferente y es un halógeno o un éster alcanoico con uno o seis átomos de C del mismo. Los compuestos preferidos de fórmula II incluyen: 3,5 -dicloro-2,6-dimertil-4-piridinol; 3,5-dibromo-2,6-dimetil-4-piridinol
UY24036A 1983-04-14 1995-09-13 Mejoras en (o relativas a) agentes anti- protozoarios UY24036A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838310140A GB8310140D0 (en) 1983-04-14 1983-04-14 Antiprotozoal agents

Publications (1)

Publication Number Publication Date
UY24036A1 true UY24036A1 (es) 1995-09-18

Family

ID=10541104

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24036A UY24036A1 (es) 1983-04-14 1995-09-13 Mejoras en (o relativas a) agentes anti- protozoarios

Country Status (13)

Country Link
US (1) US5053418A (es)
EP (2) EP0401875B1 (es)
JP (1) JPS59205316A (es)
AT (2) ATE67089T1 (es)
AU (1) AU574354B2 (es)
CY (1) CY1862A (es)
DE (2) DE3485033D1 (es)
GB (1) GB8310140D0 (es)
HK (1) HK129695A (es)
IL (1) IL71546A (es)
PH (1) PH22010A (es)
UY (1) UY24036A1 (es)
ZA (1) ZA842796B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8500292D0 (en) * 1985-01-07 1985-02-13 Wellcome Found Treatment of babesiosis
US5225184A (en) * 1988-08-16 1993-07-06 Burroughs Wellcome Co. Medicaments
GB8819477D0 (en) * 1988-08-16 1988-09-21 Wellcome Found Medicaments
AU633836B2 (en) * 1988-08-16 1993-02-11 Wellcome Foundation Limited, The Medicaments
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
GB8921516D0 (en) * 1989-09-22 1989-11-08 Wellcome Found Medicaments
EP0567162A1 (en) * 1989-09-22 1993-10-27 The Wellcome Foundation Limited Medicaments for the treatment of toxoplasmosis
GB8923254D0 (en) * 1989-10-16 1989-12-06 Wellcome Found Medicaments
GB9005518D0 (en) * 1990-03-12 1990-05-09 Wellcome Found Heterocyclic compounds
US5403934A (en) * 1990-03-12 1995-04-04 Burroughs Wellcome Co. Heterocyclic compounds
GB9126874D0 (en) * 1991-12-18 1992-02-19 Wellcome Found Medicaments
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
GB9226905D0 (en) * 1992-12-24 1993-02-17 Wellcome Found Pharmaceutical preparation
GB9410299D0 (en) * 1994-05-20 1994-07-13 British Tech Group Naphthoquinone derivatives
US5684035A (en) * 1996-07-17 1997-11-04 Kapadia; Govind J. Antimalarial agents
BRPI0513951A (pt) * 2004-07-30 2008-05-20 Japan Health Science Found agente antiprotozoário
EP2246329A1 (en) 2009-01-19 2010-11-03 Glaxo Group Limited 4(1H)-pyridinone derivatives and their use as antimalaria agents
WO2010081904A1 (en) 2009-01-19 2010-07-22 Glaxo Group Limited 4 ( 1h) -pyridinone derivatives and their use as antimalaria agents
EP2408467A2 (en) * 2009-03-20 2012-01-25 University Of South Florida A method and composition using a dual specificity protein tyrosine phosphatase as an antimalarial drug target

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553647A (en) * 1946-03-20 1951-05-22 Research Corp Naphthoquinone antimalarials
US2553648A (en) 1948-01-08 1951-05-22 Research Corp Naphthoquinone compounds
NL124395C (es) 1963-09-25
US3347742A (en) 1965-05-28 1967-10-17 Merck & Co Inc 2-(4-cyclohexylcyclohexyl)-3-hydroxy-1, 4-naphthoquinone in controlling coccidiosis in poultry
US3367830A (en) 1965-06-23 1968-02-06 Merck & Co Inc Controlling coccidiosis in poultry with 1,4-naphthoquinones
AU458235B2 (en) * 1971-02-09 1975-02-20 Shionogi & Co., Ltd Quinone derivatives and compositions containing thesame
FI762480A (es) 1975-09-15 1977-03-16 Du Pont
GB1553424A (en) 1976-02-10 1979-09-26 Wellcome Found Method of treating protozal diseases
EG14152A (en) 1977-11-22 1983-12-31 Wellcome Found Antitheilerial naphtoquinone derivatives
US4485116A (en) 1981-10-16 1984-11-27 Hudson Alan T Antiprotozoal compounds
US4485117A (en) * 1981-10-16 1984-11-27 Hudson Alan T Antiprotozoal compounds
GB8310141D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Naphthoquinone derivatives

Also Published As

Publication number Publication date
CY1862A (en) 1996-04-05
DE3486189D1 (de) 1993-09-02
JPH0481568B2 (es) 1992-12-24
EP0401875A3 (en) 1990-12-27
EP0123239A3 (en) 1987-11-25
AU574354B2 (en) 1988-07-07
DE3485033D1 (de) 1991-10-17
EP0123239A2 (en) 1984-10-31
ATE67089T1 (de) 1991-09-15
US5053418A (en) 1991-10-01
ATE91892T1 (de) 1993-08-15
GB8310140D0 (en) 1983-05-18
DE3486189T2 (de) 1994-03-03
HK129695A (en) 1995-08-24
IL71546A0 (en) 1984-07-31
EP0123239B1 (en) 1991-09-11
EP0401875B1 (en) 1993-07-28
PH22010A (en) 1988-05-02
IL71546A (en) 1987-08-31
JPS59205316A (ja) 1984-11-20
EP0401875A2 (en) 1990-12-12
AU2679784A (en) 1984-10-18
ZA842796B (en) 1985-11-27

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Legal Events

Date Code Title Description
VENC Patent expired

Effective date: 20140615